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    • 3. 发明申请
    • PROGRAMMABLE MOLECULAR MANIPULATING PROCESSES
    • 可编程分子控制方法
    • WO2006040253A1
    • 2006-04-20
    • PCT/EP2005/054786
    • 2005-09-23
    • INTERNATIONAL BUSINESS MACHINES CORPORATIONIBM UNITED KINGDOM LIMITEDBERSTIS, Viktors
    • BERSTIS, Viktors
    • B82B3/00
    • B82B3/00G01Q70/06G01Q80/00
    • A system manipulates molecules using a set of proximal probes such as those used in atomic force microscopes. An electrostatic pattern is placed on a set of proximal probes such that each proximal probe may exert an electrostatic force. A molecule is captured using those electrostatic forces, after which the molecule can be manipulated while the molecule remains captured by the proximal probes. The electrostatic pattern can be modified such that the molecule moves and/or rotates over the set of proximal probes while the molecule remains captured by the set of proximal probes. The electrostatic pattern can be used to bend or split the molecule while the molecule remains captured by the set of proximal probes, thereby allowing the system to engage the molecule in chemical reactions, e.g., to act as a synthetic catalyst or a synthetic enzyme.
    • 系统使用一组近端探针(例如在原子力显微镜中使用的那些)进行操纵分子。 静电图案放置在一组近端探针上,使得每个近端探针可以施加静电力。 使用这些静电力捕获分子,之后可以在分子保持被近端探针捕获的同时操纵分子。 可以修改静电图案,使得分子在近端探针组上移动和/或旋转,同时分子保持被该组近端探针俘获。 静电图案可以用于在分子保持被该组近端探针捕获的同时弯曲或分裂分子,从而允许系统使化学反应例如用作合成催化剂或合成酶的化学反应。