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1. 发明公开

EP3052100A2 SMALL MOLECULE SECURININE AND NORSECURININE ANALOGS AND THEIR USE IN CANCERS INFLAMMATORY DISEASES AND INFECTIONS 审中-公开
标题翻译：小分子SECURININ-和NORSECURININ类似物和它们在肿瘤，炎症性疾病和感染
公开(公告)号：EP3052100A2
公开(公告)日：2016-08-10
申请号：EP14851213.0
申请日：2014-10-03
申请人： Invenio Therapeutics Inc. , Gundluru, Mahesh, K. , Agarwal, Mukesh , Xia, Zhiqing , Karan, Goutam , Wald, David
发明人： GUNDLURU, Mahesh, K. , AGARWAL, Mukesh , XIA, Zhiqing , KARAN, Goutam , WALD, David
IPC分类号： A61K31/439 , C07D491/18
CPC分类号： A61K31/437 , A61K31/407 , A61K31/439 , A61K31/4439 , A61K31/496 , A61K31/5365 , A61K31/537 , A61K31/55 , A61K31/695 , A61K45/06 , C07D491/18 , C07D498/18 , C07D519/00 , C07F7/1856 , C12N9/99
摘要： The present invention relates to novel securinine and norsecurine analogs and their applicapility in treating cellular proliferative disorders.

2. 发明申请

WO2015051284A2 SMALL MOLECULE SECURININE AND NORSECURININE ANALOGS AND THEIR USE IN CANCERS INFLAMMATORY DISEASES AND INFECTIONS 审中-公开
标题翻译：小分子杀虫蛋白和Norsicurinine类似物及其在癌症中的应用炎症性疾病和感染
公开(公告)号：WO2015051284A2
公开(公告)日：2015-04-09
申请号：PCT/US2014/059112
申请日：2014-10-03
申请人： INVENIO THERAPEUTICS INC. , GUNDLURU, Mahesh, K. , AGARWAL, Mukesh , XIA, Zhiqing , KARAN, Goutam , WALD, David
发明人： GUNDLURU, Mahesh, K. , AGARWAL, Mukesh , XIA, Zhiqing , KARAN, Goutam , WALD, David
IPC分类号： A61K31/4741 , C07D491/18
CPC分类号： A61K31/437 , A61K31/407 , A61K31/439 , A61K31/4439 , A61K31/496 , A61K31/5365 , A61K31/537 , A61K31/55 , A61K31/695 , A61K45/06 , C07D491/18 , C07D498/18 , C07D519/00 , C07F7/1856 , C12N9/99
摘要： The present invention relates to novel securinine and norsecurine analogs and their applicapility in treating cellular proliferative disorders.
摘要翻译：本发明涉及新型叶酸和诺昔地宁类似物及其在治疗细胞增殖性疾病中的适用性。

3. 发明申请

WO2015051276A1 SMALL MOLECULE SECURININE AND NORSECURININE ANALOGS AND THEIR USE IN INHIBITING MYELOPEROXIDASE 审中-公开
标题翻译：小分子SECURININE和诺司康宁类似物及其在抑制MYELOPEROXIDASE中的应用
公开(公告)号：WO2015051276A1
公开(公告)日：2015-04-09
申请号：PCT/US2014/059104
申请日：2014-10-03
申请人： MiRx Pharmaceuticals, LLC , GUNDLURU, Mahesh, K. , AGARWAL, Mukesh , XIA, Zhiqing , KARAN, Goutam , WALD, David
发明人： GUNDLURU, Mahesh, K. , AGARWAL, Mukesh , XIA, Zhiqing , KARAN, Goutam , WALD, David
IPC分类号： C07D491/18 , A61K45/06 , A61K31/439
CPC分类号： A61K31/437 , A61K31/407 , A61K31/439 , A61K31/4439 , A61K31/496 , A61K31/5365 , A61K31/537 , A61K31/55 , A61K31/695 , A61K45/06 , C07D491/18 , C07D498/18 , C07D519/00 , C07F7/1856 , C12N9/99
摘要： The present invention relates to novel securinine and norsecurine analogs that have reduced or non-reduced gamma-delta bond. The present invention also provides for methods of using securinine analogs, comprising administering one or more of the analogs to a myeloperoxidase enzyme, such as an enzyme with or proximal to a cell. As set out herein, the securinine analogs directly bind to and inhibit myeloperoxidase (MPO) activity. Accordingly, contacting or administering the analogs to an MPO enzyme allows for inhibition of MPO activity.
摘要翻译：本发明涉及具有还原型或非还原型γ-δ键的新型硫嘌呤类和新西兰嘌呤类似物。本发明还提供了使用证明嘌呤类似物的方法，其包括将一种或多种类似物施用于髓过氧化物酶，例如与细胞或细胞附近的酶。如本文所述，证实类似物直接结合并抑制髓过氧化物酶（MPO）活性。因此，将类似物与MPO酶的接触或给药允许抑制MPO活性。

4. 发明申请

WO2016061344A1 GSK3 INHIBITORS AND THEIR USES 审中-公开
标题翻译： GSK3抑制剂及其用途
公开(公告)号：WO2016061344A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/055727
申请日：2015-10-15
申请人： MIRX PHARMACEUTICALS LLC , WALD, David , KARAN, Goutam , AGARWAL, Mukesh , XIA, Zhiqiang
发明人： WALD, David , KARAN, Goutam , AGARWAL, Mukesh , XIA, Zhiqiang
IPC分类号： A61K31/4245 , C07D271/10
CPC分类号： A61K31/4245 , A61K31/4439 , A61K31/497 , C07D271/113 , C07D413/04
摘要： The present invention identifies a novel class of compounds that have demonstrated activity as inhibitors of GSK3 activity. The ability to inhibit GSK3 applies to administering the compounds to subjects with identified aberrant GSK3 activity, such as acute myeloid leukemia. The present invention also relates to the use of GSK3 inhibitors in combination with all trans retinoic acid (ATRA).
摘要翻译：本发明鉴定出已经证明作为GSK3活性抑制剂的活性的新一类化合物。抑制GSK3的能力适用于将化合物施用于具有鉴定的异常GSK3活性的受试者，例如急性骨髓性白血病。本发明还涉及GSK3抑制剂与全反式视黄酸（ATRA）的组合的用途。

5. 发明申请

WO2022106908A1 WATER SOLUBLE ANTIVIRAL AND ANTIMICROBIAL COMPOUND AND PROCESS FOR PREPARATION THEREOF 审中-公开
公开(公告)号：WO2022106908A1
公开(公告)日：2022-05-27
申请号：PCT/IB2021/053948
申请日：2021-05-10
申请人： DEB, Nilanjan , AGARWAL, Mukesh
发明人： DEB, Nilanjan , AGARWAL, Mukesh
IPC分类号： A61K31/00
摘要： The present invention discloses compound of Formula A represented by the structure Formula A

6. 发明申请

WO2017077554A2 AUTOMATED PREPARATION OF BREADS 审中-公开
标题翻译：自动制备面包
公开(公告)号：WO2017077554A2
公开(公告)日：2017-05-11
申请号：PCT/IN2016/050383
申请日：2016-11-04
申请人： AGARWAL, Mukesh
发明人： AGARWAL, Mukesh , SHARMA, Arvind Kumar
CPC分类号： A21B7/005 , A21C11/00
摘要： Apparatuses and methods for preparation of breads are described. The apparatuses include a press unit that can receive a dough ball and flatten the dough ball. The press unit includes a top plate and a bottom plate, each of which is in an inclined arrangement. The top plate swivels towards and away from the bottom plate. A dough ball is flattened between the top plate and the bottom plate. The bottom plate is heated, thereby heating a first face of the flattened dough in contact with the bottom plate. A flipper connected to at least one of the top plate and the bottom plate guides the flattened dough to a heated cooking surface. The guiding enables a second face of the flattened dough to come in contact with the cooking surface, thereby heating the flattened dough and forming the bread.
摘要翻译：描述了用于制备面包的设备和方法。该装置包括一个可以接收面团球并压扁面团球的压力单元。压机单元包括顶板和底板，每个顶板和底板呈倾斜布置。顶板朝向和远离底板旋转。面团球在顶板和底板之间变平。底板被加热，从而加热扁平面团的第一面与底板接触。连接到顶板和底板中的至少一个的鳍状物将扁平的面团引导到加热的烹饪表面。该引导使扁平面团的第二面与烹饪表面接触，由此加热扁平面团并形成面包。

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