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1. 发明专利

AU2005214352A1 Compounds and compositions as protein kinase inhibitors 未知
公开(公告)号：AU2005214352A1
公开(公告)日：2005-09-01
申请号：AU2005214352
申请日：2005-02-14
申请人： IRM LLC
发明人： JIANG TAO , YANG KUNYONG , SIM TAEBO , GU XIANG-JU , GRAY NATHANAEL SCHIANDER , CHOI HA-SOON , LIU YI , RICHMOND WENDY , HE YUN , HE XIAOHUI , WANG ZHICHENG
IPC分类号： C07D487/04 , A61K31/519 , C07D471/04

2. 发明专利

DK1713806T3 Forbindelser og sammensætninger som proteinkinaseinhibitorer 未知
公开(公告)号：DK1713806T3
公开(公告)日：2013-08-05
申请号：DK05713510
申请日：2005-02-14
申请人： IRM LLC
发明人： CHOI HA-SOON , WANG ZHICHENG , GRAY NATHANAEL SCHIANDER , GU XIANG-JU , HE XIAOHUI , HE YUN , JIANG TAO , LIU YI , RICHMOND WENDY , SIM TAEBO , YANG KUNYONG
IPC分类号： C07D471/04 , A61K31/519 , C07D487/04

3. 发明专利

AU2005214352B2 Compounds and compositions as protein kinase inhibitors 未知
公开(公告)号：AU2005214352B2
公开(公告)日：2009-11-12
申请号：AU2005214352
申请日：2005-02-14
申请人： IRM LLC
发明人： JIANG TAO , YANG KUNYONG , SIM TAEBO , GU XIANG-JU , GRAY NATHANAEL SCHIANDER , CHOI HA-SOON , LIU YI , RICHMOND WENDY , HE YUN , HE XIAOHUI , WANG ZHICHENG
IPC分类号： C07D487/04 , A61K31/519 , C07D471/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the FAK, Abl, BCR-Abl, PDGF-R, c-Kit, NPM-ALK, Flt-3, JAK2 and c-Met kinases.

4. 发明公开

EP1713806A4 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 有权
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：EP1713806A4
公开(公告)日：2009-11-11
申请号：EP05713510
申请日：2005-02-14
申请人： IRM LLC
发明人： CHOI HA-SOON , WANG ZHICHENG , GRAY NATHANAEL SCHIANDER , GU XIANG-JU , HE XIAOHUI , HE YUN , JIANG TAO , LIU YI , RICHMOND WENDY , SIM TAEBO , YANG KUNYONG
IPC分类号： C07D471/04 , A61K31/519 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04

5. 发明申请

WO2006015259A3 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS 审中-公开
标题翻译：作为甾体激素核受体的调节剂的化合物和组合物
公开(公告)号：WO2006015259A3
公开(公告)日：2008-10-16
申请号：PCT/US2005027086
申请日：2005-07-28
申请人： IRM LLC , MICHELLYS PIERRE-YVES , PETRASSI H MICHAEL , RICHMOND WENDY , PEI WEI
发明人： MICHELLYS PIERRE-YVES , PETRASSI H MICHAEL , RICHMOND WENDY , PEI WEI
IPC分类号： C07D417/04 , A61K31/498 , A61K31/536 , C07D403/04 , C07D403/14 , C07D417/14
CPC分类号： C07D263/58 , C07D265/36 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activation of steroid hormone nuclear receptors.
摘要翻译：本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与类固醇激素核受体激活相关的疾病或病症的方法。

6. 发明公开

EP1778242A4 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS 审中-公开
标题翻译：化合物和组合物类固醇激素核受体调节剂
公开(公告)号：EP1778242A4
公开(公告)日：2010-10-20
申请号：EP05776623
申请日：2005-07-28
申请人： IRM LLC
发明人： MICHELLYS PIERRE-YVES , PETRASSI H MICHAEL , RICHMOND WENDY , PEI WEI
IPC分类号： C07D417/04 , A61K31/498 , A61K31/536 , C07D403/04 , C07D403/14 , C07D417/14
CPC分类号： C07D263/58 , C07D265/36 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14

7. 发明专利

ES2424642T3 Compuestos y composiciones como inhibidores de la proteína quinasa 未知
公开(公告)号：ES2424642T3
公开(公告)日：2013-10-07
申请号：ES05713510
申请日：2005-02-14
申请人： IRM LLC
发明人： CHOI HA-SOON , WANG ZHICHENG , GRAY NATHANAEL SCHIANDER , GU XIANG-JU , HE XIAOHUI , HE YUN , JIANG TAO , LIU YI , RICHMOND WENDY , SIM TAEBO , YANG KUNYONG
IPC分类号： C07D471/04 , A61K31/519 , C07D487/04
摘要： Un compuesto de Fórmula Ia:**Fórmula** en la cual: n es 0 o 1; W se selecciona de -NR4- y -O-; en donde R4 se selecciona de hidrógeno y alquilo C1-6; R1 se selecciona de arilo C6-10-alquilo C0-4, heteroarilo C5-10-alquilo C0-4, cicloalquilo C3-12-alquilo C0-4 yheterocicloalquilo C3-8-alquilo C0-4; en donde cualquiera de arilalquilo, heteroarilalquilo, cicloalquilalquilo oheterocicloalquilalquilo de R1 opcionalmente se sustituye por 1 a 3 radicales independientemente seleccionados dehalo, nitro, ciano, arilo C6-10, heteroarilo C5-10, cicloalquilo C3-12, heterocicloalquilo C3-8, alquilo C1-6, alcoxi C1-6, alquiloC1-6- halo sustituido, alcoxi C1-6 - halo sustituido, - XNR5R5, -XNR5XNR5R5, -XNR5XOR5, -XOR5, -XSR5, -XS(O)R5, -XS(O)2R5, -XC(O) NR5R5, -XOXR6 y -XC(O)R6; en donde X es un enlace o alquileno C1-6; R5 se selecciona dehidrógeno, alquilo C1-6 y cicloalquilo C3-12-alquilo C0-4; y R6 se selecciona de heterocicloalquilo C3-8-alquilo C0-4 yheteroarilo C5-10- alquilo C0-4 opcionalmente sustituido por 1 a 3 radicales seleccionados de alquilo C1-6 y - C(O)OH;en donde cualquier sustituyente arilo, heteroarilo, cicloalquilo o heterocicloalquilo de R1 además es opcionalmentesustituido por 1 a 5 radicales independientemente seleccionados de alquilo C1-6 y alcoxi C1-6; R2 se selecciona de arilo C6-10-alquilo C0-4 y heteroarilo C5-10-alquilo C0-4; en donde cualquier arilalquilo oheteroarilalquilo de R2 opcionalmente se sustituye por 1 a 3 radicales independientemente seleccionados de halo,nitro, ciano, alquilo C1-6, alquenilo C1-6, alcoxi C1-6, alquilo C1-6- halo sustituido, heteroarilo C3-8-alquilo C0-4, -XNR5R5,-XOR5, -XSR5, -XS(O)2NR5R5, -XC (O)OR5, -XOC(O)R5, - XC(O)NR5XNR5R5, -XC(O)NR5XC(O)OR5, -XC(O)NR5XNR5C(O)R5, - XC(O) NR5XNR5C(O)OR5, -XC(O)NR5XOR5, -XC(O)N(XOR5)2, -XNR5C(O)R5, -XC(O)NR5R6, -XC(O)R6, -XR7, -XR6 y -XC(O)NR5XR7; en donde X es un enlace o alquileno C1-6; y R5 se seleccionade hidrógeno, alquilo C1-6 y cicloalquilo C3-12-alquilo C0-4; R6 se selecciona de heterocicloalquilo C3-8-alquilo C0-4 yheteroarilo C5-10-alquilo C0-4 opcionalmente sustituido por 1 a 3 radicales seleccionados de alquilo C1-6 y -C(O)OH; yR7 es ciano; R3 se selecciona de halo, hidroxi, -C(O)OH y -C(O)OCH3; y las sales de estos farmacéuticamente aceptables

8. 发明专利

CA2553785C COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 未知
公开(公告)号：CA2553785C
公开(公告)日：2011-02-08
申请号：CA2553785
申请日：2005-02-14
申请人： IRM LLC
发明人： CHOI HA-SOON , WANG ZHICHENG , GRAY NATHANAEL SCHIANDER , GU XIANG-JU , HE XIAOHUI , HE YUN , JIANG TAO , LIU YI , RICHMOND WENDY , SIM TAEBO , YANG KUNYONG
IPC分类号： C07D471/04 , A61K31/519 , C07D487/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the FAK, Abl, BCR-Abl, PDGF-R, c-Kit, NPM-ALK, Flt-3, JAK2 and c-Met kinases. The novel class of compounds is a compound of Formula Ia: (see formula Ia) in which: n is selected from 0, 1 and 2; W is selected from -NR4-, -S-, -O-, -S(O)- and -S(O)2-; wherein R4 is selected from hydrogen and C1-6alkyl; R1 is selected from C6-10aryl-C0-4alkyl, C5-10heteroaryl-C0-4alkyl, C3-12cycloalkyl-C0-4alkyl and C3-8heterocycloalkyl-C0-4alkyl; wherein any arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl of R1 is optionally substituted by 1 to 3 radicals independently selected from halo, nitro, cyano, C6-10aryl, C5-10heteroaryl, C3-12cycloalkyl, C3-8heterocycloalkyl, C1-6alkyl, C1-6alkoxy, halo-substituted-C1-6alkyl, halo-substituted-C1-6alkoxy, -XNR5R5, -XNR5XNR5R5, -XNR5XOR5, -XOR5, -XSR5, -XS(O)R5, -XS(O)2R5, -XC(O)NR5R5, -XOXR6 and -XC(O)R6; wherein X is a bond or C1-6alkylene; R5 is selected from hydrogen, C1-6alkyl and C3-12cycloalkyl-C0-4alkyl; and R6 is selected from C3-8heterocycloalkyl-C0-4alkyl and C5-10heteroaryl-C0-4alkyl optionally substituted by 1 to 3 radicals selected from C1-6alkyl and -C(O)OH; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl substituent of R1 is further optionally substituted by 1 to 5 radicals independently selected from C1-6alkyl and C1-6alkoxy; R2 is selected from C6-10aryl-C0-4alkyl, C5-10heteroaryl-C0-4alkyl, C3-12cycloalkyl-C0-4alkyl and C3-8heterocycloalkyl-C0-4alkyl; wherein any arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl of R2 is optionally substituted by 1 to 3 radicals independently selected from halo, nitro, cyano, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6alkoxy, halo-substituted-C1-6alkyl, halo-substituted-C1-6alkoxy, C3-8heteroarylC0-4alkyl, -XNR5R5, -XOR5, -XSR5, -XS(O)R5, -XS(O)2R5, -XSNR5R5, -XS(O)NR5R5, -XS(O)2NR5R5, -XC(O)OR5, -XOC(O)R5, -XC(O)R5, -XC(O)NR5XNR5R5, -XC(O)NR5R5, -XC(O)NR5XC(O)OR5, -XC(O)NR5XNR5C(O)R5, -XC(O)NR5XNR5C(O)OR5, -XC(O)NR5XOR5, -XC(O)N(XOR5)2, -XNR5C(O)R5, -XC(O)NR5R6, -XC(O)R6, -XR7, -XC(O)R7, -XR6 and -XC(O)NR5XR7; wherein X is a bond or C1-6alkylene; and R5 is selected from hydrogen, C1-6alkyl and C3-12cycloalkyl-C0-4alkyl; R6 is selected from C3-8heterocycloalkyl-C0-4alkyl and C5-10heteroaryl-C0-4alkyl optionally substituted by 1 to 3 radicals selected from C1-6alkyl and -C(O)OH; and R7 is selected from halo and cyano; R3 is selected from halo, hydroxy, -XSR5, -XS(O)R5, -XS(O)2R5, -XC(O)R5 and -XC(O)OR5; wherein X is a bond or C1-6alkylene; and R5 is selected from hydrogen, C1-6alkyl and C3-12cycloalkyl-C0-4alkyl; or a pharmaceutically acceptable salt, hydrate, solvate, isomer or prodrug thereof.

9. 发明专利

BRPI0507668A 未知
公开(公告)号：BRPI0507668A
公开(公告)日：2007-07-17
申请号：BRPI0507668
申请日：2005-02-14
申请人： IRM LLC
发明人： CHOI HA-SOON , WANG ZHICHENG , GRAY NATHANAEL SCHIANDER , GU XIANG-JU , HE XIAOHUI , HE YUN , JIANG TAO , LIU YI , RICHMOND WENDY , SIM TAEBO , YANG KUNYONG
IPC分类号： C07D471/04 , A61K31/519 , C07D487/04

10. 发明专利

CA2553785A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 未知
公开(公告)号：CA2553785A1
公开(公告)日：2005-09-01
申请号：CA2553785
申请日：2005-02-14
申请人： IRM LLC
发明人： JIANG TAO , HE YUN , LIU YI , RICHMOND WENDY , HE XIAOHUI , GRAY NATHANAEL SCHIANDER , YANG KUNYONG , GU XIANG-JU , CHOI HA-SOON , WANG ZHICHENG , SIM TAEBO
IPC分类号： C07D471/04 , A61K31/519 , C07D487/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositio ns comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activatio n of the FAK, Abl, BCR-Abl, PDGF-R, c-Kit, NPM-ALK, Flt-3, JAK2 and c-Met kinases.

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