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    • 2. 发明授权
    • System to provide myocardial and neural stimulation
    • 系统提供心肌和神经刺激
    • US07660628B2
    • 2010-02-09
    • US11087935
    • 2005-03-23
    • Imad LibbusQingsheng ZhuScott VanderlindeAndrew P. KramerAnkur GargKristofer J. James
    • Imad LibbusQingsheng ZhuScott VanderlindeAndrew P. KramerAnkur GargKristofer J. James
    • A61N1/36
    • A61N1/36114A61N1/36057A61N1/36117A61N1/36128A61N1/3621A61N1/3627
    • Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.
    • 各种方面提供可植入装置。 在各种实施例中,该装置包括至少一个端口,其中每个端口适于将引线与电极连接到该装置。 所述装置还包括刺激平台,包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路,以将刺激信号通过所述刺激通道传递到 电极。 刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。 感测和刺激电路适用于执行CRM功能。 该装置还包括连接到感测电路和刺激电路的控制器,以控制神经刺激疗法和CRM治疗。 本文提供了其它方面和实施例。
    • 3. 发明授权
    • System to provide myocardial and neural stimulation
    • 系统提供心肌和神经刺激
    • US08478397B2
    • 2013-07-02
    • US12686704
    • 2010-01-13
    • Imad LibbusQingsheng ZhuScott VanderlindeAndrew P. KramerAnkur GargKristofer J. James
    • Imad LibbusQingsheng ZhuScott VanderlindeAndrew P. KramerAnkur GargKristofer J. James
    • A61N1/36
    • A61N1/36114A61N1/36057A61N1/36117A61N1/36128A61N1/3621A61N1/3627
    • Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.
    • 各种方面提供可植入装置。 在各种实施例中,该装置包括至少一个端口,其中每个端口适于将引线与电极连接到该装置。 所述装置还包括刺激平台,包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路,以将刺激信号通过所述刺激通道传递到 电极。 刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。 感测和刺激电路适用于执行CRM功能。 该装置还包括连接到感测电路和刺激电路的控制器,以控制神经刺激疗法和CRM治疗。 本文提供了其它方面和实施例。
    • 5. 发明申请
    • SENSING WITH COMPENSATION FOR NEURAL STIMULATOR
    • 感觉神经刺激器补偿
    • US20080021507A1
    • 2008-01-24
    • US11621194
    • 2007-01-09
    • Imad LibbusQingsheng ZhuSteven Girouard
    • Imad LibbusQingsheng ZhuSteven Girouard
    • A61N1/365
    • A61N1/36117A61N1/36135A61N1/36564
    • An aspect relates to an implantable medical system. An embodiment of the system comprises a baroreflex stimulator, a cardiac event detector, and communication circuitry. The stimulator includes a pulse generator to apply baroreflex stimulation therapy. The detector includes a sensor to detect electrical signals indicative of cardiac events, and a controller connected to the sensor to determine an occurrence of a cardiac event from the electrical signals using an event detection routine. The communication circuitry communicates between the baroreflex stimulator and the cardiac event detector to account for applied baroreflex stimulation therapy and enable the cardiac event detector to discriminate the electrical signals indicative of the cardiac event from the applied baroreflex stimulation therapy.
    • 一个方面涉及可植入医疗系统。 系统的一个实施例包括压力反射刺激器,心脏事件检测器和通信电路。 刺激器包括脉冲发生器以应用压力反射刺激疗法。 检测器包括用于检测指示心脏事件的电信号的传感器,以及连接到传感器的控制器,以使用事件检测程序从电信号确定心脏事件的发生。 通信电路在压力反射刺激器和心脏事件检测器之间进行通信,以解决所施加的压力反射刺激治疗,并且使得心脏事件检测器能够将指示心脏事件的电信号与施加的压力反射刺激疗法区分开。
    • 6. 发明申请
    • Sensing with compensation for neural stimulator
    • 感应神经刺激器补偿
    • US20050149133A1
    • 2005-07-07
    • US10746847
    • 2003-12-24
    • Imad LibbusQingsheng ZhuSteven Girouard
    • Imad LibbusQingsheng ZhuSteven Girouard
    • A61N1/36A61N1/365A61N1/362
    • A61N1/36117A61N1/36135A61N1/36564
    • An aspect of the present subject matter relates to an implantable medical system. An embodiment of the system comprises a baroreflex stimulator, a cardiac event detector, and communication circuitry. The stimulator includes a pulse generator to apply baroreflex stimulation therapy. The detector includes a sensor to detect electrical signals indicative of cardiac events, and a controller connected to the sensor to determine an occurrence of a cardiac event from the electrical signals using an event detection routine. The communication circuitry communicates between the baroreflex stimulator and the cardiac event detector to account for applied baroreflex stimulation therapy and enable the cardiac event detector to discriminate the electrical signals indicative of the cardiac event from the applied baroreflex stimulation therapy. Other aspects are provided herein.
    • 本主题的一个方面涉及可植入医疗系统。 系统的一个实施例包括压力反射刺激器,心脏事件检测器和通信电路。 刺激器包括脉冲发生器以应用压力反射刺激疗法。 检测器包括用于检测指示心脏事件的电信号的传感器,以及连接到传感器的控制器,以使用事件检测程序从电信号确定心脏事件的发生。 通信电路在压力反射刺激器和心脏事件检测器之间进行通信,以解决所施加的压力反射刺激治疗,并且使得心脏事件检测器能够将指示心脏事件的电信号与施加的压力反射刺激疗法区分开。 本文提供了其他方面。