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1. 发明授权

US07122538B2 Sulfonamide derivatives as antipsychotic agents 失效
公开(公告)号：US07122538B2
公开(公告)日：2006-10-17
申请号：US10530538
申请日：2003-10-06
申请人： Ian Thomson Forbes , Andrew Derrick Gribble , Andrew P. Lightfoot , Andrew H. Payne
发明人： Ian Thomson Forbes , Andrew Derrick Gribble , Andrew P. Lightfoot , Andrew H. Payne
IPC分类号： C07D223/16 , C07D209/44 , A61K31/55 , A61D31/4035
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR5R6, —SO2NR5R6, —(CH2)NR5R6, —(CH2)pNR5COR6, optionally substituted aryl ring, optionally substituted heteroaryl ring or optionally substituted heterocyclyl ring; R3 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR7R8, —SO2NR7R8, —(CH2)pNR7R8 or —(CH2)pNR7COR8; R4represents hydrogen, hydroxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, trifluoromethyl, trifluoromethoxy, halogen, —OSO2CF3, —(CH2)pC3-6cycloalkyl, —(CH2)qOC1-6alkyl or —(CH2)pOC3-6cycloalkyl; R5 and R6 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring; R7 and R8 each independently represent hydrogen or C1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; q independently represents an integer selected from 1, 2 and 3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that the compounds 8-hydroxy-3-methyl-7-phenylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 8-hydroxy-7-4-(hydroxyphenyl)sulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 7-phenylsulfonyl-1,2,3,4-tetrahydroisoquinoline and 7-phenylsulfonyl-1,2,3,4-tetrahydroisoquinoline hydrochloride are excluded. The compounds are useful in therapy, in particular as antipsychotic agents.

2. 发明授权

US07504392B2 2,3,4,5-tetrahydro-1H-3-benzazepines and their medical use 失效
标题翻译： 2,3,4,5-四氢-1H-3-苯并氮杂及其医疗用途
公开(公告)号：US07504392B2
公开(公告)日：2009-03-17
申请号：US10515998
申请日：2003-05-28
申请人： Ian Thomson Forbes , Vincenzo Garzya , Andrew Derrick Gribble , Andrew Lightfoot , Andrew H. Payne , Graham Walker
发明人： Ian Thomson Forbes , Vincenzo Garzya , Andrew Derrick Gribble , Andrew Lightfoot , Andrew H. Payne , Graham Walker
IPC分类号： A61P25/36 , A61K31/4035 , A61K31/4704 , A61K31/55 , C07D209/44 , C07D217/02 , C07D223/16
CPC分类号： C07D223/16 , C07D209/44 , C07D217/02
摘要： The invention provides compounds of the formula or a pharmaceutically acceptable salts thereof. The compounds are useful in therapy, in particular as antipsychotic agents.
摘要翻译：本发明提供下式的化合物或其药学上可接受的盐。该化合物可用于治疗，特别是抗精神病药。

3. 发明申请

US20080269197A1 AROMATIC SULFONES AND THEIR MEDICAL USE 审中-公开
公开(公告)号：US20080269197A1
公开(公告)日：2008-10-30
申请号：US12144917
申请日：2008-06-24
申请人： Ian Thomson Forbes , Vincenzo Garzya , Andrew Derrick Gribble , Andrew Lightfoot , Andrew H. Payne , Graham Walker
发明人： Ian Thomson Forbes , Vincenzo Garzya , Andrew Derrick Gribble , Andrew Lightfoot , Andrew H. Payne , Graham Walker
IPC分类号： A61K31/55 , C07D223/16 , C07D217/00 , A61K31/472 , C07D209/48 , A61K31/4035 , A61P3/00 , A61P15/00 , A61P25/00
CPC分类号： C07D223/16 , C07D209/44 , C07D217/02
摘要： The invention provides compounds of formula (I): whereinA and B represent the groups —(CH2)m— and —(CH2)n— respectively;R1 represents hydrogen or C1-6alkyl;R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxy C1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR5R6, —SO2NR5R6, —(CH2)pNR5R6, —(CH2)pNR5COR6, optionally substituted aryl ring, optionally substituted heteroaryl ring or optionally substituted heterocyclyl ring;R3 represents optionally substituted aryl ring or optionally substituted heteroaryl ring;R4 represents hydrogen, hydroxy, C1-6alkyl, C1-6alkoxy, trifluoromethyl, trifluoromethoxy, halogen, —OSO2CF3, —(CH2)pC3-6cycloalkyl, —(CH2)qOC1-6alkyl or —(CH2)pOC3-6cycloalkyl;R5 and R6 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring;Z represents —(CH2)rX— wherein the —(CH2)r— group is attached to R3, or —X(CH2)r— wherein X is attached to R3, and wherein any of the —CH2— groups may be optionally substituted by one or more C1-6alkyl groups;X represents oxygen, —NR7 or —CH2— wherein the —CH2— group may be optionally substituted by one or more C1-6alkyl groups;R7 represents hydrogen or C1-6alkyl;m and n independently represent an integer selected from 1 and 2;p independently represents an integer selected from 0, 1, 2 and 3;q independently represents an integer selected from 1, 2 and 3;r independently represents an integer selected from 0, 1, and 2;or a pharmaceutically acceptable salt or solvate thereof.The compounds are useful in therapy, in particular as antipsychotic agents.

4. 发明授权

US06667410B2 Conversion of &agr;,&bgr;-unsaturated ketones and &agr;,&bgr;-unsaturated esters into &agr;-hydroxy ketones and &agr;-hydroxy esters using Mn(III) catalyst, phenylsilane and dioxygen 失效
公开(公告)号：US06667410B2
公开(公告)日：2003-12-23
申请号：US09952326
申请日：2001-09-14
申请人： Philip D. Magnus , Andrew H. Payne
发明人： Philip D. Magnus , Andrew H. Payne
IPC分类号： C07J500
CPC分类号： C07C403/16 , C07B2200/07 , C07C45/62 , C07C45/64 , C07C2601/14 , C07C2601/16 , C07F7/1892 , C07J13/005 , C07C49/04 , C07C49/647 , C07C49/21 , C07C49/403 , C07C49/792 , C07C49/17 , C07C49/747 , C07C49/707 , C07C49/743 , C07C49/713
摘要： The present invention provides a novel process for the conversion of &agr;,&bgr;-unsaturated ketones. This invention is an improvement over existing processes in that it operates at neutral reaction conditions that prevent the formation of side reactions and that it is a single step, which proceeds with complete selectivity and gives a yield that is approximately 30% higher than the currently used processes. An example of this process is the conversion of 16-dehydroprogesterone into 17 &agr;-hydroxyprogesterone.

5. 发明授权

US5199121A Adjustable fill comforter 失效
标题翻译：可调填充棉
公开(公告)号：US5199121A
公开(公告)日：1993-04-06
申请号：US958932
申请日：1992-10-09
申请人： Andrew H. Payne
发明人： Andrew H. Payne
IPC分类号： A47G9/02
CPC分类号： A47G9/0207 , A47G9/023
摘要： A comforter comprising an outer fabric shell containing a fill of down or down-like material. The shell comprises a top panel and a bottom panel sewn together about their peripheral edges with the fill contained therebetween. The top and bottom shell panels are additionally joined together along at least one seam dividing the comforter into at least two areas. Along a portion at least of the at least one seam, the joinder of the top and bottom shell panels is releaable and restorable, forming a closable gap or passage in the seam through which the fill material can be shifted from one areas to the other to adjust the amount of fill in each area of the comforter.
摘要翻译：一种棉被，包括外部织物外壳，其包含向下或向下的材料填充物。壳体包括顶板和底板，它们围绕其周边边缘缝合在一起，并且其间包含填充物。顶部和底部外壳面板沿着至少两个将毯子分成至少两个区域的接缝另外连接在一起。沿着至少一个接缝中的至少一个部分，顶部和底部壳板的接合是相关的和可恢复的，在接缝中形成可闭合的间隙或通道，填充材料可以通过该间隙或通道从一个区域移动到另一个区域调整被子每个区域的填充量。

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