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    • 2. 发明申请
    • Pyrazolopyrimidines
    • 吡唑并嘧啶
    • US20030176450A1
    • 2003-09-18
    • US10286687
    • 2002-11-01
    • Icagen, Inc.
    • Robert N. AtkinsonMichael F. GrossAlbert M. van Rhee
    • A61K031/519
    • C07D487/04A61K31/519
    • Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
    • 提供的化合物,组合物和方法可用于通过电压依赖性钠通道抑制钠离子通量来治疗疾病。 更具体地,本发明提供了可用于治疗中枢或周围神经系统疾病,特别是疼痛和慢性疼痛的吡唑并嘧啶类,组合物和方法,其通过阻断与所述病症的发作或复发有关的钠通道。 本发明的化合物,组合物和方法特别用于通过包含PN3亚基的通道抑制离子通量来治疗神经性或炎性疼痛。