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1. 发明申请

WO2012149495A1 MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION 审中-公开
标题翻译： APOLIPOPROTEIN CIII（APOCIII）表达的调控
公开(公告)号：WO2012149495A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/035694
申请日：2012-04-27
申请人： ISIS PHARMACEUTICALS, INC. , MULLICK, Adam , CROOKE, Rosanne, M. , GRAHAM, Mark, J. , DOBIE, Kenneth, W. , BELL, Thomas, A. , LEE, Richard
发明人： MULLICK, Adam , CROOKE, Rosanne, M. , GRAHAM, Mark, J. , DOBIE, Kenneth, W. , BELL, Thomas, A. , LEE, Richard
IPC分类号： A61K31/7088 , A61P3/06
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , A61K45/06 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/351 , A61K2300/00
摘要： Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof.
摘要翻译：本文提供了用于在动物中降低ApoCIII mRNA和蛋白质表达的方法，化合物和组合物。本文还提供了用于增加HDL水平和/或改善动物体内TG与HDL的比例以及降低血浆脂质和血浆葡萄糖的方法，化合物和组合物。这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或代谢紊乱或其症状中的任何一种或多种。

2. 发明申请

WO2011085271A2 MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION 审中-公开
标题翻译：神经营养素样3的表达调控
公开(公告)号：WO2011085271A2
公开(公告)日：2011-07-14
申请号：PCT/US2011/020606
申请日：2011-01-07
申请人： ISIS PHARMACEUTICALS, INC. , CROOKE, Rosanne, M. , GRAHAM, Mark, J. , LEE, Richard , DOBIE, Kenneth, W.
发明人： CROOKE, Rosanne, M. , GRAHAM, Mark, J. , LEE, Richard , DOBIE, Kenneth, W.
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , C12N15/1136 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , C12N2310/3521
摘要： Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof.
摘要翻译：本文提供了用于减少动物中ANGPTL3 mRNA和蛋白质表达的方法，化合物和组合物。本文还提供了用于降低动物体内血浆脂质，血浆葡萄糖和动脉粥样硬化斑块的方法，化合物和组合物。这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或代谢疾病或其症状中的任何一种或多种。

3. 发明申请

WO2012149386A1 MODULATION OF CIDEB EXPRESSION 审中-公开
标题翻译： CIDEB表达式的调制
公开(公告)号：WO2012149386A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/035543
申请日：2012-04-27
申请人： ISIS PHARMACEUTICALS, INC. , LEE, Richard , CROOKE, Rosanne, M. , GRAHAM, Mark, J.
发明人： LEE, Richard , CROOKE, Rosanne, M. , GRAHAM, Mark, J.
IPC分类号： C12N15/11 , A61K48/00 , C07H21/04
CPC分类号： C07H21/04 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/322 , C12N2310/341 , C12N2310/3525
摘要： Provided herein are methods, compounds, and compositions for reducing expression of a CideB mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing lipids and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof.
摘要翻译：本文提供了用于减少动物体内CideB mRNA和蛋白质表达的方法，化合物和组合物。本文还提供了用于降低动物体内脂质和动脉粥样硬化斑块的方法，化合物和组合物。这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或代谢疾病或其症状中的任何一种或多种。

4. 发明公开

EP2701713A1 MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION 有权
标题翻译：调节剂APOLIPOPROTEIN CIII（AOPCIII） - 表达
公开(公告)号：EP2701713A1
公开(公告)日：2014-03-05
申请号：EP12776385.2
申请日：2012-04-27
申请人： Isis Pharmaceuticals, Inc.
发明人： MULLICK, Adam , CROOKE, Rosanne, M. , GRAHAM, Mark, J. , DOBIE, Kenneth, W. , BELL, Thomas, A. , LEE, Richard
IPC分类号： A61K31/7088 , A61P3/06
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , A61K45/06 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/351 , A61K2300/00
摘要： Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof.

5. 发明公开

EP2521556A2 MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION 有权转让
标题翻译：调制血管生成素3相似的表达的
公开(公告)号：EP2521556A2
公开(公告)日：2012-11-14
申请号：EP11732249.5
申请日：2011-01-07
申请人： Isis Pharmaceuticals, Inc.
发明人： CROOKE, Rosanne, M. , GRAHAM, Mark, J. , LEE, Richard , DOBIE, Kenneth, W.
IPC分类号： A61K31/7105 , C07H21/02
CPC分类号： C12N15/113 , C12N15/1136 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , C12N2310/3521
摘要： Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof.

6. 发明申请

WO2016025798A2 TABLE TENNIS TABLE WITH A HONEYCOMB CORE AND A METHOD FOR ITS MANUFACTURE 审中-公开
标题翻译：具有蜂窝骨芯的表格表及其制造方法
公开(公告)号：WO2016025798A2
公开(公告)日：2016-02-18
申请号：PCT/US2015/045212
申请日：2015-08-14
申请人： LEE, Richard
发明人： LEE, Richard
CPC分类号： A63B67/04 , A47B25/003 , F16B5/01
摘要： A table tennis table that utilizes a honeycomb core for its structure and stability. The honeycomb core has top tabs and bottom tabs which fold at approximately a right angle to each tabs' respective original plane. The bent tabs provide more surface area (and hence more contact) between an upper surface on top of the honeycomb core and a bottom surface on a bottom of the honeycomb core. A method of manufacturing the table utilizes a tab bending guide in order to efficiently bend each tab. The table (without its upper and lower surface) is pushed through the tab bending guide which bends the tabs accordingly, upon which the upper and lower surfaces can then be fixed using glue to the honeycomb core.
摘要翻译：乒乓球桌采用蜂窝芯的结构和稳定性。蜂窝芯具有顶部突片和底部突出部，其与每个突片相应的原始平面以大致直角折叠。弯曲的突片在蜂窝芯的顶部上表面和蜂窝芯的底部的底表面之间提供更多的表面积（因此更多的接触）。制造桌子的方法利用翼片弯曲导向器，以有效地弯曲每个翼片。桌子（没有其上，下表面）被推动通过折片弯折引导件，该弯折引导件相应地弯曲翼片，然后使用胶将上表面和下表面固定在蜂窝芯上。

7. 发明申请

WO2012174060A1 LEFT ATRIAL APPENDAGE OCCLUDER 审中-公开
标题翻译：左侧ATRIAL APPENDAGE OCCLUDER
公开(公告)号：WO2012174060A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/042172
申请日：2012-06-13
申请人： NORTHWESTERN UNIVERSITY , LEE, Richard
发明人： LEE, Richard
IPC分类号： A61B17/00 , A61B17/12
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B2017/00592 , A61B2017/00597 , A61B2017/00632
摘要： Systems and methods for occluding a left atrial appendage are disclosed. A left atrial appendage may be covered with a first occluder device to obstruct the passage of blood out of the left atrial appendage. The first occluder device may include an expandable member, a cover attached to and covering an end of the expandable member, and a one-way valve disposed in the cover. The cover may form a flexible pocket between the cover and the expandable member. The cover may be made of bioprosthetic material. A second occluder device may also be disposed within the left atrial appendage by inserting the second occluder device through the one-way valve in the cover of the first occluder device. The second occluder device may be used to stretch the left atrial appendage to obliterate the left atrial appendage.
摘要翻译：公开了用于闭塞左心耳的系统和方法。可以用第一封堵器装置覆盖左心耳以阻止血液从左心耳通过。第一封堵器装置可以包括可扩张构件，附接到并覆盖可扩张构件的端部的盖以及设置在盖中的单向阀。盖可以在盖和可扩张构件之间形成柔性袋。盖可以由生物纤维材料制成。通过将第二封堵器装置插入第一封堵装置的盖中的单向阀，也可以将第二封堵器装置设置在左心耳内。第二封堵器装置可用于拉伸左心耳以消除左心耳。

8. 发明申请

WO2016081212A1 CONVERTIBLE GAME SYSTEM 审中-公开
标题翻译：可变游戏系统
公开(公告)号：WO2016081212A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/059624
申请日：2015-11-06
申请人： LEE, Richard
发明人： LEE, Richard
IPC分类号： A63B71/04
CPC分类号： A63B69/0071 , A63B24/0021 , A63B63/00 , A63B63/004 , A63B63/008 , A63B63/06 , A63B63/08 , A63B63/083 , A63B69/00 , A63B69/0002 , A63B69/002 , A63B71/0054 , A63B71/023 , A63B71/0622 , A63B2024/0037 , A63B2063/001 , A63B2063/002 , A63B2063/065 , A63B2071/0625 , A63B2102/18 , A63B2102/182 , A63B2208/0204 , A63B2210/50 , A63B2243/0025 , A63B2243/007
摘要： A convertible game system configured to be used by a player at home who wishes to practice skills from multiple sports on an apparatus that does not require extensive space requirements. The game system has a frame, with a hopper section and a mounting section, a ball return, and a rotational component. The rotational component is mounted to the frame at the mounting section by a locking bearing system. For use, a player unlocks the locking bearing system, rotates the rotational component to display the desired game face, then re- locks the locking bearing system before beginning game play. The rotational component can have as few as 3 faces, and as many as 8 faces.
摘要翻译：一种可转换的游戏系统，被配置为由希望在不需要大量空间要求的装置上从多个运动中练习技能的家庭玩家使用。游戏系统具有框架，具有料斗部分和安装部分，回球部和旋转部件。旋转部件通过锁定轴承系统在安装部分处安装到框架。为了使用，玩家解锁锁定轴承系统，旋转旋转部件以显示所需的游戏面部，然后在开始玩游戏之前重新锁定锁定轴承系统。旋转部件可以具有少至3个面，多达8个面。

9. 发明申请

WO2010078523A1 METHODS AND TECHNIQUES FOR ADAPTIVE SEARCH 审中-公开
标题翻译：自适应搜索的方法和技术
公开(公告)号：WO2010078523A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069964
申请日：2009-12-31
申请人： TIVO INC. , GLENNON, Shelly , BEACH, Brian , CHENG, James , LEE, Richard , PALUCH, Kimberly , PONIATOWSKI, Robert F. , SCHMIDT, Margret
发明人： GLENNON, Shelly , BEACH, Brian , CHENG, James , LEE, Richard , PALUCH, Kimberly , PONIATOWSKI, Robert F. , SCHMIDT, Margret
IPC分类号： G06F3/00
CPC分类号： H04N5/44543 , G06F3/0482 , G06F17/30634 , G06F17/30699 , H04N21/482 , H04N21/4828
摘要： A method and apparatus for an adaptive search user interface is provided. An interface is provided that returns search results upon receiving each alphanumeric character of a search query term. Correlations of prefixes of alphanumeric characters and search results selected from previous searches are stored in a correlation matrix. Based upon the correlations in the correlation matrix, relevance rankings for search results with respect to the prefixes of alphanumeric characters are updated. Search results may be grouped based upon one or more common traits. Relevance rankings are also updated based upon the rate of change of selections recorded for a search result.
摘要翻译：提供了一种用于自适应搜索用户界面的方法和装置。提供了一种接口，用于在接收到搜索查询项的每个字母数字字符时返回搜索结果。字母数字字符的前缀与先前搜索中选择的搜索结果的相关性存储在相关矩阵中。基于相关矩阵中的相关性，更新关于字母数字字符的前缀的搜索结果的相关性排名。搜索结果可以基于一个或多个共同特征分组。相关性排名也根据搜索结果记录的选择的变化率更新。

10. 发明申请

WO2008051505A2 PROTEASE RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE 审中-公开
标题翻译：基质细胞衍生因子-1在组织损伤修复中的抗蛋白酶突变体
公开(公告)号：WO2008051505A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/022394
申请日：2007-10-22
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , LEE, Richard , SEGERS, Vincent
发明人： LEE, Richard , SEGERS, Vincent
IPC分类号： A61K38/00 , A61K38/48 , A61P43/00 , C07H21/04 , C07K16/00 , C12N9/50
CPC分类号： C07K14/521 , A61K38/00 , C07K14/52 , C07K2319/735 , C12N5/0652
摘要： The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-I to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.
摘要翻译：本发明涉及基质细胞衍生的因子-1肽，其已被突变以使其抵抗蛋白酶二肽基肽酶IV（DPPIV）和基质金属蛋白酶-2（MMP-2）的消化，但是其保持天然SDF-1吸引T细胞的能力。突变体可以附着到自组装肽形成的膜上，然后植入组织损伤部位以帮助促进修复。

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