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1. 发明授权

US06177419B1 Bipyridine manganese complexes 失效
标题翻译：联吡啶锰络合物
公开(公告)号：US06177419B1
公开(公告)日：2001-01-23
申请号：US09376044
申请日：1999-08-17
申请人： Ian Baxter Campbell , Ann Louise Walker , Philip Charles Box , Gerard Martin Paul Giblin , George Edward Tranter
发明人： Ian Baxter Campbell , Ann Louise Walker , Philip Charles Box , Gerard Martin Paul Giblin , George Edward Tranter
IPC分类号： A61K3133
CPC分类号： C07D213/53 , A61K33/32 , C07F5/04 , C07F13/005
摘要： Compounds and methods of preparing compounds represented by structural formula (I): wherein X represents any suitable counter-anion; R1 and R2 independently represent hydrogen, C1-6 alkoxy or nitro; R3, R4, R5 and R6 each independently represents hydrogen, hydroxy, halo, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy; and R7, R8, R9 and R10 each independently represents hydrogen, hydroxy, halo, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy. Compounds represented by structural formula (I) are useful in treating or preventing free radical-associated diseases or conditions in mammals.
摘要翻译：制备由结构式（I）表示的化合物的化合物和方法：其中X表示任何合适的抗衡阴离子; R 1和R 2独立地表示氢，C 1-6烷氧基或硝基; R 3，R 4，R 5和R 6各自独立地表示氢，羟基，卤素，C 1-6烷基，C 2-6烯基或C 1-6烷氧基; 和R 7，R 8，R 9和R 10各自独立地表示氢，羟基，卤素，C 1-6烷基，C 2-6烯基或C 1-6烷氧基。结构式（I）表示的化合物可用于治疗或预防自由基相关疾病或哺乳动物的条件。

2. 发明授权

US06541490B1 Bipyridine manganese complexes 失效
标题翻译：联吡啶锰络合物
公开(公告)号：US06541490B1
公开(公告)日：2003-04-01
申请号：US09722799
申请日：2000-11-27
申请人： Ian Baxter Campbell , Ann Louise Walker , Philip Charles Box , Gerard Martin Paul Giblin , George Edward Tranter
发明人： Ian Baxter Campbell , Ann Louise Walker , Philip Charles Box , Gerard Martin Paul Giblin , George Edward Tranter
IPC分类号： A61K3144
CPC分类号： C07D213/53 , A61K33/32 , C07F5/04 , C07F13/005
摘要： Compounds and methods of preparing compounds represented by structural formula (I): wherein X represents any suitable counter-anion; R1 and R2 independently represent hydrogen, C1-6 alkoxy or nitro; R3, R4, R5 and R6 each independently represents hydrogen, hydroxy, halo, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy; and R7, R8, R9 and R10 each independently represents hydrogen, hydroxy, halo, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy. Compounds represented by structural formula (I) are useful in treating or preventing free radical-associated diseases or conditions in mammals.
摘要翻译：制备由结构式（I）表示的化合物的化合物和方法：其中X表示任何合适的抗衡阴离子; R 1和R 2独立地表示氢，C 1-6烷氧基或硝基; R 3，R 4，R 5和R 6各自独立地表示氢，羟基，卤素，C 1-6烷基，C 2-6烯基或C 1-6烷氧基; 和R 7，R 8，R 9和R 10各自独立地表示氢，羟基，卤素，C 1-6烷基，C 2-6烯基或C 1-6烷氧基。由结构式（I）表示的化合物可用于治疗或预防自由基相关疾病或哺乳动物的条件。

3. 发明授权

US07732622B2 Naphthalene derivatives 失效
标题翻译：萘衍生物
公开(公告)号：US07732622B2
公开(公告)日：2010-06-08
申请号：US12111989
申请日：2008-04-30
申请人： Miles Stuart Congreve , Gerard Martin Paul Giblin , Andrew McMurtrie Mason , Neil Derek Miller , Susan Roomans , Ann Louise Walker
发明人： Miles Stuart Congreve , Gerard Martin Paul Giblin , Andrew McMurtrie Mason , Neil Derek Miller , Susan Roomans , Ann Louise Walker
IPC分类号： C07D209/60 , A61K31/40
CPC分类号： C07D209/66 , C07D209/64
摘要： A compound of formula (I) wherein R1 and R3 are the same or different and represent ═O, hydrogen, C1-6alkyl, C1-6dialkyl, ═CHC1-C5alkyl, ═S, or a 5- or 6-membered aryl; R4 to R9 are the same or different and represent hydrogen, C1-6alkoxy, OCF3, OCH2CF3, O-cyclopropyl, OCH2-cyclopropyl, C1-C6alkyl, S-alkyl, NR210 where R10 is hydrogen or C1-6alkyl, halogen, NO2, OH, CH2OC1-C6alkyl, CH2OH, or CF3; Q1 is hydrogen, C1-6alkyl, C1-6dialkyl, C1-6alkoxy, NHAc, NR210 where R10 is hydrogen or C1-6alkyl, difluoro, fluoro, ═O, or OH; Q2, Q3, Q4 and Q5 are the same or different and represent hydrogen, C1-6alkoxy, OCF3, OCH2CF3, O-cyclopropyl, OCH2-cyclopropyl, C1-C6alkyl, S-alkyl, NR210 where R10 is hydrogen or C1-6alkyl, halogen, NO2, OH, CH2OC1-C6alkyl, CH2OH, or a 5- or 6-membered aryl; with the proviso that the compounds [4-(1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]-2-propionic acid, sodium salt and [4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetic acid are excluded; and pharmaceutically acceptable derivatives thereof.
摘要翻译：式（I）的化合物，其中R 1和R 3相同或不同并且表示≡O，氢，C 1-6烷基，C 1-6二烷基，= CHCl-C 5烷基，= S或5或6元芳基; R4至R9相同或不同，表示氢，C1-6烷氧基，OCF3，OCH2CF3，O-环丙基，OCH2-环丙基，C1-C6烷基，S-烷基，NR210，其中R10为氢或C1-6烷基，卤素， OH，CH 2 OC 1 -C 6烷基，CH 2 OH或CF 3; Q1是氢，C1-6烷基，C1-6二烷基，C1-6烷氧基，NHAc，NR210，其中R10是氢或C1-6烷基，二氟，氟，= O或OH; Q2，Q3，Q4和Q5相同或不同，表示氢，C1-6烷氧基，OCF3，OCH2CF3，O-环丙基，OCH2-环丙基，C1-C6烷基，S-烷基，NR210，其中R10是氢或C1-6烷基，卤素，NO 2，OH，CH 2 OC 1 -C 6烷基，CH 2 OH或5或6元芳基; 条件是化合物[4-（1-氧代-1,3-二氢-2H-苯并[f]异吲哚-2-基）苯基] -2-丙酸钠盐和[4-（4,9 - 二乙氧基-1-氧代-1,3-二氢-2H-苯并[f]异吲哚-2-基）苯基]乙酸; 和它们的药用衍生物。

4. 发明申请

US20080234358A1 NAPHTHALENE DERIVATIVES 失效
公开(公告)号：US20080234358A1
公开(公告)日：2008-09-25
申请号：US12111989
申请日：2008-04-30
申请人： Miles Stuart Congreve , Gerard Martin, Paul Giblin , Andrew McMurtrie Mason , Neil Derek Miller , Susan Roomans , Ann Louise Walker
发明人： Miles Stuart Congreve , Gerard Martin, Paul Giblin , Andrew McMurtrie Mason , Neil Derek Miller , Susan Roomans , Ann Louise Walker
IPC分类号： A61K31/4035 , C07D209/44 , A61P29/00
CPC分类号： C07D209/66 , C07D209/64
摘要： A compound of formula (I) wherein R1 and R3 are the same or different and represent ═O, hydrogen, C1-6alkyl, C1-6dialkyl, ═CHC1-C5alkyl, ═S, or a 5- or 6-membered aryl; R4 to R9 are the same or different and represent hydrogen, C1-6alkoxy, OCF3, OCH2CF3, O-cyclopropyl, OCH2-cyclopropyl, C1-C6alkyl, S-alkyl, NR210 where R10 is hydrogen or C1-6alkyl, halogen, NO2, OH, CH2OC1-C6alkyl, CH2OH, or CF3; Q1 is hydrogen, C1-6alkyl, C1-6dialkyl, C1-6alkoxy, NHAc, NR210 where R10 is hydrogen or C1-6alkyl, difluoro, fluoro, ═O, or OH; Q2, Q3, Q4 and Q5 are the same or different and represent hydrogen, C1-6alkoxy, OCF3, OCH2CF3, O-cyclopropyl, OCH2-cyclopropyl, C1-C6alkyl, S-alkyl, NR210 where R10 is hydrogen or C1-6alkyl, halogen, NO2, OH, CH2OC1-C6alkyl, CH2OH, or a 5- or 6-membered aryl; with the proviso that the compounds [4-(1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]-2-propionic acid, sodium salt and [4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetic acid are excluded; and pharmaceutically acceptable derivatives thereof.

5. 发明授权

US07166631B2 Benzo[f]isoindole derivatives with affinity to the EP4 receptor 失效
标题翻译：对EP4受体具有亲和力的苯并[f]异吲哚衍生物
公开(公告)号：US07166631B2
公开(公告)日：2007-01-23
申请号：US10467487
申请日：2002-02-07
申请人： Miles Stuart Congreve , Gerard Martin Paul Giblin , Ann Louise Walker
发明人： Miles Stuart Congreve , Gerard Martin Paul Giblin , Ann Louise Walker
IPC分类号： A61K31/40 , C07D209/56
CPC分类号： C07D209/66 , C07D209/64
摘要： The present invention relates to a compound of formula (I): corresponding pharmaceutical compositions, preparation processes, and/or methods of using the aforementioned compounds and/or compositions.
摘要翻译：本发明涉及式（I）化合物：相应的药物组合物，制备方法和/或使用上述化合物和/或组合物的方法。

6. 发明授权

US06924297B2 Naphathalene derivatives which bind to the EP4 receptor 失效
标题翻译：与EP4受体结合的萘磺草衍生物
公开(公告)号：US06924297B2
公开(公告)日：2005-08-02
申请号：US10450891
申请日：2001-12-20
申请人： Gerard Martin Paul Giblin , Haydn Terence Jones , Andrew McMurtrie Mason , Neil Derek Miller , Susan Roomans , Stephen Edward Shanahan , Ann Louise Walker
发明人： Gerard Martin Paul Giblin , Haydn Terence Jones , Andrew McMurtrie Mason , Neil Derek Miller , Susan Roomans , Stephen Edward Shanahan , Ann Louise Walker
IPC分类号： C07D401/12 , A61K31/403 , A61K31/42 , A61K31/427 , A61K31/4439 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/12 , A61P1/16 , A61P3/00 , A61P3/02 , A61P3/10 , A61P3/14 , A61P5/10 , A61P5/18 , A61P7/02 , A61P7/06 , A61P7/12 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/04 , A61P13/12 , A61P15/10 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/04 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/02 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P27/02 , A61P27/06 , A61P27/14 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/16 , A61P31/18 , A61P35/00 , A61P37/06 , A61P39/02 , A61P43/00 , C07D209/64 , C07D209/66 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D209/60
CPC分类号： C07D209/64 , C07D209/66
摘要： Compounds of formula (I) and pharmaceutically acceptable derivatives thereof bind with high affinity to the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, immunological, bone, neurodegenerative or renal disorder.
摘要翻译：式（I）化合物及其药学上可接受的衍生物以高亲和力结合EP4受体，并且可用于治疗或预防诸如疼痛，炎症，免疫学，骨骼，神经变性或肾脏疾病的病症。

7. 发明授权

US07838540B2 3-aminocarbonyl, 6-phenyl substituted pyridine-1-oxides as p38 kinase inhibitors 有权
标题翻译： 3-氨基羰基，6-苯基取代的吡啶-1-氧化物作为p38激酶抑制剂
公开(公告)号：US07838540B2
公开(公告)日：2010-11-23
申请号：US10568121
申请日：2004-08-09
申请人： Ann Louise Walker
发明人： Ann Louise Walker
IPC分类号： C07D213/70 , A61K31/44
CPC分类号： C07D213/89
摘要： Compounds of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译：式（I）化合物或其药学上可接受的衍生物及其作为药物的用途，特别是作为p38激酶抑制剂。

8. 发明授权

US07432289B2 5-Acylamino-1,1′-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors 失效
标题翻译： 5-酰氨基-1,1'-联苯-4-甲酰胺衍生物及其作为P38激酶抑制剂的用途
公开(公告)号：US07432289B2
公开(公告)日：2008-10-07
申请号：US10492605
申请日：2002-10-16
申请人： Richard Martyn Angell , Nicola Mary Aston , Paul Bamborough , Mark James Bamford , George Stuart Cockerill , Stephen Sean Flack , Dramane Ibrahim Lainé , Suzanne Joy Merrick , Kathryn Jane Smith , Ann Louise Walker
发明人： Richard Martyn Angell , Nicola Mary Aston , Paul Bamborough , Mark James Bamford , George Stuart Cockerill , Stephen Sean Flack , Dramane Ibrahim Lainé , Suzanne Joy Merrick , Kathryn Jane Smith , Ann Louise Walker
IPC分类号： A61K31/44 , A61K31/04 , A61K31/34 , A61K33/44 , C07D307/02 , C07C241/00
CPC分类号： C07D207/27 , C07C237/42 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/327 , C07D213/81 , C07D213/82 , C07D215/50 , C07D239/28 , C07D239/42 , C07D241/24 , C07D241/26 , C07D261/18 , C07D277/56 , C07D307/24 , C07D307/54 , C07D307/68 , C07D309/08 , C07D333/38 , C07D401/04 , C07D405/04 , C07D409/04 , C07D417/04
摘要： Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译：式（I）化合物或其药学上可接受的盐或溶剂合物，以及它们作为药物的用途，特别是作为p38激酶抑制剂。

9. 发明授权

US07384963B2 2′-Methyl-5-(1,3,4-oxadiazol-2-yl)1, 1′-biphenyl-4-carboxaide derivatives and their use as p38 kinase 失效
标题翻译： 2'-甲基-5-（1,3,4-恶二唑-2-基）1,1'-联苯-4-羧酸衍生物及其作为p38激酶的用途
公开(公告)号：US07384963B2
公开(公告)日：2008-06-10
申请号：US10492713
申请日：2002-10-16
申请人： Richard Martyn Angell , Paul Bamborough , George Stuart Cockerill , Ann Louise Walker
发明人： Richard Martyn Angell , Paul Bamborough , George Stuart Cockerill , Ann Louise Walker
IPC分类号： A61K31/4245 , C07D271/10
CPC分类号： C07D271/10 , C07D231/12 , C07D233/56 , C07D249/08 , C07D413/12
摘要： Compounds of formula (I), wherein R1 is a phenyl group which may be optionally substituted; R2 is selected from hydrogen, C1-6 alkyl and (CH2)p—C3-7cycloalkyl; R3 is the group: (Formula II), R4 is selected from hydrogen and C1-4 alkyl; U is selected from methyl and halogen; X and Y are each selected independently from hydrogen, methyl and halogen; m is selected from 0, 1, 2, 3 and 4, and may be optionally substituted with up to two groups selected independently from C1-6 alkyl; n is selected from 0, 1 and 2; p is selected from 0, 1 and 2; or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors
摘要翻译：式（I）的化合物，其中R 1是可任意取代的苯基; R 2选自氢，C 1-6烷基和（CH 2 CH 2）n-C≡S<！ - SIPO < > 3-7环烷基; R 3是下列基团：（式II），R 4选自氢和C 1-4烷基; U选自甲基和卤素; X和Y各自独立地选自氢，甲基和卤素; m选自0,1,2,3和4，并且可以任选地被至多两个独立地选自C 1-6烷基的基团取代; n选自0,1和2; p选自0，1和2; 或其药学上可接受的盐或溶剂化物，以及它们作为药物的用途，特别是作为p38激酶抑制剂

10. 发明授权

US07166623B2 2′-Methyl-5′-(1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors 失效
标题翻译： 2'-甲基-5' - （1,3,4-恶二唑-2-基）-1,1'-联苯-4-甲酰胺衍生物及其作为p38激酶抑制剂的用途
公开(公告)号：US07166623B2
公开(公告)日：2007-01-23
申请号：US10492497
申请日：2002-10-16
申请人： Richard Martyn Angell , Paul Bamborough , George Stuart Cockerill , Kathryn Jane Smith , Ann Louise Walker
发明人： Richard Martyn Angell , Paul Bamborough , George Stuart Cockerill , Kathryn Jane Smith , Ann Louise Walker
IPC分类号： A01N43/36 , C07D271/10
CPC分类号： C07D271/10
摘要： Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译：式（I）化合物或其药学上可接受的盐或溶剂合物，以及它们作为药物的用途，特别是作为p38激酶抑制剂。

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