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1. 发明申请

WO2014207618A1 MICROFLUIDIC CHIP WITH DIELECTROPHORETIC ELECTRODES EXTENDING IN HYDROPHILIC FLOW PATH 审中-公开
标题翻译：具有放电电极的微电极芯片在水文流程中扩展
公开(公告)号：WO2014207618A1
公开(公告)日：2014-12-31
申请号：PCT/IB2014/062345
申请日：2014-06-18
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM RESEARCH GMBH , SIX SEMICONDUTORES
发明人： AZPIROZ, Jaione Tirapu , DELAMARCHE, Emmanuel , GUENZLER, Tobias , KAIGALA, Govind , TEMIZ, Yuksel , TREIBER, Tino
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502707 , B01L2200/0668 , B01L2300/0877 , B01L2300/0883 , B01L2400/0406 , B01L2400/0418 , B01L2400/0424 , B03C5/005 , B03C5/026 , B03C2201/26 , G01N27/44713 , G01N27/44717 , G01N27/44743 , G01N27/44791
摘要： The present invention is notably directed to a microfluidic chip (1, 1a) comprising: a flow path (22) defined by a hydrophilic surface; a liquid input (24, 24a, 24b) on one side of the 4 flow path; at least one electrical circuit (62), hereafter DEP circuit, comprising at least one pair of dielectrophoretic electrodes (E21, E22), hereafter DEP electrodes, wherein: each of the DEP electrodes extends transverse to the flow path; and the DEP circuit is configured to generate a dielectrophoretic force, hereafter DEP force, at the level of the DEP electrodes. 8 The chip may further include one or more electroosmotic circuits. The present invention is further directed to methods of operation of such a microfluidic chip.
摘要翻译：本发明特别涉及一种微流体芯片（1,1a），包括：由亲水表面限定的流路（22）; 在四个流动路径的一侧上的液体输入（24,24a，24b）; 至少一个电路（62），以下称为DEP电路，包括至少一对介电电泳电极（E21，E22），以下称为DEP电极，其中：每个DEP电极横向于流路延伸; 并且DEP电路被配置为在DEP电极的电平处产生介电电泳力（下文称为DEP力）。芯片还可以包括一个或多个电渗电路。本发明还涉及这种微流控芯片的操作方法。

2. 发明申请

WO2014207617A1 FABRICATION OF MICROFLUIDIC CHIPS HAVING ELECTRODES LEVEL WITH MICROCHANNEL WALLS 审中-公开
标题翻译：具有微电极水平的电极水平的微流控晶体的制造
公开(公告)号：WO2014207617A1
公开(公告)日：2014-12-31
申请号：PCT/IB2014/062343
申请日：2014-06-18
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM RESEARCH GMBH , SIX SEMICONDUTORES
发明人： DELAMARCHE, Emmanuel , GUENZLER, Tobias , TEMIZ, Yuksel , TREIBER, Tino
IPC分类号： B01L3/00 , B81C1/00
CPC分类号： B01L3/502707 , B01L2200/0668 , B01L2200/0684 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , B01L2400/0418 , B05D1/005 , B81B2201/058 , B81B2203/04 , B81C1/00119 , H01J37/32009 , H01J2237/334
摘要： The present invention is notably directed to method of fabrication of a microfluidic chip (1), comprising: providing (S1 – S7) a substrate (10), a face (F) of which is covered by an electrically insulating layer (30); obtaining (S8) a resist layer (40) covering one or more selected portions (P1) of the electrically insulating layer (30), at least a remaining portion (P2) of said electrically insulating layer (30) not being covered by the resist layer; partially etching (S9) with a wet etchant (E) a surface of the remaining portion (P2) of the electrically insulating layer (30) to create a recess (40r) and/or an undercut (40u) under the resist layer (40); depositing (S10) the electrically conductive layer (50) on the etched surface (35), such that the electrically conductive layer reaches the created recess (40r) and/or undercut (40u); and removing (S11) the resist layer (40) to expose a portion (P1) of the electrically insulating layer adjoining a contiguous portion (P2) of the electrically conductive layer (50). The present invention is further directed to microfluidic chips obtainable by such methods.
摘要翻译：本发明特别涉及微流控芯片（1）的制造方法，其特征在于，包括：提供（S1-S7）基板（10），其表面（F）由电绝缘层（30）覆盖; 获得（S8）覆盖电绝缘层（30）的一个或多个选定部分（P1）的抗蚀剂层（40），所述电绝缘层（30）的至少剩余部分（P2）不被抗蚀剂覆盖层; 使用湿蚀刻剂（E）部分地蚀刻（S9）电绝缘层（30）的剩余部分（P2）的表面，以在抗蚀剂层（40）下面形成凹部（40r）和/或底切（40u））; 在所述蚀刻表面（35）上沉积（S10）所述导电层（50），使得所述导电层到达所产生的凹部（40r）和/或底切（40u）; 去除（S11）抗蚀剂层（40）以暴露与导电层（50）的邻接部分（P2）邻接的电绝缘层的部分（P1）。本发明还涉及通过这些方法获得的微流控芯片。

3. 发明申请

WO2017077409A1 CONTINUOUS, CAPACITANCE-BASED MONITORING OF LIQUID FLOWS IN A MICROFLUIDIC DEVICE 审中-公开
标题翻译：微流控装置中连续，电容式液体流动监测
公开(公告)号：WO2017077409A1
公开(公告)日：2017-05-11
申请号：PCT/IB2016/056131
申请日：2016-10-13
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM (CHINA) INVESTMENT COMPANY LTD. , IBM RESEARCH GMBH
发明人： DELAMARCHE, Emmanuel , TEMIZ, Yuksel
IPC分类号： G01R27/26 , G01N27/22
CPC分类号： B01L3/50273 , B01L3/502715 , B01L2200/027 , B01L2200/0605 , B01L2200/0621 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2400/0406 , G01F1/00 , G01N27/22
摘要： A microfluidic chip (10) comprising a microchannel (11,11a) fillable with a liquid (5), the microchannel (11,11a) comprises a pair of electrodes (21,22,21a,22a), and a liquid flow path (12) defined between the electrodes (21,22,21a,22a), wherein each of the electrodes (21,22,21a,22a) extends along the flow path (12) and parallel to a direction of a liquid (5) filling the microchannel (11,11a), in operation, and an electrical circuitry connected to each of the electrodes (21,22,21a,22a) and configured to continuously measure, via the electrodes (21,22,21a,22a), a capacitance of the electrodes (21,22,21a,22a) being wet by a liquid (5) continuously filling the flow path (12), as a function of time, in operation.
摘要翻译：微流体芯片（10）包括可用液体（5）填充的微通道（11,11a），微通道（11,11a）包括一对电极（21,22,21a，22a ）和限定在电极（21,22,21a，22a）之间的液体流动路径（12），其中每个电极（21,22,21a，22a）沿着流动路径（12）延伸并平行于在操作中填充微通道（11,11a）的液体（5）的方向以及连接到每个电极（21,22,21a，22a）并被配置为经由电极（21,22,21a， 22,21a，22a），在操作中，电极（21,22,21a，22a）的电容由连续填充流动路径（12）的液体（5）随时间而变湿。

4. 发明申请

WO2016146710A1 MICROFLUIDIC DEVICE WITH ANTI-WETTING, VENTING AREAS 审中-公开
标题翻译：具有防潮，露天区域的微流体装置
公开(公告)号：WO2016146710A1
公开(公告)日：2016-09-22
申请号：PCT/EP2016/055733
申请日：2016-03-16
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM RESEARCH GMBH
发明人： DELAMARCHE, Emmanuel , TEMIZ, Yuksel
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/502723 , B01L2200/0615 , B01L2200/0684 , B01L2200/12 , B01L2200/141 , B01L2300/0645 , B01L2300/0851 , B01L2300/0858 , B01L2300/0867 , B01L2300/165 , B01L2400/0406 , B01L2400/0424 , B01L2400/086 , B01L2400/088 , B81C1/00
摘要： Amicrofluidic device and method for fabrication includes a microfluidic channel that has a closed portion, which comprises: a liquid pathway formed by a wetting area; and an anti- wetting area extending along and contiguously with the liquid pathway. The anti-wetting area is configured so as to provide a vent to evacuate gas along the anti-wetting area.
摘要翻译：微流体装置和制造方法包括具有封闭部分的微流体通道，其包括：由润湿区域形成的液体通路; 以及与液体通道一起并且与液体通路连续的抗湿润区域。防湿区域被构造成提供排气口以沿着防潮湿区域抽空气体。

5. 发明申请

WO2014207619A1 FABRICATION OF A MICROFLUIDIC CHIP PACKAGE OR ASSEMBLY WITH SEPARABLE CHIPS 审中-公开
标题翻译：微流芯片包装的制造或组装与可分离的CHIPS
公开(公告)号：WO2014207619A1
公开(公告)日：2014-12-31
申请号：PCT/IB2014/062346
申请日：2014-06-18
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM RESEARCH GMBH
发明人： DELAMARCHE, Emmanuel , TEMIZ, Yuksel
IPC分类号： B01L3/00 , B81C1/00 , G01N33/487
CPC分类号： B01L3/502707 , B01L2300/044 , B01L2300/0627 , B01L2300/0816 , B01L2300/0883 , B01L2300/0887 , B81C1/00888 , G01N33/487
摘要： The present invention is notably directed to methods of fabrication of a microfluidic chip package or assembly (1), comprising: providing (S1) a substrate (10, 30) having at least one block (14, 14a) comprising one or more microfluidic structures on a face (F) of the substrate; partially cutting (S2) into the substrate to obtain partial cuts (10c), such that a residual 6 thickness of the substrate at the level of the partial cuts (10c) enables singulation of said at least one block (14, 14a); cleaning (S4) said at least one block; and applying (S5 – S7) a cover-film (62) to cover said at least one block (14, 14a), whereby at least one covered block is obtained, the applied cover film still enabling singulation of each covered block, wherein each covered block corresponds to a microfluidic chip after singulation. The present invention is further directed to microfluidic chips, packing or assembly, obtainable with such 12 methods.
摘要翻译：本发明特别涉及制造微流体芯片封装或组件（1）的方法，包括：（S1）具有至少一个包含一个或多个微流体结构的块（14,14a）的衬底（10,30）在基材的表面（F）上; 部分切割（S2）到基板中以获得部分切割（10c），使得在部分切口（10c）的水平处的基板的残余6厚度使得能够对所述至少一个块（14,14a）进行分割; 清洁（S4）至少一块; 以及施加（S5-S7）覆盖膜（62）以覆盖所述至少一个块（14,14a），由此获得至少一个覆盖块，所施加的覆盖膜仍然能够对每个被覆盖的块进行分割，其中每个覆盖块对应于分离后的微流体芯片。本发明进一步涉及可用这种12种方法获得的微流控芯片，包装或组装。

6. 发明申请

WO2015145280A1 MICROFLUIDIC CHIP WITH CONIC BEAD TRAPPING CAVITIES AND FABRICATION THEREOF 审中-公开
标题翻译：微波芯片，带有中高品质的珠子及其制作工艺
公开(公告)号：WO2015145280A1
公开(公告)日：2015-10-01
申请号：PCT/IB2015/051579
申请日：2015-03-04
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM (CHINA) INVESTMENT COMPANY LTD. , IBM RESEARCH GMBH
发明人： DELAMARCHE, Emmanuel , TEMIZ, Yuksel
IPC分类号： G01N33/53 , G01N33/554 , G01N33/543 , H01L21/00
CPC分类号： B01L3/502761 , B01L3/502707 , B01L2200/0668 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2400/086
摘要： A microfluidic chip (100) comprises a layer (10, 60) with an array (30) of bead trapping cavities (20) provided in that layer (10, 60), wherein each of the cavities (20) has a conic shape, defined by one or more lateral walls (21-24) that are, each, hydrophilic, and wherein each of the cavities (20) extends as a blind hole in the thickness of said layer (10, 60). Methods of fabrication of such a chip are further provided.
摘要翻译：微流体芯片（100）包括具有设置在该层（10,60）中的珠粒捕获腔（20）的阵列（30）的层（10,60），其中每个空腔（20）具有圆锥形状，由一个或多个侧壁（21-24）限定，每个侧壁是亲水的，并且其中每个空腔（20）作为所述层（10,60）的厚度中的盲孔延伸。进一步提供这种芯片的制造方法。

7. 发明申请

WO2018083563A1 MICROFLUIDIC CHIP WITH BEAD INTEGRATION SYSTEM 审中-公开
标题翻译： MICROFLUIDIC芯片与珠集成系统
公开(公告)号：WO2018083563A1
公开(公告)日：2018-05-11
申请号：PCT/IB2017/056502
申请日：2017-10-19
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , IBM (CHINA) INVESTMENT COMPANY LIMITED
发明人： TEMIZ, Yuksel , LIM, Michel , DELAMARCHE, Emmanuel
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L2200/0668 , B01L2200/0689 , B01L2200/12 , B01L2300/041 , B01L2300/0645 , B01L2300/0816 , B01L2300/0838 , B01L2300/0848 , B01L2300/0887 , B01L2400/0406 , B01L2400/0688 , B01L2400/086
摘要： The present invention is notably directed to a microfluidic chip. The chip comprises a main microfluidic channel, on one side of the chip, and a bead integration system. The bead integration system is arranged on said one side of the chip. It comprises an auxiliary microfluidic channel transverse to and in fluidic communication with the main microfluidic channel, so as to form an intersection therewith. The intersection is delimited by structural elements arranged in the main microfluidic channel. The structural elements are configured to retain, at said intersection, beads flowed in a bead suspension liquid advancing in said auxiliary microfluidic channel and passing the intersection. In addition, such structural elements are configured to let liquid advancing in the main microfluidic channel pass the intersection through the structural elements. The invention is further directed to related devices and methods.
摘要翻译：本发明特别针对微流控芯片。该芯片包括在芯片的一侧上的主微流体通道和珠集成系统。焊珠集成系统布置在芯片的所述一侧上。它包括横向于主微流体通道并与主微流体通道流体连通的辅助微流体通道，以便与其形成交点。交叉点由安排在主微流体通道中的结构元件限定。所述结构元件被配置为在所述交叉点处保留珠流入在所述辅助微流体通道中前进并通过所述交点的珠悬浮液中。另外，这样的结构元件被配置为使得主要微流体通道中的液体前进穿过结构元件的交点。本发明还涉及相关的装置和方法。

8. 发明申请

WO2021152380A1 MICROFLUIDIC CHIPS WITH INTEGRATED ELECTRONIC SENSORS 审中-公开
公开(公告)号：WO2021152380A1
公开(公告)日：2021-08-05
申请号：PCT/IB2020/061682
申请日：2020-12-09
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM ISRAEL - SCIENCE &TECHNOLOGY LTD. , IBM (CHINA) INVESTMENT COMPANY LTD.
发明人： ZAFAR, Sufi , TEMIZ, Yuksel , DELAMARCHE, Emmanuel
IPC分类号： G01N27/30 , G01N27/26
摘要： Apparatuses and methods of manufacturing thereof, regarding microfluidic chips with integrated electronic sensors, comprise a conductive plug(104) of a reference electrode structure, the conductive plug(104) extending from within a microfluidic channel(108) to within a reference fluid holding chamber(102) that is in fluid isolation from the microfluidic channel(108). Thus it can eliminate a requirement to insert a reference electrode(106) into a microfluidic chip(100) at the moment of use.

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