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1. 发明申请

US20110319991A1 Low Profile Transcatheter Heart Valve 有权
标题翻译：薄型经导管心脏瓣膜
公开(公告)号：US20110319991A1
公开(公告)日：2011-12-29
申请号：US13167549
申请日：2011-06-23
申请人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh Khanna , Son Nguyen , Tamir Levi , Itai Pelled
发明人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh Khanna , Son Nguyen , Tamir Levi , Itai Pelled
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2/95 , A61F2002/9522 , A61F2220/0033 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , Y10T29/49863
摘要： An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.
摘要翻译：根据一个实施例的可植入人造瓣膜包括框架，小叶结构和裙部构件。框架可以具有由多个圆周支柱互连的多个轴向支柱。小叶结构包括多个传单（例如，安排形成三尖瓣的三个小叶）。小叶结构具有固定到框架的扇形下边缘部分。裙部构件可以设置在小叶结构和框架之间。

2. 发明授权

US08454685B2 Low profile transcatheter heart valve 有权
标题翻译：低调的经导管心脏瓣膜
公开(公告)号：US08454685B2
公开(公告)日：2013-06-04
申请号：US13167549
申请日：2011-06-23
申请人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh Khanna , Son Nguyen , Tamir Levi , Itai Pelled
发明人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh Khanna , Son Nguyen , Tamir Levi , Itai Pelled
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2/95 , A61F2002/9522 , A61F2220/0033 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , Y10T29/49863
摘要： An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.
摘要翻译：根据一个实施例的可植入人造瓣膜包括框架，小叶结构和裙部构件。框架可以具有由多个圆周支柱互连的多个轴向支柱。小叶结构包括多个传单（例如，安排形成三尖瓣的三个小叶）。小叶结构具有固定到框架的扇形下边缘部分。裙部构件可以设置在小叶结构和框架之间。

3. 发明授权

US07993394B2 Low profile transcatheter heart valve 有权
标题翻译：低调的经导管心脏瓣膜
公开(公告)号：US07993394B2
公开(公告)日：2011-08-09
申请号：US12480603
申请日：2009-06-08
申请人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh Khanna , Son Nguyen , Tamir Levi , Itai Pelled
发明人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh Khanna , Son Nguyen , Tamir Levi , Itai Pelled
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2/95 , A61F2002/9522 , A61F2220/0033 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , Y10T29/49863
摘要： An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.
摘要翻译：根据一个实施例的可植入人造瓣膜包括框架，小叶结构和裙部构件。框架可以具有由多个圆周支柱互连的多个轴向支柱。小叶结构包括多个传单（例如，安排形成三尖瓣的三个小叶）。小叶结构具有固定到框架的扇形下边缘部分。裙部构件可以设置在小叶结构和框架之间。

4. 发明申请

US20100036484A1 LOW PROFILE TRANSCATHETER HEART VALVE 有权
标题翻译：低剖面转盘心阀
公开(公告)号：US20100036484A1
公开(公告)日：2010-02-11
申请号：US12480603
申请日：2009-06-08
申请人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhoh , Rajesh Khanna , Son V. Nguyen , Tamir Levi , Itai Pelled
发明人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhoh , Rajesh Khanna , Son V. Nguyen , Tamir Levi , Itai Pelled
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2/95 , A61F2002/9522 , A61F2220/0033 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , Y10T29/49863
摘要： An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.
摘要翻译：根据一个实施例的可植入人造瓣膜包括框架，小叶结构和裙部构件。框架可以具有由多个圆周支柱互连的多个轴向支柱。小叶结构包括多个传单（例如，安排形成三尖瓣的三个小叶）。小叶结构具有固定到框架的扇形下边缘部分。裙部构件可以设置在小叶结构和框架之间。

5. 发明申请

US20120226349A1 Mitral Valve Repair 有权
标题翻译：二尖瓣修复
公开(公告)号：US20120226349A1
公开(公告)日：2012-09-06
申请号：US13038097
申请日：2011-03-01
申请人： Yosi Tuval , Ilia Hariton
发明人： Yosi Tuval , Ilia Hariton
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61B17/0401 , A61B2017/00243 , A61B2017/00292 , A61B2017/00783 , A61B2017/0409 , A61B2017/0417 , A61B2017/0441 , A61B2017/0443 , A61B2017/06095 , A61B2017/0649 , A61B2017/22038 , A61F2/2445 , A61F2/2457
摘要： Apparatus and methods are provided for use with a mitral valve of a heart of a subject. The apparatus includes a P1-anchor, a P2-anchor, and a P3-anchor, that are anchored to tissue in a vicinity of, respectively, P1, P2 and P3 segments of a posterior leaflet of the mitral valve, a tether being fixedly coupled to the P2-anchor, and slidably coupled to the P1 and P3 anchors. A cardiac-site anchor anchors the tether to an anchoring location that is at a cardiac site that is anterior and inferior to the posterior leaflet. Other embodiments are also described.
摘要翻译：提供了与受试者心脏的二尖瓣一起使用的装置和方法。该装置包括分别固定在二尖瓣后叶的P1，P2和P3段附近的组织的P1锚，P2锚和P3锚，系固固定耦合到P2锚，并且可滑动地联接到P1和P3锚。心脏锚定点将系绳锚固到位于前叶和下叶的心脏部位的锚定位置。还描述了其它实施例。

6. 发明授权

US09445898B2 Mitral valve repair 有权
标题翻译：二尖瓣修复
公开(公告)号：US09445898B2
公开(公告)日：2016-09-20
申请号：US13038097
申请日：2011-03-01
申请人： Yosi Tuval , Ilia Hariton
发明人： Yosi Tuval , Ilia Hariton
IPC分类号： A61F2/24 , A61B17/04 , A61B17/00 , A61B17/06 , A61B17/064 , A61B17/22
CPC分类号： A61F2/2409 , A61B17/0401 , A61B2017/00243 , A61B2017/00292 , A61B2017/00783 , A61B2017/0409 , A61B2017/0417 , A61B2017/0441 , A61B2017/0443 , A61B2017/06095 , A61B2017/0649 , A61B2017/22038 , A61F2/2445 , A61F2/2457
摘要： Apparatus and methods are provided for use with a mitral valve of a heart of a subject. The apparatus includes a P1-anchor, a P2-anchor, and a P3-anchor, that are anchored to tissue in a vicinity of, respectively, P1, P2and P3segments of a posterior leaflet of the mitral valve, a tether being fixedly coupled to the P2-anchor, and slidably coupled to the P1and P3anchors. A cardiac-site anchor anchors the tether to an anchoring location that is at a cardiac site that is anterior and inferior to the posterior leaflet. Other embodiments are also described.
摘要翻译：提供了与受试者心脏的二尖瓣一起使用的装置和方法。该装置包括分别位于二尖瓣后叶的P1，P2和P3附近的组织附近的P1锚，P2锚和P3锚，系固固耦合到 P2锚，并且可滑动地联接到P1和P3撑杆。心脏锚定点将系绳锚固到位于前叶和下叶的心脏部位的锚定位置。还描述了其它实施例。

7. 发明申请

US20110208297A1 Mitral Prosthesis and Methods for Implantation 审中-公开
标题翻译：二尖瓣假体和植入方法
公开(公告)号：US20110208297A1
公开(公告)日：2011-08-25
申请号：US12914611
申请日：2010-10-28
申请人： Yosi Tuval , Ilia Hariton , Igor Kovalsky , Eli Ben-Hamou
发明人： Yosi Tuval , Ilia Hariton , Igor Kovalsky , Eli Ben-Hamou
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2436 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0013 , A61F2230/005 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2250/0039 , A61F2250/006
摘要： Apparatus and methods are provided including a mitral valve prosthesis. The prosthesis includes an inner support structure having downstream and upstream sections, the upstream section having a cross-sectional area greater than the downstream section. The inner support structure is configured to be positioned on an atrial side of the native valve complex, and to prevent the prosthesis from being dislodged into the left ventricle. A prosthetic valve having prosthetic valve leaflets is coupled to the inner support structure. An outer support structure has engagement arms, downstream ends of the engagement arms being coupled to the inner support structure. The prosthesis is configured such that, upon implantation thereof: downstream ends of the native valve leaflets, downstream ends of the engagement arms, and downstream ends of the prosthetic leaflets, are disposed at a longitudinal distance from one another of less than 3 mm. Other embodiments are also described.
摘要翻译：提供了包括二尖瓣假体的装置和方法。所述假体包括具有下游部分和上游部分的内部支撑结构，所述上游部分具有大于所述下游部分的横截面面积。内部支撑结构被配置为定位在天然瓣膜复合体的心房侧，并且防止假体被移动到左心室中。具有假体瓣膜小叶的人工瓣膜联接到内部支撑结构。外部支撑结构具有接合臂，接合臂的下游端连接到内部支撑结构。所述假体被构造成使得在植入时：所述天然瓣膜的下游端，所述接合臂的下游端和所述假体小叶的下游端彼此以小于3mm的纵向距离设置。还描述了其它实施例。

8. 发明授权

US10433956B2 Mitral prosthesis and methods for implantation 有权
公开(公告)号：US10433956B2
公开(公告)日：2019-10-08
申请号：US12914611
申请日：2010-10-28
申请人： Yosi Tuval , Ilia Hariton , Igor Kovalsky , Eli Ben-Hamou
发明人： Yosi Tuval , Ilia Hariton , Igor Kovalsky , Eli Ben-Hamou
IPC分类号： A61F2/24
摘要： Apparatus and methods are provided including a mitral valve prosthesis. The prosthesis includes an inner support structure having downstream and upstream sections, the upstream section having a cross-sectional area greater than the downstream section. The inner support structure is configured to be positioned on an atrial side of the native valve complex, and to prevent the prosthesis from being dislodged into the left ventricle. A prosthetic valve having prosthetic valve leaflets is coupled to the inner support structure. An outer support structure has engagement arms, downstream ends of the engagement arms being coupled to the inner support structure. The prosthesis is configured such that, upon implantation thereof: downstream ends of the native valve leaflets, downstream ends of the engagement arms, and downstream ends of the prosthetic leaflets, are disposed at a longitudinal distance from one another of less than 3 mm. Other embodiments are also described.

9. 发明申请

US20110208298A1 Mitral Prosthesis and Methods for Implantation 有权
标题翻译：二尖瓣假体和植入方法
公开(公告)号：US20110208298A1
公开(公告)日：2011-08-25
申请号：US12914678
申请日：2010-10-28
申请人： Yosi Tuval , Ilia Hariton , Igor Kovalsky , Eli Ben-Hamou
发明人： Yosi Tuval , Ilia Hariton , Igor Kovalsky , Eli Ben-Hamou
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0013 , A61F2230/005 , A61F2230/008 , A61F2250/0039 , A61F2250/006
摘要： Apparatus and methods are provided, including a mitral valve prosthesis for implantation at a native mitral valve complex of a subject. The prosthesis includes an inner support structure having a downstream section, and an upstream section, the upstream section having a cross-sectional area greater than the downstream section, the inner support structure being configured to be positioned at least partially on an atrial side of the native valve complex, and to apply an axial force directed toward a left ventricle. The prosthesis further includes an outer support structure having two or more engagement arms, the engagement arms being coupled to the inner support structure. The prosthesis is configured, upon implantation thereof, to clamp portions of leaflets of the native valve between the inner support structure and the engagement arms. Other embodiments are also described.
摘要翻译：提供了装置和方法，包括用于植入受试者的天然二尖瓣复合体的二尖瓣假体。所述假体包括具有下游部分的内部支撑结构，以及上游部分，所述上游部分具有大于所述下游部分的横截面面积，所述内部支撑结构构造成至少部分地定位在所述下游部分的心房侧天然瓣膜复合物，并施加指向左心室的轴向力。所述假体还包括具有两个或更多个接合臂的外部支撑结构，所述接合臂联接到所述内部支撑结构。假体在植入时构造成将内部支撑结构和接合臂之间的天然瓣膜的小叶的部分夹紧。还描述了其它实施例。

10. 发明授权

US09072603B2 Mitral prosthesis and methods for implantation 有权
标题翻译：二尖瓣假体和植入方法
公开(公告)号：US09072603B2
公开(公告)日：2015-07-07
申请号：US12914678
申请日：2010-10-28
申请人： Yosi Tuval , Ilia Hariton , Igor Kovalsky , Eli Ben-Hamou
发明人： Yosi Tuval , Ilia Hariton , Igor Kovalsky , Eli Ben-Hamou
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0013 , A61F2230/005 , A61F2230/008 , A61F2250/0039 , A61F2250/006
摘要： Apparatus and methods are provided, including a mitral valve prosthesis for implantation at a native mitral valve complex of a subject. The prosthesis includes an inner support structure having a downstream section, and an upstream section, the upstream section having a cross-sectional area greater than the downstream section, the inner support structure being configured to be positioned at least partially on an atrial side of the native valve complex, and to apply an axial force directed toward a left ventricle. The prosthesis further includes an outer support structure having two or more engagement arms, the engagement arms being coupled to the inner support structure. The prosthesis is configured, upon implantation thereof, to clamp portions of leaflets of the native valve between the inner support structure and the engagement arms. Other embodiments are also described.
摘要翻译：提供了装置和方法，包括用于植入受试者的天然二尖瓣复合体的二尖瓣假体。所述假体包括具有下游部分的内部支撑结构，以及上游部分，所述上游部分具有大于所述下游部分的横截面积，所述内部支撑结构被配置为至少部分地定位在所述下游部分的心房侧天然瓣膜复合物，并施加指向左心室的轴向力。所述假体还包括具有两个或更多个接合臂的外部支撑结构，所述接合臂联接到所述内部支撑结构。假体在植入时构造成将内部支撑结构和接合臂之间的天然瓣膜的小叶的部分夹紧。还描述了其它实施例。

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