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    • 3. 发明申请
    • Basic drug compositions with enhanced bioavailability
    • 具有增强的生物利用度的基本药物组合物
    • US20050049223A1
    • 2005-03-03
    • US10412399
    • 2003-04-11
    • William CuratoloJames NightingaleRavi ShankerSteven Sutton
    • William CuratoloJames NightingaleRavi ShankerSteven Sutton
    • A61K9/00A61K9/14A61K9/16A61K9/20A61K9/48A61K47/38A61K31/716
    • A61K47/38A61K9/146A61K9/1652A61K9/2054A61K9/4866Y10S977/915
    • A composition comprising a basic drug, a drug which forms a zwitterion, or a salt of either entity, admixed with a polymer selected from hydroxypropylmethylcellulose acetate succinate (HPMCAS), cellulose acetate trimellitate (CAT), cellulose acetate phthalate (CAP), hydroxypropylcellulose acetate phthalate (HPCAP), hydroxypropylmethyl-cellulose acetate phthalate (HPMCAP), and methylcellulose acetate phthalate (MCAP). The compositions having improved solubility, hence bioavailability, in the small intestine; Processes for testing such compositions, and methods of using such compositions. The compositions comprise the basic drug, zwitterion, or salt and one or more of the aforementioned polymers. The invention further relates to a method for increasing the bioavailability of a basic or a zwitterionic drug comprising co-administering the basic drug, the zwitterionic drug, or the salt, with one or more of the aforementioned polymers.
    • 包含碱性药物,形成两性离子的药物或任一实体的盐,与选自羟丙基甲基纤维素乙酸酯琥珀酸酯(HPMCAS),醋酸偏苯三酸纤维素(CAT),乙酸邻苯二甲酸纤维素(CAP),羟丙基纤维素乙酸酯 邻苯二甲酸酯(HPCAP),羟丙基甲基纤维素乙酸邻苯二甲酸酯(HPMCAP)和甲基纤维素乙酸邻苯二甲酸酯(MCAP)。 所述组合物在小肠中具有改善的溶解度,因此具有生物利用度; 用于测试这些组合物的方法,以及使用这些组合物的方法。 组合物包含碱性药物,两性离子或盐和一种或多种上述聚合物。 本发明还涉及增加碱性或两性离子药物的生物利用度的方法,包括将一种或多种上述聚合物共同给予碱性药物,两性离子药物或盐。
    • 4. 发明授权
    • Clamp-type article hanger
    • 夹式衣架
    • US07299957B1
    • 2007-11-27
    • US10925698
    • 2004-08-25
    • Steven Sutton
    • Steven Sutton
    • A41D27/22
    • A47G25/485
    • An article hanger including a body having at least one clamp. The clamp has first and second jaw members with opposed first and second gripping pads, respectively. The first gripping pad includes a first gripping surface that has a relief structure formed by projections that have a depth between 0.01 mm and 0.5 mm (and most preferably between 0.01 mm and 0.25 mm). The second gripping pad includes a second gripping surface that is substantially smooth. The projections of the relief structure may have pointed ends or planar end surfaces, and may be part of a texture or pattern (e.g., a pattern of cross-hatched grooves) that is imparted to the first gripping surface. The gripping pads of the jaw members are integrally formed therewith preferably with the same thermoplastic material or other suitable material. In the preferred embodiment, the hanger body is integrally formed together with at least one jaw member of the clamp(s) and its gripping pad.
    • 一种衣架,包括具有至少一个夹具的主体。 夹具具有分别具有相对的第一和第二夹持垫的第一和第二钳口构件。 第一夹持垫包括第一夹持表面,其具有由具有在0.01mm至0.5mm之间(最优选在0.01mm至0.25mm之间)的深度的凸起形成的浮雕结构。 第二夹持垫包括基本平滑的第二夹持表面。 浮雕结构的突起可以具有尖端或平面端面,并且可以是赋予第一夹持表面的纹理或图案(例如,交叉阴影线槽的图案)的一部分。 夹爪构件的夹持垫优选用相同的热塑性材料或其它合适的材料一体地形成。 在优选实施例中,衣架主体与夹具的至少一个钳口构件及其夹紧垫一体形成。
    • 7. 发明授权
    • Indicator for garment hanger
    • 衣架指示器
    • US07318540B1
    • 2008-01-15
    • US11423033
    • 2006-06-08
    • Steven SuttonLeslie Blitz
    • Steven SuttonLeslie Blitz
    • A41D27/22
    • A47G25/485A47G25/1421A47G25/16
    • A top indicating means for a hanger having a metal hook includes two mounting portions and an indicator. Each of the mounting portions includes a base defining a curved channel, engagement structure to couple the mounting portions together, and preferably alignment structure for aligning the mounting portions relative to each other. Each of the mounting portions also includes an indicator support having a web and locking structure for locking the indicator on the web. In use, the mounting portions are positioned on either side of the upper portion of the metal hook of the hanger and locked together. The indicator is then pushed over the top of the adjacent web portions and locked thereon.
    • 具有金属钩的衣架的顶部指示装置包括两个安装部分和指示器。 每个安装部分包括限定弯曲通道的基部,用于将安装部分联接在一起的接合结构,并且优选地将安装部分相对于彼此对准的对准结构。 每个安装部分还包括具有腹板和用于将指示器锁定在腹板上的锁定结构的指示器支撑件。 在使用中,安装部分位于衣架的金属钩的上部的任一侧上并锁定在一起。 然后将指示器推到相邻腹板部分的顶部上并锁定在其上。
    • 8. 发明授权
    • Garment hanger with removable side indicator
    • 服装衣架与可拆卸的侧面指示器
    • US07278559B1
    • 2007-10-09
    • US11191298
    • 2005-07-28
    • Steven SuttonJohn G. Warmath
    • Steven SuttonJohn G. Warmath
    • A41D27/22
    • A47G25/1435
    • A hanger according to the invention includes a cross member with a centrally located hook. A web is formed between the hook and the cross member and is adapted to receive a conventional indicator. The web includes a rib, followed by a valley, followed by a ramp, followed by a plateau. According to the invention, the rib is beveled at the one end and a notch is provided in the web adjacent the beveled end of the rib, the notch extending from the rib to the ramp or to the plateau. The indicator is easily removed from the rib by pressing it into the notch, then sliding it off the web.
    • 根据本发明的衣架包括具有中心定位的钩子的横梁。 腹板形成在钩和横向构件之间并适于接收常规的指示器。 网包括一个肋,其次是一个山谷,随后是一个坡道,其次是一个高原。 根据本发明,肋在一端是倾斜的,并且相邻于肋的倾斜端部的腹板中设有凹口,凹口从肋延伸到斜面或平台。 该指示器通过将其压入凹口中而容易地从肋上移除,然后将其从网上滑出。