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1. 发明申请

WO2004091454A1 REED VALVE FOR IMPLANTATION INTO MAMMALIAN BLOOD VESSELS AND HEART WITH TEMPORARY OR PERMANENT SUPPORT BY TWO STENTS 审中-公开
标题翻译：用于植入MAMMALIAN血液血管和心脏的REED阀，具有两步的临时或永久支持
公开(公告)号：WO2004091454A1
公开(公告)日：2004-10-28
申请号：PCT/US2004/010678
申请日：2004-04-07
申请人： INTERNATIONAL HEART INSTITUTE OF MONTANA FOUNDATION
发明人： DURAN, Carlos, M., G.
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2427 , A61F2/243 , A61F2220/0075
摘要： A multi-leaflet valve (15) adapted to serve as a prosthesis for diseased native valve of a mammal is constructed of biologic membrane or of biocompatible synthetic membrane. The valve has the shape of a truncated cone that has an inflow and an outflow orifice with leaflets forming the outflow orifice and forming a plurality of commissures (20). A first flexible stent (17) is removably affixed in a substantially circular fashion around the truncated cone in proximity of the inflow orifice, and a second flexible stent (18) is removably affixed at the location of the commissures to form a circle around the truncated cone in proximity of the outflow orifice. The stents maintain the shape of the valve during the surgical implantation procedure. Each stent independently can be left in the valve or can be removed during the implantation procedure based upon the judgement of the cardiac surgeon performing the implantation procedure. A holder designed to maintain the geometry of the valve during implantation to a mammal is also disclosed.
摘要翻译：适于作为哺乳动物患病自然瓣膜的假体的多瓣瓣（15）由生物膜或生物相容性合成膜构成。该阀具有截头锥体的形状，其具有流入口和流出口，叶片形成流出孔并形成多个连合部（20）。第一柔性支架（17）以大致圆形的方式可移除地固定在靠近流入孔的截头圆锥体上，并且第二柔性支架（18）可移除地固定在连合处的位置，以形成围绕截断的圆锥体靠近流出口。在手术植入过程中，支架保持瓣膜的形状。基于执行植入程序的心脏外科医生的判断，每个支架可以独立地留在瓣膜中或者可以在植入过程期间被移除。还公开了一种设计用于在植入哺乳动物期间保持阀的几何形状的保持器。

2. 发明申请

WO2004091455A3 SIGMOID VALVE 审中-公开
公开(公告)号：WO2004091455A3
公开(公告)日：2004-10-28
申请号：PCT/US2004/010763
申请日：2004-04-07
申请人： INTERNATIONAL HEART INSTITUTE OF MONTANA FOUNDATION
发明人： DURAN, Carlos, M., G.
IPC分类号： A61F2/24
摘要： A multi-leaflet valve (15) adapted to serve as a prosthesis for diseased native valve of a mammal is incorporated in self-expandable or inflatable endovascular stents or stents (27,28) to form a combination which is introduced on a catheter with a guide wire into the circulatory system of the mammal to replace the diseased native valve. Once the combination is at the desired location the stent is caused to expand and affix itself to the patient's vessel wall. The prosthetic valve has the shape of a truncated cone that has an inflow and an outflow orifice with leaflets forming the outflow orifice and forming a plurality of commissures. A first flexible circular support (17) is affixed in a substantially circular fashion around the truncated cone in proximity of the inflow orifice, and a second flexible circular support (18) is affixed at the location of the commissures to form a circle around the truncated cone in proximity of the outflow orifice. The circular supports maintain the shape of the valve during the surgical implantation procedure and thereafter.

3. 发明公开

EP1089776A1 PROCESS FOR MAKING COMPLIANT DEHYDRATED TISSUE FOR IMPLANTATION 有权
标题翻译：用于生产弹性脱水体植入组织
公开(公告)号：EP1089776A1
公开(公告)日：2001-04-11
申请号：EP99931880.1
申请日：1999-06-23
申请人： International Heart Institute of Montana Foundation
发明人： DURAN, Carlos, M., G. , CHEUNG, David, T. , PANG, David, C.
IPC分类号： A61L27/00
CPC分类号： A61L27/3691 , A61L27/3604 , A61L27/3687 , Y10S623/915 , Y10S623/917
摘要： A process for preparing pliable soft tissue specimen which are resistant to cracking and devoid of viable cells includes the steps of treating native soft tissue obtained from a donor by a gradually increasing gradient of aliphatic alcohol or other suitable water miscible polar organic solvent until the last alcohol (or other solvent) solution has at least 25 % by volume of the organic liquid. Thereafter, the tissue specimen is treated with a solution containing glycerol or low molecular weight (

4. 发明公开

EP1622548A1 REED VALVE FOR IMPLANTATION INTO MAMMALIAN BLOOD VESSELS AND HEART WITH TEMPORARY OR PERMANENT SUPPORT BY TWO STENTS 有权
标题翻译：蝶阀种植体哺乳动物的血管和临时或永久支持两个支架上的心
公开(公告)号：EP1622548A1
公开(公告)日：2006-02-08
申请号：EP04759202.7
申请日：2004-04-07
申请人： International Heart Institute of Montana Foundation
发明人： DURAN, Carlos, M., G.
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2427 , A61F2/243 , A61F2220/0075
摘要： A multi-leaflet valve (15) adapted to serve as a prosthesis for diseased native valve of a mammal is constructed of biologic membrane or of biocompatible synthetic membrane. The valve has the shape of a truncated cone that has an inflow and an outflow orifice with leaflets forming the outflow orifice and forming a plurality of commissures (20). A first flexible stent (17) is removably affixed in a substantially circular fashion around the truncated cone in proximity of the inflow orifice, and a second flexible stent (18) is removably affixed at the location of the commissures to form a circle around the truncated cone in proximity of the outflow orifice. The stents maintain the shape of the valve during the surgical implantation procedure. Each stent independently can be left in the valve or can be removed during the implantation procedure based upon the judgement of the cardiac surgeon performing the implantation procedure. A holder designed to maintain the geometry of the valve during implantation to a mammal is also disclosed.

5. 发明授权

EP1622548B1 REED VALVE FOR IMPLANTATION INTO MAMMALIAN BLOOD VESSELS AND HEART WITH TEMPORARY OR PERMANENT SUPPORT BY TWO STENTS 有权
标题翻译：蝶阀种植体哺乳动物的血管和临时或永久支持两个支架上的心
公开(公告)号：EP1622548B1
公开(公告)日：2008-11-05
申请号：EP04759202.7
申请日：2004-04-07
申请人： International Heart Institute of Montana Foundation
发明人： DURAN, Carlos, M., G.
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2427 , A61F2/243 , A61F2220/0075
摘要： A multi-leaflet valve (15) adapted to serve as a prosthesis for diseased native valve of a mammal is constructed of biologic membrane or of biocompatible synthetic membrane. The valve has the shape of a truncated cone that has an inflow and an outflow orifice with leaflets forming the outflow orifice and forming a plurality of commissures (20). A first flexible stent (17) is removably affixed in a substantially circular fashion around the truncated cone in proximity of the inflow orifice, and a second flexible stent (18) is removably affixed at the location of the commissures to form a circle around the truncated cone in proximity of the outflow orifice. The stents maintain the shape of the valve during the surgical implantation procedure. Each stent independently can be left in the valve or can be removed during the implantation procedure based upon the judgement of the cardiac surgeon performing the implantation procedure. A holder designed to maintain the geometry of the valve during implantation to a mammal is also disclosed.

6. 发明公开

EP1296619A2 HEART VALVE PROSTHESIS 审中-公开
标题翻译：人工心脏瓣膜
公开(公告)号：EP1296619A2
公开(公告)日：2003-04-02
申请号：EP01946542.6
申请日：2001-06-20
申请人： International Heart Institute of Montana Foundation
发明人： DURAN, Carlos, M., G.
IPC分类号： A61F2/24
CPC分类号： A61F2/2496 , A61F2/2412 , A61F2/2457
摘要： An anatomically designed atrioventricular valve is made of biologically compatible synthetic membrane or biological membrane of autologous, homologous or heterologous origin. A single piece of the selected membrane material is trimmed so as to form two unequal sheaths similar to the normal anterior and posterior mammalian mitral valve leaflets with a wide upper base to be sutured to the host's mitral annulus. These two leaflets are prolonged and tapered into two thin bands to be connected to the papillary muscles serving as replacements for the natural marginal chordae tendinae of the normal mitral valve. The two lateral sides of the membrane are joined to form a truncated cone with a wider upper circular base and a narrow extremity formed by the thin chordal bands. A set of sutures are placed between selected points at the base of the cone and the two thin prolongations serving as replacements for the strut or stay basal chords of the natural mitral valve. Thus, the mitral valve prosthesis is anatomical because it is stentless, bicuspid and supported by marginal and basal chordae. Obturators and sizers in the configuration of rods of varying diameter, to measure the host's valve annulus diameter and select the appropriate size of the prosthesis are used during implantation of the prosthesis. A rod shaped holder maintains the prosthesis during implantation, and a curved bodied measuring instrument is used to determine the precise location where the chordae tendinae of the prosthesis are to be sutured to the papillary muscles of a recipient mammal.

7. 发明公开

EP1615594A2 SIGMOID VALVE 审中-公开
标题翻译： S形心脏瓣膜
公开(公告)号：EP1615594A2
公开(公告)日：2006-01-18
申请号：EP04749869.6
申请日：2004-04-07
申请人： International Heart Institute of Montana Foundation
发明人： DURAN, Carlos, M., G.
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2220/0075
摘要： A multi-leaflet valve (15) adapted to serve as a prosthesis for diseased native valve of a mammal is incorporated in self-expandable or inflatable endovascular stents or stents (27,28) to form a combination which is introduced on a catheter with a guide wire into the circulatory system of the mammal to replace the diseased native valve. Once the combination is at the desired location the stent is caused to expand and affix itself to the patient's vessel wall. The prosthetic valve has the shape of a truncated cone that has an inflow and an outflow orifice with leaflets forming the outflow orifice and forming a plurality of commissures. A first flexible circular support (17) is affixed in a substantially circular fashion around the truncated cone in proximity of the inflow orifice, and a second flexible circular support (18) is affixed at the location of the commissures to form a circle around the truncated cone in proximity of the outflow orifice. The circular supports maintain the shape of the valve during the surgical implantation procedure and thereafter.

8. 发明授权

EP1089776B1 PROCESS FOR MAKING COMPLIANT DEHYDRATED TISSUE FOR IMPLANTATION 有权
标题翻译：用于生产弹性脱水体植入组织
公开(公告)号：EP1089776B1
公开(公告)日：2002-05-29
申请号：EP99931880.1
申请日：1999-06-23
申请人： International Heart Institute of Montana Foundation
发明人： DURAN, Carlos, M., G. , CHEUNG, David, T. , PANG, David, C.
IPC分类号： A61L27/00
CPC分类号： A61L27/3691 , A61L27/3604 , A61L27/3687 , Y10S623/915 , Y10S623/917
摘要： A process for preparing pliable soft tissue specimen which are resistant to cracking and devoid of viable cells includes the steps of treating native soft tissue obtained from a donor by a gradually increasing gradient of aliphatic alcohol or other suitable water miscible polar organic solvent until the last alcohol (or other solvent) solution has at least 25 % by volume of the organic liquid. Thereafter, the tissue specimen is treated with a solution containing glycerol or low molecular weight (

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