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1. 发明专利

JP2010019864A Differential diagnosis of neurodegeneration 有权
标题翻译：神经元的差异诊断
公开(公告)号：JP2010019864A
公开(公告)日：2010-01-28
申请号：JP2009247559
申请日：2009-10-28
申请人： Innogenetics Nv , イノジェネティックス・ナムローゼ・フェンノートシャップInnogenetics N.V.
发明人： VANMECHELEN EUGEEN , VANDERSTICHELE HUGO , VAN DE VOORDE ANDRE
IPC分类号： G01N33/53 , G01N33/531 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2835 , G01N2800/52
摘要： PROBLEM TO BE SOLVED: To provide a new method for the specific detection and differential test of neurodegeneration. SOLUTION: This new method is for specific detection, quantification, and/or differential diagnosis of neurodegeneration of an individual and uses a combination assay detecting at least three neurological markers in one bodily fluid or more of the individual, and the type and degree of neurodegeneration are further reflected in the quantitative changes of the levels of all the neurological markers that are compared with a control sample. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于神经变性特异性检测和差异检验的新方法。解决方案：这种新方法用于个体的神经变性的特异性检测，定量和/或鉴别诊断，并且使用检测至少三种神经学标记物在一种体液或多种个体中的组合测定法，以及类型和神经退行性进一步反映在与对照样品相比较的所有神经标志物的水平的定量变化中。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2006091025A Differential diagnosis of neurodegeneration 审中-公开
标题翻译：神经元的差异诊断
公开(公告)号：JP2006091025A
公开(公告)日：2006-04-06
申请号：JP2005326503
申请日：2005-11-10
申请人： Innogenetics Nv , イノジェネティックス・ナムローゼ・フェンノートシャップInnogenetics N.V.
发明人： VANMECHELEN EUGEEN , VANDERSTICHELE HUGO , VAN DE VOORDE ANDRE
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2835 , G01N2800/52
摘要： PROBLEM TO BE SOLVED: To provide a new method for the specific detection and differential test of neurodegeneration. SOLUTION: This new method is for specific detection, quantification, and/or differential diagnosis of neurodegeneration and uses a combination assay detecting at least three neurological markers in one bodily fluid or more of an individual, and the type and degree of neurodegeneration are reflected in the quantitative changes in the level of all the neurological markers that are compared with a control sample. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于神经变性特异性检测和差异检验的新方法。解决方案：这种新方法用于神经变性的特异性检测，定量和/或鉴别诊断，并且使用在一种体液或个体以上检测至少三种神经标志物的组合测定法，以及神经变性的类型和程度反映在与对照样品相比较的所有神经标志物的水平的定量变化中。版权所有（C）2006，JPO＆NCIPI

3. 发明申请

WO9900670A8 METHODS FOR COVALENT IMMOBILISATION OF BIOMOLECULES TO A CARRIER BY MEANS OF A HIS-TAG 审中-公开
标题翻译：通过其标签将生物分子对载体进行共价偶联的方法
公开(公告)号：WO9900670A8
公开(公告)日：2000-03-02
申请号：PCT/EP9803883
申请日：1998-06-25
申请人： INNOGENETICS NV , BOSMAN ALFONS , WIJNENDAELE FRANS VAN , DEN BROECK DIRK VAN , VOORDE ANDRE VAN DE
发明人： BOSMAN ALFONS , VAN WIJNENDAELE FRANS , VAN DEN BROECK DIRK , VAN DE VOORDE ANDRE
IPC分类号： C07K17/00 , C07K17/06 , C12N11/00 , C12N11/06 , G01N33/543 , G01N33/547
CPC分类号： C12N11/00 , G01N33/54353 , G01N33/54393
摘要： The present invention relates to methods for covalent immobilisation of biomolecules to carriers and membranes, wherein the presence of a His-tag is exploited, and wherein the amino acid residues that comprise said His-tag are directly involved in the covalent bond. The present invention also provides several strategies that further augment the probability of covalent immobilisation through said His-tags, such as improving the presentation of said His-tag, choosing the appropriate reaction conditions such as pH, temperature, concentration of reagent and kinetics, increasing contact between His-tag and reactive groups of said carrier or membrane, by for instance the use of IDA or anti-His antibodies or increasing the hydrophobicity of the membrane, or shielding the rest of the biomolecule from reaction by for instance increasing the hydrophobicity of said carrier or membrane or addition of substrate or competitors or blocking otherwise reactive groups, or by choosing chemical reactions that have a high selectivity for histidine residues. A carrier can also be another biomolecule. The present invention thus also relates to a method that allows covalent cross-linking between identical or different biomolecules. When such biomolecules have a natural tendency to interact with each other to form homo- or heterodimers, a strategy of increasing contact between the reactive groups (two His-tags or one His-tag and another reactive group) can be exploited. The present invention also relates to a method of providing a simultaneous and universal system for detection of biomolecules through said His-tag.
摘要翻译：本发明涉及用于共价固定生物分子到载体和膜的方法，其中使用His标签的存在，其中包含所述His-标签的氨基酸残基直接参与共价键。本发明还提供了几种策略，其进一步增加通过所述His标签共价固定的概率，例如改善所述His标签的呈现，选择合适的反应条件，例如pH，温度，试剂浓度和动力学，增加 His标签和所述载体或膜的反应性基团之间的接触，例如使用IDA或抗His抗体或增加膜的疏水性，或屏蔽其余生物分子免受反应，例如增加疏水性所述载体或膜或添加底物或竞争剂或阻断另外的反应性基团，或通过选择对组氨酸残基具有高选择性的化学反应。载体也可以是另一种生物分子。因此，本发明还涉及允许相同或不同生物分子之间共价交联的方法。当这种生物分子具有彼此相互作用以形成同二聚体或异二聚体的天然趋势时，可以利用增加反应性基团（两个His-标签或一个His-标签和另一个反应性基团）之间接触的策略。本发明还涉及提供用于通过所述His标签检测生物分子的同时和通用系统的方法。

4. 发明申请

WO0002053A2 DIFFERENTIAL DIAGNOSIS OF NEURODEGENERATION 审中-公开
标题翻译：神经细胞的差异性诊断
公开(公告)号：WO0002053A2
公开(公告)日：2000-01-13
申请号：PCT/EP9904483
申请日：1999-06-29
申请人： INNOGENETICS NV , VANMECHELEN EUGEEN , VANDERSTICHELE HUGO , VOORDE ANDRE VAN DE
发明人： VANMECHELEN EUGEEN , VANDERSTICHELE HUGO , VAN DE VOORDE ANDRE
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2835 , G01N2800/52
摘要： The present invention relates to new methods for the specific detection, quantification and/or differential diagnosis of neurodegeneration in an individual making use of a combination assay detecting at least three neurological markers in one or more body fluids of said individual, the type and degree of neurodegeneration being reflected in the quantitative changes in the level of all of said neurological markers compared to the control sample. The present invention also relates to methods for the detection of Rab3a, SNAP25 and alpha -synuclein in cerebrospinal fluid and to the use of these methods in a combination assay for specific detection, quantification and/or differential diagnosis of neurodegeneration.
摘要翻译：本发明涉及用于使用组合测定法对个体中的神经变性进行特异性检测，定量和/或鉴别诊断的新方法，所述组合测定法检测所述个体的一种或多种体液中的至少三种神经学标志物，与对照样品相比，神经变性反映在所有所述神经标志物水平的定量变化中。本发明还涉及用于检测脑脊液中的Rab3a，SNAP25和α-突触核蛋白的方法以及这些方法在组合测定中用于神经变性的特异性检测，定量和/或鉴别诊断的用途。

5. 发明专利

ES2270421T3 ANTICUERPOS MONOCLONALES ESPECIFICOS PARA PHF-TAU, HIBRIDOMAS QUE SECRETAN LOS MISMOS, RECONOCIMIENTO DE ANTIGENO POR ESTOS ANTICUERPOS Y SUS APLICACIONES. 未知
公开(公告)号：ES2270421T3
公开(公告)日：2007-04-01
申请号：ES95903798
申请日：1994-12-14
申请人： INNOGENETICS NV
发明人： VANDERMEEREN MARC , VANMECHELEN EUGEEN , VAN DE VOORDE ANDRE
IPC分类号： C07K16/18 , G01N33/53 , C07K7/06 , C07K14/47 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/68
摘要： LA INVENCION SE REFIERE MAS PARTICULARMENTE A UN ANTICUERPO MONOCLONAL QUE FORMA UN COMPLEJO INMUNOLOGICO CON UN EPITOPO FOSFORILADO DE UN ANTIGENO QUE PERTENECE AL TAU ANORMALMENTE FOSFORILADO (PHF-TAU) QUE RESIDE EN LAS POSICIONES QUE SE EXTIENDEN EN LA REGION (143-254), Y CON EL ANTICUERPO MONOCLONAL CARACTERIZANDOSE POR EL HECHO DE QUE ES CAPAZ DE DETECTAR ESPECIFICAMENTE LA PROTEINA DEL TAU ANORMALMENTE FOSFORILADO (PHF-TAU) EN EL FLUIDO CEREBROESPINAL (CSF).

6. 发明专利

DE69920487T2 未知
公开(公告)号：DE69920487T2
公开(公告)日：2006-03-09
申请号：DE69920487
申请日：1999-09-07
申请人： INNOGENETICS NV
发明人： HULSTAERT FRANK , VANMECHELEN EUGEEN , VANDERSTICHELE HUGO , VAN DE VOORDE ANDRE , VAN GOOL STEFAAN
IPC分类号： G01N33/53 , C07K16/18 , G01N33/15 , G01N33/50 , G01N33/574 , G01N33/577 , G01N33/68

7. 发明专利

CA2121599C MONOCLONAL ANTIBODIES DIRECTED AGAINST THE MICROTUBULE-ASSOCIATED PROTEIN TAU 未知
公开(公告)号：CA2121599C
公开(公告)日：2007-04-10
申请号：CA2121599
申请日：1992-10-17
申请人： INNOGENETICS NV
发明人： MERCKEN MARC , MANDELKOW EVA-MARIA , VANDERMEEREN MARC , VANMECHELEN EUGEEN , VAN DE VOORDE ANDRE
IPC分类号： C12P21/08 , G01N33/53 , C07K2/00 , C07K7/04 , C07K14/47 , C07K16/00 , C07K16/18 , C12N5/10 , C12N5/18 , C12N5/20 , C12N15/02 , C12N15/06 , C12P21/02 , C12R1/91 , G01N33/566 , G01N33/577
摘要： A monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau proteine. The tau protein can be obtaine d from a brain homogenate, itself isolated from the cerebral cortex of a patient having Alzheimer's disease.

8. 发明专利

DE69434811D1 未知
公开(公告)号：DE69434811D1
公开(公告)日：2006-09-14
申请号：DE69434811
申请日：1994-12-14
申请人： INNOGENETICS NV
发明人： VANDERMEEREN MARC , VANMECHELEN EUGEEN , VAN DE VOORDE ANDRE
IPC分类号： C07K16/18 , G01N33/53 , C07K7/06 , C07K14/47 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/68

9. 发明专利

DE69928809D1 未知
公开(公告)号：DE69928809D1
公开(公告)日：2006-01-12
申请号：DE69928809
申请日：1999-06-29
申请人： INNOGENETICS NV
发明人： VANMECHELEN EUGEEN , VANDERSTICHELE HUGO , VAN DE VOORDE ANDRE
IPC分类号： G01N33/53 , G01N33/68

10. 发明专利

DE69332406T2 未知
公开(公告)号：DE69332406T2
公开(公告)日：2003-06-26
申请号：DE69332406
申请日：1993-04-28
申请人： INNOGENETICS NV
发明人： FRANSEN LUCIA , DEVOS KATHLEEN , VAN DE VOORDE ANDRE , VAN HEUVERSWYN HUGO
IPC分类号： A01K67/027 , A61K38/00 , A61K39/00 , A61P7/00 , A61P29/00 , A61P33/02 , A61P35/00 , A61P37/00 , A61P43/00 , C07K1/20 , C07K14/00 , C07K14/52 , C07K14/525 , C07K14/54 , C07K14/555 , C07K14/57 , C07K16/00 , C07K19/00 , C12N1/21 , C12N5/02 , C12N15/00 , C12N15/11 , C12N15/19 , C12P21/02 , C12P21/08
摘要： The invention relates: to a polypeptide containing in its peptidic chain the amino acid sequence of 311 amino acids of FIG. 3, or a fragment of this sequence, with said fragment being such that it is liable to produce antibodies capable of forming a complex with the amino acid sequence of FIG. 3, or an amino acid sequence having a percentage of homology of at least 50%, preferably 75%, and advantageously 90% with the amino acid sequence of FIG. 3, and to pharmaceutical compositions containing, as active substance, at least one of the polypeptides of the invention or of the antagonists of the polypeptides of the invention as antitumor compounds, or antiinflammatory compounds or as growth activators of T-cells and B-cells, as bone repair compounds as inducer of immunosuppressive cells, as inhibitors of anti-colony stimulating factor; or as trypoanocidal agents; or part of the polypeptides of the invention, capable of binding to the above-defined receptor.

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