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    • 6. 发明授权
    • Chemiluminescent 1,2-dioxetanes
    • 化学发光的1,2-二氧杂环丁烷
    • US6140495A
    • 2000-10-31
    • US296539
    • 1999-04-22
    • Irena BronsteinBrooks EdwardsAlison Sparks
    • Irena BronsteinBrooks EdwardsAlison Sparks
    • C07D321/00C07D327/06C07F9/02C07F9/06C07F9/28C07H19/04
    • C07D321/00
    • Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an enzyme with which the dioxetane is permitted to come in contact with. The T.sub.1/2 kinetics of the chemiluminescent reaction, as well as the signal intensity, or quantum yield of the chemiluminescent reaction, can be altered by selection of an electron-withdrawing or an electron-donating group Z, at positions on the aromatic substituent other than those adjacent the point of attachment to the dioxetane. Signal strength can further be enhanced by recognized chemiluminescent enhancers.
    • 具有烷氧基取代基的双金刚烷基二氧杂环丁烷和二氧杂环丁烷环上苯基或萘基的芳族取代基可以被活化成化学发光,如果芳族取代基具有指定为OX的部分,其中X被允许二氧杂环丁烷的酶切割 在与接触。 化学发光反应的T + E,1/2 + EE动力学以及化学发光反应的信号强度或量子产率可以通过选择吸电子基团或给电子基团Z来改变, 在芳族取代基上除了与二氧杂环丁烷的连接点相邻的位置之外的位置。 信号强度可以通过认可的化学发光增强剂进一步增强。
    • 7. 发明授权
    • Chemiluminescent 1,2-dioxetanes
    • 化学发光的1,2-二氧杂环丁烷
    • US6022964A
    • 2000-02-08
    • US904847
    • 1997-08-01
    • Irena BronsteinBrooks EdwardsAlison Sparks
    • Irena BronsteinBrooks EdwardsAlison Sparks
    • C07D321/00C07D327/06C07F9/02C07F9/06C07F9/28C07H19/04
    • C07D321/00
    • Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an enzyme with which the dioxetane is permitted to come in contact with. The T.sub.1/2 kinetics of the chemiluminescent reaction, as well as the signal intensity, or quantum yield of the chemiluminescent reaction, can be altered by selection of an electron-withdrawing or an electron-donating group Z, at positions on the aromatic substituent other than those adjacent the point of attachment to the dioxetane. Signal strength can further be enhanced by recognized chemiluminescent enhancers.
    • 具有烷氧基取代基的双金刚烷基二氧杂环丁烷和二氧杂环丁烷环上苯基或萘基的芳族取代基可以被活化成化学发光,如果芳族取代基具有指定为OX的部分,其中X被允许二氧杂环丁烷的酶切割 在与接触。 化学发光反应的T1 / 2动力学,以及化学发光反应的信号强度或量子产率可以通过选择吸电子基团或给电子基团Z来改变芳香族取代基上的位置 比邻近二氧杂环丁烷的点附近的那些。 信号强度可以通过认可的化学发光增强剂进一步增强。
    • 8. 发明授权
    • Chemiluminescent 1,2-dioxetanes
    • 化学发光的1,2-二氧杂环丁烷
    • US06346615B1
    • 2002-02-12
    • US09656213
    • 2000-09-06
    • Irena BronsteinBrooks EdwardsAlison Sparks
    • Irena BronsteinBrooks EdwardsAlison Sparks
    • C07H1904
    • C07D321/00
    • Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an enzyme with which the dioxetane is permitted to come in contact with. The T½ kinetics of the chemiluminescent reaction, as well as the signal intensity, or quantum yield of the chemiluminescent reaction, can be altered by selection of an electron-withdrawing or an electron-donating group Z, at positions on the aromatic substituent other than those adjacent the point of attachment to the dioxetane. Signal strength can further be enhanced by recognized chemiluminescent enhancers.
    • 具有烷氧基取代基的双金刚烷基二氧杂环丁烷和二氧杂环丁烷环上苯基或萘基的芳族取代基可以被活化成化学发光,如果芳族取代基具有指定为OX的部分,其中X被允许二氧杂环丁烷的酶切割 在与接触。 化学发光反应的T 1/2动力学,以及化学发光反应的信号强度或量子产率可以通过选择吸电子基团或给电子基团Z来改变芳香族取代基以外的芳香族取代基的位置 邻近二氧杂环丁烷的连接点。 信号强度可以通过认可的化学发光增强剂进一步增强。