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1. 发明申请

WO2005019455A1 SYNTHETIC GENE ENCODING RHESUS MONKEY CARCINOEMBRYONIC ANTIGEN AND USES THEREOF 审中-公开
标题翻译：合成基因编码RHESUS MONKEY CARCINOEMBRYONIC抗原及其用途
公开(公告)号：WO2005019455A1
公开(公告)日：2005-03-03
申请号：PCT/EP2004/009239
申请日：2004-08-17
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA , AURISICCHIO, Luigi , CILIBERTO, Gennaro , GIANNETTI, Patrizia , LA MONICA, Nicola
发明人： AURISICCHIO, Luigi , CILIBERTO, Gennaro , GIANNETTI, Patrizia , LA MONICA, Nicola
IPC分类号： C12N15/12
CPC分类号： C12N15/86 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N15/8509 , C12N2710/10343
摘要： Synthetic polynucleotides encoding rhesus monkey carcinoembryonic antigen (CEA) are provided, the synthetic polynucleotides being codon-optimized for expression in a human cellular environment. The gene encoding CEA is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the CEA tumor-associated antigen, wherein aberrant CEA expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector and plasmid constructs carrying codon-optimed rhesus monkey CEA and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
摘要翻译：提供了编码恒河猴癌胚抗原（CEA）的合成多核苷酸，所述合成多核苷酸被密码子优化用于在人细胞环境中表达。编码CEA的基因通常与人类癌的发展有关。本发明提供了引发或增强由CEA肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常CEA表达与癌症或其发展相关。本发明具体提供携带密码子优化的恒河猴CEA的腺病毒载体和质粒构建体，并公开了它们在预防和治疗癌症的疫苗和药物组合物中的用途。

2. 发明申请

WO2007042169A2 MATRIX METALLOPROTEINASE 11 VACCINE 审中-公开
公开(公告)号：WO2007042169A2
公开(公告)日：2007-04-19
申请号：PCT/EP2006/009536
申请日：2006-10-03
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA , CILIBERTO, Gennaro , LAZZARO, Domenico , MORI, Federica , PERUZZI, Daniela , AURISICCHIO, Luigi , LA MONICA, Nicola
发明人： AURISICCHIO, Luigi , LA MONICA, Nicola
IPC分类号： C07K14/435 , C12N9/64 , C07K19/00 , A61K39/00
CPC分类号： C12N9/6416 , A61K39/00 , C07K2319/00 , Y02A50/472
摘要： Compositions comprising matrix metalloproteinase 11 (MMP-11) or stromelysin-3 (ST-3) or the nucleic acid encoding the MMP-11 for use in vaccines for treating tumors and cancers, which overexpress MMP-11, are described. In particular embodiments, the compositions comprise a nucleic acid encoding a fusion polypeptide that includes the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element wherein the codons encoding the MMP-11 and the immunoenhancing element have been optimized for enhanced expression of the fusion polypeptide in human cells. In other embodiments, the compositions comprise the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element. The compositions can be used alone or in synergy with vaccines against other tumor associated antigens as well as with conventional therapies such as radiation therapy and chemotherapy.
摘要翻译：描述了包含基质金属蛋白酶11（MMP-11）或基质溶素-3（ST-3）的组合物或编码用于治疗过表达MMP-11的肿瘤和癌症的疫苗中的MMP-11的核酸。在具体实施方案中，组合物包含编码融合多肽的核酸，其包含在C-末端连接至免疫增强元件的催化失活的MMP-11，其中编码MMP-11和免疫增强元件的密码子已被优化以增强表达的人类细胞中的融合多肽。在其它实施方案中，组合物包含在C末端与免疫增强元件连接的催化失活的MMP-11。组合物可以单独使用或与抗其他肿瘤相关抗原的疫苗以及常规疗法如放射治疗和化学疗法协同使用。

3. 发明申请

WO2005077977A3 CARCINOEMBRYONIC ANTIGEN FUSIONS PROTEINS AND USES THEREOF 审中-公开
公开(公告)号：WO2005077977A3
公开(公告)日：2005-08-25
申请号：PCT/EP2005/001114
申请日：2005-02-03
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA , LA MONICA, Nicola , FACCIABENE, Andrea , AURISICCHIO, Luigi
发明人： LA MONICA, Nicola , FACCIABENE, Andrea , AURISICCHIO, Luigi
IPC分类号： C07K14/705
摘要： Polynucleotides encoding carcinoembryonic antigen (CEA) fusion proteins are provided, the CEA fusion proteins comprising a CEA protein, or functional variant thereof, fused to a substantial portion of an immunoenhancing element. The polynucleotides of the present invention can elicit an immune response in a mammal, which, in preferred embodiments, is stronger than the immune response elicited by a wild-type CEA. The gene encoding CEA is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the CEA tumor-associated antigen, wherein aberrant CEA expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector and plasmid constructs carrying polynucleotides encoding CEA fusion proteins and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.

4. 发明申请

WO2004099247A2 SYNTHETIC GENE ENCODING HUMAN CARCINOEMBRYONIC ANTIGEN AND USES THEREOF 审中-公开
标题翻译：合成基因编码人类纤维蛋白原抗原及其用途
公开(公告)号：WO2004099247A2
公开(公告)日：2004-11-18
申请号：PCT/EP2004/004802
申请日：2004-05-03
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA , LA MONICA, Nicola , LAHM, Armin , MENNUNI, Carmela , SAVINO, Rocco
发明人： LA MONICA, Nicola , LAHM, Armin , MENNUNI, Carmela , SAVINO, Rocco
IPC分类号： C07K14/70
CPC分类号： C07K14/4748 , A61K39/00 , A61K2039/53 , C07K14/70503 , C12N2799/022
摘要： Synthetic polynucleotides encoding human carcinoembryonic antigen (CEA) are provided, the synthetic polynucleotides being codon-optimized for expression in a human cellular environment. The gene encoding CEA is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the CEA tumor-associated antigen, wherein aberrant CEA expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector and plasmid constructs carrying codon-optimed human CEA and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
摘要翻译：提供了编码人癌胚抗原（CEA）的合成多核苷酸，所述合成多核苷酸被密码子优化用于在人细胞环境中表达。编码CEA的基因通常与人类癌的发展有关。本发明提供了引发或增强由CEA肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常CEA表达与癌症或其发展相关。本发明具体提供携带密码子优化的人CEA的腺病毒载体和质粒构建体，并公开了它们在预防和治疗癌症的疫苗和药物组合物中的用途。

5. 发明申请

WO2008012237A1 MULTI-ANTIGEN CONSTRUCT AND USES THEREOF 审中-公开
标题翻译：多抗结构及其用途
公开(公告)号：WO2008012237A1
公开(公告)日：2008-01-31
申请号：PCT/EP2007/057358
申请日：2007-07-17
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA , AURISICCHIO, Luigi , CILIBERTO, Gennaro , LA MONICA, Nicola
发明人： AURISICCHIO, Luigi , CILIBERTO, Gennaro , LA MONICA, Nicola
IPC分类号： C12N15/09
CPC分类号： C12N15/86 , A61K2039/5256 , C07K14/4705 , C07K14/70503 , C12N2710/10343
摘要： Dicistronic adenovirus and plasmid vectors expressing both the carcinoembryonic antigen (CEA) tumor-associated antigen, or portion thereof, and the human epidermal growth factor 2/neu antigen (HER2/neu), or portion thereof, are provided. The present invention also provides methods for inducing an immune response against CEA and/or HER2-associated tumors using the compositions and molecules disclosed herein. The CEA and HER2 genes encode antigens that are commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein products expressed by the CEA and/or HER2/neu tumor-associated antigens, wherein aberrant CEA and/or HER2 expression is associated with a carcinoma or its development. The dicistronic vectors of the present invention are useful in vaccines and pharmaceutical compositions for the prevention and/or treatment of cancer.
摘要翻译：提供表达癌胚抗原（CEA）肿瘤相关抗原或其一部分和人表皮生长因子2 / neu抗原（HER2 / neu）或其部分的双顺反子腺病毒和质粒载体。本发明还提供使用本文公开的组合物和分子诱导针对CEA和/或HER2相关肿瘤的免疫应答的方法。 CEA和HER2基因编码通常与人类癌发展有关的抗原。本发明提供了引发或增强对由CEA和/或HER2 / neu肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常CEA和/或HER2表达与癌症或其发展相关。本发明的双顺反子载体可用于预防和/或治疗癌症的疫苗和药物组合物。

6. 发明申请

WO2004072287A1 RHESUS CARCINO EMBRYONIC ANTIGEN, NUCLEOTIDES ENCODING SAME, AND USES THEREOF 审中-公开
标题翻译： RHESUS CARCINO胚胎抗原，编码其的核苷酸及其用途
公开(公告)号：WO2004072287A1
公开(公告)日：2004-08-26
申请号：PCT/EP2004/001181
申请日：2004-02-09
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA , AURISICCHIO, Luigi , CILIBERTO, Gennaro , LAHM, Armin , LA MONICA, Nicola , MONACI, Paolo , PALOMBO, Fabio
发明人： AURISICCHIO, Luigi , CILIBERTO, Gennaro , LAHM, Armin , LA MONICA, Nicola , MONACI, Paolo , PALOMBO, Fabio
IPC分类号： C12N15/63
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/5256 , A61K2039/53 , C07K14/70503 , C07K16/3007
摘要： DNAs encoding rhesus monkey carcinoembryonic antigen (rhCEA) have been isolated, cloned and sequenced. The gene encoding CEA is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the CEA tumor-associated antigen, wherein aberrant CEA expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector constructs carrying rhCEA and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
摘要翻译：已经分离，克隆和测序编码恒河猴癌胚抗原（rhCEA）的DNA。编码CEA的基因通常与人类癌的发展有关。本发明提供了引发或增强由CEA肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常CEA表达与癌症或其发展相关。本发明具体提供携带rhCEA的腺病毒载体构建体，并公开了它们在预防和治疗癌症的疫苗和药物组合物中的用途。

7. 发明申请

WO2009002418A2 T-CELL PEPTIDE EPITOPES FROM CARCINOEMBRYONIC ANTIGEN, IMMUNOGENIC ANALOGS, AND USES THEREOF 审中-公开
标题翻译：来自癌细胞抗原，免疫原性类似物的T细胞肽抗体及其用途
公开(公告)号：WO2009002418A2
公开(公告)日：2008-12-31
申请号：PCT/US2008/007551
申请日：2008-06-17
申请人： MERCK & CO., INC. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , AURISICCHIO, Luigi , SCARSELLI, Elisa , LA MONICA, Nicola , CILIBERTO, Gennaro , FRIDMAN, Arthur , PAK, Irene , BAGCHI, Ansuman
发明人： AURISICCHIO, Luigi , SCARSELLI, Elisa , LA MONICA, Nicola , CILIBERTO, Gennaro , FRIDMAN, Arthur , PAK, Irene , BAGCHI, Ansuman
IPC分类号： A61K39/00
CPC分类号： A61K39/0011
摘要： The present invention provides vaccines and pharmaceutical compositions which can, when administered to a patient, elicit an immune response to the carcinoembryonic antigen (CEA). Immunogenic peptide epitopes of human CEA are provided, as well as immunogenic peptide analogs which can induce an immune response cross-reactive against CEA which response is superior in quality to that induced by the corresponding wild-type epitope. Also disclosed herein are pharmaceutical compositions and vaccines comprising one or more of said peptides and analogs for prophylaxis and/or treatment of cancer. This invention further provides polynucleotides encoding at least one of the CEA analogs described herein, and vectors and host cells comprising said polynucleotides. Methods of inducing an immune response in a patient, in addition to methods of treatment using the immunogenic peptides, peptide analogs and polynucleotides disclosed herein are also disclosed.
摘要翻译：本发明提供疫苗和药物组合物，其可以在给予患者时引发对癌胚抗原（CEA）的免疫应答。提供了人CEA的免疫原性肽表位，以及可以诱导针对CEA交叉反应的免疫应答的免疫原性肽类似物，其反应性质优于相应的野生型表位诱导。本文还公开了包含用于预防和/或治疗癌症的一种或多种所述肽和类似物的药物组合物和疫苗。本发明还提供编码本文所述的至少一种CEA类似物的多核苷酸，以及包含所述多核苷酸的载体和宿主细胞。还公开了在患者体内诱导免疫应答的方法，除了使用本文公开的免疫原性肽，肽类似物和多核苷酸的治疗方法。

8. 发明申请

WO2008043760A1 TELOMERASE REVERSE TRANSCRIPTASE FUSION PROTEIN, NUCLEOTIDES ENCODING IT, AND USES THEREOF 审中-公开
标题翻译： TELOMERASE逆转录酶融合蛋白，编码其的核苷酸及其用途
公开(公告)号：WO2008043760A1
公开(公告)日：2008-04-17
申请号：PCT/EP2007/060713
申请日：2007-10-09
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA , CILIBERTO, Gennaro , LA MONICA, Nicola , MENNUNI, Carmela , SCARSELLI, Elisa
发明人： CILIBERTO, Gennaro , LA MONICA, Nicola , MENNUNI, Carmela , SCARSELLI, Elisa
IPC分类号： C07K14/435
CPC分类号： C07K14/245 , C07K2319/00 , C07K2319/036 , C12N9/1241 , C12Y207/07049
摘要： Polynucleotides encoding telomerase reverse transcriptase (TERT) fusion proteins are provided, the TERT fusion proteins comprising a TERT protein, or functional variant thereof, fused to a substantial portion of the B subunit of heat labile enterotoxin (LTB). TERT variants useful in TERT-LTB fusion proteins of the invention comprise mutations that function to eliminate telomerase catalytic activity. The polynucleotides of the present invention can elicit an immune response in a mammal, which, in preferred embodiments, is stronger than the immune response elicited by a wild-type TERT. TERT expression is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the TERT tumor-associated antigen, wherein aberrant TERT expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector and plasmid constructs carrying polynucleotides encoding TERT fusion proteins and TERT variants and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
摘要翻译：提供了编码端粒酶逆转录酶（TERT）融合蛋白的多核苷酸，包含与热不稳定肠毒素（LTB）的B亚基的大部分融合的TERT蛋白或其功能变体的TERT融合蛋白。在本发明的TERT-LTB融合蛋白中有用的TERT变体包含用于消除端粒酶催化活性的突变。本发明的多核苷酸可以在哺乳动物中引发免疫应答，在优选的实施方案中，其比由野生型TERT引起的免疫应答更强。 TERT表达通常与人类癌的发展有关。本发明提供了引发或增强对由TERT肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常TERT表达与癌症或其发展相关。本发明具体提供了携带编码TERT融合蛋白和TERT变体的多核苷酸的腺病毒载体和质粒构建体，并公开了它们在预防和治疗癌症的疫苗和药物组合物中的用途。

9. 发明申请

WO2004061105A1 RHESUS HER2/NEU, NUCLEOTIDES ENCODING SAME, AND USES THEREOF 审中-公开
标题翻译： RHESUS HER2 / NEU，编码其的核苷酸及其用途
公开(公告)号：WO2004061105A1
公开(公告)日：2004-07-22
申请号：PCT/EP2003/014997
申请日：2003-12-29
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA , CILIBERTO, Gennaro , LAHM, Armin , LA MONICA, Nicola , MONACI, Paolo , NUZZO, Maurizio
发明人： CILIBERTO, Gennaro , LAHM, Armin , LA MONICA, Nicola , MONACI, Paolo , NUZZO, Maurizio
IPC分类号： C12N15/12
CPC分类号： A61K38/1709 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C07K14/71 , C12N15/86 , C12N2710/10343 , C12N2799/022
摘要： Polynucleotides encoding rhesus monkey HER2/neu have been isolated, cloned and sequenced. The gene encoding the HER2/neu is commonly associated with the development of epithelial-derived human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the HER2/neu tumor-associated antigen, wherein aberrant HER2/neu expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector constructs carrying rhHER2/neu and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
摘要翻译：编码恒河猴HER2 / neu的多核苷酸已被分离，克隆和测序。编码HER2 / neu的基因通常与上皮衍生的人类癌的发展有关。本发明提供了引发或增强对由HER2 / neu肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常HER2 / neu表达与癌症或其发展相关。本发明具体提供携带rhHER2 / neu的腺病毒载体构建体，并公开了它们在预防和治疗癌症的疫苗和药物组合物中的用途。

10. 发明申请

WO2003045438A1 INCREASING ELECTRO-GENE TRANSFER OF NUCLEIC ACID MOLECULES INTO HOST TISSUE 审中-公开
标题翻译：将核酸分子电转基因转移到宿主组织
公开(公告)号：WO2003045438A1
公开(公告)日：2003-06-05
申请号：PCT/EP2002/013097
申请日：2002-11-21
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA , FATTORI, Elena , LA MONICA, Nicola , MENNUNI, Carmela
发明人： FATTORI, Elena , LA MONICA, Nicola , MENNUNI, Carmela
IPC分类号： A61K47/42
CPC分类号： A61K31/711 , A61K38/47 , A61K2300/00
摘要： A method of delivering a pharmaceutical agent, such as a nucleic acid molecule, to a vertebrate host is disclosed which comprises combining the synergistic steps of electrical stimulation with administration of a biologically active amount of hyaluronidase. Additionally, formulations which comprise hyaluronidase and a pharmaceutical agent, such as a nucleic acid molecule, are disclosed. The hyaluronidase preparation is preferably administered prior to or simultaneous with the pharmaceutical agent and in conjunction with an applied electrical stimulation, thus affecting increased transfer of the population of a pharmaceutical agent into the target tissue when compared to the affect of electrical stimulation alone. The combination of hyaluronidase administration and electrostimulation results in a substantial increase in the transfer of the pharmaceutical agent, such as a nucleic acid molecule, to the target vertebrate host tissue.
摘要翻译：公开了将药剂如核酸分子递送至脊椎动物宿主的方法，其包括将电刺激的协同步骤与施用生物活性量的透明质酸酶组合。此外，公开了包含透明质酸酶和药剂如核酸分子的制剂。透明质酸酶制剂优选在药物之前或与药剂同时施用，并与施用的电刺激结合施用，因此与单独的电刺激的影响相比，影响药物剂群进入靶组织的增加的转移。透明质酸酶施用和电刺激的组合导致药剂如核酸分子转移到目标脊椎动物宿主组织的显着增加。

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