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1. 发明公开

EP3033353A1 T CELL RECEPTORS 审中-公开
标题翻译： T细胞受体
公开(公告)号：EP3033353A1
公开(公告)日：2016-06-22
申请号：EP14761391.3
申请日：2014-08-12
申请人： Immunocore Ltd.
发明人： SU, Qin , MOLLOY, Peter , LIDDY, Nathaniel
IPC分类号： C07K14/05
CPC分类号： C07K14/05 , A61K39/12 , A61K2039/6056 , C07K14/7051 , C07K16/2809 , C07K2317/622 , C07K2319/00 , C07K2319/03 , C07K2319/30 , C12N7/00 , C12N2710/16222 , C12N2710/16234 , C12N2710/16271
摘要： The present invention relates to T cell receptors (TCRs) which bind the HLA-A2 restricted CLGGLLTMV peptide derived from the LMP2A protein from Epstein Barr Virus (EBV). TCRs of the invention comprise a TCR alpha chain variable domain and/or a TCR beta variable domain. Certain preferred TCRs also bind the natural peptide variants SLGGLLTMV and CLGGLITMV presented as a peptide-HLA-A2 complex. The TCRs of the invention demonstrate excellent specificity profiles for those LMP2A epitopes and have binding affinities for the complex which result in an enhanced ability to recognize the complex compared to a soluble reference TCR having the extracellular sequence of the native EBV LMP2A TCR alpha chain given in Figure 3 (SEQ ID No: 4) and the extracellular sequence of the native EBV LMP2A TCR beta chain given in Figure 4 (SEQ ID No: 5)
摘要翻译：本发明涉及结合源自来自EB病毒（EBV）的LMP2A蛋白的HLA-A2限制性CLGGLLTMV肽的T细胞受体（TCR）。本发明的TCR包含TCRα链可变结构域和/或TCRβ可变结构域。某些优选的TCR还结合呈现为肽-HLA-A2复合物的天然肽变体SLGGLLTMV和CLGGLITMV。本发明的TCR显示出对于那些LMP2A表位具有优异的特异性概况并且对复合物具有结合亲和力，与具有天然EBV LMP2ATCRα链的细胞外序列的可溶性参考TCR相比，这导致识别复合物的能力增强图3（SEQ ID No：4）和图4中给出的天然EBV LMP2ATCRβ链的胞外序列（SEQ ID No：4）

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