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1. 发明公开

EP2369345A1 Glycoconjugates and their use as potential vaccines against infection by shigella flexneri 有权
标题翻译： Glycokonjugate，und deren Verwendung als potentielle Impfstoffe gegen志贺氏菌志贺氏菌感染。
公开(公告)号：EP2369345A1
公开(公告)日：2011-09-28
申请号：EP10011475.0
申请日：2004-07-02
申请人： Institut Pasteur , INSERM - Institut National de la Santé et de la Recherche Médicale , Centre National De La Recherche Scientifique CNRS
发明人： Phalipon, Armelle , Nato, Farida , Mulard, Laurence , Sansonetti, Philippe , Baleux, Francoise , Belot, Frédéric , Grandjean, Cyrille
IPC分类号： G01N33/569 , C07K16/12 , A61K47/48 , C07H3/06 , G01N33/563 , A61K39/112
CPC分类号： A61K39/0283 , A61K47/557 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6031 , A61K2039/6037 , A61K2039/625 , C07H3/06 , C07K16/1228 , C07K2317/565 , C08B37/006 , G01N33/563 , G01N33/56916 , Y02A50/476
摘要： The present invention relates to a saccharide selected from the group consisting of:

{B(E)CD}

{(E)CDAB}n

{AB(E)CD}n

Wherein A, B, C, E, D and n are as defined in claim 1. The invention also relates to derivatives thereof, pharmaceutical compositions comprising said derivatives, and kit for the diagnostic of Shigella flexneri type 2a infection comprising said derivatives.
摘要翻译：本发明涉及一种选自以下的糖类：ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{B（E）CD}€ƒ€ƒ€ƒ€ƒ€ƒ€ ƒ€ƒ{（E）CDAB} n€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{AB（E）CD} n其中A，B，C，E，D和n如本发明还涉及其衍生物，包含所述衍生物的药物组合物和用于诊断包括所述衍生物的福氏志贺氏菌2a型感染的试剂盒。

2. 发明授权

EP2369345B1 Glycoconjugates and their use as potential vaccines against infection by shigella flexneri 有权
标题翻译：糖复合物，并感染其用作抗痢疾杆菌潜在的疫苗。
公开(公告)号：EP2369345B1
公开(公告)日：2014-10-01
申请号：EP10011475.0
申请日：2004-07-02
申请人： Institut Pasteur , INSERM - Institut National de la Santé et de la Recherche Médicale , Centre National de la Recherche Scientifique (CNRS)
发明人： Phalipon, Armelle , Nato, Farida , Mulard, Laurence , Sansonetti, Philippe , Baleux, Francoise , Belot, Frédéric , Grandjean, Cyrille
IPC分类号： G01N33/569 , C07K16/12 , A61K47/48 , C07H3/06 , G01N33/563 , A61K39/112
CPC分类号： A61K39/0283 , A61K47/557 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6031 , A61K2039/6037 , A61K2039/625 , C07H3/06 , C07K16/1228 , C07K2317/565 , C08B37/006 , G01N33/563 , G01N33/56916 , Y02A50/476
摘要： The present invention relates to a saccharide selected from the group consisting of: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{B(E)CD} €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{(E)CDAB}n €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{AB(E)CD}n Wherein A, B, C, E, D and n are as defined in claim 1. The invention also relates to derivatives thereof, pharmaceutical compositions comprising said derivatives, and kit for the diagnostic of Shigella flexneri type 2a infection comprising said derivatives.

3. 发明公开

EP2567968A1 Polypeptides targeting glycosylated Muc2 proteins, methods of synthesis, their nucleic acids and uses therof 审中-公开
标题翻译：针对糖基化的蛋白质MUC2多肽，合成的方法中，核酸和它们的用途
公开(公告)号：EP2567968A1
公开(公告)日：2013-03-13
申请号：EP11290403.2
申请日：2011-09-09
申请人： Institut Pasteur
发明人： Marteyn, Benoit Sébastien , Coic, Yves-Marie , Baleux, Françoise , Sansonetti, Philippe
IPC分类号： C07K14/195 , C07K14/335 , C07K1/06 , A61K38/16 , C12N1/15 , C12N1/21 , C12N5/10 , G01N33/68 , G01N33/58
CPC分类号： C07K14/335 , C07K7/08 , C07K14/195 , C07K14/315 , C07K2319/60 , C07K2319/61 , C12P21/02 , G01N33/6893
摘要： The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence comprises or consists of the consensus sequence P1(X a )P3(X b )P5(X c )P6(X d )P7, presenting specific patterns.
The polypeptides of the invention target glycosylated Muc2 proteins. The invention also relates to methods of synthesis of such polypeptides, to their nucleic acids and uses thereof. The polypeptidic sequence of the polypeptides of the invention can be part of the N-terminal sequence of a mucus-binding (MUB) domain, especially a mucus-binding (MUB) domain of several species. The invention also relates to chimeric molecule(s) comprising such polypeptides, which are labelled, and vectors, especially plasmids and population of cells or composition comprising polypeptides of the invention.
Synthesis methods encompass biotechnological or chemical production.
Polypeptides of the invention can be used in staining experiments, as a probe or marker for staining Muc2 protein(s) contained in mucus layer(s), to detect in vitro mucus production or mucus composition in human colon or monitoring any one of the following disease conditions: neoplasic disease(s), including mucinous carcinoma(s), gastric cancer(s) or colorectal cancer(s), especially colon cancer(s), cystic fibrosis, intestine inflammatory disease(s) such as inflammatory bowel disease (IBD) and ulcerative colitis.
The invention also relates to a method for manufacturing a medicament.
In a particular embodiment, use of polypeptides of the invention can be made for marking neutrophiles.
摘要翻译：本发明涉及通过共有序列定义的多肽，具有10至80个氨基酸残基，且其对多肽类序列包含或共有序列P1（XA）P3（X B）P5（X c）中的besteht长度 P6（X D）P7，呈现特定图案。本发明目标的多肽糖基化的蛋白质MUC2。因此，本发明涉及谋求多肽及其核酸及其用途的合成方法。本发明的多肽的多肽性序列可以是粘液结合（MUB）结构域的N-末端序列的一部分，尤其是爱粘液结合（MUB）几个物种的结构域。因此，本发明涉及嵌合分子（多个）被标记包括搜索多肽和载体，质粒特别喜欢和细胞或组合物包含本发明的多肽的群体。合成方法包括生物技术和化工生产。本发明的多肽可以在染色实验中使用，作为探针或标记物用于染色包含在粘液层（一个或多个）MUC2蛋白（S），以检测在体外粘液产生或在人结肠粘液组合物或监测以下中的任何一个疾病病症：肿瘤性疾病（一个或多个），包括粘液癌（S），胃癌（S）或结肠直肠癌（S），特别是结肠癌（S），囊性纤维化，肠的炎性疾病（一个或多个）：如炎性肠疾病（ IBD）和溃疡性结肠炎。因此本发明涉及一种用于制造药物的方法。在特定实施例中，使用本发明的多肽可用于标记的中性粒细胞进行。

4. 发明公开

EP2915878A1 Method and device for conserving viable and functional human polymorphonuclear neutrophils 审中-公开
标题翻译：对于可行的和功能性人中性粒细胞的保存方法和装置
公开(公告)号：EP2915878A1
公开(公告)日：2015-09-09
申请号：EP14158437.5
申请日：2014-03-07
申请人： INSTITUT PASTEUR
发明人： Marteyn, Benoit , Sansonetti, Philippe , Monceaux, Valérie , Ungeheuer, Marie-Noelle
IPC分类号： C12N5/0787
CPC分类号： C12N5/0642 , C12N2500/02 , C12N2500/34 , C12N2501/73
摘要： A method for keeping leukocytes alive ex vivo or in vitro, comprising maintaining the leukocytes in a medium comprising from 3 to 10 mM of glucose, in hypoxic conditions with P(O 2 ) ≤ 10 mM Hg.
摘要翻译：一种用于保活白细胞离体或在体外，包括在包含3至葡萄糖，在缺氧条件下用P（O 2）‰¤10毫米汞柱10mM的介质维护白细胞的方法。

5. 发明公开

EP0170584A3 DNA probe and method for the detection of Shigella and entero-invasive strains of Escherichia coli 有权
标题翻译： DNA探针及其检测方法，用于检测鹅掌楸和肠内寄生菌株
公开(公告)号：EP0170584A3
公开(公告)日：1986-03-12
申请号：EP85401435
申请日：1985-07-12
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： Sansonetti, Philippe , Boileau, Catherine , D'Hauteville, Hélène
IPC分类号： C12Q01/68 , C12Q01/10
CPC分类号： C07K14/25 , C12Q1/689 , Y10S435/81 , Y10S436/808

6. 发明公开

EP1703281A1 Souches bactériennes induisant une diminution de l'expression de Rbx1 审中-公开
标题翻译： Bakterienstämme，die einer Abnahme der Expression von Rbx1 leiten
公开(公告)号：EP1703281A1
公开(公告)日：2006-09-20
申请号：EP05290579.1
申请日：2005-03-16
申请人： COMPAGNIE GERVAIS DANONE , INSTITUT PASTEUR
发明人： Pedron, Thierry , Sansonetti, Philippe , Girardin, Stéphane , Bourdet-Sicard, Raphaelle
IPC分类号： G01N33/50 , C12Q1/04 , C12R1/24 , C12R1/225
CPC分类号： C12R1/225 , C12N1/20 , G01N33/5064
摘要： L'invention concerne la sélection de souches bactériennes dotées de propriétés anti-inflammatoires, sur la base de leur capacité à diminuer l'expression du gène Rbxl.
摘要翻译：在不存在细菌的情况下，将观察到的细菌存在的基因表达水平与对照培养物进行比较，并且观察到的水平的细菌的选择比观察到的对照培养物低4倍。细胞在10-10 3 u.f.c（克隆形成单位）存在下细胞培养16小时。基因表达的水平通过评估转录基因的量/测量由细胞表达的蛋白质rbx-1来确定，并且该方法进一步包括实施和培养所选择的细菌。筛选具有抗炎特性的细菌，包括孵育上皮细胞培养物，确定rbx-1基因表达水平，比较观察到的水平和在观察到的水平存在下选择细菌。在不存在细菌的情况下，将观察到的细菌存在的基因表达水平与对照培养物进行比较，并且观察到的水平的细菌的选择比观察到的对照培养物低4倍。细胞在10-10 3 cfu（菌落形成单位）存在下细胞培养16小时。基因表达的水平通过评估转录基因的量/测量由细胞表达的蛋白质rbx-1来确定，并且该方法进一步包括实施和培养所选择的细菌。还包括：（1）细菌; （2）包含细菌的食物组合物; 和（3）合奏。

7. 发明公开

EP0351322A1 Transformed Shigella 有权
标题翻译：变形杆菌志贺氏菌
公开(公告)号：EP0351322A1
公开(公告)日：1990-01-17
申请号：EP89402024.7
申请日：1989-07-13
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： Sansonetti, Philippe , Fontaine, Annick
IPC分类号： C12N15/00 , A61K39/112
CPC分类号： C12N15/00 , A61K39/0283 , A61K2039/522 , C07K14/25 , Y02A50/476
摘要： A method for modifying a wild strain of an entero-invasive Shigella to produce a modified strain of Shigella that can be used for making a vaccine against the wild strain of Shigella . The genome of the wild strain of Shigella is transformed so that it cannot substantially invade cells of a human host and cannot spread substantially within infected cells and from infected to uninfected cells of the host and cannot produce toxins which will kill substantial numbers of the host's infected, as well as uninfected, cells. A first gene of the wild strain of Shigella , coding for a protein necessary for the Shigella to invade cells of the host, and a second gene, coding for a protein necessary for the Shigella to spread within infected cells and between the infected and uninfected cells of the host, are mutagenized.
摘要翻译：一种用于修饰入侵性志贺氏菌的野生株以产生可用于制备针对志贺氏菌野生株的疫苗的志贺氏菌的修饰菌株的方法。转基因野生型志贺氏菌的基因组，使其不能基本上侵入人宿主的细胞，并且不能在感染的细胞内基本上扩散并且不能被感染到宿主的未感染细胞，并且不能产生将杀死大量宿主感染的毒素，以及未感染的细胞。志贺氏菌野生型菌株的第一个基因，编码志贺氏菌入侵宿主细胞所必需的蛋白质，第二个基因编码志贺氏菌在感染细胞内和感染细胞和未感染细胞之间传播所必需的蛋白质的宿主，被诱变。

8. 发明公开

EP0170584A2 Sonde d'ADN et procédé pour la détection de "Shigelles" et des souches entéro-invasives de Escherichia coli 有权
标题翻译：用于检测志贺氏菌和大肠杆菌的肠 - 接合菌株的DNA探针和方法。
公开(公告)号：EP0170584A2
公开(公告)日：1986-02-05
申请号：EP85401435.4
申请日：1985-07-12
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： Sansonetti, Philippe , Boileau, Catherine , D'Hauteville, Hélène
IPC分类号： C12Q1/68 , C12Q1/10
CPC分类号： C07K14/25 , C12Q1/689 , Y10S435/81 , Y10S436/808
摘要： L'invention concerne une sonde pour la détection des shigelles et des E.coli entéro-invasifs, comprenant une séquence d'acide nucléique originaire du plasmide de virulence de 140 Mdal de la souche M 90 T Shigella flexneri, ayant une taille au plus égale à environ 27 kb et comprenant la totalité ou une partie du fragment Bam HI de 27 kb. Cette sonde permet le diagnostic in vitro de syndromes de dysentries ou de diarrhées, du type Shigelloses.

9. 发明公开

EP2036989A1 Single cell based reporter assay to monitor gene expression patterns with high spatio-temporal resolution 有权
标题翻译：基于与高空间和时间分辨率的监控基因表达模式适合于单个细胞的测定法的多核苷酸
公开(公告)号：EP2036989A1
公开(公告)日：2009-03-18
申请号：EP07291093.8
申请日：2007-09-12
申请人： INSTITUT PASTEUR
发明人： Mhlanga, Musa , Enninga, Jost , Sansonetti, Philippe , Nehrbass, Ulf
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897 , C12Q2563/179 , C12Q2525/301 , C12Q2565/1015
摘要： The invention relates to a double-stranded polynucleotide comprising on its positive strand considered from its 5' end to its 3' end, (i) a promoter of a gene of interest or several promoters of various genes of interest selected among genes which are endogenous to a determined cell, and, (ii) one or several barcode(s) wherein each barcode contains at least one barcode unit formed of at least one, especially of multiple, recognition binding sites each binding site being composed of a nucleotide sequence, and wherein each of said barcode(s) is under the control of at least one of said promoter(s) for transcription.
It further concerns use of said polynucleotide to monitor gene expression patterns in living cells, especially in single cells, with a rapid and high spatio-temporal resolution.

10. 发明授权

EP0441071B1 Transformed shigella 失效
标题翻译：变形杆菌志贺氏菌
公开(公告)号：EP0441071B1
公开(公告)日：1994-09-21
申请号：EP90400326.6
申请日：1990-02-06
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： Sansonetti, Philippe , Bernardini Maria Lina , Fontaine, Annick
IPC分类号： C12N15/00
CPC分类号： C12N15/00 , A61K39/0283 , A61K2039/522 , Y02A50/476
摘要： A method for modifying a wild strain of an entero-invasive Shigella to produce a modified strain of Shigella that can be used for making a vaccine against the wild strain. The genome of the wild strain is transformed by deleting all or a substantial part of: a) both its ompR and envZ genes; or b) its ompF gene. This renders the strain substantially less invasive. One or more additional genes of the wild strain, such as the icsA gene, are also deleted in whole or in part so that the so-modified strain is sufficiently non-invasive to be safe for use in a vaccine but sufficiently active to provide protection against the wild strain.

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