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    • 1. 发明授权
    • Process and apparatus for the agglomeration of hydrolytically sensitive
substances by means of steam
    • 通过蒸汽凝结水解敏感物质的方法和设备
    • US5955036A
    • 1999-09-21
    • US240033
    • 1999-01-29
    • Ina SeyffertHans UhlemannReinhardt WalterJoachim Martin Maasz
    • Ina SeyffertHans UhlemannReinhardt WalterJoachim Martin Maasz
    • B01J2/16A61K9/16B01J2/04B01J2/28C08F5/02B05D7/00
    • A61K9/1694B01J2/04B01J2/16
    • In the process for the agglomeration of slightly soluble and hydrolytically sensitive substances, a powder of the slightly soluble substance is conducted, together with at least one water-soluble binder, in free fall through a steam atmosphere at temperatures between 85.degree. C. and 105.degree. C. essentially without the action of compacting forces. In this process, the residence time in the steam atmosphere is approximately 0.5 to 10 seconds. The agglomerates formed are then dried in free fall, so that small solid bridges form from the binder liquid bridges formed at the points of contact between the primary particles. In a following integrated fluidized-bed dryer, the final drying then takes place to a water content of less than 0.5% by weight. The process is carried out in a steam jet agglomerator in which a freely falling product curtain of the pulverulent mixture to be agglomerated is impinged by steam using steam jet nozzles (5, 6). A fluidized-bed dryer (2) is connected at the lower part of the agglomerator (1) in such a manner that the agglomerated particles (4) fall directly into the fluidized bed.
    • 在微溶性和水解敏感性物质结块的过程中,将微溶性物质的粉末与至少一种水溶性粘合剂一起在85℃至105℃的温度自由落体通过蒸汽气氛 基本上没有压实力的作用。 在该方法中,在蒸气气氛中的停留时间为约0.5〜10秒。 然后形成的附聚物在自由落体下干燥,从而在形成于初级颗粒之间的接触点处的粘合剂液体桥形成小的固体桥。 在随后的集成流化床干燥器中,最后的干燥发生到小于0.5重量%的含水量。 该方法在蒸汽喷射附聚器中进行,其中待凝聚的粉状混合物的自由落下的产品帘幕使用蒸汽喷嘴(5,6)被蒸汽冲击。 流化床干燥器(2)以附聚颗粒(4)直接落入流化床的方式连接在附聚器(1)的下部。