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1. 发明专利

AU2017257377B2 Novel substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase 未知
公开(公告)号：AU2017257377B2
公开(公告)日：2022-06-23
申请号：AU2017257377
申请日：2017-04-24
申请人： IOMET PHARMA LTD , MERCK SHARP & DOHME LLC
发明人： COWLEY PHILLIP , MCGOWAN MEREDETH ANN , BROWN THOMAS J , HAN YONGXIN , LIU KUN , PU QINGLIN , WISE ALAN , ZHANG HONGJUN , ZHOU HUA
IPC分类号： A61P35/00 , C07D401/10
摘要： Disclosed herein are substituted imidazopyridine compounds of formula (I) which are inhibitors of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) enzymes: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder.

2. 发明公开

KR20180053337A 제약 화합물 审中-公开
公开(公告)号：KR20180053337A
公开(公告)日：2018-05-21
申请号：KR20187010068
申请日：2016-09-12
申请人： IOMET PHARMA LTD , MERCK SHARP & DOHME
发明人： COWLEY PHILLIP M , HAN YONGXIN
IPC分类号： C07D403/12 , A61K31/404 , A61K31/4155 , A61P29/00 , A61P35/00 , C07D209/30
CPC分类号： A61K31/404 , C07D209/30 , C07D403/12 , A61K2300/00
摘要： 화학식 (I)을갖는화합물이제공되며:여기서 R는 -Cl, -Br 및 -CN으로부터선택되고; R및 R는 -H 및 -F로부터독립적으로선택되고; R, R, R및 R는 -H, -F 및치환또는비치환된 C-C알킬기로부터독립적으로선택되고; R및 R는 -H 및치환또는비치환된 C-C알킬기 및치환또는비치환된페닐기로부터독립적으로선택되고; 여기서 R, R, R, R및 R중적어도하나는 -H가아니거나, 또는여기서 R, R, R, R및 R모두가 -H인경우에, R은 Me 또는 Et가아니다.

4. 发明专利

AU2016324013B2 Substituted 1H-indole-2-carboxamide compounds as indoleamine-2,3-dioxygenase inhibitors 未知
公开(公告)号：AU2016324013B2
公开(公告)日：2020-07-23
申请号：AU2016324013
申请日：2016-09-12
申请人： IOMET PHARMA LTD , MERCK SHARP & DOHME
发明人： COWLEY PHILLIP M , HAN YONGXIN
IPC分类号： C07D209/30 , A61K31/404
摘要： Provided is a compound having formula (I): wherein R

5. 发明专利

CA3021589A1 NOVEL SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS AS INHIBITORS OF INDOLEAMINE2,3-DIOXYGENASE AND/OR TRYPTOPHAN-2,3-DIOXYGENASE 未知
公开(公告)号：CA3021589A1
公开(公告)日：2017-11-02
申请号：CA3021589
申请日：2017-04-24
申请人： MERCK SHARP & DOHME , IOMET PHARMA LTD
发明人： COWLEY PHILLIP M , MCGOWAN MEREDETH ANN , BROWN THOMAS J , HAN YONGXIN , LIU KUN , PU QINGLIN , WISE ALAN , ZHANG HONGJUN , ZHOU HUA
IPC分类号： C07D519/00 , A61K31/438
摘要： Disclosed herein are substituted imidazopyridine compounds of formula (I) which are inhibitors of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) enzymes: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder.

6. 发明专利

AU2017257377A1 Novel substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase 未知
公开(公告)号：AU2017257377A1
公开(公告)日：2018-10-11
申请号：AU2017257377
申请日：2017-04-24
申请人： IOMET PHARMA LTD , MERCK SHARP & DOHME
发明人： COWLEY PHILLIP , MCGOWAN MEREDETH ANN , BROWN THOMAS J , HAN YONGXIN , LIU KUN , PU QINGLIN , WISE ALAN , ZHANG HONGJUN , ZHOU HUA
IPC分类号： A61P35/00 , C07D401/10
摘要： Disclosed herein are substituted imidazopyridine compounds of formula (I) which are inhibitors of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) enzymes: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder.

7. 发明专利

MA42840A COMPOSÉ PHARMACEUTIQUE 未知
公开(公告)号：MA42840A
公开(公告)日：2018-07-25
申请号：MA42840
申请日：2016-09-12
申请人： IOMET PHARMA LTD , MERCK SHARP & DOHME
发明人： COWLEY PHILLIP M , HAN YONGXIN
IPC分类号： A61K31/404 , C07D209/30

8. 发明专利

CA2998186A1 PHARMACEUTICAL COMPOUND 未知
公开(公告)号：CA2998186A1
公开(公告)日：2017-03-23
申请号：CA2998186
申请日：2016-09-12
申请人： IOMET PHARMA LTD , MERCK SHARP & DOHME
发明人： COWLEY PHILLIP M , HAN YONGXIN
IPC分类号： A61K31/404 , C07D209/30
摘要： Provided is a compound having formula (I): wherein R2 is selected from -C1, -Br and -CN; R1 and R4 are independently selected from H and -F; R631, R632, R641 and R642 are independently selected from -H, -F and substituted or unsubstituted C1-C3 alkyl groups; and R651 and R652 are independently selected from H and substituted or unsubstituted C1-C3 alkyl groups and substituted or unsubstituted phenyl groups; and wherein at least one of R631, R632, R641, R642 and R652 is not -H, or wherein when all of R631, R632, R641, R642 and R652 are -H, R651 is not Me or Et.

9. 发明专利

RU2730842C2 ФАРМАЦЕВТИЧЕСКОЕ СОЕДИНЕНИЕ 未知
公开(公告)号：RU2730842C2
公开(公告)日：2020-08-26
申请号：RU2018113339
申请日：2016-09-12
申请人： IOMET PHARMA LTD
发明人： COWLEY PHILLIP M , HAN YONGXIN
IPC分类号： C07D403/12 , A61K31/4155 , A61P35/00 , A61P35/02
摘要： Настоящееизобретениеотноситсяк областиорганическойхимии, аименнок соединениюформулы (I)илиегофармацевтическиприемлемойсоли. Вформуле (I) Rвыбраниз -Cl, Br и–CN, Rи Rнезависимовыбраныиз -Ни –F, R, R, Rи Rнезависимовыбраныиз -Н, -F и C-Салкила, Rи RнезависимовыбраныизН и C-Салкила, ипоменьшеймереодиниз R, R, R, Rи Rнепредставляетсобой -Нилиесливсеиз R, R, R, Rи Rпредставляютсобой -Н, Rнепредставляетсобой Me или Et. Такжепредложенвариантсоединения, фармацевтическаякомпозицияи применениеуказанныхсоединений. Техническийрезультат: предложеныновыеорганическиесоединения, которыеотносятсяк ингибитораминдоламин-2,3-Диоксигеназы (IDO) имогутбытьиспользованыдляизготовлениялекарственныхсредствдлялеченияяичникапутемингибирования IDO. 4 н. и 8 з.п. ф-лы, 2 ил., 2 табл., 10 пр.

10. 发明专利

AU2016324013A1 Pharmaceutical compound 未知
公开(公告)号：AU2016324013A1
公开(公告)日：2018-03-29
申请号：AU2016324013
申请日：2016-09-12
申请人： IOMET PHARMA LTD , MERCK SHARP & DOHME
发明人： COWLEY PHILLIP M , HAN YONGXIN
IPC分类号： C07D209/30 , A61K31/404
摘要： Provided is a compound having formula (I): wherein R

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