会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 9. 发明申请
    • LOCALIZED DELIVERY SYSTEM FOR PHENSTATIN USING N-ISOPROPYLACRYLAMIDE
    • 使用N-异丙基丙烯酰胺的本地化递送系统
    • WO2004009127A1
    • 2004-01-29
    • PCT/US2003/022833
    • 2003-07-21
    • ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF, ARIZONA STATE UNIVERSITYVERNON, BrentPOWELL, Steven
    • VERNON, BrentPOWELL, Steven
    • A61K47/48
    • C07H15/18A61K31/222A61K47/58C07H15/10
    • An injectable drug delivery system for localized release of Phenstatin to a tumor site over a period of time is provided. The drug delivery system comprises the thermoresponsive polymer N-isopropylacrylamide (NIPAAm) and Phenstatin, a toxic antineoplastic agent. The drug delivery system has a critical solution temperature (LCST) that causes it to change from the liquid state at room temperature when injected to a gel or semi-solid state after reaching the temperature of the human body in situ . Methods are given for delivering Phenstatin to a cancerous tumor. In these methods, the drug delivery system is injected into a tissue or into a tumor where it forms a gel. Phenstatin is slowly released from the polymer and exerts its cytotoxic, tublin-related effects on the tumor. Tumors that may be treated by the present methods include, but are not limited to breast, prostate, lung and bowel cancerous tumors.
    • 提供了一种用于在一段时间内将苯达汀局部释放到肿瘤部位的可注射药物递送系统。 药物递送系统包括热反应性聚合物N-异丙基丙烯酰胺(NIPAAm)和苯达汀,一种有毒的抗肿瘤剂。 药物递送系统具有临界溶解温度(LCST),其在室温下达到人体温度后注入凝胶或半固体状态时,使其从室温下的液态变化。 给予方便将苯达汀递送至癌性肿瘤。 在这些方法中,将药物递送系统注射到组织或肿瘤中,在其中形成凝胶。 苯达汀从聚合物缓慢释放,并对肿瘤发挥细胞毒性,都柏林相关作用。 可以通过本发明方法治疗的肿瘤包括但不限于乳腺癌,前列腺癌,肺癌和肠癌性肿瘤。