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1. 发明申请

US20100003331A1 SUSTAINED RELEASE DOSAGE FORMS OF ZIPRASIDONE 审中-公开
标题翻译：持续释放ZIPRASIDONE剂量
公开(公告)号：US20100003331A1
公开(公告)日：2010-01-07
申请号：US12261678
申请日：2009-09-03
申请人： Imran Ahmed , Leah Elizabeth Appel , Walter Christian Babcock , Dwayne Thomas Friesen , Scott Herbig , David Keith Lyon , Sheri L. Shamblin , Ravi Mysore Shanker , Daniel Tod Smithey , Steven C. Sutton , Avinash Govind Thombre , Kenneth C. Waterman , Jaymin C. Shah , Parag Suresh Shah , Peter Wisniecki , Dawn Renee Wagner
发明人： Imran Ahmed , Leah Elizabeth Appel , Walter Christian Babcock , Dwayne Thomas Friesen , Scott Herbig , David Keith Lyon , Sheri L. Shamblin , Ravi Mysore Shanker , Daniel Tod Smithey , Steven C. Sutton , Avinash Govind Thombre , Kenneth C. Waterman , Jaymin C. Shah , Parag Suresh Shah , Peter Wisniecki , Dawn Renee Wagner
IPC分类号： A61K9/14 , A61K31/501
CPC分类号： A61K9/1617 , A61K9/0004 , A61K9/1652 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/2081 , A61K9/209 , A61K9/2846 , A61K9/5047 , A61K31/496 , A61K31/4965
摘要： A sustained release solid oral dosage form for treatment of a psychotic disorder, for example schizophrenia, in a mammal is provided, which oral dosage form comprises ziprasidone in an amount effective in treating said psychotic disorder and a pharmaceutically acceptable carrier.
摘要翻译：提供了用于治疗哺乳动物中的精神病症例如精神分裂症的持续释放固体口服剂型，该口服剂型包含有效治疗所述精神病性障碍的量的齐拉西酮和药学上可接受的载体。

2. 发明申请

US20080305161A1 INJECTABLE DEPOT FORMULATIONS AND METHODS FOR PROVIDING SUSTAINED RELEASE OF NANOPARTICLE COMPOSITIONS 审中-公开
标题翻译：用于提供纳米复合材料的持续释放的注射剂配方和方法
公开(公告)号：US20080305161A1
公开(公告)日：2008-12-11
申请号：US12043014
申请日：2008-03-05
申请人： Jaymin C. Shah , Parag Suresh Shah , Peter Wisniecki , Dawn Renee Wagner
发明人： Jaymin C. Shah , Parag Suresh Shah , Peter Wisniecki , Dawn Renee Wagner
IPC分类号： A61K9/14 , A61K9/16 , A61K31/501 , A61K9/00 , A61K9/22 , A61K9/48 , A61K9/26
CPC分类号： A61K9/145 , A61K9/0019 , A61K9/19 , A61K31/496 , A61K31/501
摘要： Pharmaceutical formulations comprising: a compound selected from the group consisting of ziprasidone, having a maximum average particle size; a carrier; and preferably at least two surface stabilizers are disclosed. The present invention also comprises methods of treating psychosis with such a formulation and processes for making such a formulation.
摘要翻译：药物制剂，其包含：选自具有最大平均粒径的齐拉西酮的化合物; 承运人并且优选地公开至少两个表面稳定剂。本发明还包括用这种制剂治疗精神病的方法和制备这种制剂的方法。

3. 发明申请

US20080193542A1 Injectable Deopot Formulations and Methods For Providing Sustained Release of Nanoparticle Compositions 审中-公开
标题翻译：用于提供纳米颗粒组合物的持续释放的注射脱胶制剂和方法
公开(公告)号：US20080193542A1
公开(公告)日：2008-08-14
申请号：US11911457
申请日：2006-04-10
申请人： Jaymin C. Shah , Parag Suresh Shah , Peter Wisniecki , Dawn Renee Wagner
发明人： Jaymin C. Shah , Parag Suresh Shah , Peter Wisniecki , Dawn Renee Wagner
IPC分类号： A61K31/497 , A61K9/51 , A61P25/18
CPC分类号： A61K31/496 , A61K9/0024 , A61K9/145 , A61K9/146
摘要： Pharmaceutical formulations comprising: a compound selected from the group consisting of ziprasidone, having a maximum average particle size; a carrier; and preferably at least two surface stabilizers are disclosed. The present invention also comprises methods of treating psychosis with such a formulation and processes for making such a formulation.
摘要翻译：药物制剂，其包含：选自具有最大平均粒径的齐拉西酮的化合物; 承运人并且优选地公开至少两个表面稳定剂。本发明还包括用这种制剂治疗精神病的方法和制备这种制剂的方法。

4. 发明申请

US20080166411A1 Injectable Depot Formulations And Methods For Providing Sustained Release Of Poorly Soluble Drugs Comprising Nanoparticles 审中-公开
标题翻译：可注射药物制剂和提供包含纳米颗粒的不良溶解药物持续释放的方法
公开(公告)号：US20080166411A1
公开(公告)日：2008-07-10
申请号：US11911432
申请日：2006-04-10
申请人： Jaymin C. Shah , Parah Suresh Shah , Dawn Renee Wagner , Peter Wisniecki
发明人： Jaymin C. Shah , Parah Suresh Shah , Dawn Renee Wagner , Peter Wisniecki
IPC分类号： A61K9/16
CPC分类号： A61K9/145 , A61K9/0019 , A61K9/10 , A61K9/146 , A61K9/19
摘要： Pharmaceutical formulations comprising: a compound of low water solubility, having a maximum average particle size; a carrier; and at least two surface stabilizers are disclosed. The present invention also comprises methods of treating various conditions with such a formulation and processes for making such a formulation.
摘要翻译：药物制剂，其包含：具有最大平均粒度的低水溶性化合物; 承运人并且公开了至少两种表面稳定剂。本发明还包括用这种制剂治疗各种病症的方法和制备这种制剂的方法。

5. 发明申请

US20080293796A1 Parenteral and oral formulations of benzimidazoles 审中-公开
标题翻译：苯并咪唑的肠胃外和口服制剂
公开(公告)号：US20080293796A1
公开(公告)日：2008-11-27
申请号：US12220364
申请日：2008-07-24
申请人： Diana Shu-Lian Chow , Pranav Gupta , Yulan Qi , Jaymin Shah , Peter Wisniecki
发明人： Diana Shu-Lian Chow , Pranav Gupta , Yulan Qi , Jaymin Shah , Peter Wisniecki
IPC分类号： A61K31/4184 , A61P35/00
CPC分类号： A61K9/0019 , A61K9/0095 , A61K9/1075 , A61K31/4184
摘要： Provided herein are drug delivery systems comprising nanosuspension formulations suitable for parenteral delivery to a subject. The nanosuspension formulations may comprise a benzimidazole derivative, e.g., mebendazole, and surface stabilizers, such as block copolymer(s), e.g., Pluronic F108, and surfactant(s), e.g., Tween 80, and, optionally, water. Provided are methods for defining nanosuspensions of a benzimidazole derivative as having maximum therapeutic efficacy for a treatment regimen by adjusting and/or selecting particles size(s) based on pharmacokinetic parameters of the derivative in the tissue. Also provided are methods for improving the bioavailability of a benzimidazole derivative during treatment of a pathophysiological condition and for treating a cancer by using formulation(s) combining particle diameters whereby the retention of the benzimidazole derivative within the particles increases as the diameter increases such that, upon administration, release of the benzimidazole derivative from the particles into tissue is continuous over a range of time as determined by the particle diameters.
摘要翻译：本文提供的药物递送系统包括适于肠胃外递送给个体的纳米悬浮制剂。纳米悬浮液制剂可以包含苯并咪唑衍生物，例如甲苯咪唑和表面稳定剂，例如嵌段共聚物，例如Pluronic F108和表面活性剂，例如吐温80和任选的水。提供了通过基于组织中衍生物的药代动力学参数调节和/或选择颗粒大小来定义苯并咪唑衍生物的纳米悬浮液对于治疗方案具有最大治疗功效的方法。还提供了用于在治疗病理生理状况期间改善苯并咪唑衍生物的生物利用度和通过使用结合粒径的配方治疗癌症的方法，由此直径增加时，颗粒内苯并咪唑衍生物的保留增加，在施用时，将苯并咪唑衍生物从颗粒中释放到组织中在由颗粒直径确定的时间范围内是连续的。

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