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1. 发明申请

WO2004053141A3 METHODS FOR RAPID FORENSIC ANALYSIS OF MITOCHONDRIAL DNA AND CHARACTERIZATION OF MITOCHONDRIAL DNA HETEROPLASMY 审中-公开
标题翻译：麻醉DNA快速鉴别分析方法及MITOCHONDRIAL DNA HETEROPLASMY的表征
公开(公告)号：WO2004053141A3
公开(公告)日：2005-06-23
申请号：PCT/US0338505
申请日：2003-12-05
申请人： ISIS PHARMACEUTICALS INC , ECKER DAVID J , CROOKE STANLEY T , BLYN LAWRENCE B , HALL THOMAS A , JIANG YUN , GRIFFEY RICHARD H , SAMPATH RANGARAJAN , HOFSTADLER STEVEN A , MCNEIL JOHN , HANNIS JAMES C , WHITE NEILL , SAMANT VIVEK , ESHOO MARK W , DRADER JARED J
发明人： ECKER DAVID J , CROOKE STANLEY T , BLYN LAWRENCE B , HALL THOMAS A , JIANG YUN , GRIFFEY RICHARD H , SAMPATH RANGARAJAN , HOFSTADLER STEVEN A , MCNEIL JOHN , HANNIS JAMES C , WHITE NEILL , SAMANT VIVEK , ESHOO MARK W , DRADER JARED J
IPC分类号： C07H21/04 , C12P19/34 , C12Q20060101 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译：本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。

2. 发明申请

WO2005116263A2 METHODS FOR RAPID FORENSIC ANALYSIS OF MITOCHONDRIAL DNA 审中-公开
标题翻译：方法快速检测麻醉DNA
公开(公告)号：WO2005116263A2
公开(公告)日：2005-12-08
申请号：PCT/US2005018031
申请日：2005-05-24
申请人： ISIS PHARMACEUTICALS INC , HOFSTADLER STEVEN A , HALL THOMAS A , ECKER DAVID J , BLYN LAWRENCE , ESHOO MARK W , SAMANT VIVEK , WHITE NEILL
发明人： HOFSTADLER STEVEN A , HALL THOMAS A , ECKER DAVID J , BLYN LAWRENCE , ESHOO MARK W , SAMANT VIVEK , WHITE NEILL
IPC分类号： C12Q1/68 , G01N27/447 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G01N27/62 , C12Q1/683 , C12Q1/6846 , G01N27/447 , G06F19/28 , C12Q2565/627 , C12Q2521/301
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.
摘要翻译：本发明提供了通过扩增含有限制性位点的线粒体DNA片段，用限制酶消化线粒体DNA片段，测定限制性片段的分子量和比较分子质量与分子质量的线粒体DNA的快速法医分析方法已知线粒体DNA序列的理论限制性消化存储在数据库中。

3. 发明申请

WO2005036369A3 DATABASE FOR MICROBIAL INVESTIGATIONS 审中-公开
标题翻译：数据库微软调查
公开(公告)号：WO2005036369A3
公开(公告)日：2006-07-06
申请号：PCT/US2004033742
申请日：2004-10-12
申请人： ISIS PHARMACEUTICALS INC , HARI KUMAR , MCNEIL JOHN , ECKER DAVE , WHITE NEILL , SAMANT VIVEK , ZAPP VANESSA , GOATES ALAN
发明人： HARI KUMAR , MCNEIL JOHN , ECKER DAVE , WHITE NEILL , SAMANT VIVEK , ZAPP VANESSA , GOATES ALAN
IPC分类号： G01N33/48 , G06F20060101 , G06F19/00
CPC分类号： G06F19/325 , G16H50/70 , G16H50/80 , Y02A90/24 , Y02A90/26
摘要： A centralized system provides for locating, storing and providing microbial-related information, including pathogens, diseases, symptoms, genetic information, and related documentation. A centralized database relates pathogens to diseases that they cause, symptoms of those diseases, genetic information about the pathogens, and documentation that is associated with any of the above. By analyzing the stored data, the system recognizes duplicated information, for example a pathogen present in the database twice, each time under a different taxonomical name, and creates a link from one instance of the pathogen to the other. The system additionally identifies common genes and sequences among related organisms. A researcher uses the system to perform investigations. For example, a medical doctor can enter patient symptoms to obtain a list of consistent diseases and associated pathogens. The system also tracks the progression of an outbreak and identifies similar occurrences by searching the World Wide Web and reporting results.
摘要翻译：一个集中系统提供定位，存储和提供微生物相关信息，包括病原体，疾病，症状，遗传信息和相关文件。集中的数据库将病原体与其引起的疾病，这些疾病的症状，关于病原体的遗传信息以及与上述任何相关的文献相关联。通过分析存储的数据，系统每次以不同的分类名称识别重复信息，例如数据库中存在的病原体两次，并创建从病原体的一个实例到另一个的链接。该系统另外鉴定相关生物体中的常见基因和序列。研究人员利用该系统进行调查。例如，医生可以进入患者症状以获得一致的疾病和相关病原体的清单。该系统还跟踪疫情的进展，并通过搜索万维网和报告结果来识别类似的情况。

4. 发明专利

CA2510007A1 METHODS FOR RAPID FORENSIC ANALYSIS OF MITOCHONDRIAL DNA ANDCHARACTERIZATION OF MITOCHONDRIAL DNA HETEROPLASMY 未知
公开(公告)号：CA2510007A1
公开(公告)日：2004-06-24
申请号：CA2510007
申请日：2003-12-05
申请人： ISIS PHARMACEUTICALS INC
发明人： GRIFFEY RICHARD H , SAMPATH RANGARAJAN , JIANG YUN , MCNEIL JOHN , HOFSTADLER STEVEN A , DRADER JARED J , ESHOO MARK W , SAMANT VIVEK , WHITE NEILL , HANNIS JAMES C , HALL THOMAS A , BLYN LAWRENCE B , CROOKE STANLEY T , ECKER DAVID J
IPC分类号： C07H21/04 , C12P19/34 , C12Q20060101 , C12Q1/68 , C12Q1/70
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondri al DNA, which can be used to assess the progression of mitochondrial diseases.

5. 发明专利

CA2510007C METHODS FOR RAPID FORENSIC ANALYSIS OF MITOCHONDRIAL DNA AND CHARACTERIZATION OF MITOCHONDRIAL DNA HETEROPLASMY 未知
公开(公告)号：CA2510007C
公开(公告)日：2014-07-08
申请号：CA2510007
申请日：2003-12-05
申请人： ISIS PHARMACEUTICALS INC
发明人： ECKER DAVID J , CROOKE STANLEY T , BLYN LAWRENCE B , HALL THOMAS A , JIANG YUN , GRIFFEY RICHARD H , SAMPATH RANGARAJAN , HOFSTADLER STEVEN A , MCNEIL JOHN , HANNIS JAMES C , WHITE NEILL , SAMANT VIVEK , ESHOO MARK W , DRADER JARED J
IPC分类号： C07H21/04 , C12N15/09 , C12P19/34 , C12Q20060101 , C12Q1/44 , C12Q1/68 , C12Q1/70
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.

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