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1. 发明申请

WO1995002613A2 HEPARIN DERIVATIVES HAVING ANTIMETASTATIC ACTIVITY 审中-公开
标题翻译：具有抗肿瘤活性的HEPARIN衍生物
公开(公告)号：WO1995002613A2
公开(公告)日：1995-01-26
申请号：PCT/EP1994002133
申请日：1994-06-30
申请人： ITALFARMACO S.P.A. , CARETTO, Patrizia , SCIUMBATA, Teresa , LEONI, Flavio , GROMO, Gianni
发明人： ITALFARMACO S.P.A.
IPC分类号： C08B37/00
CPC分类号： A61K31/715 , A61K31/727 , C08B37/0075 , C08B37/0078
摘要： Heparin fragments and fractions and/or derivatives having antimetastatic activity.
摘要翻译：肝素片段和具有抗转移活性的级分和/或衍生物。

2. 发明申请

WO1995010531A1 OLIGOPEPTIDES DERIVED FROM C-REACTIVE PROTEIN FRAGMENTS 审中-公开
标题翻译：来自C反应蛋白质片段的寡核苷酸
公开(公告)号：WO1995010531A1
公开(公告)日：1995-04-20
申请号：PCT/EP1994001574
申请日：1994-05-16
申请人： ITALFARMACO S.P.A. , CARETTO, Patrizia , LEONI, Flavio , MARCUCCI, Fabrizio , GROMO, Gianni , MASCAGNI, Paolo , PINORI, Massimo , CAPPELLETTI, Silvana
发明人： ITALFARMACO S.P.A.
IPC分类号： C07K05/04
CPC分类号： C07K14/4737 , A61K38/00
摘要： The present invention relates to oligopeptides derived from fragments of the C-reactive protein (hereinafter CRP), and to their use as immunomodulating agents, and in the therapy of cardiovascular and inflammatory diseases.
摘要翻译：本发明涉及衍生自C-反应蛋白（以下称为CRP）的片段的寡肽及其作为免疫调节剂的用途以及用于心血管和炎性疾病的治疗。

3. 发明申请

WO1995023128A1 DIESTERS OF CARBONIC ACID ENDOWED WITH ANTIVIRAL AND ANTI-INFLAMMATORY ACTIVITY 审中-公开
标题翻译：含有抗病毒和抗炎活性的碳酸钙
公开(公告)号：WO1995023128A1
公开(公告)日：1995-08-31
申请号：PCT/EP1995000637
申请日：1995-02-22
申请人： ITALFARMACO S.P.A. , SALA, Alberto , BERTOLINI, Giorgio , PAVICH, Gianfranco , MARUCCI, Fabrizio , GROMO, Gianni , PORRO, Giuliana
发明人： ITALFARMACO S.P.A.
IPC分类号： C07C219/16
CPC分类号： C07D207/08 , C07C219/16 , C07C219/22 , C07C219/24 , C07C219/32 , C07C2601/14 , C07D211/22 , C07D295/088
摘要： Diesters of carbonic acid disubstituted with primary, secondary or tertiary amine groups, pharmaceutically acceptable salts thereof, and their use as antiviral and anti-inflammatory agents.
摘要翻译：用伯胺，仲胺或叔胺二取代的碳酸二酯，其药学上可接受的盐，以及它们作为抗病毒和抗炎剂的用途。

4. 发明申请

WO1993013072A1 5-ISOQUINOLINESULFONAMIDE DERIVATIVES AS PROTEIN KINASE INHIBITING AGENTS 审中-公开
标题翻译：作为蛋白激酶抑制剂的5-异喹啉衍生物衍生物
公开(公告)号：WO1993013072A1
公开(公告)日：1993-07-08
申请号：PCT/EP1992002869
申请日：1992-12-11
申请人： ITALFARMACO S.P.A. , LEVI, Silvio , GROMO, Gianni , MAORET, Tiziana , SALA, Alberto
发明人： ITALFARMACO S.P.A.
IPC分类号： C07D217/02
CPC分类号： C07D217/02
摘要： 5-isoquinolinesulfonamide derivatives of formula (I) wherein R is the group alpha , where R1 and R2 are independently hydrogen, methyl, ethyl, straight or branched C3-C6 alkyl, benzyl, optionally substituted by at least one substituent selected from the group consisting of C1-C8 alkyl, halogen, hydroxy, C1-C6 alkoxy, nitro, amino, C1-C6 alkylamino di-C1-C6 alkylamino, aliphatic C2-C6 acylamino, C1-C6 carboxyamido, carbonyl, carboxyl, esterified carboxyl, cyano, methylenedioxy, and R3 is straight or branched (C2-C6)alkylene, optionally substituted by benzyl or benzyl substituted by at least one substituent selected from the group consisting of C1-C8 alkyl, halogen, hydroxy, C1-C6 alkoxy, nitro, amino, C1-C6 alkylamino di-C1-C6 alkylamino, aliphatic C2-C6 acylamino, C1-C6 carboxyamido, carbonyl, carboxyl, esterified carboxyl, cyano, methylenedioxy or C5-C8 cycloalkylene; or R is the bivalent residue beta where a and b are independently methylene, ethylene or propylene, optionally substituted by at least one C1-C4 alkyl group; X is an aromatic, partially or totally hydrogenated isoquinoline group, optionally substituted by at least one C1-C4 alkyl group, or the partially or totally hydrogenated naphthyl group and optionally substituted with at least one C1-C4 alkyl group; the salts with pharmaceutically acceptable acids thereof; said derivatives are useful as protein kinases inhibiting agents.
摘要翻译：式（I）的5-异喹啉磺酰胺衍生物，其中R是基团α，其中R 1和R 2独立地是氢，甲基，乙基，直链或支链C 3 -C 6烷基，苄基，任选地被至少一个选自以下的取代基 C 1 -C 8烷基，卤素，羟基，C 1 -C 6烷氧基，硝基，氨基，C 1 -C 6烷基氨基二-C 1 -C 6烷基氨基，脂族C 2 -C 6酰氨基，C 1 -C 6羧酰胺基，羰基，羧基，酯化羧基，氰基，亚甲二氧基，R 3是直链或支链（C 2 -C 6）亚烷基，任选被苄基或被至少一个选自C 1 -C 8烷基，卤素，羟基，C 1 -C 6烷氧基，硝基，氨基 C 1 -C 6烷基氨基二-C 1 -C 6烷基氨基，脂族C 2 -C 6酰氨基，C 1 -C 6羧酰胺基，羰基，羧基，酯化羧基，氰基，亚甲二氧基或C 5 -C 8亚环烷基; 或R是二价残基β，其中a和b独立地是亚甲基，乙烯或丙烯，任选被至少一个C 1 -C 4烷基取代; X是任选被至少一个C 1 -C 4烷基或部分或全部氢化的萘基取代并任选被至少一个C 1 -C 4烷基取代的芳族部分或完全氢化的异喹啉基; 与其药学上可接受的酸的盐; 所述衍生物可用作蛋白激酶抑制剂。

5. 发明申请

WO1996016083A1 PEPTIDES ENDOWED WITH ANTIINFLAMMATORY ACTIVITY 审中-公开
标题翻译：具有抗炎活性的肽
公开(公告)号：WO1996016083A1
公开(公告)日：1996-05-30
申请号：PCT/EP1995004566
申请日：1995-11-20
申请人： ITALFARMACO S.P.A. , LUCIETTO, Pierluigi , GIULIANI, Paola , FOSSATI, Gianluca , MASCAGNI, Paolo , GROMO, Gianni
发明人： ITALFARMACO S.P.A.
IPC分类号： C07K14/35
CPC分类号： C07K14/35 , A61K38/00
摘要： Peptides consisting of 25 aminoacids having a sequence with an h omology of at least 25 % with the 1-25 fragment of the 10 Kda heat shock protein from Mycobacterium tubercolosis are disclosed. The peptides of the invention are endowed with antiinflammatory activity.
摘要翻译：公开了由具有至少25％的序列的25个氨基酸组成的肽和来自结核分枝杆菌的10个Kda热休克蛋白的1-25个片段。本发明的肽具有抗炎活性。

6. 发明申请

WO1995004048A1 BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY 审中-公开
标题翻译：含有治疗活性的苯并嗪和苯并噻嗪酮
公开(公告)号：WO1995004048A1
公开(公告)日：1995-02-09
申请号：PCT/EP1994002354
申请日：1994-07-18
申请人： ITALFARMACO S.P.A. , LEVI, Silvio , BENEDINI, Francesca , BERTOLINI, Giorgio , GROMO, Gianni , MIZRHAI, Jacques , SALA, Alberto
发明人： ITALFARMACO S.P.A.
IPC分类号： C07D265/22
CPC分类号： C07D265/22 , C07D279/08
摘要： Compounds of general formula (I) wherein X is an oxygen or sulfur atom; Y is alkylene or cycloalkylene; A is hydroxy, alkoxy, acyloxy, mercapto, alkyl-sulfonyloxy, phenyl-sulfonyloxy, (a) or (b) wherein R3 is an alkyl or alkylene group omega -substituted by 2,3-dihydro-4H-1,3-benzoxazin-4-one-N-yl; R is hydrogen, alkyl or phenyl; R1 and R2 are independently hydrogen, halogen, alkoxy, trifluoromethyl or alkyl; and the pharmaceutically acceptable acid and base salts thereof, are useful as therapeutically active substances.
摘要翻译：通式（I）的化合物，其中X是氧或硫原子; Y是亚烷基或亚环烷基; A是羟基，烷氧基，酰氧基，巯基，烷基磺酰氧基，苯基磺酰氧基，（a）或（b）其中R3是被2,3-二氢-4H-1,3-苯并恶嗪 -4-酮-N基; R是氢，烷基或苯基; R1和R2独立地是氢，卤素，烷氧基，三氟甲基或烷基; 及其药学上可接受的酸和碱盐可用作治疗活性物质。

7. 发明申请

WO1993025542A1 BENZOXAZINONE AND BENZOTHIAZINONE DERIVATIVES HAVING CARDIOVASCULAR ACTIVITY 审中-公开
标题翻译：具有心血管活性的苯唑西酮和苯并噻嗪酮衍生物
公开(公告)号：WO1993025542A1
公开(公告)日：1993-12-23
申请号：PCT/EP1993001377
申请日：1993-06-01
申请人： ITALFARMACO S.P.A. , LEVI, Silvio , BENEDINI, Francesca , BERTOLINI, Giorgio , DONA, Giancarlo , GROMO, Gianni , SALA, Alberto
发明人： ITALFARMACO S.P.A.
IPC分类号： C07D265/26
CPC分类号： C07D265/24 , C07D265/26 , C07D279/08
摘要： Benzoxazinone and benzothiazinone derivatives having cardiovascular activity and the salts thereof with pharmaceutically acceptable acids and bases are of formula (I), wherein Y is methylene, optionally branched (C3-C6) alkylene or cyclopentylene, cyclohexylene or cycloheptylene; X and Z are independently S or O.
摘要翻译：具有心血管活性的苯并嗪酮和苯并噻嗪酮衍生物及其药学上可接受的酸和碱的盐具有式（I），其中Y是亚甲基，任选支链（C 3 -C 6）亚烷基或亚环戊基，亚环己基或环亚庚基; X和Z独立地为S或O.

8. 发明申请

WO1996015105A1 FLUORENYL-HYDROXAMIC DERIVATIVES ENDOWED WITH IMMUNOSUPPRESSIVE AND ANTI-INFLAMMATORY ACTIVITY 审中-公开
标题翻译：具有免疫抑制和抗炎活性的氟代氢氧化物衍生物
公开(公告)号：WO1996015105A1
公开(公告)日：1996-05-23
申请号：PCT/EP1995004388
申请日：1995-11-08
申请人： ITALFARMACO S.P.A. , BERTOLINI, Giorgio , AQUINO, Mario , CHIAFFARINO, Francesca , GROMO, Gianni , SALA, Alberto , VALTOLINA, Marinella
发明人： ITALFARMACO S.P.A.
IPC分类号： C07C271/22
CPC分类号： C07C271/28 , C07C271/22 , C07C2603/18
摘要： The present invention refers to hydroxamic derivatives of fluorenylaminoacids and their use as immunosuppressant and anti-inflammatory agents.
摘要翻译：本发明涉及芴基氨基酸的异羟肟酸衍生物及其作为免疫抑制剂和抗炎剂的用途。

9. 发明申请

WO1993021163A1 QUINAZOLONES HAVING CARDIOVASCULAR ACTIVITY 审中-公开
标题翻译：具有心血管活性的喹诺酮
公开(公告)号：WO1993021163A1
公开(公告)日：1993-10-28
申请号：PCT/EP1993000841
申请日：1993-04-05
申请人： ITALFARMACO S.P.A. , SALA, Alberto , BENEDINI, Francesca , BERTOLINI, Giorgio , DONA', Giancarlo , GROMO, Gianni , LEVI, Silvio
发明人： ITALFARMACO S.P.A.
IPC分类号： C07D239/90
CPC分类号： C07D239/90 , C07D239/96
摘要： Compounds of general formula (I), the pharmaceutically acceptable salts thereof, a process for the preparation and the use thereof as antianginal agents.
摘要翻译：通式（I）的化合物，其药学上可接受的盐，其制备方法及其作为抗心绞痛剂的用途。

10. 发明申请

WO1993008830A1 COMPOUNDS OF BIOAVAILABLE IRON WITH ACYLATED OVOTRANSFERRIN OR WITH ACYLATED HYDROLYSIS DERIVATIVES THEREOF 审中-公开
标题翻译：具有ACYLATED OVOTRANSFERRIN或其ACLLATED HYDROLYSIS衍生物的生物可利用铁的化合物
公开(公告)号：WO1993008830A1
公开(公告)日：1993-05-13
申请号：PCT/EP1992002489
申请日：1992-10-30
申请人： ITALFARMACO S.P.A. , BARANI, Roberto , CARIONI, Ivano , SALA, Alberto , GROMO, Gianni
发明人： ITALFARMACO S.P.A.
IPC分类号： A61K37/14
CPC分类号： A61K38/40
摘要： Compounds of bioavailable iron with acylated ovotransferrin or with acylated hydrolysis derivatives thereof, useful in the treatment of iron deficiencies.
摘要翻译：具有酰化转铁蛋白或其酰化水解衍生物的生物可利用铁的化合物，其可用于治疗铁缺乏。

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