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1. 发明申请

WO2008112008A3 SENSOR PROTEINS AND ASSAY METHODS 审中-公开
标题翻译：传感器蛋白质和测定方法
公开(公告)号：WO2008112008A3
公开(公告)日：2009-03-26
申请号：PCT/US2007075705
申请日：2007-08-10
申请人： INVITROGEN CORP , RIDDLE STEVEN , NEWMAN RHONDA , VOGEL KURT
发明人： RIDDLE STEVEN , NEWMAN RHONDA , VOGEL KURT
IPC分类号： C12N15/09 , C07H21/04 , C07K14/00 , G01N33/53
CPC分类号： G01N33/542 , G01N33/84 , Y10T436/16
摘要： The present invention relates to biosensors. In some embodiments, the biosensors are modified ligand binding molecules. In some embodiments, the modified ligand binding molecule is a phosphate binding protein (PBP). In some embodiments, the modified ligand binding molecules are labeled to be capable of RET, e.g., comprising a donor and acceptor moiety. In some embodiments of the invention, there is a detectable change in RET (e.g., FRET) when the modified ligand binding molecule binds and/or releases the ligand (e.g., phosphate). The invention also provides related methods, reactions and assays.
摘要翻译：本发明涉及生物传感器。在一些实施方案中，生物传感器是修饰的配体结合分子。在一些实施方案中，修饰的配体结合分子是磷酸结合蛋白（PBP）。在一些实施方案中，修饰的配体结合分子被标记为能够RET，例如包含供体和受体部分。在本发明的一些实施方案中，当修饰的配体结合分子结合和/或释放配体（例如磷酸盐）时，在RET（例如，FRET）中存在可检测的变化。本发明还提供相关方法，反应和测定。

2. 发明申请

WO2008112008A9 SENSOR PROTEINS AND ASSAY METHODS 审中-公开
标题翻译：传感器蛋白质和测定方法
公开(公告)号：WO2008112008A9
公开(公告)日：2008-11-20
申请号：PCT/US2007075705
申请日：2007-08-10
申请人： INVITROGEN CORP , RIDDLE STEVEN , NEWMAN RHONDA , VOGEL KURT
发明人： RIDDLE STEVEN , NEWMAN RHONDA , VOGEL KURT
IPC分类号： C12N15/09 , C07H21/04 , C07K14/00 , G01N33/53
CPC分类号： G01N33/542 , G01N33/84 , Y10T436/16
摘要： The present invention relates to biosensors. In some embodiments, the biosensors are modified ligand binding molecules. In some embodiments, the modified ligand binding molecule is a phosphate binding protein (PBP). In some embodiments, the modified ligand binding molecules are labeled to be capable of RET, e.g., comprising a donor and acceptor moiety. In some embodiments of the invention, there is a detectable change in RET (e.g., FRET) when the modified ligand binding molecule binds and/or releases the ligand (e.g., phosphate). The invention also provides related methods, reactions and assays.
摘要翻译：本发明涉及生物传感器。在一些实施方案中，生物传感器是修饰的配体结合分子。在一些实施方案中，修饰的配体结合分子是磷酸结合蛋白（PBP）。在一些实施方案中，修饰的配体结合分子被标记为能够RET，例如包含供体和受体部分。在本发明的一些实施方案中，当修饰的配体结合分子结合和/或释放配体（例如磷酸盐）时，在RET（例如，FRET）中存在可检测的变化。本发明还提供相关方法，反应和测定。

3. 发明申请

WO2005026730A2 MULTIPLEX BINDING AND ACTIVITY ASSAYS 审中-公开
标题翻译：多重绑定和活动测试
公开(公告)号：WO2005026730A2
公开(公告)日：2005-03-24
申请号：PCT/US2004029099
申请日：2004-09-08
申请人： INVITROGEN CORP , VOGEL KURT
发明人： VOGEL KURT
IPC分类号： C12Q1/00 , C12Q1/68 , G01N21/64 , G01N33/53 , G01N33/537 , G01N33/542 , G01N33/543 , G01N33/58
CPC分类号： G01N33/573 , G01N21/6428 , G01N21/6445 , G01N33/542 , G01N33/582 , G01N2500/02
摘要： Compositions, including antibodies, polypeptides, and organic molecules, kits, apparatuses, and methods for probing molecular interactions using fluorescence polarization (FP) and/or time-resolved resonance energy transfer (TR-RET) are provided.
摘要翻译：提供了包括用于使用荧光偏振（FP）和/或时间分辨的共振能量转移（TR-RET）探测分子相互作用的组合物，包括抗体，多肽和有机分子，试剂盒，装置和方法。

4. 发明申请

WO02068931A3 SCREENING FOR ENZYME STEREOSELECTIVITY UTILIZING MASS SPECTROMETRY 审中-公开
标题翻译：筛选使用质谱的酶选择性
公开(公告)号：WO02068931A3
公开(公告)日：2003-02-27
申请号：PCT/US0205646
申请日：2002-02-22
申请人： MAXYGEN INC , DAVIS S CHRISTOPHER , CHEN YONG HONG , GIVER LORRAINE J , VOGEL KURT
发明人： DAVIS S CHRISTOPHER , CHEN YONG HONG , GIVER LORRAINE J , VOGEL KURT
IPC分类号： C12Q1/34 , C12Q1/44
CPC分类号： C12Q1/34 , H01J49/00
摘要： Methods of screening for enzyme stereoselectivity that include detecting isotopically labeled products by mass spectrometry are provided. The methods are particularly suitable for screening enzyme libraries for stereoselectivity.
摘要翻译：提供了通过质谱法检测同位素标记产物的酶立体选择性筛选方法。该方法特别适用于筛选立体选择性酶库。

5. 发明申请

WO0210750A2 BIOSENSORS, REAGENTS AND DIAGNOSTIC APPLICATIONS OF DIRECTED EVOLUTION 审中-公开
标题翻译：生物传感器，试剂和指导性进化的诊断应用
公开(公告)号：WO0210750A2
公开(公告)日：2002-02-07
申请号：PCT/US0124182
申请日：2001-07-31
申请人： MAXYGEN INC , MINSHULL JEREMY , DAVIS S CHRISTOPHER , WELCH MARK , RAILLARD SUN AI , VOGEL KURT , KREBBER CLAUS
发明人： MINSHULL JEREMY , DAVIS S CHRISTOPHER , WELCH MARK , RAILLARD SUN AI , VOGEL KURT , KREBBER CLAUS
IPC分类号： C12N9/12 , C12N15/10 , C12P19/34 , C12Q1/68 , G01N33/50
CPC分类号： C12N9/1252 , C12N15/1055 , C12P19/34 , C12Q1/6888
摘要： Methods for sensing test stimuli using arrays of biopolymers are provided. Libraries of biopolymers, such nucleic acid variants, and expression products encoded by nucleic acid variants are provided. Reusable library arrays, and methods for their use are provided.
摘要翻译：提供使用生物聚合物阵列感测测试刺激的方法。提供了生物聚合物，核酸变体和由核酸变体编码的表达产物的文库。提供了可重用库数组及其使用方法。

6. 发明申请

WO0109352A3 USE OF ASPERGILLUS SOJAE AS HOST FOR RECOMBINANT PROTEIN PRODUCTION 审中-公开
标题翻译：用作重组蛋白生产的“ASPERGILLUS”SOJAE作为主机的使用
公开(公告)号：WO0109352A3
公开(公告)日：2001-11-08
申请号：PCT/NL0000544
申请日：2000-07-28
申请人： TNO , HOFFMANN LA ROCHE , HEERIKHUISEN MARGREET , DEN HONDEL CORNELIS VAN , PUNT PETER , BIEZEN NICK VAN , ALBERS ALWIN , VOGEL KURT
发明人： HEERIKHUISEN MARGREET , VAN DEN HONDEL CORNELIS , PUNT PETER , VAN BIEZEN NICK , ALBERS ALWIN , VOGEL KURT
IPC分类号： C12N15/09 , C12N1/14 , C12N1/15 , C12N9/16 , C12N9/58 , C12N15/10 , C12N15/67 , C12N15/80 , C12R1/66
CPC分类号： C12N15/80 , C12N9/58
摘要： A recombinant Aspergillus sojae comprising an introduced acetamidase S ( amdS ) gene as selectable marker is disclosed. An Aspergillus sojae exhibiting growth with medium comprising uracil and fluoro-orotic acid, said Aspergillus sojae further not exhibiting growth on medium comprising uridine and fluoro-orotic acid i.e. said Aspergillus sojae exhibiting uracil auxotrophy, said Aspergillus sojae being unable to utilize uridine, said Aspergillus sojae being pyrG negative, said Aspergillus sojae exhibiting resistance to fluoro-orotic acid, said uracil auxotrophy and said fluoro-orotic acid resistance being relievable upon complementation with an active introduced pyrG gene, is described. The Aspergillus sojae further comprises a nucleic acid sequence encoding a phytase or a protein having phytase activity or any other heterologous protein or polypeptide and can be used for the biotechnological production of said phytase or said other heterologous proteins or polypeptides. Additional mutants exhibiting amended morphology are also disclosed. Methods of producing such expression hosts are described.
摘要翻译：公开了包含引入的乙酰胺酶S（amdS）基因作为选择标记的重组曲霉大肠杆菌。表达与包含尿嘧啶和氟代乳清酸的培养基一起生长的曲霉菌，所述的曲霉大肠杆菌在包含尿苷和氟 - 乳清酸的培养基上进一步不显示生长，即所述的< 表现出尿嘧啶营养缺陷型的曲霉大肠杆菌（Aspergillus sojae），所说的曲霉菌（Aspergillus sojae）不能利用尿苷，所说的曲霉菌（Aspergillus sojae）是pyrG阴性的，所说的Aspergillus sojae 表现出对氟乳清酸的抗性，所述尿嘧啶营养缺陷型和所述氟 - 乳清酸抗性在与活性引入的pyrG基因互补时可缓解。曲霉菌还包含编码植酸酶或具有植酸酶活性的蛋白质或任何其它异源蛋白质或多肽的核酸序列，并可用于生物技术生产所述植酸酶或所述其它异源蛋白质或多肽。还公开了表现出修饰形态的另外的突变体。描述了产生这种表达宿主的方法。

7. 发明申请

WO0206457A3 NOVEL LIPASE GENES 审中-公开
标题翻译：新的脂肪酶基因
公开(公告)号：WO0206457A3
公开(公告)日：2002-10-17
申请号：PCT/US0122160
申请日：2001-07-13
申请人： MAXYGEN INC , GIVER LORRAINE J , MINSHULL JEREMY , VOGEL KURT
发明人： GIVER LORRAINE J , MINSHULL JEREMY , VOGEL KURT
IPC分类号： A61K38/00 , C12N9/20 , C12N15/10 , C12N15/00 , A61K38/46 , C07K14/32 , C11D3/386 , C12N15/75 , C12P41/00
CPC分类号： C12N15/1089 , A61K38/00 , C12N9/20
摘要： New lipase enzymes (both nucleic acids and polypeptides) are provided. Compositions which include these polypeptides, proteins, nucleic acids, recombinant cells, as well as methods involving the enzymes, antibodies to the enzymes, and methods of using the enzymes are also provided.
摘要翻译：提供了新的脂肪酶（核酸和多肽）。还提供了包含这些多肽，蛋白质，核酸，重组细胞的组合物，以及涉及酶的方法，酶的抗体以及使用该酶的方法。

8. 发明申请

WO2009108905A3 FLUORESCENCE POLARIZATION HERG ASSAY 审中-公开
标题翻译：荧光极化法测定
公开(公告)号：WO2009108905A3
公开(公告)日：2009-10-29
申请号：PCT/US2009035591
申请日：2009-02-27
申请人： LIFE TECHNOLOGIES CORP , PIPER DAVID , VOGEL KURT , SHEKHANI MOHAMMED SALEH , HESS STEPHEN , DUFF STEVE , LIVELLI THOMAS , ZHONG ZHONG
发明人： PIPER DAVID , VOGEL KURT , SHEKHANI MOHAMMED SALEH , HESS STEPHEN , DUFF STEVE , LIVELLI THOMAS , ZHONG ZHONG
IPC分类号： G01N33/58
CPC分类号： G01N33/582 , C07D491/107 , G01N33/6872 , Y10T436/13
摘要： Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein make use of the binding interaction between novel fluorescent tracers and the hERG K+ channel, and the propensity of a test compound to influence that binding interaction.
摘要翻译：公开了用于筛选测试化合物在受试者中诱导心脏毒性的能力的测定，方法和试剂盒。特别地，测试化合物是否具有延长通过人心电图测量的Q-T间期的作用。本文公开的测定法，方法和试剂盒利用新型荧光示踪剂和hERG K +通道之间的结合相互作用以及测试化合物影响该结合相互作用的倾向。

9. 发明专利

DE102006048544A1 Method for evaporation of sols or sol containing fluids, particularly for bedrooms or living rooms, involves accumulating ambient air in fluid container with sol containing particles by air sucking blower and again flows back 未知
公开(公告)号：DE102006048544A1
公开(公告)日：2008-06-05
申请号：DE102006048544
申请日：2006-10-13
申请人： VOGEL KURT
发明人： VOGEL KURT
IPC分类号： F24F3/14 , F24F6/00
摘要： The method involves accumulating the ambient air in a fluid container with sol containing particles by an air sucking blower and again flows back. The ambient air (8.1) is guided inwards to the sol containing fluid area perpendicularly above in jet form and released radial all sides onto the sols after the leakage and thrown out over the fluid areas in expanding manner with decelerated flowing speed. The ambient air implements an accumulation with sol containing particles in the fluid container and eventually reaches above the fluid container with decelerated flowing speed. An independent claim is also included for an evaporation unit for the implementation of a method.

10. 发明专利

DD161139A1 未知
公开(公告)号：DD161139A1
公开(公告)日：1985-02-20
申请号：DD23118781
申请日：1981-06-26
申请人： SCHNEIDER NORBERT , HABEL HEINZ , LUX GUENTER , VOGEL KURT
发明人： SCHNEIDER NORBERT , HABEL HEINZ , LUX GUENTER , VOGEL KURT
IPC分类号： F23B7/00

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