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1. 发明专利

JP2010166971A Method and apparatus for reinforcing or restoring movement of muscle 审中-公开
标题翻译：用于增强或恢复肌肉运动的方法和装置
公开(公告)号：JP2010166971A
公开(公告)日：2010-08-05
申请号：JP2009010212
申请日：2009-01-20
申请人： Ifg Inc , Tohoku Univ , 国立大学法人東北大学 , 株式会社Ifg
发明人： ABE TOSHIHIKO , TAKAGI TOSHIYUKI , IZUE SHINICHI , NAGATOMI RYOICHI , NAKAZATO NOBUKAZU , YASHIMA KAZUMI , MATSUZAKA YOSHIYA , ICHIHARA TOSHIAKI , ISHII KENJI
IPC分类号： A61N2/00
摘要： PROBLEM TO BE SOLVED: To provide a method and an apparatus for reinforcing or restoring the movement of muscles by moving the muscles whose voluntary movement is difficult because of the paralysis, generating a pulse magnetic field with the electric potential generated at the time as a trigger signal and generating a large muscular constriction; and to provide technologies for effectively implementing rehabilitation by constructing a nerve network with the plasticity especially of the brain and nerves. SOLUTION: Magnetic pulses are generated in a magnetic stimulation coil 7 connected to a pulse power supply 6 with one of the electric potential acquired by detecting the myoelectric potential accompanying the autonomic movement of muscles or the joint movement accompanying the movement of a joint by a sensor and converting the detected movement into an electric signal, or the action potential from the brain waves accompanying the planning and execution of the autonomic movement, or the electric potential acquired by detecting the change of the cerebral blood flow from near-infrared spectroscopy and converting the detected change into an electric signal as a trigger signal 5, and next, the motor area of the cerebrum or the muscles are stimulated with magnetism of the magnetic pulses. According to the method, the movement of the muscles is reinforced or restored. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过由于瘫痪而移动自愿运动困难的肌肉来增强或恢复肌肉运动的方法和装置，产生具有当时产生的电位的脉冲磁场作为触发信号并产生大的肌肉收缩; 并提供技术，通过构建神经网络，特别是脑和神经的可塑性，有效实施康复。解决方案：在连接到脉冲电源6的磁刺激线圈7中产生磁脉冲，其中通过检测伴随肌肉自主运动的肌电势获得的电位之一或伴随关节运动的关节运动而获得的电位之一通过传感器将检测到的运动转换成电信号，或伴随着自主运动的规划和执行的脑波的动作电位或通过从近红外光谱检测脑血流的变化而获得的电位并将检测到的变化转换为电信号作为触发信号5，接着，用磁脉冲的磁力刺激大脑或肌肉的运动区域。根据该方法，肌肉的运动被加强或恢复。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2010207268A Method and device for therapeutic magnetic stimulation of living body 审中-公开
标题翻译：用于生活体内治疗磁刺激的方法和装置
公开(公告)号：JP2010207268A
公开(公告)日：2010-09-24
申请号：JP2009053473
申请日：2009-03-06
申请人： Ifg Inc , Tohoku Univ , 国立大学法人東北大学 , 株式会社Ifg
发明人： ABE TOSHIHIKO , TAKAGI TOSHIYUKI , IZUE SHINICHI , NAGATOMI RYOICHI , NAKAZATO NOBUKAZU , YASHIMA KAZUMI , MATSUZAKA YOSHIYA , ICHIHARA TOSHIAKI , ISHII KENJI
IPC分类号： A61N2/00
摘要： PROBLEM TO BE SOLVED: To provide a method for therapeutic magnetic stimulation of a living body by which an electrometer is not broken by excessive voltage generated due to a magnetic stimulation coil installed near the electrometer, as a method for strengthening or recovering muscle which becomes difficult to exercise a voluntary movement due to paralysis. SOLUTION: In the method for strengthening or recovering movements of the muscle by magnetically stimulating a motor area of the brain or the muscle by a magnetic pulse generated by a magnetic stimulator with myoelectric potential detected by the electrometer or active potential from the brain wave as a trigger, after the myoelectric potential or action potential is detected by the electrometer, an input circuit of the electrometer is electrically cut off, then magnetic stimulation is given by a magnetic pulse, influences of induced voltage by the magnetic pulse disappear, and then the input circuit is conducted again. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于治疗磁刺激的方法，其通过静电计不会由于安装在静电计附近的磁刺激线圈产生的过大电压而破坏，作为强化或恢复肌肉的方法由于瘫痪而变得难以行使自愿行动。解决方案：在通过用磁刺激器产生的磁脉冲通过磁刺激脑或肌肉的运动区域来强化或恢复肌肉运动的方法中，该磁刺激器由静电计检测到肌电势或来自脑的活动电位波作为触发器，在电位计检测到肌电位或动作电位后，静电计的输入电路被电切断，然后用磁脉冲给出磁刺激，磁脉冲引起的感应电压的影响消失，然后再次进行输入电路。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2009039326A Converging magnetic field generation coil for transcranial magnetic stimulation 审中-公开
标题翻译：用于跨磁电刺激的磁场生成线圈
公开(公告)号：JP2009039326A
公开(公告)日：2009-02-26
申请号：JP2007207730
申请日：2007-08-09
申请人： Ifg Inc , Tohoku Univ , 国立大学法人東北大学 , 株式会社Ifg
发明人： ABE TOSHIHIKO , TAKAGI TOSHIYUKI , IZUE SHINICHI , NAGATOMI RYOICHI , YASHIMA YOSHINOBU , NAKAZATO NOBUKAZU
IPC分类号： A61N2/00 , A61B5/05
摘要： PROBLEM TO BE SOLVED: To provide a converging magnetic field generation coil for transcranial magnetic stimulation capable of magnetically stimulating a brain deep part by a relatively simple apparatus. SOLUTION: The converging magnetic field generation coil for the transcranial magnetic stimulation is characterized by that a pair of coils 1 and 2 are disposed facing each other, the coils 1 and 2 are excited respectively in opposite directions and a ring 3 of the conductor of a closed circuit is disposed between the coils. The converging magnetic field generation coil for the transcranial magnetic stimulation is characterized by that the ring 3 of the conductor of the closed circuit comprises one or two or more stages of the ring. The converging magnetic field generation coil for the transcranial magnetic stimulation is characterized by that, in the case that a set of the coils 1 and 2 arranged facing each other comprise multi-stage coils, the respective centers of the multi-stage coil are arranged at a position three-dimensionally away from the center of the coil facing each other. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供能够通过相对简单的装置磁刺激脑深部的经颅磁刺激的会聚磁场产生线圈。解决方案：用于经颅磁刺激的会聚磁场产生线圈的特征在于一对线圈1和2彼此相对设置，线圈1和2分别在相反方向被激励，并且环3 闭合电路的导体设置在线圈之间。用于经颅磁刺激的会聚磁场产生线圈的特征在于闭合电路的导体的环3包括环的一个或两个或多个阶段。用于经颅磁刺激的收敛磁场产生线圈的特征在于，在彼此面对的一组线圈1和2包括多级线圈的情况下，多级线圈的各个中心被布置在三维地离开线圈的中心彼此面对的位置。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2014161323A Cell culture method, and magnetic stimulation coil and power supply cable used for the same 有权
标题翻译：细胞培养方法和磁刺激线圈及其使用的电源电缆
公开(公告)号：JP2014161323A
公开(公告)日：2014-09-08
申请号：JP2013037822
申请日：2013-02-27
申请人： Tohoku Univ , 国立大学法人東北大学 , Ifg Inc , 株式会社Ifg
发明人： IZUE SHINICHI , KANETAKA HIROYASU , TAKAGI TOSHIYUKI , NAGATOMI RYOICHI , KUDO SHIRO , ABE TOSHIHIKO , MORI HITOSHI
IPC分类号： C12N5/079 , C12M1/42
摘要： PROBLEM TO BE SOLVED: To provide a method of noninvasively controlling cell differentiation in conducting cell culture.SOLUTION: Provided is a method of accelerating differentiation of a cell by conducting cell culture in a sequentially pulsed magnetic field, inducing the morphological and functional change of the cell, and forming a neurite of a nerve cell and accelerating acetylcholine esterase activity of the nerve cell by the morphological and functional change of the cell. In the method, the sequentially pulsed magnetic field is a magnetic field of intensity of 0.2 to 2 tesla, its pulse width is 0.01 to 10 ms and its time interval is 1 ms to 10 s. In addition, in the method, the morphological growth direction of the cell is controlled by the direction of a magnetic field to be applied to a cell culture vessel.
摘要翻译：要解决的问题：提供一种非侵入性地控制细胞培养中的细胞分化的方法。解决方案：提供一种通过在顺序脉冲磁场中进行细胞培养来促进细胞分化的方法，诱导细胞的形态和功能变化并通过细胞的形态和功能变化形成神经细胞的神经突，并加速神经细胞的乙酰胆碱酯酶活性。在该方法中，顺序脉冲磁场是强度为0.2-2斯特拉的磁场，其脉冲宽度为0.01至10毫秒，其时间间隔为1毫秒至10秒。此外，在该方法中，通过施加于细胞培养容器的磁场的方向来控制细胞的形态生长方向。

5. 发明专利

JP2013103121A Magnetic stimulation rehabilitation device 有权
标题翻译：磁刺激康复装置
公开(公告)号：JP2013103121A
公开(公告)日：2013-05-30
申请号：JP2011264090
申请日：2011-11-14
申请人： Ifg Inc , 株式会社Ifg , Tohoku Univ , 国立大学法人東北大学
发明人： IZUE SHINICHI , KANETAKA HIROYASU , TAKAGI TOSHIYUKI , NAGATOMI RYOICHI , NAKAZATO NOBUKAZU , KASE SHUICHIRO , SUZUKI EIZABURO , ABE TOSHIHIKO , MORI HITOSHI , YABUGAMI MAKOTO
IPC分类号： A61N1/40 , A61H1/02
CPC分类号： A61H1/02 , A61B5/1107 , A61H1/0285 , A61H2201/5002 , A61H2201/5064 , A61H2201/5092 , A61N2/006 , A61N2/02
摘要： PROBLEM TO BE SOLVED: To provide a technique for effectively performing a rehabilitation by moving a muscle or joint difficult to be voluntarily moved due to paralysis even a little by an individual's will and effort, detecting the site, direction and intensity of a motion caused on this occasion, generating a pulse magnetic field according to the level of a sensor signal to cause large muscle contraction by magnetic stimulation, thereby enhancing the intensity of the motion of the muscle, and creating a neural network using the plasticity of the brain.SOLUTION: A displacement caused in the muscle or joint by voluntary exercise is detected by an optical sensor, or an ultrasonic sensor, or a magnetic sensor, and a sensor output potential corresponding to the site, direction and intensity thereof is used as a trigger signal. A magnetic pulse of the intensity and frequency corresponding to the level of the trigger signal is generated in one or a plurality of magnetic stimulation coils connected to a pulse power source. The motor area of the cerebrum or the muscle is magnetically stimulated by this magnetic pulse, whereby the motion of the paralyzed muscle is enhanced.
摘要翻译：要解决的问题：提供一种通过移动由于瘫痪而难以自主移动的肌肉或关节的技术，甚至通过个人的意愿和努力来进行康复，检测位置，方向和强度在这种情况下引起的运动，根据传感器信号的电平产生脉冲磁场，以通过磁刺激引起大的肌肉收缩，从而增强肌肉运动的强度，并且使用大脑的可塑性产生神经网络。解决方案：通过光学传感器或超声波传感器或磁性传感器检测肌肉或关节中由自愿运动引起的位移，并将与其位置，方向和强度对应的传感器输出电位用作一个触发信号。在连接到脉冲电源的一个或多个磁刺激线圈中产生与触发信号的电平相对应的强度和频率的磁脉冲。通过该磁脉冲对大脑或肌肉的运动区域进行磁力刺激，从而增强了瘫痪肌肉的运动。版权所有（C）2013，JPO＆INPIT

6. 发明专利

JP2010051562A Method and apparatus for stimulating depth of living body 审中-公开
标题翻译：刺激身体深度的方法和装置
公开(公告)号：JP2010051562A
公开(公告)日：2010-03-11
申请号：JP2008219938
申请日：2008-08-28
申请人： Ifg Inc , Tohoku Univ , 国立大学法人東北大学 , 株式会社Ifg
发明人： ABE TOSHIHIKO , TAKAGI TOSHIYUKI , IZUE SHINICHI , NAGATOMI RYOICHI , NAKAZATO NOBUKAZU , YASHIMA KAZUMI
IPC分类号： A61N1/36
摘要： PROBLEM TO BE SOLVED: To provide a method and an apparatus for electrically stimulating the target region of the depth of a living body by indwelling a small open circuit coil inside a body and generating an inductive voltage in the indwelling coil by a pulse magnetic field to be given from an extracorporeal magnet-exciting coil. SOLUTION: The method for stimulating the depth of the living body is characterized by indwelling the open circuit coil in a region to be electrically stimulated inside the living body, generating the pulse magnetic field from the magnet-exciting coil arranged at the outside the body, and electrically stimulating a very small region inside the body through the indwelling coil by the electromotive force. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过将身体内的小型开路线圈留置并通过脉冲在留置线圈中产生感应电压来电刺激生物体的深度的目标区域的方法和装置来自体外磁体激励线圈的磁场。解决方案：用于刺激生物体深度的方法的特征在于，在活体内部被电刺激的区域内留置开路线圈，从布置在外部的励磁线圈产生脉冲磁场并通过电动势通过留置线圈电动刺激身体内的非常小的区域。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2006255314A Magnetic field generator 审中-公开
标题翻译：磁场发生器
公开(公告)号：JP2006255314A
公开(公告)日：2006-09-28
申请号：JP2005080173
申请日：2005-03-18
申请人： Material Sendai:Kk , Nippon Sozai Kk , Tohoku Univ , 国立大学法人東北大学 , 日本素材株式会社 , 株式会社マテリアル仙台
发明人： ENDO HISASHI , TAKAGI TOSHIYUKI , UCHIKAZU TETSUYA , ABE TOSHIHIKO , NAGATOMI RYOICHI , IZUE SHINICHI , YASHIMA YOSHINOBU , WANG XINMIN , MATSUMURA RYOZO , INOUE AKIHISA
IPC分类号： A61N2/00
摘要： PROBLEM TO BE SOLVED: To provide a magnetic field generator which generates a magnetic field of desired distribution or strength for use in measuring eddy current, exciting transcranial magnetic stimulation, or supplying magnetic energy. SOLUTION: A loop coil array obtained by aggregating a plurality of loop coils to be a magnetic field source is arranged, or a permanent magnet or a magnetic body core is arranged together with the loop coil array, the mutual magnetic operation between them is calculated based on numeric analysis. On the basis of the calculation result, the selection of a loop coil to be energized, the shape and arrangement of the permanent magnet or the magnetic body core, and the magnitude and direction of electric current to be made to flow in the loop coils are determined, so that the magnetic field of the desired distribution and strength is obtained. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种磁场发生器，其产生用于测量涡流，激发经颅磁刺激或提供磁能的所需分布或强度的磁场。解决方案：通过将多个环形线圈聚集成为磁场源而获得的环形线圈阵列被布置，或者永磁体或磁性体芯与环形线圈阵列一起布置，它们之间的相互磁性操作是基于数值分析计算的。在计算结果的基础上，选择要通电的环形线圈，永磁体或磁性体芯的形状和布置以及要在环形线圈中流动的电流的大小和方向是确定，从而获得所需分布和强度的磁场。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2019024987A 磁気刺激装置审中-公开
公开(公告)号：JP2019024987A
公开(公告)日：2019-02-21
申请号：JP2017147463
申请日：2017-07-31
申请人： IFG INC , NIPPON SOZAI KK
发明人： TAKAGI TOSHIYUKI , IZUE SHINICHI , KAGAYA HITOSHI , ABE TOSHIHIKO , MORI HITOSHI , YASHIMA KENJI , MORI KAZUMI
IPC分类号： A61H1/00 , A61N2/04
摘要：【課題】手軽に使用でき、電気刺激時の疼痛がなく、体毛などによる使用部位の制限も受けない小型の磁気刺激装置を提供する。【解決手段】磁気刺激装置は、磁気発生部6と励磁電流供給部20とで構成される。磁気発生部6は、U字形コア6a、及び前記U字形コア6aの先端部分6b・6cに巻着された導体6p・6qとで構成される。導体6p・6qは通電電流が互いに反対方向に流れるように巻着されている。励磁電流供給部20は、導体6p・6qに励磁電流13を供給する。U字形コア6aは、その側面6iに対して交差する、互いに反対側に位置する前面6gと背面6h間の外寸Sが64mm以下に構成されている。磁気発生部6の磁力線発生面3mには、患部の設置位置を示す目印3nが設けられている。【選択図】図1

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