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1. 发明授权

US08163743B2 4-carboxamide indazole derivatives useful as inhibitors of PI3-kinases 有权
标题翻译：可用作PI3激酶抑制剂的4-甲酰胺吲唑衍生物
公开(公告)号：US08163743B2
公开(公告)日：2012-04-24
申请号：US12994246
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
IPC分类号： C07D231/56 , C07D401/04 , A61K31/416 , A61K31/4439 , A61P11/00
CPC分类号： C07D231/56
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of P13-kinase activity.
摘要翻译：本发明涉及某些新化合物。具体地，本发明涉及式（I）的化合物及其盐。本发明的化合物是P13-激酶活性的抑制剂。

2. 发明申请

US20110112070A1 4-CARBOXAMIDE INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF P13-KINASES 有权
标题翻译：用作P13-激酶抑制剂的4-羧酰胺吲哚衍生物
公开(公告)号：US20110112070A1
公开(公告)日：2011-05-12
申请号：US12994246
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
IPC分类号： A61K31/416 , C07D401/12 , C07D231/56 , C07D417/14 , C07D417/12 , C07D413/14 , A61K31/4439 , A61K31/427 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/541 , A61K31/553 , A61P11/00
CPC分类号： C07D231/56
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of P13-kinase activity.
摘要翻译：本发明涉及某些新化合物。具体地，本发明涉及式（I）的化合物及其盐。本发明的化合物是P13-激酶活性的抑制剂。

3. 发明申请

US20130165433A1 Novel Use 有权
标题翻译：小说使用
公开(公告)号：US20130165433A1
公开(公告)日：2013-06-27
申请号：US13821594
申请日：2011-09-06
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Zoe Alicia Harrison , Katherine Louise Jones , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Charlotte Jane Mitchell , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christopher Alan Paul Smethurst , Yoshiaki Washio
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Zoe Alicia Harrison , Katherine Louise Jones , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Charlotte Jane Mitchell , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christopher Alan Paul Smethurst , Yoshiaki Washio
IPC分类号： C07D413/14
CPC分类号： A61K31/5377 , A61K31/416 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5386 , C07D413/14
摘要： The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.
摘要翻译：本发明涉及用于治疗或预防流感病毒感染的化合物。

4. 发明申请

US20090291949A1 SUBSTITUTE ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS 审中-公开
标题翻译：替代治疗疾病如癌症和甲状腺功能亢进症
公开(公告)号：US20090291949A1
公开(公告)日：2009-11-26
申请号：US10595912
申请日：2004-11-17
申请人： Yoshiaki Washio
发明人： Yoshiaki Washio
IPC分类号： A61K31/4725 , C07D217/02 , C07D217/22 , C07D401/12 , C07D417/12 , C07D413/12 , A61K31/47 , A61K31/5377
CPC分类号： C07D217/14 , C07D217/22
摘要： A compound of Formula (I): or a salt or solvate thereof, wherein: One of R1 and R2 is H and the other represents —NHCONHR4, wherein R4 represents a phenyl or naphthyl group which may be optionally substituted by one or more substituents independently selected from —C1-6 alkyl, —C1-6 haloalkyl, halogen, C1-6 alkoxy, C1-6 haloalkoxy, OH, NO2, C3-7 cycloalkyl, indanyl, or R4 together with the NH to which it is bonded forms a morpholino group; and R3 is H or NHR5 wherein R5 is H, -quinolinyl or -isoquinolinyl, —(CONH)p phenyl wherein p is 0 or 1 and the phenyl is optionally substituted by one or more substituents independently selected from halogen, —C1-6 alkyl, —C1-6 haloalkyl, -morpholino, —SO2NH2, and methyl substituted benzothiazole.
摘要翻译：式（I）的化合物或其盐或溶剂合物，其中：R 1和R 2之一为H，另一个为-NHCONHR 4，其中R 4表示可任意被一个或多个取代基独立地取代的苯基或萘基选自-C 1-6烷基，-C 1-6异氰基烷基，卤素，C 1-6烷氧基，C 1-6卤代烷氧基，OH，NO 2，C 3-7环烷基，茚满基或R 4与其键合的NH一起形成吗啉基并且R 3是H或NHR 5，其中R 5是H， - 喹啉基或 - 异喹啉基， - （CONH）p苯基，其中p是0或1，并且苯基任选地被一个或多个独立地选自卤素，-C 1-6烷基，-C 1-6异氰基，吗啉代，-SO 2 NH 2和甲基取代的苯并噻唑。

5. 发明授权

US5510672A Fluorescent display device 失效
标题翻译：荧光显示装置
公开(公告)号：US5510672A
公开(公告)日：1996-04-23
申请号：US183348
申请日：1994-01-18
申请人： Yoshiaki Washio , Hiroshi Yamaguchi
发明人： Yoshiaki Washio , Hiroshi Yamaguchi
IPC分类号： H01J31/15 , G09F13/22 , G09G3/22 , H01J29/30 , H01J29/52
CPC分类号： G09G3/22 , G09F13/22
摘要： A dot matrix type fluorescent display device including anode segments arranged at fine pitches is provided which is capable of facilitating arrangement of grids and substantially preventing leakage luminance. A plurality of anode segments are arranged to defined a matrix. Each three wiring conductors are arranged for every anode row. The anode segments in each row are connected to the same writing conductors at every third interval. Each one mesh grid is arranged in correspondence to every two columns of anode segments. The anodes each are arranged so as to outwardly extend by distance one third as large as a dimension thereof from the grid. Each adjacent two grids are applied thereto a positive potential and shifted one by one. Of four columns of anodes corresponding to two grids, two columns of anodes positioned inside the grids are fed with a display signal. Unselected anodes adjacent thereto are likewise fed with the display signal, however, impingement of electrons on the unselected anodes is effectively prevented because an interval between the grids adjacent to each other is increased.
摘要翻译：提供了一种点阵型荧光显示装置，其包括以细间距排列的阳极段，其能够有利于格栅的布置并且基本上防止泄漏亮度。布置多个阳极段以定义矩阵。每三个布线导体布置在每个阳极排。每行的阳极段以每三个间隔连接到相同的写入导体。每个网格格栅对应于每两列阳极段布置。阳极各自被布置成向外延伸距离格栅的尺寸的三分之一大的尺寸。将每个相邻的两个栅格施加到其上一个正电位并逐个移位。在对应于两个栅格的四列阳极中，位于栅格内部的两列阳极被馈送显示信号。与其相邻的未选择的阳极同样被馈送显示信号，然而，由于彼此相邻的格栅之间的间隔增加，因此有效地防止了电子在未选择的阳极上的撞击。

6. 发明授权

US07501512B2 Chemical compounds 失效
标题翻译：化合物
公开(公告)号：US07501512B2
公开(公告)日：2009-03-10
申请号：US10564123
申请日：2004-07-07
申请人： Hideyuki Sato , Mio Takada , Yoshiaki Washio
发明人： Hideyuki Sato , Mio Takada , Yoshiaki Washio
IPC分类号： C07D239/00 , C07D239/70 , C07D471/00 , C07D487/00
CPC分类号： C07D471/04
摘要： This invention relates to newly identified inhibitors of kinases for treating various disorders.
摘要翻译：本发明涉及新鉴定的用于治疗各种疾病的激酶抑制剂。

7. 发明申请

US20060178384A1 Novel chemical compounds 失效
标题翻译：新型化合物
公开(公告)号：US20060178384A1
公开(公告)日：2006-08-10
申请号：US10564123
申请日：2004-07-07
申请人： Hideyuki Sato , Mio Takada , Yoshiaki Washio
发明人： Hideyuki Sato , Mio Takada , Yoshiaki Washio
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D471/04
摘要： This invention relates to newly identified inhibitors of kinases for treating various disorders.
摘要翻译：本发明涉及新鉴定的用于治疗各种疾病的激酶抑制剂。

8. 发明授权

US08842093B2 Touch sensor and fluorescent display having the same 有权
标题翻译：触摸传感器和荧光显示屏具有相同的功能
公开(公告)号：US08842093B2
公开(公告)日：2014-09-23
申请号：US13220236
申请日：2011-08-29
申请人： Tsuyoshi Magami , Yoshiaki Washio , Yoshiteru Kawashima
发明人： Tsuyoshi Magami , Yoshiaki Washio , Yoshiteru Kawashima
IPC分类号： G06F3/045 , H03K17/96 , H01J31/12 , G06F3/044
CPC分类号： H03K17/9622 , G06F3/044 , H01J31/125 , H03K2017/9602 , H03K2217/96046 , H03K2217/960705
摘要： An electrostatic capacitance type touch sensor is provided. The touch sensor includes a substrate and a grid pattern formed on a surface of the substrate by a plurality of first linear wires and a plurality of second linear wires, the first linear wires being arranged parallel to each other at a predetermined interval, and the second linear wires being arranged parallel to each other at a predetermined interval and intersecting with the first linear wires. A separation portion is provided to the first linear wires and the second linear wires to form a sensor portion and a dummy sensor portion which are located next to each other and electrically separated from each other. The shape of a gap between the sensor portion and the dummy sensor portion located next to each other is improved not being formed into a band-like shape surrounded by two parallel conductive linear wires, and a boundary between the sensor portion and the dummy sensor portion located next to each other can be less-visible thereby improving the appearance, and the capacitance between the sensor portion and the dummy sensor portion located next to each other is reduced, thereby improving the accuracy of detecting a touch by adjusting the sensitivity.
摘要翻译：提供一种静电电容型触摸传感器。触摸传感器包括通过多个第一线性线和多个第二线性线形成在基板的表面上的基板和网格图案，第一线性线以预定间隔彼此平行地布置，第二线性线线状线以预定间隔彼此平行地布置并与第一线性线相交。分离部分设置在第一线性线和第二直线上，以形成彼此相邻且彼此电分离的传感器部分和虚拟传感器部分。传感器部分和彼此相邻的虚拟传感器部分之间的间隙的形状被改善成不被形成由两条平行的导电线性导线包围的带状形状，并且传感器部分和虚拟传感器部分之间的边界彼此相邻的位置可以不太可见，从而改善外观，并且彼此相邻的传感器部分和虚拟传感器部分之间的电容减小，从而通过调整灵敏度来提高检测触摸的精度。

9. 发明申请

US20120050222A1 Touch Sensor And Fluorescent Display Having The Same 有权
标题翻译：触摸传感器和荧光显示屏具有相同的功能
公开(公告)号：US20120050222A1
公开(公告)日：2012-03-01
申请号：US13220236
申请日：2011-08-29
申请人： Tsuyoshi Magami , Yoshiaki Washio , Yoshiteru Kawashima
发明人： Tsuyoshi Magami , Yoshiaki Washio , Yoshiteru Kawashima
IPC分类号： G06F3/044 , H03K17/96
CPC分类号： H03K17/9622 , G06F3/044 , H01J31/125 , H03K2017/9602 , H03K2217/96046 , H03K2217/960705
摘要： An electrostatic capacitance type touch sensor is provided. The touch sensor includes a substrate and a grid pattern formed on a surface of the substrate by a plurality of first linear wires and a plurality of second linear wires, the first linear wires being arranged parallel to each other at a predetermined interval, and the second linear wires being arranged parallel to each other at a predetermined interval and intersecting with the first linear wires. A separation portion is provided to the first linear wires and the second linear wires to form a sensor portion and a dummy sensor portion which are located next to each other and electrically separated from each other. The shape of a gap between the sensor portion and the dummy sensor portion located next to each other is improved not being formed into a band-like shape surrounded by two parallel conductive linear wires, and a boundary between the sensor portion and the dummy sensor portion located next to each other can be less-visible thereby improving the appearance, and the capacitance between the sensor portion and the dummy sensor portion located next to each other is reduced, thereby improving the accuracy of detecting a touch by adjusting the sensitivity.
摘要翻译：提供一种静电电容型触摸传感器。触摸传感器包括通过多个第一线性线和多个第二线性线形成在基板的表面上的基板和网格图案，第一线性线以预定间隔彼此平行地布置，第二线性线线状线以预定间隔彼此平行地布置并与第一线性线相交。分离部分设置在第一线性线和第二直线上，以形成彼此相邻且彼此电分离的传感器部分和虚拟传感器部分。传感器部分和彼此相邻的虚拟传感器部分之间的间隙的形状被改善成不被形成由两条平行的导电线性导线包围的带状形状，并且传感器部分和虚拟传感器部分之间的边界彼此相邻的位置可以不太可见，从而改善外观，并且彼此相邻的传感器部分和虚拟传感器部分之间的电容减小，从而通过调整灵敏度来提高检测触摸的精度。

10. 发明申请

US20070249600A1 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：US20070249600A1
公开(公告)日：2007-10-25
申请号：US11763524
申请日：2007-06-15
申请人： Mui Cheung , Philip Harris , Masaichi Hasegawa , Satoru Ida , Kazuya Kano , Naohiko Nishigaki , Hideyuki Sato , James Veal , Yoshiaki Washio , Rob West
发明人： Mui Cheung , Philip Harris , Masaichi Hasegawa , Satoru Ida , Kazuya Kano , Naohiko Nishigaki , Hideyuki Sato , James Veal , Yoshiaki Washio , Rob West
IPC分类号： A61K31/4184 , A61K31/41 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/519 , A61K31/5377 , C07D235/30 , C07D277/82 , C07D401/12 , C07D403/06 , C07D413/06 , C07D417/10 , C07D471/04 , C07D487/14
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D235/30 , C07D235/32 , C07D263/58 , C07D277/82 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04
摘要： Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译：本文描述了可用作TIE-2和/或VEGFR2抑制剂的苯并咪唑衍生物。所述的发明还包括制备这种苯并咪唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。

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