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1. 发明申请

WO2012056369A1 MULTILAYER MICROFLUIDIC PROBE HEAD WITH IMMERSION CHANNELS AND FABRICATION THEREOF 审中-公开
标题翻译：多层微流体探头，具有浸没通道及其制造
公开(公告)号：WO2012056369A1
公开(公告)日：2012-05-03
申请号：PCT/IB2011/054614
申请日：2011-10-18
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , DELAMARCHE, Emmanuel , KAIGALA, Govind , LOVCHIK, Robert
发明人： DELAMARCHE, Emmanuel , KAIGALA, Govind , LOVCHIK, Robert
IPC分类号： B01J19/00 , B01L3/00
CPC分类号： F03B11/00 , B01L3/502707 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2200/0694 , B01L2200/12 , B01L2300/0887 , Y10T137/0318 , Y10T137/8593
摘要： The invention is directed to a microfluidic probe head (100) with a base layer (120) comprising: at least two processing liquid microchannel (123, 124) in fluid communication with a processing liquid aperture (121, 122) on a face of the base 10 layer; and an immersion liquid microchannel (223, 224) in fluid communication with a immersion liquid aperture (221, 222) on a face of the base layer, wherein the microfluidic probe head is configured to allow, in operation, processing liquid provided through the processing liquid aperture to merge into immersion liquid provided through the immersion liquid aperture. An additional layer can be provided 15 to close the microchannels. Such a multilayered head is compact and easier to fabricate than heads made with unitary construction. The head can further be interfaced with tubing using e.g. a standard fitting for tubing port.
摘要翻译：本发明涉及一种具有基层（120）的微流体探针头（100），包括：至少两个处理液体微通道（123,124），其与所述基底层（120）的表面上的处理液孔（121,122）流体连通基10层; 以及与所述基底层的表面上的浸没液体孔（221,222）流体连通的浸没液体微通道（223,224），其中所述微流体探针头被配置为允许在操作中通过所述处理提供的处理液体液体孔径合并成通过浸没液体孔提供的浸液。可以提供附加层15以关闭微通道。这种多层头部比用单一构造的头部紧凑并且容易制造。头部可以进一步与管道连接，使用例如油管口的标准配件。

2. 发明申请

WO2010128483A2 MULTILAYER MICROFLUIDIC PROBE HEAD AND METHOD OF FABRICATION THEREOF 审中-公开
标题翻译：多层微流体探头及其制造方法
公开(公告)号：WO2010128483A2
公开(公告)日：2010-11-11
申请号：PCT/IB2010/052018
申请日：2010-05-07
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , DELAMARCHE, Emmanuel , DRECHSLER, Ute , LOVCHIK, Robert
发明人： DELAMARCHE, Emmanuel , DRECHSLER, Ute , LOVCHIK, Robert
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00367 , B01J2219/00527 , B01J2219/00743 , B01L3/0241 , B01L3/502707 , B01L2300/0874 , B01L2300/0887 , Y10T29/494 , Y10T137/0318 , Y10T137/0402 , Y10T137/2224 , Y10T137/8359 , Y10T137/8593 , Y10T137/87153 , Y10T137/87885
摘要： The invention is directed to a multilayer microfluidic probe (MFP) head (100). The head typically comprises a first (110) and second (120) layers facing each others, and at least one tubing port (182), extending from the first layer (110). The first layer comprises one or more via (112), whereby fluid communication is enabled through the first layer towards the second layer. The second layer comprises at least one microchannel (124), relaying fluid communication to an aperture (122). Such a multilayered MFP head is easier to fabricate than heads made with unitary construction. In particular, a microchannel can advantageously be engraved a groove (124) at the level of the interface between the two layers. The MFP head can further be interfaced with tubing using e.g. a standard fitting for tubing port. The invention has substantial potential for e.g. patterning continuous and discontinuous patterns of biomolecules on surfaces as well as for direct processing of resist materials in a non- contact mode.
摘要翻译：本发明涉及一种多层微流体探针（MFP）头（100）。头部通常包括彼此面对的第一（110）和第二（120）层，以及从第一层（110）延伸的至少一个管口（182）。第一层包括一个或多个通孔（112），由此通过第一层朝向第二层的流体连通。第二层包括至少一个微通道（124），将流体连通中继到孔（122）。与单一构造的头相比，这种多层MFP头比制造更容易。特别地，微通道可以有利地在两层之间的界面的水平刻划凹槽（124）。 MFP头可以进一步与例如管道连接。油管口的标准配件。本发明具有实质的潜力。在表面上形成生物分子的连续和不连续图案，以及在非接触模式下直接处理抗蚀剂材料。

3. 发明申请

WO2009153763A1 MICROFLUIDIC SELECTION OF LIBRARY ELEMENTS 审中-公开
标题翻译：微型选择图书馆元素
公开(公告)号：WO2009153763A1
公开(公告)日：2009-12-23
申请号：PCT/IB2009/052644
申请日：2009-06-19
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , DELAMARCHE, Emmanuel , LOVCHIK, Robert , SOLIS, Daniel J.
发明人： DELAMARCHE, Emmanuel , LOVCHIK, Robert , SOLIS, Daniel J.
IPC分类号： B01L3/00 , G01N33/543 , G01N33/545 , B01J19/00
CPC分类号： C40B60/12 , B01J2219/00353 , B01J2219/00414 , B01J2219/00418 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , B01L3/502715 , B01L2200/027 , B01L2200/0631 , B01L2200/10 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0851 , B01L2300/0887 , B01L2300/12 , B01L2300/163 , B01L2400/0406 , B01L2400/049 , G01N33/54366
摘要： Disclosed herein is a system comprising a chip; a flow channel disposed in the chip; the flow channel being in communication with an entry port and an exit port; the flow channel being operative to permit the flow of a library from the entry port to the exit port; a substrate; the substrate being disposed upon the chip; the substrate being operative to act as an upper wall for the flow channel; and a receptor; the receptor being disposed on the substrate; the receptor being operative to interact with a component from the library.
摘要翻译：本文公开了一种包括芯片的系统; 设置在所述芯片中的流路; 所述流通道与入口和出口通信; 所述流动通道可操作以允许库从入口到出口的流动; 底物; 所述基板设置在所述芯片上; 所述基底可用作所述流动通道的上壁; 和受体; 所述受体被设置在所述基底上; 受体可操作以与文库中的组分相互作用。

4. 发明申请

WO2010106456A2 MICROORGANISM CULTURE DEVICE AND METHOD OF OPERATION THEREOF 审中-公开
标题翻译：微生物培养装置及其操作方法
公开(公告)号：WO2010106456A2
公开(公告)日：2010-09-23
申请号：PCT/IB2010/050941
申请日：2010-03-04
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , DELAMARCHE, Emmanuel , LOVCHIK, Robert
发明人： DELAMARCHE, Emmanuel , LOVCHIK, Robert
IPC分类号： C12M1/00
CPC分类号： C12M23/16 , B01L3/502723 , B01L2200/0642 , B01L2300/0816 , B01L2400/0406 , B01L2400/084
摘要： The invention is directed to a microorganism culture device (100), such as a micro fluidic cell culture device. The device comprises an open chamber (10), wherein microorganisms are likely to be deposited within a liquid for subsequent study. The open chamber simplifies the deposition of the microorganisms. The chamber is further provided with retention features (11), whereby microorganisms can be retained therein. In addition, the device comprises an overflow area (20), wherein capillary structures (22) are configured to retain excess liquid overflowing from the open chamber, e.g. when covering the device with a cover. As such, it allows for confining microorganism in the chamber, while excess fluid is captured externally, e.g. to seal the device with a cover.
摘要翻译：本发明涉及微生物培养装置（100），例如微流体细胞培养装置。该装置包括开放室（10），其中微生物可能沉积在液体中用于随后的研究。开放室简化了微生物的沉积。该室还设置有保留特征（11），由此微生物可以保留在其中。另外，该装置包括溢流区域（20），其中毛细结构（22）被配置为保留从开放腔室溢出的多余液体，例如，当用盖子覆盖设备时。这样，它允许将微生物限制在室中，同时过量的流体从外部捕获，例如，用盖子密封设备。

5. 发明申请

WO2019150189A1 MICROFLUIDIC PROBE HEAD WITH ASPIRATION POSTS 审中-公开
公开(公告)号：WO2019150189A1
公开(公告)日：2019-08-08
申请号：PCT/IB2019/000007
申请日：2019-02-05
申请人： URI, Yochanan , BARAK, Itay , LOVCHIK, Robert , TAYLOR, David, P. , BUERGE, Marcel , KAIGALA, Govind, V. , BIO-RAD EUROPE GMBH , BIO-RAD LABORATORIES, INC.
发明人： URI, Yochanan , BARAK, Itay , LOVCHIK, Robert , TAYLOR, David, P. , BUERGE, Marcel , KAIGALA, Govind, V.
IPC分类号： B01L3/00 , B01L99/00 , B01L3/02
CPC分类号： B01L3/502707 , B01L3/0293 , B01L3/502761 , B01L99/00 , B01L2200/027 , B01L2200/0642 , B01L2200/0647 , B01L2200/141 , B01L2300/0832
摘要： The present disclosure is notably directed to a microfluidic probe head (202), or MFP head, comprising a processing surface (204) having liquid injection and liquid aspiration apertures, as well as projections (205) extending from the processing surface (204). The arrangement of injection and aspiration apertures provides for a hydrodynamic flow confinement within a processing region that is formed between the processing surface (204) and a substrate (104) or sample surface (for example, the bottom of a microtiter plate sample well (102)), typically located beneath the processing surface (204). The disclosure is further directed to related microfluidic probe devices, and methods of operation of such an MFP head, notably to deposit cells on a surface.

6. 发明申请

WO2019150189A8 MICROFLUIDIC PROBE HEAD WITH ASPIRATION POSTS 审中-公开
公开(公告)号：WO2019150189A8
公开(公告)日：2019-08-08
申请号：PCT/IB2019/000007
申请日：2019-02-05
申请人： LOVCHIK, Robert , TAYLOR, David, P. , BUERGE, Marcel , KAIGALA, Govind, V. , BIO-RAD EUROPE GMBH , BIO-RAD LABORATORIES, INC.
发明人： LOVCHIK, Robert , TAYLOR, David, P. , BUERGE, Marcel , KAIGALA, Govind, V. , URI, Yochanan , BARAK, Itay
IPC分类号： B01L3/00 , B01L99/00 , B01L3/02
摘要： The present disclosure is notably directed to a microfluidic probe head (202), or MFP head, comprising a processing surface (204) having liquid injection and liquid aspiration apertures, as well as projections (205) extending from the processing surface (204). The arrangement of injection and aspiration apertures provides for a hydrodynamic flow confinement within a processing region that is formed between the processing surface (204) and a substrate (104) or sample surface (for example, the bottom of a microtiter plate sample well (102)), typically located beneath the processing surface (204). The disclosure is further directed to related microfluidic probe devices, and methods of operation of such an MFP head, notably to deposit cells on a surface.

7. 发明申请

WO2015132686A1 FABRICATION OF ANNULAR MICROFLUIDIC PROBE HEADS 审中-公开
标题翻译：环形微流体探头的制造
公开(公告)号：WO2015132686A1
公开(公告)日：2015-09-11
申请号：PCT/IB2015/051075
申请日：2015-02-13
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM (CHINA) INVESTMENT COMPANY LTD. , IBM RESEARCH GMBH
发明人： BUERGE, Marcel , DELAMARCHE, Emmanuel , KAIGALA, Govind , LOVCHIK, Robert
IPC分类号： B01J19/00
CPC分类号： B01L3/502707 , B01L3/0255 , B01L2300/0645 , B01L2300/0803 , B01L2300/0887 , B01L2300/1827 , H01J49/167
摘要： A method of fabrication of microfluidic probe heads (100) is provided, the method comprising: providing (S16) a set of n microfluidic probe head layouts (14) on a same bilayer substrate (10, 10a) that comprises two layers (11, 12), said layouts being annularly distributed on that bilayer substrate, and wherein each of said layouts comprises: a first layer (110), which corresponds to a portion of one (11) of said two layers (11, 12) of the bilayer substrate; and a second layer (120), which corresponds to a portion of another one (12) of said two layers (11, 12) of the bilayer substrate; and comprises at least one microchannel (123, 124) defined by a groove open on an upper surface (120u) of the second layer (120) and closed by a portion of a lower surface (1101) of the first layer (110); machining (S20) a hole (16) substantially at the center of the bilayer substrate (10), to create a cylinder wall (18) that delimits said hole and intercepts each of the at least one microchannel of the layouts (14), such that said at least one microchannel (123, 124) of each of said layouts extends up to at least one respective aperture (121, 122) formed at an end of the groove at the level of said cylinder wall (18); and, finally, singulating (S30) each of the n layouts to obtain n microfluidic probe heads (100). MFP heads accordingly obtained are further provided.
摘要翻译：提供了一种制造微流体探针头（100）的方法，所述方法包括：在同一双层基板（10,10a）上提供（S16）一组n个微流体探针头布局（14），所述双层基板包括两层（11，所述布局环形地分布在所述双层基板上，并且其中每个所述布局包括：第一层（110），其对应于所述双层的所述两个层（11,12）中的一个（11）的一部分基质; 以及对应于所述双层基板的所述两层（11,12）中的另一层（12）的一部分的第二层（120）。并且包括由在第二层（120）的上表面（120u）上开口并由第一层（110）的下表面（1101）的一部分封闭的凹槽限定的至少一个微通道（123,124）。加工（S20）基本上在双层基板（10）的中心的孔（16），以形成限定所述孔并且拦截布局（14）的至少一个微通道中的每一个的气缸壁（18），例如每个所述布局的至少一个微通道（123,124）延伸到形成在所述凹槽的在所述气缸壁（18）的水平处的端部处的至少一个相应的孔（121,122）; 最后，对n个布局中的每一个进行单片化（S30）以获得n个微流体探针头（100）。进一步提供相应获得的MFP头。

8. 发明申请

WO2014001935A1 MICROFLUIDIC SURFACE PROCESSING DEVICE AND METHOD 审中-公开
标题翻译：微流表面处理装置及方法
公开(公告)号：WO2014001935A1
公开(公告)日：2014-01-03
申请号：PCT/IB2013/054773
申请日：2013-06-11
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM (CHINA) INVESTMENT COMPANY LTD. , IBM RESEARCH GMBH
发明人： DUERIG, Urs T. , LOVCHIK, Robert
IPC分类号： B81B1/00 , B81B5/00 , B05C5/02
CPC分类号： C23C2/04 , B05C3/02 , B05C11/1007 , B05D1/18 , G01N27/447 , G01Q60/42 , G01Q80/00
摘要： A microfluidic surface processing device (10a-10h), comprising: a microfluidic probe head (16) with at least one aperture (11) on a face (17) thereof, said at least one aperture (11) comprising at least an outlet aperture (11); and a surface processing structure (21, 21a, 22) extending outwardly and perpendicularly with respect to said face (17), the processing structure being further dimensioned and located with respect to the outlet aperture (11) such that it can intercept a flowpath of liquid (15) dispensed via the outlet aperture, in operation. Related apparatuses and methods are provided.
摘要翻译：一种微流体表面处理装置（10a-10h），包括：在其面（17）上具有至少一个孔（11）的微流体探针头（16），所述至少一个孔（11）包括至少一个出口孔（11）; 以及相对于所述面（17）向外并垂直延伸的表面处理结构（21,21a，22），所述处理结构相对于所述出口孔（11）进一步尺寸设置并定位成使得其可以拦截在操作中经由出口孔分配的液体（15）。提供了相关的装置和方法。

9. 发明申请

WO2013061199A1 MICROFLUIDIC DEVICE WITH INTERCONNECTS 审中-公开
标题翻译：具有互连的微流量器件
公开(公告)号：WO2013061199A1
公开(公告)日：2013-05-02
申请号：PCT/IB2012/055535
申请日：2012-10-12
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM JAPAN, LTD. , IBM RESEARCH GMBH
发明人： DELAMARCHE, Emmanuel , KAIGALA, Govind , LOVCHIK, Robert
IPC分类号： F04B53/16 , B81B1/00 , G01N37/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00813 , B01L3/502715 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , F16L41/00 , Y10T29/49826 , Y10T137/85938
摘要： The invention is notably directed to a microfluidic device (100) comprising: a first layer (10); a second layer (20), the first layer and the second layer assembled such as to face each other; a microchannel (30) in the second layer; a tapered conduit (50) having a tapered portion (52), wherein the tapered portion (52) is inserted in a correspondingly shaped via (11) formed in the first layer at the level of an end of the microchannel such that fluid communication is enabled between the microchannel and the conduit, and blocked in the via by way of the assembled first layer and second layer.
摘要翻译：本发明特别涉及一种微流体装置（100），包括：第一层（10）; 第二层（20），所述第一层和所述第二层被组装成彼此面对; 第二层中的微通道（30）; 具有锥形部分（52）的锥形导管（50），其中所述锥形部分（52）插入形成在所述第一层中的所述微通道的端部的水平处的相应形状的通孔（11）中，使得流体连通在微通道和导管之间启用，并且通过组装的第一层和第二层在通孔中阻塞。

10. 发明申请

WO2017187284A1 VERTICAL MICROFLUIDIC PROBE HEAD WITH LARGE SCALE SURFACE PROCESSING APERTURES 审中-公开
标题翻译：大尺寸表面处理孔径的垂直微流控探头
公开(公告)号：WO2017187284A1
公开(公告)日：2017-11-02
申请号：PCT/IB2017/051765
申请日：2017-03-28
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM (CHINA) INVESTMENT COMPANY LTD. , IBM RESEARCH GMBH
发明人： KAIGALA, Govind , LOVCHIK, Robert , TAYLOR, David Philipp , ZEAF, Ismael
IPC分类号： B01J19/00
摘要： One or more embodiments of the present invention are directed to a vertical microfluidic probe head, which comprises a middle layer of material and two outer layers. The middle layer comprises two opposite, main surfaces, which are, each, grooved up to a same edge surface that adjoins each of the main surfaces, so as to form two sets of n microchannel cavities, n > 1, on each of the opposite main surfaces. The middle layer is furthermore arranged between the two outer layers, which (at least partly) close the microchannel cavities grooved on the two main surfaces. This way, two sets of n microchannels are formed, which are, each, open on the edge surface, such that two opposite sets of n orifices are formed on the edge surface. Thus, the length of the apertures is not limited by the thickness of the middle layer.
摘要翻译：本发明的一个或多个实施例涉及垂直微流体探针头，其包括中间层材料和两个外层。中间层包括两个相对的主表面，每个主表面都开槽到与每个主表面邻接的同一边缘表面，从而形成两组n个微通道腔体，n 1，在每个相对的主表面上。此外，中间层布置在两个外层之间，其（至少部分地）封闭在两个主表面上开槽的微通道空腔。这样，形成两组n个微通道，每个微通道都在边缘表面上开口，使得在边缘表面上形成两组相对的孔。因此，孔的长度不受中间层厚度的限制。

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