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    • 6. 发明授权
    • Method for producing optically active compound or salt thereof
    • 光学活性化合物或其盐的制备方法
    • US08969585B2
    • 2015-03-03
    • US13982707
    • 2012-01-31
    • Osamu OnomuraYutaro TsudaMasami KuriyamaToshiharu YanagiKazuya Kodama
    • Osamu OnomuraYutaro TsudaMasami KuriyamaToshiharu YanagiKazuya Kodama
    • C07D263/14C07D413/04C07B53/00C07D417/04
    • C07D263/14C07B53/00C07D413/04C07D417/04
    • Provided is a process for producing an optically active compound represented by Formula (3): (wherein R1 is an alkyl group, an alkynyl group, an alkenyl group, an aliphatic heterocyclic group, a cycloalkyl group, an aryl group, an aralkyl group, or an aromatic heterocyclic group, and any hydrogen atom of R1 may be replaced with a substituent; R2 is a hydrogen atom or a group which is not reactive in the reaction below; and * represents a chiral center) or a salt thereof by subjecting a compound represented by Formula (1): (wherein R1 and R2 have the same meanings as defined in Formula (3)) to a ring closure reaction in the presence of a chiral ligand having 1 or more coordination sites, a Lewis acid represented by Formula (2): MmZn  (2) (wherein M is a metal ion, Z is a counter anion of M, and m and n are integers of 1 to 4), and a sulfonyl halide having an optionally substituted alkyl or phenyl group.
    • 提供一种制备由式(3)表示的光学活性化合物的方法:(其中R1是烷基,炔基,烯基,脂族杂环基,环烷基,芳基,芳烷基, 或芳族杂环基,R 1的任何氢原子可以被取代基取代; R2是氢原子或下述反应中不具有反应性的基团;和*表示手性中心)或其盐,通过使 由式(1)表示的化合物:其中R1和R2与式(3)中定义相同)在具有1个或多个配位点的手性配位体存在下进行闭环反应,式 (2):MmZn(2)(其中M是金属离子,Z是M的抗衡阴离子,m和n是1〜4的整数)和具有任选取代的烷基或苯基的磺酰卤。
    • 9. 发明申请
    • METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND OR SALT THEREOF
    • 用于生产光学活性化合物或其盐的方法
    • US20140012010A1
    • 2014-01-09
    • US13982707
    • 2012-01-31
    • Osamu OnomuraYutaro TsudaMasami KuriyamaToshiharu YanagiKazuya Kodama
    • Osamu OnomuraYutaro TsudaMasami KuriyamaToshiharu YanagiKazuya Kodama
    • C07D263/14C07D413/04
    • C07D263/14C07B53/00C07D413/04C07D417/04
    • Provided is a process for producing an optically active compound represented by Formula (3): (wherein R1 is an alkyl group, an alkynyl group, an alkenyl group, an aliphatic heterocyclic group, a cycloalkyl group, an aryl group, an aralkyl group, or an aromatic heterocyclic group, and any hydrogen atom of R1 may be replaced with a substituent; R2 is a hydrogen atom or a group which is not reactive in the reaction below; and * represents a chiral center) or a salt thereof by subjecting a compound represented by Formula (1): (wherein R1 and R2 have the same meanings as defined in Formula (3)) to a ring closure reaction in the presence of a chiral ligand having 1 or more coordination sites, a Lewis acid represented by Formula (2): MmZn  (2) (wherein M is a metal ion, Z is a counter anion of M, and m and n are integers of 1 to 4), and a sulfonyl halide having an optionally substituted alkyl or phenyl group
    • 提供一种制备由式(3)表示的光学活性化合物的方法:(其中R1是烷基,炔基,烯基,脂族杂环基,环烷基,芳基,芳烷基, 或芳族杂环基,R 1的任何氢原子可以被取代基取代; R2是氢原子或下述反应中不具有反应性的基团;和*表示手性中心)或其盐,通过使 由式(1)表示的化合物:其中R1和R2与式(3)中定义相同)在具有1个或多个配位点的手性配位体存在下进行闭环反应,式 (2):MmZn(2)(其中M是金属离子,Z是M的抗衡阴离子,m和n是1〜4的整数)和具有任选取代的烷基或苯基的磺酰卤