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1. 发明授权

US07435386B2 Reagentless and reusable biosensors with tunable differential binding affinities and methods of making 有权
标题翻译：具有可调节差异结合亲和力和制备方法的无菌和可重复使用的生物传感器
公开(公告)号：US07435386B2
公开(公告)日：2008-10-14
申请号：US11094540
申请日：2005-03-25
申请人： Igor L. Medintz , Ellen R. Goldman , George P. Anderson , J. Matthew Mauro
发明人： Igor L. Medintz , Ellen R. Goldman , George P. Anderson , J. Matthew Mauro
IPC分类号： G01N21/00 , G01N21/01 , G01N21/64 , G01N33/53 , G01N33/553
CPC分类号： C12Q1/6818 , B82Y5/00 , B82Y10/00 , C12Q1/6825 , G01N21/6428 , G01N2021/6441 , C12Q2565/607 , C12Q2565/101
摘要： The biosensor comprises a modular biorecognition element and a modular flexible arm element. The biorecognition element and the flexible arm element are each labeled with a signaling element. The flexible arm contains an analog of an analyte of interest that binds with the biorecognition element, bringing the two signaling elements in close proximity, which establishes a baseline fluorescence resonance energy transfer (FRET). When an analyte of interest is provided to the biosensor, the analyte will displace the analyte analog, and with it, the signaling module of the modular flexible arm, causing a measurable change in the FRET signal in a analyte concentration dependent manner. The modularity of different portions of the biosensor allows functional flexibility. The biosensor-operates without additional development reagents, requiring only the presence of analyte or target for function.
摘要翻译：生物传感器包括模块化生物识别元件和模块化柔性臂元件。生物识别元件和柔性臂元件各自用信号元件标记。柔性臂包含与生物识别元件结合的感兴趣分析物的类似物，使得两个信号元件紧密相邻，这建立了基线荧光共振能量转移（FRET）。当感兴趣的分析物被提供给生物传感器时，分析物将置换分析物类似物，并且借助于该模块化柔性臂的信号模块，以分析物浓度依赖的方式引起FRET信号的可测量的变化。生物传感器的不同部分的模块化允许功能灵活性。生物传感器无需额外的开发试剂即可进行操作，仅需要分析物或靶标的功能。

2. 发明申请

US20090048123A1 Reagentless and Reusable Biosensors with Tunable Differential Binding Affinities and Methods of Making 有权
标题翻译：具有可调节差异结合亲和力的制剂和可重复使用的生物传感器和制备方法
公开(公告)号：US20090048123A1
公开(公告)日：2009-02-19
申请号：US12103778
申请日：2008-04-16
申请人： Igor L. Medintz , Ellen R. Goldman , George P. Anderson , J. Matthew Mauro
发明人： Igor L. Medintz , Ellen R. Goldman , George P. Anderson , J. Matthew Mauro
IPC分类号： C40B40/04 , G01N21/64 , C12M1/00 , C40B50/00
CPC分类号： C12Q1/6818 , B82Y5/00 , B82Y10/00 , C12Q1/6825 , G01N21/6428 , G01N2021/6441 , C12Q2565/607 , C12Q2565/101
摘要： The biosensor comprises a modular biorecognition element and a modular flexible arm element. The biorecognition element and the flexible arm element are each labeled with a signaling element. The flexible arm contains an analog of an analyte of interest that binds with the biorecognition element, bringing the two signaling elements in close proximity, which establishes a baseline fluorescence resonance energy transfer (FRET). When an analyte of interest is provided to the biosensor, the analyte will displace the analyte analog, and with it, the signaling module of the modular flexible arm, causing a measurable change in the FRET signal in a analyte concentration dependent manner. The modularity of different portions of the biosensor allows functional flexibility. The biosensor operates without additional development reagents, requiring only the presence of analyte or target for function.
摘要翻译：生物传感器包括模块化生物识别元件和模块化柔性臂元件。生物识别元件和柔性臂元件各自用信号元件标记。柔性臂包含与生物识别元件结合的感兴趣分析物的类似物，使得两个信号元件紧密相邻，这建立了基线荧光共振能量转移（FRET）。当感兴趣的分析物被提供给生物传感器时，分析物将置换分析物类似物，并且借助于该模块化柔性臂的信号模块，以分析物浓度依赖的方式引起FRET信号的可测量的变化。生物传感器的不同部分的模块化允许功能灵活性。生物传感器无需额外的开发试剂即可运行，仅需要分析物或靶标的存在才能发挥作用。

3. 发明授权

US09970049B2 Use of modular nucleic acid scaffolds to create nanoscale energy harvesting and focusing arrays 有权
公开(公告)号：US09970049B2
公开(公告)日：2018-05-15
申请号：US14685836
申请日：2015-04-14
申请人： Susan Buckhout-White , Mario Ancona , Ellen R. Goldman , Igor L. Medintz , Joseph S. Melinger
发明人： Susan Buckhout-White , Mario Ancona , Ellen R. Goldman , Igor L. Medintz , Joseph S. Melinger
IPC分类号： C12Q1/68 , G01N21/64
CPC分类号： C12Q1/6818 , G01N21/6428 , C12Q2563/155
摘要： The invention relates to a nanoscale antenna including a nucleic acid scaffold having a structure selected from the group consisting of a Holliday junction, a star, and a dendrimer; and a plurality of fluorophores attached to the scaffold and configured as a FRET cascade comprising at least three different types of fluorophores, arranged with (a) a plurality of initial donor fluorophores fixed in exterior positions on the structure, (b) a terminal acceptor fluorophore fixed in a central position on the structure, and (c) a plurality of intermediate fluorophores fixed in positions on the scaffold between the initial acceptor fluorophores and the terminal acceptor fluorophores.

4. 发明申请

US20150293022A1 Use of Modular Nucleic Acid Scaffolds to Create Nanoscale Energy Harvesting and Focusing Arrays 有权
标题翻译：使用模块化核酸支架创建纳米级能量收集和聚焦数组
公开(公告)号：US20150293022A1
公开(公告)日：2015-10-15
申请号：US14685836
申请日：2015-04-14
申请人： Susan Buckhout-White , Mario Ancona , Ellen R. Goldman , Igor L. Medintz , Joseph S. Melinger
发明人： Susan Buckhout-White , Mario Ancona , Ellen R. Goldman , Igor L. Medintz , Joseph S. Melinger
IPC分类号： G01N21/64 , C12Q1/68
CPC分类号： C12Q1/6818 , G01N21/6428 , C12Q2563/155
摘要： The invention relates to a nanoscale antenna including a nucleic acid scaffold having a structure selected from the group consisting of a Holliday junction, a star, and a dendrimer; and a plurality of fluorophores attached to the scaffold and configured as a FRET cascade comprising at least three different types of fluorophores, arranged with (a) a plurality of initial donor fluorophores fixed in exterior positions on the structure, (b) a terminal acceptor fluorophore fixed in a central position on the structure, and (c) a plurality of intermediate fluorophores fixed in positions on the scaffold between the initial acceptor fluorophores and the terminal acceptor fluorophores.
摘要翻译：本发明涉及纳米尺度天线，其包括具有选自Holliday结，星形和树枝状大分子的结构的核酸支架; 和多个荧光团，其连接到支架并被配置为包含至少三种不同类型的荧光团的FRET级联，其布置为（a）固定在结构上的外部位置的多个初始供体荧光团，（b）末端受体荧光团固定在结构上的中心位置，和（c）固定在起始受体荧光团和末端受体荧光团之间的支架上的位置上的多个中间荧光团。

5. 发明授权

US09304124B2 Compact multifunctional ligand to enhance colloidal stability of nanoparticles 有权
公开(公告)号：US09304124B2
公开(公告)日：2016-04-05
申请号：US13942983
申请日：2013-07-16
申请人： Igor L. Medintz , Kimihiro Susumu , Michael H. Stewart
发明人： Igor L. Medintz , Kimihiro Susumu , Michael H. Stewart
IPC分类号： C07D339/04 , C07D293/00 , C07D285/16 , C07D487/00 , A61K9/14 , G01N33/50 , C07K17/14 , C07D409/12 , C07D251/70 , C07D295/13 , B82Y5/00 , B82Y15/00
CPC分类号： G01N33/5005 , A61K9/14 , B82Y5/00 , B82Y15/00 , C07D251/70 , C07D295/13 , C07D339/04 , C07D409/12 , C07K17/14 , Y10S977/774 , Y10S977/788
摘要： A ligand design allows compact nanoparticle materials, such as quantum dots (QDs), with excellent colloidal stability over a wide range of pH and under high salt concentrations. Self-assembled biomolecular conjugates with QDs can be obtained which are stable in biological environments. Energy transfer with these ligands is maximized by minimizing distances between QDs/nanoparticles and donors/acceptors directly attached to the ligands or assembled on their surfaces.

6. 发明授权

US09139614B2 Modular linkers for conjugation of organic substances to substantially inorganic substances and methods of manufacture and use thereof 有权
标题翻译：用于将有机物质与基本上无机物质共轭的模块化接头及其制造方法和用途
公开(公告)号：US09139614B2
公开(公告)日：2015-09-22
申请号：US11739969
申请日：2007-04-25
申请人： Igor L. Medintz , Lorenzo Berti , Paolo Facci , Hedi M. Mattoussi
发明人： Igor L. Medintz , Lorenzo Berti , Paolo Facci , Hedi M. Mattoussi
IPC分类号： A61K38/00 , C07K7/06
CPC分类号： C07K7/06
摘要： A modular linker includes an inorganic binding entity having an affinity for a substantially inorganic substance, and an organic binding entity capable of binding with an organic substance covalently bonded thereto. The modular linker is capable of being stored in a stable condition for later use. The modular linker may be synthesized by modifying the inorganic binding entity to be covalently bonded to an organic binding entity and storing the modular linker in an inert environment from about a day up to at least 1 week. The modular linker may be conjugated to an organic substance and to a substantially inorganic substance in substantially a 1:1 ratio. The modular linker may have more than one organic binding entity covalently bonded to an inorganic binding entity or vice-versa. Also, a particular modular linker may have an organic binding entity capable of binding with a nucleic acid sequence.
摘要翻译：模块化接头包括对基本上无机物质具有亲和力的无机结合实体，以及能够与共价键合的有机物结合的有机结合实体。模块化连接器能够在稳定的条件下储存以供以后使用。可以通过将无机结合实体改性为共价键合到有机结合实体并将模块化连接体从大约一天至少至少1周存储在惰性环境中来合成模块化接头。模块化接头可以以基本上1:1的比例与有机物质和基本上无机物质缀合。模块化接头可以具有多于一个共价结合到无机结合实体的有机结合实体，反之亦然。而且，特定的模块化接头可以具有能够与核酸序列结合的有机结合实体。

7. 发明授权

US09120967B2 Concentric forster resonance energy transfer relay for the parallel detection of two bio/physicochemical process 有权
标题翻译：同心福斯特共振能量转移继电器用于并行检测两个生物/物理化学过程
公开(公告)号：US09120967B2
公开(公告)日：2015-09-01
申请号：US14201279
申请日：2014-03-07
申请人： Igor L. Medintz , W. Russ Algar
发明人： Igor L. Medintz , W. Russ Algar
IPC分类号： H01L29/06 , H01L21/00 , H01L33/26 , C09K11/02 , C09K11/06 , C09K11/56 , C09K11/88 , G01N21/64 , G01N33/58 , G01N33/542 , A61K49/00 , H01L33/06 , H01L51/56
CPC分类号： C09K11/02 , A61K49/0093 , C09K11/025 , C09K11/06 , C09K11/565 , C09K11/883 , G01N21/6428 , G01N33/542 , G01N33/582 , G01N33/588 , G01N2021/6441 , H01L21/00 , H01L33/06 , H01L51/56
摘要： Described herein is a Förster (or fluorescence) resonance energy transfer (FRET) configuration with three energy transfer pathways between three luminescent components, where two of the energy transfer steps occur in sequence as a relay, and the first step of the relay is in competition with a third energy transfer process (energy transfer from the donor to the intermediary is in competition with energy transfer from the donor directly to the terminal acceptor).
摘要翻译：这里描述的是Förster（或荧光）共振能量传递（FRET）配置，其中三个发光组件之间具有三个能量传递路径，其中两个能量传递步骤依次作为继电器发生，并且继电器的第一步骤是竞争的第三种能量转移过程（从供体到中间体的能量转移与从供体直接向终端受体的能量转移竞争）。

8. 发明授权

US08859284B2 Delivery of nanoparticles to neurons 有权
标题翻译：纳米颗粒递送到神经元
公开(公告)号：US08859284B2
公开(公告)日：2014-10-14
申请号：US13679335
申请日：2012-11-16
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman , Kimihiro Susumu , Michael H. Stewart , Ryan Walters
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman , Kimihiro Susumu , Michael H. Stewart , Ryan Walters
IPC分类号： C12N5/00 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K47/20 , C12Q1/02 , B82Y5/00 , A61K47/48 , A61K49/00 , G01N33/50
CPC分类号： A61K47/20 , A61K47/48192 , A61K47/4823 , A61K47/48238 , A61K47/48861 , A61K47/48884 , A61K47/59 , A61K47/61 , A61K47/62 , A61K47/6923 , A61K47/6929 , A61K49/0067 , B82Y5/00 , C12Q1/02 , G01N33/5058
摘要： A peptide attached to a nanoparticles (such as quantum dots) selectively directs the nanoparticles to neurons in a tissue or organism.
摘要翻译：连接到纳米颗粒（例如量子点）的肽选择性地将纳米颗粒引导到组织或生物体中的神经元。

9. 发明申请

US20130309671A1 Spectro-Temporal Optical Encoding of Information Using a Time-Gated Fluorescence Resonance Energy Transfer (FRET) 审中-公开
标题翻译：使用时间门控荧光共振能量转移（FRET）的信息的光谱时间光编码
公开(公告)号：US20130309671A1
公开(公告)日：2013-11-21
申请号：US13911157
申请日：2013-06-06
申请人： W. Russ Algar , Niko Hildebrandt , Alan L. Huston , Igor L. Medintz
发明人： W. Russ Algar , Niko Hildebrandt , Alan L. Huston , Igor L. Medintz
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , B82Y15/00 , B82Y20/00 , G01N21/6408 , G01N21/6428 , G01N33/542 , G01N33/588 , G01N2021/6441
摘要： Described herein is a time-gated, two-step FRET relay effective to provide temporal transference of a prompt FRET pathway, or provide spectro-temporal encoding analytical signals and other information. A FRET relay assembly includes a long lifetime FRET donor (for example, a lanthanide complex), a semiconductor quantum dot (QD) configured as an intermediate acceptor/donor in FRET, and a fluorescent dye configured as a terminal FRET acceptor, wherein the long lifetime FRET donor has an excited state lifetime of at least one microsecond and the QD and fluorescent dye each have excited state lifetimes of less than 100 nanoseconds.
摘要翻译：这里描述的是时间选择的两步FRET继电器，其有效地提供快速FRET通路的时间转移，或提供频谱编码分析信号和其他信息。 FRET继电器组件包括长寿命FRET供体（例如镧系元素络合物），配置为FRET中的中间受体/供体的半导体量子点（QD）和配置为末端FRET受体的荧光染料，其中长时间寿命FRET供体具有至少1微秒的激发态寿命，并且QD和荧光染料各自具有小于100纳秒的激发态寿命。

10. 发明申请

US20120248409A1 Simultaneous Modulation of Quantum Dot Photoluminescence using Orthogonal Fluorescence Resonance Energy Transfer (FRET) and Charge Transfer Quenching (CTQ) 有权
标题翻译：使用正交荧光共振能量转移（FRET）和电荷转移淬火（CTQ）同时调制量子点光致发光
公开(公告)号：US20120248409A1
公开(公告)日：2012-10-04
申请号：US13439003
申请日：2012-04-04
申请人： Igor L. Medintz , W. Russ Algar , Michael H. Stewart , Kimihiro Susumu
发明人： Igor L. Medintz , W. Russ Algar , Michael H. Stewart , Kimihiro Susumu
IPC分类号： H01L33/06 , H01L33/26
CPC分类号： H01L33/06 , C09K11/06 , H01L27/3244 , H01L33/26 , H01L51/56
摘要： Quantum dots are modified with varying amounts of (a) a redox-active moiety effective to perform charge transfer quenching, and (b) a fluorescent dye effective to perform fluorescence resonance energy transfer (FRET), so that the modified quantum dots have a plurality of photophysical properties. The FRET and charge transfer pathways operate independently, providing for two channels of control for varying luminescence of quantum dots having the same innate properties.
摘要翻译：用不同量的（a）有效进行电荷转移淬灭的氧化还原活性部分修饰量子点，和（b）有效进行荧光共振能量转移（FRET）的荧光染料，使得修饰的量子点具有多个的光物理性质。 FRET和电荷转移通路独立运行，为具有相同固有特性的量子点的变化发光提供两个通道控制。

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