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1. 发明授权

EP0954341B1 LENTILLE INTRAOCULAIRE CONTENANT UN MEDICAMENT RELARGABLE 失效
标题翻译： LENTILLE INTRAOCULAIRE CONTENTANT UNARMAMENT RELARGABLE
公开(公告)号：EP0954341B1
公开(公告)日：2007-02-28
申请号：EP97951333.0
申请日：1997-12-15
申请人： Ioltechnologie-Production
发明人： AIACHE, Jean-Marc , SERPIN, Gilbert , EL MESKI, Said , TOURRETTE, Philippe
IPC分类号： A61L27/54 , A61F2/16
CPC分类号： A61L27/54 , A61L2300/41 , A61L2300/602 , A61L2430/16
摘要： The invention relates to an intraocular lens, of a hard or soft material, intended for implantation in the eye of a subject, and notably for substitution during a surgical operation of a defective crystalline lens. The lens comprises a polymer with a specified hydrophilic rate, containing a medicated product spread throughout its mass, the effects of which are suited to the circumstances of the operation, and in particular the at least partial inhibition of the post-operative reactions of the eye. The combination of the polymer and the medicated product results in the gradual release of the product into the aqueous humor. The figure herewith demonstrates the evolution of the indomethacin content in the aqueous humor and plasma of a rabbit implanted with a hydroxyethyl methacrylate lens containing in its mass this anti-inflammatory. Clinically, the inflammatory response had disappeared prior to the second day.
摘要翻译：本发明涉及用于植入对象眼睛中的硬或软材料的人工晶状体，特别是用于在有缺陷晶状体的外科手术过程中进行替代。该镜片包含具有特定亲水速率的聚合物，其含有散布在其整个团块中的药物，其作用适合于手术情况，特别是至少部分抑制眼睛的手术后反应。聚合物和加药产品的组合导致产品逐渐释放到房水中。本图显示了植入甲基丙烯酸羟乙酯晶状体的兔子的房水和血浆中吲哚美辛含量的变化，所述甲基丙烯酸羟乙基酯晶状体大量含有这种抗炎剂。临床上，炎症反应在第二天之前已经消失。

2. 发明授权

EP0954341B9 LENTILLE INTRAOCULAIRE CONTENANT UN MEDICAMENT RELARGABLE 失效
标题翻译：药物人工晶状体分配
公开(公告)号：EP0954341B9
公开(公告)日：2007-09-19
申请号：EP97951333.0
申请日：1997-12-15
申请人： Ioltechnologie-Production
发明人： AIACHE, Jean-Marc , SERPIN, Gilbert , EL MESKI, Said , TOURRETTE, Philippe
IPC分类号： A61L27/54 , A61F2/16
CPC分类号： A61L27/54 , A61L2300/41 , A61L2300/602 , A61L2430/16
摘要： The invention relates to an intraocular lens, of a hard or soft material, intended for implantation in the eye of a subject, and notably for substitution during a surgical operation of a defective crystalline lens. The lens comprises a polymer with a specified hydrophilic rate, containing a medicated product spread throughout its mass, the effects of which are suited to the circumstances of the operation, and in particular the at least partial inhibition of the post-operative reactions of the eye. The combination of the polymer and the medicated product results in the gradual release of the product into the aqueous humor. The figure herewith demonstrates the evolution of the indomethacin content in the aqueous humor and plasma of a rabbit implanted with a hydroxyethyl methacrylate lens containing in its mass this anti-inflammatory. Clinically, the inflammatory response had disappeared prior to the second day.

3. 发明公开

EP0954341A1 LENTILLE INTRAOCULAIRE CONTENANT UN MEDICAMENT RELARGABLE 失效
标题翻译：药物人工晶状体分配
公开(公告)号：EP0954341A1
公开(公告)日：1999-11-10
申请号：EP97951333.0
申请日：1997-12-15
申请人： Ioltechnologie-Production
发明人： AIACHE, Jean-Marc , SERPIN, Gilbert , EL MESKI, Said , TOURRETTE, Philippe
IPC分类号： A61L27 , A61F2
CPC分类号： A61L27/54 , A61L2300/41 , A61L2300/602 , A61L2430/16
摘要： The invention relates to an intraocular lens, of a hard or soft material, intended for implantation in the eye of a subject, and notably for substitution during a surgical operation of a defective crystalline lens. The lens comprises a polymer with a specified hydrophilic rate, containing a medicated product spread throughout its mass, the effects of which are suited to the circumstances of the operation, and in particular the at least partial inhibition of the post-operative reactions of the eye. The combination of the polymer and the medicated product results in the gradual release of the product into the aqueous humor. The figure herewith demonstrates the evolution of the indomethacin content in the aqueous humor and plasma of a rabbit implanted with a hydroxyethyl methacrylate lens containing in its mass this anti-inflammatory. Clinically, the inflammatory response had disappeared prior to the second day.

4. 发明授权

EP1465594B1 FORME GALENIQUE SOLIDE POUR L ADMINISTRATION OCULAIRE DE PRINCIPE ACTIF, INSERT OPHTALMIQUE SOLIDE ET SOLUBLE ET PROCEDE DE FABRICATION D'UN TEL INSERT 有权转让
标题翻译： “固体剂型用于生产活性物质的眼应用，可溶性固形物的眼科插入并处理”的
公开(公告)号：EP1465594B1
公开(公告)日：2010-07-21
申请号：EP02804932.8
申请日：2002-12-17
申请人： Ioltechnologie-Production
发明人： EL MESKI, Said , TOURRETTE, Philippe , AIACHE, Jean-Marc , DI BATTISTA, Marie , SERPIN, Gilbert
IPC分类号： A61K9/00 , A61K47/38
CPC分类号： A61K47/38 , A61K9/0051

5. 发明公开

EP1465594A1 FORME GALENIQUE SOLIDE POUR L ADMINISTRATION OCULAIRE DE PRINCIPE ACTIF, INSERT OPHTALMIQUE SOLIDE ET SOLUBLE ET PROCEDE DE FABRICATION D'UN TEL INSERT 有权转让
标题翻译： “固体剂型用于生产活性物质的眼应用，可溶性固形物的眼科插入并处理”的
公开(公告)号：EP1465594A1
公开(公告)日：2004-10-13
申请号：EP02804932.8
申请日：2002-12-17
申请人： Ioltechnologie-Production
发明人： EL MESKI, Said , TOURRETTE, Philippe , AIACHE, Jean-Marc , DI BATTISTA, Marie , SERPIN, Gilbert
IPC分类号： A61K9/00 , A61K47/38
CPC分类号： A61K47/38 , A61K9/0051
摘要： The invention relates to a solid dosage form for the ocular administration of an active principle comprising at least one biocompatible, water-soluble excipient for ophthalmic use. The inventive form is obtained using a method which is selected from among the following: direct compression, dry compression, wet compression, compression of a lyophilizate, said compression being carried out a temperature below 45 °C, or lyophilisation, such that the form can disintegrate and release the active principle in the conjunctival sac. The invention also relates to an ophthalmic insert comprising the aforementioned dosage form which is appropriately dimensioned for ocular administration.

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