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1. 发明申请

WO2010102031A2 METHODS FOR TREATING OCULAR INFLAMMATORY DISEASES 审中-公开
标题翻译：治疗眼部炎症性疾病的方法
公开(公告)号：WO2010102031A2
公开(公告)日：2010-09-10
申请号：PCT/US2010/026086
申请日：2010-03-03
申请人： INSITE VISION INCORPORATED , BOWMAN, Lyle, M. , HOSSEINI, Kamran
发明人： BOWMAN, Lyle, M. , HOSSEINI, Kamran
IPC分类号： A61K31/573 , A61K31/57 , A61P27/02 , A61P27/00
CPC分类号： A61K31/56
摘要： A method of treating blepharitis includes administering to the affected eye of a subject an effective amount of an active ingredient in an ophthalmically acceptable vehicle for a sufficient period of time to treat blepharitis. The active ingredient consists essentially of a glucocorticoid in an ophthalmically acceptable vehicle that includes an aqueous polymer suspension that when mixed with tear fluid provides a sustained release of said active ingredient. The aqueous polymer suspension includes a carboxyl-containing polymer having less than about 5% by weight cross-linking agent and has a viscosity in a range from about 1,000 to about 30,000 centipoises. A kit includes: (a) a composition comprising about 0.1% by weight dexamethasone in this ophthalmically acceptable vehicle and (b) instructions for using the composition of (a) for the treatment of blepharitis.
摘要翻译：一种治疗睑炎的方法包括向受试者的受影响的眼睛施用有效量的眼科可接受载体中的活性成分足够的时间以治疗睑炎。活性成分基本上由眼科可接受的媒介物中的糖皮质激素组成，其包括当与泪液混合时提供所述活性成分的持续释放的水性聚合物悬浮液。含水聚合物悬浮液包括含有少于约5重量％交联剂的含羧基聚合物，其粘度范围为约1,000至约30,000厘泊。试剂盒包括：（a）在该眼科可接受的载体中包含约0.1重量％的地塞米松的组合物和（b）（a）用于治疗睑炎的组合物的说明书。

2. 发明申请

WO2013103830A1 METHODS AND KITS FOR EXTENDING CONTACT LENS USE 审中-公开
标题翻译：用于扩展接触镜片的方法和工具
公开(公告)号：WO2013103830A1
公开(公告)日：2013-07-11
申请号：PCT/US2013/020303
申请日：2013-01-04
申请人： INSITE VISION INCORPORATED , BOWMAN, Lyle, M. , HOSSEINI, Kamran
发明人： BOWMAN, Lyle, M. , HOSSEINI, Kamran
IPC分类号： A61K9/08 , B29D11/00
CPC分类号： C11D3/3765 , A61K9/0048 , C11D3/0078
摘要： Method and kits extend the wear-time of a contact lens. The method includes applying an amount of an ophthalmically acceptable solution to the contact lens to improve the comfort of the eye when the contact lens is in the eye. The solution includes an aqueous suspension and chitosan. The aqueous suspension includes about 0.1 % to about 6.5% by weight of a carboxyl-containing polymer prepared by polymerizing one or more carboxylcontaining monoethylenically unsaturated monomers and less than about 5% by weight of a cross-linking agent. Upon contact with tear fluid, the solution gels to a second viscosity which is greater than the first viscosity. The kit includes contact lenses, an ophthalmically acceptable solution and instructions for applying the solution to improve the comfort of the eye when the contact lens is in the eye.
摘要翻译：方法和试剂盒可以延长隐形眼镜的磨损时间。该方法包括将一定量的眼科可接受的溶液施加到隐形眼镜，以在隐形眼镜在眼睛中时提高眼睛的舒适度。该溶液包括水性悬浮液和壳聚糖。含水悬浮液包含约0.1重量％至约6.5重量％的通过聚合一种或多种含羧基的单烯属不饱和单体和少于约5重量％的交联剂制备的含羧基聚合物。当与泪液接触时，溶液凝胶化至大于第一粘度的第二粘度。该套件包括隐形眼镜，眼科可接受的解决方案以及当隐形眼镜在眼睛中时施加该溶液以改善眼睛的舒适性的说明书。

3. 发明申请

WO2013003731A3 METHODS OF TREATING RECURRENT MEIBOMIAN GLANDS DISORDER AND THEREBY DECREASING THE FREQUENCY OF RECURRENCE 审中-公开
公开(公告)号：WO2013003731A3
公开(公告)日：2013-01-03
申请号：PCT/US2012/044949
申请日：2012-06-29
申请人： INSITE VISION INCORPORATED , HOSSEINI, Kamran , BOWMAN, Lyle
发明人： HOSSEINI, Kamran , BOWMAN, Lyle
IPC分类号： A61K31/573 , A61K31/7052 , A61P3/00
摘要： A method of treating a recurring meibomian gland disorder in a patient, includes administering to a patient suffering from recurring meibomian gland disorder a composition comprising a therapeutically effective amount of an azalide antibiotic and a glucocorticoid. The method may thereby reduce the frequency of recurrence of the meibomian gland disorder.

4. 发明申请

WO2010102192A2 NON-STEROIDAL ANTI-INFLAMMATORY OPHTHALMIC COMPOSITIONS 审中-公开
标题翻译：非甾体抗炎药物组合物
公开(公告)号：WO2010102192A2
公开(公告)日：2010-09-10
申请号：PCT/US2010/026338
申请日：2010-03-05
申请人： INSITE VISION INCORPORATED , HOSSEINI, Kamran , BOWMAN, Lyle, M. , SI, Erwin, C. , PHAM, Stephen
发明人： HOSSEINI, Kamran , BOWMAN, Lyle, M. , SI, Erwin, C. , PHAM, Stephen
IPC分类号： A61K31/195 , A61K9/08 , A61K47/48 , A61K47/30 , A61P27/02
CPC分类号： A61K31/192 , A61K9/0048 , A61K45/06 , A61K47/32 , A61K47/34 , A61K2300/00
摘要： The disclosure provides compositions and systems for topical ophthalmic application, which include an aqueous mixture of bromfenac and flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye.
摘要翻译：本公开提供了用于局部眼用药的组合物和系统，其包括溴芬酸和可流动粘膜粘附聚合物的水性混合物，用于治疗眼睛的炎症和炎症状况。

5. 发明申请

WO2013096857A1 COMBINATION ANTI-INFLAMMATORY OPHTHALMIC COMPOSITIONS 审中-公开
标题翻译：组合抗炎手淫组合物
公开(公告)号：WO2013096857A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/071409
申请日：2012-12-21
申请人： INSITE VISION INCORPORATED , LINDSTROM, Richard, L. , HOSSEINI, Kamran , BOWMAN, Lyle, M.
发明人： LINDSTROM, Richard, L. , HOSSEINI, Kamran , BOWMAN, Lyle, M.
IPC分类号： A61P27/02 , A61P27/14
CPC分类号： A61K31/573 , A61K9/0048 , A61K9/08 , A61K31/196 , A61K31/57 , A61K45/06 , A61K2300/00
摘要： Compositions and systems for topical ophthalmic application, which include an aqueous mixture of steroidal and non-steroidal anti-inflammatory agents in a flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye.
摘要翻译：用于局部眼科应用的组合物和系统，其包括可流动粘膜粘附聚合物中的类固醇和非甾体抗炎剂的水性混合物，用于治疗眼睛的炎症和炎症状况。

6. 发明申请

WO2017007609A1 OCULAR TREATMENT WITH REDUCED INTRAOCULAR PRESSURE 审中-公开
标题翻译：具有降低内分泌压的OCULAR治疗
公开(公告)号：WO2017007609A1
公开(公告)日：2017-01-12
申请号：PCT/US2016/038996
申请日：2016-06-23
申请人： INSITE VISION INCORPORATED
发明人： HOSSEINI, Kamran , BOWMAN, Lyle M.
IPC分类号： A61K31/573 , A61K31/7052 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61K9/00 , A61K47/32 , A61K47/34
CPC分类号： A61K31/7052 , A61K9/0048 , A61K9/08 , A61K9/10 , A61K9/1641 , A61K31/573 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K2300/00
摘要： Methods of treating a subject suffering from an ocular infection and/or ocular inflammation are disclosed. The methods include administering to an eye of a subject in need thereof a composition comprising at least two active agents in an ophthalmically acceptable vehicle that can provide a sustained release of the at least two active agents. Advantageously, the composition does not result in a statistically significant elevation in intraocular pressure in a statistically significant number of subject eyes when administered twice daily over a period of two weeks..
摘要翻译：公开了治疗患有眼部感染和/或眼部炎症的受试者的方法。所述方法包括向有需要的受试者的眼睛施用包含至少两种能够提供至少两种活性剂的持续释放的眼科可接受载体中的活性剂的组合物。有利地，当在两周的时间内每天两次施用时，组合物在统计学上显着数目的目标眼睛中不会导致统计学上的眼内压升高。

7. 发明申请

WO2015105652A1 METHODS FOR TREATMENT OF POSTOPERATIVE INFLAMMATION WITH REDUCED INTRAOCULAR PRESSURE 审中-公开
标题翻译：用减少内分泌压治疗术后炎症的方法
公开(公告)号：WO2015105652A1
公开(公告)日：2015-07-16
申请号：PCT/US2014/071132
申请日：2014-12-18
申请人： INSITE VISION INCORPORATED
发明人： HOSSEINI, Kamran , BOWMAN, Lyle
IPC分类号： A61K31/573 , A61K31/57 , A61P27/02 , A61P29/00
CPC分类号： A61K31/573 , A61K9/0048 , A61K31/568 , A61K31/78 , A61K47/32 , A61K47/36 , A61K2300/00
摘要： Compositions and methods for treating a subject after ocular surgery are disclosed. The compositions and methods include administering to an eye of a subject in need thereof a composition comprising at least one corticosteroid or an ophthalmically acceptable salt thereof in an ophthalmically acceptable vehicle that can provide a sustained release of the at least one corticosteroid or an ophthalmically acceptable salt thereof. Advantageously, the composition does not result in a statistically significant elevation in intraocular pressure in a statistically significant number of subject eyes when administered twice daily over a period of two weeks.
摘要翻译：公开了用于在眼外科手术后治疗受试者的组合物和方法。组合物和方法包括向有需要的受试者的眼睛施用包含至少一种皮质类固醇或其眼科可接受的盐的眼科可接受的载体中的组合物，其可以提供所述至少一种皮质类固醇或眼科可接受的盐的持续释放它们。有利地，当在两周的时间内每天两次施用时，组合物在统计学上显着数目的受试者眼睛中不会导致统计学上的眼压升高。

8. 发明申请

WO2014160579A1 COMBINATION ANTI-INFLAMMATORY OPHTHALMIC COMPOSITIONS 审中-公开
标题翻译：组合抗炎手淫组合物
公开(公告)号：WO2014160579A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/031260
申请日：2014-03-19
申请人： INSITE VISION INCORPORATED
发明人： LINDSTROM, Richard L. , HOSSEINI, Kamran , BOWMAN, Lyle M. , HOU, Sui Yen Eddie
IPC分类号： A61K31/192 , A61K31/167 , A61K31/573 , A61P27/02 , A61P29/00
CPC分类号： A61K31/573 , A61K9/0048 , A61K31/165 , A61K31/192 , A61K31/407 , A61K2300/00
摘要： Compositions and systems for topical ophthalmic application, which include an aqueous mixture of steroidal and non-steroidal anti-inflammatory agents in a flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye are disclosed.
摘要翻译：公开了用于局部眼科应用的组合物和系统，其包括可流动粘膜粘附聚合物中的甾体和非甾体抗炎剂的水性混合物，用于治疗眼睛的炎症和炎症状况。

9. 发明申请

WO2013016125A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR SURFACE ALLERGIES 审中-公开
标题翻译：用于治疗眼部表面过敏症的组合物和方法
公开(公告)号：WO2013016125A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/047359
申请日：2012-07-19
申请人： INSITE VISION INCORPORATED , HOSSEINI, Kamran , BOWMAN, Lyle
发明人： HOSSEINI, Kamran , BOWMAN, Lyle
IPC分类号： A61K9/08 , A61K9/10 , A61K47/30 , A61P27/02 , A61P27/00
CPC分类号： A61K31/196 , A61K9/0046 , A61K31/137 , A61K31/4164 , A61K31/4174 , A61K45/06 , A61K2300/00
摘要： The disclosure provides ophthalmic compositions, systems and methods for the treatment of ocular surface allergies. More particularly the present invention relates to compositions of bromfenac for the treatment of the signs and symptoms of ocular surface allergies due to seasonal allergies.
摘要翻译：本公开提供了用于治疗眼表过敏症的眼用组合物，系统和方法。更具体地，本发明涉及溴芬酸的组合物，用于治疗由于季节性过敏引起的眼表过敏的体征和症状。

10. 发明公开

EP3091986A1 METHODS FOR TREATMENT OF POSTOPERATIVE INFLAMMATION WITH REDUCED INTRAOCULAR PRESSURE 审中-公开
标题翻译： VERFAHREN ZUR BEHANDLUNG馄饨ON EN EN ENÜUNG UNG EN K K K K K K K K K K K K K K K
公开(公告)号：EP3091986A1
公开(公告)日：2016-11-16
申请号：EP14877878.0
申请日：2014-12-18
申请人： Insite Vision Incorporated
发明人： HOSSEINI, Kamran , BOWMAN, Lyle
IPC分类号： A61K31/573 , A61K31/57 , A61P27/02 , A61P29/00
CPC分类号： A61K31/573 , A61K9/0048 , A61K31/568 , A61K31/78 , A61K47/32 , A61K47/36 , A61K2300/00
摘要： Compositions and methods for treating a subject after ocular surgery are disclosed. The compositions and methods include administering to an eye of a subject in need thereof a composition comprising at least one corticosteroid or an ophthalmically acceptable salt thereof in an ophthalmically acceptable vehicle that can provide a sustained release of the at least one corticosteroid or an ophthalmically acceptable salt thereof. Advantageously, the composition does not result in a statistically significant elevation in intraocular pressure in a statistically significant number of subject eyes when administered twice daily over a period of two weeks.
摘要翻译：公开了在眼外科手术后治疗受试者的方法。所述方法包括给予有需要的受试者的眼睛，该组合物包含至少一种皮质类固醇或其眼科可接受的盐，其可以提供至少一种皮质类固醇或其眼用可接受的盐的持续释放。有利地，当在两周的时间内每天两次施用时，组合物在统计学上显着数目的受试者眼睛中不会导致统计学上的眼压升高。

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