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1. 发明申请

WO2006026485A3 MODULATION OF HIF1-BETA EXPRESSION 审中-公开
标题翻译： HIF1-β表达的调节
公开(公告)号：WO2006026485A3
公开(公告)日：2006-06-08
申请号：PCT/US2005030513
申请日：2005-08-25
申请人： ISIS PHARMACEUTICALS INC , MARCUSSON ERIC G , HENRY SCOTT , KIM YOUNGSOO , DOBIE KENNETH W
发明人： MARCUSSON ERIC G , HENRY SCOTT , KIM YOUNGSOO , DOBIE KENNETH W
IPC分类号： C07H21/04 , A61K48/00 , C12N15/00
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF 1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of using these compounds for modulation of HIF1-beta expression and for diagnosis and treatment of diseases and conditions associated with expression of HIFI-beta are provided.
摘要翻译：提供了用于调节HIF1-β表达的化合物，组合物和方法。该组合物包含靶向编码HIF1-β的核酸的寡核苷酸。提供了使用这些化合物调节HIF1-β表达以及诊断和治疗与HIFI-β表达相关的疾病和病症的方法。

2. 发明申请

WO2012135736A3 MODULATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) EXPRESSION 审中-公开
标题翻译：信号传导器的调制和转录3（STAT3）表达的激活剂
公开(公告)号：WO2012135736A3
公开(公告)日：2012-12-06
申请号：PCT/US2012031642
申请日：2012-03-30
申请人： ISIS PHARMACEUTICALS INC , SWAYZE ERIC E , FREIER SUSAN M , MACLEOD ROBERT A , KIM YOUNGSOO
发明人： SWAYZE ERIC E , FREIER SUSAN M , MACLEOD ROBERT A , KIM YOUNGSOO
IPC分类号： C07H21/04 , C12N15/11
CPC分类号： C12N15/113 , C07H21/00 , C07H21/04 , C12N15/00 , C12N15/11 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/321 , C12N2310/3521 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate hyperproliferative diseases.
摘要翻译：本文公开了用于降低STAT3 mRNA和蛋白质表达的反义化合物和方法。这些方法，化合物和组合物可用于治疗，预防或改善过度增殖性疾病。

3. 发明专利

IL237855D0 Modulation of androgen receptor expression 未知
公开(公告)号：IL237855D0
公开(公告)日：2015-05-31
申请号：IL23785515
申请日：2015-03-19
申请人： IONIS PHARMACEUTICALS INC , KIM YOUNGSOO , MACLEOD ROBERT A , ZHOU TIANYUAN , FREIER SUSAN M , SETH PUNIT P , SWAYZE ERIC , MONIA BRETT P
发明人： KIM YOUNGSOO , MACLEOD ROBERT A , ZHOU TIANYUAN , FREIER SUSAN M , SETH PUNIT P , SWAYZE ERIC , MONIA BRETT P
IPC分类号： C12N20060101
摘要： Certain embodiments are directed to compounds and compositions targeted to human androgen receptor (AR) for inhibiting androgen receptor levels in a cell, which can be useful for methods of treating cancer and inhibiting cancer cell growth or proliferation.

4. 发明专利

AU2003282429A1 NOVEL COMPOUND OF 6-METHYL-3-PHENETHYL-3,4-DIHYDRO-1H-QUINAZOLINE-2-THINONE, ITS PREPARATION AND A DEPIGMENTATION COMPOSITON CONTAINING THE SAME AS AN EFFECTIVE COMPONENT 未知
公开(公告)号：AU2003282429A1
公开(公告)日：2005-03-07
申请号：AU2003282429
申请日：2003-11-25
申请人： KIM YOUNGSOO
发明人： KIM YOUNGSOO , JUNG SANG-HUN , MIN KYUNG RAK , PARK JUN KYU , LEE JEE-HYUN
IPC分类号： C07D239/78 , A61K8/49 , A61K31/495 , A61Q19/02 , C07D239/80 , C07D239/93 , A61K7/48
摘要： The present invention relates to a novel compound of 6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione represented by following formula (1), a preparation method thereof, a medicinal composition for prevention and treatment of hyperpigmentation comprising the same as an effective component, and a skin-whitening cosmetic composition comprising the same as an effective component :

5. 发明专利

IL262218A Modulation of androgen receptor expression 未知
公开(公告)号：IL262218A
公开(公告)日：2020-08-31
申请号：IL26221818
申请日：2018-10-08
申请人： IONIS PHARMACEUTICALS INC , KIM YOUNGSOO , MACLEOD ROBERT A , ZHOU TIANYUAN , FREIER SUSAN M , SETH PUNIT P , SWAYZE ERIC , MONIA BRETT P
发明人： KIM YOUNGSOO , MACLEOD ROBERT A , ZHOU TIANYUAN , FREIER SUSAN M , SETH PUNIT P , SWAYZE ERIC , MONIA BRETT P
IPC分类号： A61K31/7088 , A61K31/4166 , C12N15/113
摘要： Certain embodiments are directed to compounds and compositions targeted to human androgen receptor (AR) for inhibiting androgen receptor levels in a cell, which can be useful for methods of treating cancer and inhibiting cancer cell growth or proliferation.

6. 发明专利

IL262218D0 Modulation of androgen receptor expression 未知
公开(公告)号：IL262218D0
公开(公告)日：2018-11-29
申请号：IL26221818
申请日：2018-10-08
申请人： IONIS PHARMACEUTICALS INC , KIM YOUNGSOO , MACLEOD ROBERT A , ZHOU TIANYUAN , FREIER SUSAN M , SETH PUNIT P , SWAYZE ERIC , MONIA BRETT P
发明人： KIM YOUNGSOO , MACLEOD ROBERT A , ZHOU TIANYUAN , FREIER SUSAN M , SETH PUNIT P , SWAYZE ERIC , MONIA BRETT P
IPC分类号： C12N20060101
摘要： Certain embodiments are directed to compounds and compositions targeted to human androgen receptor (AR) for inhibiting androgen receptor levels in a cell, which can be useful for methods of treating cancer and inhibiting cancer cell growth or proliferation.

7. 发明申请

WO0109404A3 SURFACE SHEET, SANDWICH STRUCTURE AND ARTICLES USING THEM 审中-公开
标题翻译：表面表，三角结构和使用它们的文章
公开(公告)号：WO0109404A3
公开(公告)日：2001-12-20
申请号：PCT/KR9900610
申请日：1999-10-11
申请人： HANKUK FIBER GLASS CO LTD , KIM YOUNGSOO
发明人： KIM YOUNGSOO
IPC分类号： B32B15/01 , B32B15/04 , B32B15/08 , B32B3/12 , B32B5/18 , B32B15/14 , B32B15/18 , B32B15/20
CPC分类号： B32B3/12 , B32B5/18 , B32B7/02 , B32B15/04 , B32B15/08 , B32B15/18 , B32B2250/40 , B32B2305/024 , B32B2307/30 , B32B2307/54 , B32B2311/30
摘要： The present invention relates to a structural surface sheet consisting of the first surface member of stainless steel and the second surface member consisting of fiber-reinforced polymer composite material having the thermal expansion coefficient similar to that of the stainless steel of the first surface member and also having mechanical characteristics similar to those of a metal in order to exhibit excellent debonding resistance so that the first surface member assumes the function of preserving inherent surface characteristics as the gracefulness, prolonged life, anti-corrosion and anti-erosion while the second surface member assumes the structural function including the reduction of weight. The present invention also relates to a surface sheet comprising the same first surface member and the same second surface member as in the above to be used for a sandwich structure in conjunction with a core member and another surface sheet as well as the resulting sandwich structure. The present invention further relates to a product based on the above-described surface sheet or sandwich structure for use as railroad vehicles, containers, cabins, external decorative building materials, partitions and outdoor constructions.
摘要翻译：本发明涉及由不锈钢的第一表面构件和由具有与第一表面构件的不锈钢的热膨胀系数相似的热膨胀系数的纤维增强聚合物复合材料构成的第二表面构件构成的结构表面片，具有与金属相似的机械特性，以便表现出优异的脱粘性，使得第一表面构件具有保持固有表面特性作为优良性，延长的使用寿命，防腐蚀和抗侵蚀的功能，同时第二表面构件呈现结构功能包括减轻重量。本发明还涉及一种包括与芯材和另一表面片一起用于夹层结构的与上述相同的第一表面构件和相同的第二表面构件的表面片以及所得的夹层结构。本发明还涉及基于上述用作铁路车辆，集装箱，小屋，外部装饰建筑材料，隔板和室外结构的表面片或夹层结构的产品。

8. 发明申请

WO2009151299A3 STYRYLBENZOFURAN DERIVATIVES AS INHIBITORS FOR BETA-AMYLOID FIBRIL FORMATION AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：作为抗坏血酸纤维素形成的抑制剂的苯乙烯苯并呋喃衍生物及其制备方法
公开(公告)号：WO2009151299A3
公开(公告)日：2010-04-01
申请号：PCT/KR2009003165
申请日：2009-06-12
申请人： KOREA INST SCI & TECH , HANMI PHARM IND CO LTD , KIM DONG JIN , YOO KYUNG HO , BYUN JI HUN , KIM YOUNGSOO , KIM HYE YUN , LEE GWAN SUN , KIM MAENG SUP , AHN YOUNG GIL , LEE JI HOON , LEE MYOUNG-HWAN , HWANG HANA , RYU JIYEON
发明人： KIM DONG JIN , YOO KYUNG HO , BYUN JI HUN , KIM YOUNGSOO , KIM HYE YUN , LEE GWAN SUN , KIM MAENG SUP , AHN YOUNG GIL , LEE JI HOON , LEE MYOUNG-HWAN , HWANG HANA , RYU JIYEON
IPC分类号： C07D307/78 , A61K31/343
CPC分类号： C07D307/81 , C07D307/80
摘要： The present invention relates to a novel compound which efficiently inhibits the formation of beta-amyloid fibrils in the brain to be useful for preventing or treating a degenerative brain disease, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.
摘要翻译：本发明涉及有效抑制脑中β-淀粉样蛋白原纤维形成以用于预防或治疗退行性脑病的新型化合物，其制备方法和含有该组合物作为活性成分的药物组合物。

9. 发明申请

WO2014059238A8 MODULATION OF ANDROGEN RECEPTOR EXPRESSION 审中-公开
标题翻译：雄激素受体表达的调控
公开(公告)号：WO2014059238A8
公开(公告)日：2015-04-16
申请号：PCT/US2013064479
申请日：2013-10-11
申请人： ISIS PHARMACEUTICALS INC
发明人： MACLEOD ROBERT A , KIM YOUNGSOO , ZHOU TIANYUAN , FREIER SUSAN M , SETH PUNIT P , SWAYZE ERIC , MONIA BRETT P
IPC分类号： A61K31/712
CPC分类号： C12N15/1138 , A61K31/4166 , A61K31/7088 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3525
摘要： Certain embodiments are directed to compounds and compositions targeted to human androgen receptor (AR) for inhibiting androgen receptor levels in a cell, which can be useful for methods of treating cancer and inhibiting cancer cell growth or proliferation. Several embodiments provided herein relate to the discovery of compounds and compositions for inhibiting androgen receptor levels in a cell, which can be useful for methods of treating cancer and inhibiting proliferation or growth of cancer cells, such as prostate, breast, ovarian, gastric or bladder cancer or cancer cells.
摘要翻译：某些实施方案涉及靶向人雄激素受体（AR）的化合物和组合物，用于抑制细胞中的雄激素受体水平，其可用于治疗癌症和抑制癌细胞生长或增殖的方法。本文提供的几个实施方案涉及用于抑制细胞中雄激素受体水平的化合物和组合物的发现，其可用于治疗癌症和抑制癌细胞例如前列腺，乳腺，卵巢，胃或膀胱的增殖或生长的方法癌症或癌细胞。

10. 发明申请

WO2012050919A3 CHIMERIC SPIDER SILK AND USES THEREOF 审中-公开
标题翻译： CHIMERIC SPIDER SILK及其用途
公开(公告)号：WO2012050919A3
公开(公告)日：2012-12-27
申请号：PCT/US2011053760
申请日：2011-09-28
申请人： UNIV NOTRE DAME , FRASER MALCOLM JAMES , LEWIS RANDY , JARVIS DON , THOMPSON KIMBERLY , HULL JOSEPH , MIAO YUN-GEN , TEULE FLORENCE , SOHN BONGHEE , KIM YOUNGSOO
发明人： FRASER MALCOLM JAMES , LEWIS RANDY , JARVIS DON , THOMPSON KIMBERLY , HULL JOSEPH , MIAO YUN-GEN , TEULE FLORENCE , SOHN BONGHEE , KIM YOUNGSOO
IPC分类号： C07K19/00 , A01K67/04 , C07K14/435 , C12N15/12 , C12N15/63
CPC分类号： C07K14/43586 , A01K67/0333 , A01K67/04 , A01K2217/052 , A01K2227/706 , A01K2267/01 , A01K2267/02 , A61K38/00 , C07K14/43518 , C07K2319/00
摘要： Disclosed are transgenic silkworms engineered to posses and express a chimeric spider silk protein gene, the chimeric spider silk protein gene encoding a chimeric spider silk protein having spider silk domains specific for a spider silk elasticity motif sequence and/or a spider silk strength motif sequence. Also provided are improved silkworm silk fibers having improved strength (tensile) and elasticity characteristics relative to native silkworm silk fibers. An improved method for preparing chimeric silk fibers employing the transgenic silkworms disclosed herein is also provided, the method employing a piggyBac based vector system and a helper plasmid. Genetic expression cassettes are provided, and are used to create a number of synthetic spider silk encoding sequences (Spider 2, Spider 4, Spider 6, Spider 8). A piggyBac vector system is used to transform mutant silkworm, in the presence of a helper plasmid, to incorporate the chimeric spider silk gene into the silkworm to provide a stable transformant. These transgenic silkworms thus provide an efficient spider silk producing organism suitable for commercial production of silk fibers.
摘要翻译：公开了用于产生和表达嵌合蜘蛛丝蛋白基因的转基因蚕，编码嵌合蜘蛛丝蛋白的嵌合蜘蛛丝蛋白基因，其具有蜘蛛丝弹性基序序列特有的蜘蛛丝结构域和/或蜘蛛丝强度基序序列。还提供了相对于天然蚕丝纤维具有改进的强度（拉伸）和弹性特征的改良的蚕丝纤维。还提供了使用本文公开的转基因蚕制备嵌合丝纤维的改进方法，该方法使用基于piggyBac的载体系统和辅助质粒。提供遗传表达盒，并用于创建一些合成蜘蛛丝编码序列（Spider 2，Spider 4，Spider 6，Spider 8）。使用piggyBac载体系统在存在辅助质粒的情况下转化突变蚕，将嵌合蜘蛛丝基因并入蚕中以提供稳定的转化体。因此，这些转基因蚕提供了适用于商业生产丝纤维的有效的蜘蛛丝生产生物。

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