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1. 发明申请

WO02059148A3 A METHOD FOR IDENTIFICATION, ISOLATION AND PRODUCTION OF ANTIGENS TO A SPECIFIC PATHOGEN 审中-公开
标题翻译：用于鉴定，分离和产生抗特异性病原体的方法
公开(公告)号：WO02059148A3
公开(公告)日：2003-07-31
申请号：PCT/EP0200546
申请日：2002-01-21
申请人： INTERCELL AG , MEINKE ANDREAS , NAGY ESZTER , AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
发明人： MEINKE ANDREAS , NAGY ESZTER , VON AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
IPC分类号： G01N33/50 , A61K39/00 , A61K39/39 , A61K39/395 , A61P31/10 , B64C9/02 , C07K14/195 , C07K14/31 , C07K16/12 , C12N15/02 , C12N15/09 , C12N15/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C40B40/02 , G01N33/15 , G01N33/53
CPC分类号： C40B40/02 , A61K39/00 , C07K14/195 , C07K14/31 , C07K16/1271 , C12N15/1037 , C12N15/1041 , C12Q1/6806 , C12Q2527/125 , C12Q2521/537
摘要： Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans.
摘要翻译：描述了用于鉴定，分离和产生来自特异性病原体，肿瘤，变应原或易于自身免疫的组织或宿主的超免疫血清反应性抗原的方法，所述抗原适用于给定类型动物的疫苗或人类。

2. 发明申请

WO02059148A8 A METHOD FOR IDENTIFICATION, ISOLATION AND PRODUCTION OF ANTIGENS TO A SPECIFIC PATHOGEN 审中-公开
标题翻译：用于鉴定，分离和产生抗特异性病原体的方法
公开(公告)号：WO02059148A8
公开(公告)日：2003-01-16
申请号：PCT/EP0200546
申请日：2002-01-21
申请人： CISTEM BIOTECHNOLOGIES GMBH , MEINKE ANDREAS , NAGY ESZTER , AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
发明人： MEINKE ANDREAS , NAGY ESZTER , VON AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
IPC分类号： G01N33/50 , A61K39/00 , A61K39/39 , A61K39/395 , A61P31/10 , B64C9/02 , C07K14/195 , C07K14/31 , C07K16/12 , C12N15/02 , C12N15/09 , C12N15/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C40B40/02 , G01N33/15 , G01N33/53
CPC分类号： C40B40/02 , A61K39/00 , C07K14/195 , C07K14/31 , C07K16/1271 , C12N15/1037 , C12N15/1041 , C12Q1/6806 , C12Q2527/125 , C12Q2521/537
摘要： Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps: - providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - screening said at least one expression library with said antibody preparation, - identifying antigens which bind in said screening to antibodies in said antibody preparation, - screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - identifying the hyperimmune serum-reactive antigen portion of said identified antigens and which hyperimmune serum-reactive antigens bind to a relevant portion of said individual antibody preparations from said individual sera and - optionally isolating said hyperimmune serum-reactive antigens and producing said hyperimmune serum-reactive antigens by chemical or recombinant methods.
摘要翻译：描述了用于鉴定，分离和产生来自特异性病原体，肿瘤，变应原或易于自身免疫的组织或宿主的超免疫血清反应性抗原的方法，所述抗原适用于给定类型动物的疫苗其特征在于以下步骤： - 提供来自所述给定类型动物的血浆池或来自人血浆池或个体血清的抗体制剂，其具有抗所述特定病原体，肿瘤，变应原或组织或宿主的抗体易于自身免疫， - 提供至少一种易于自身免疫的所述特异性病原体，肿瘤，变应原或组织或宿主的表达文库， - 用所述抗体制剂筛选所述至少一种表达文库， - 鉴定结合于对所述抗体制剂中的抗体进行筛选， - 从具有抗体的个体的个体血清中筛选鉴别的抗原针对所述特异性病原体，肿瘤，变应原或易于自身免疫的组织或宿主， - 鉴定所述鉴定的抗原的超免疫血清反应性抗原部分，以及哪些超免疫血清反应性抗原与所述单个抗体制剂的相关部分结合所述个体血清和 - 任选地分离所述超免疫血清反应性抗原并通过化学或重组方法产生所述超免疫血清反应性抗原。

3. 发明申请

WO02059148A9 A METHOD FOR IDENTIFICATION, ISOLATION AND PRODUCTION OF ANTIGENS TO A SPECIFIC PATHOGEN 审中-公开
标题翻译：用于鉴定，分离和产生抗特异性病原体的方法
公开(公告)号：WO02059148A9
公开(公告)日：2002-10-31
申请号：PCT/EP0200546
申请日：2002-01-21
申请人： CISTEM BIOTECHNOLOGIES GMBH , MEINKE ANDREAS , NAGY ESZTER , AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
发明人： MEINKE ANDREAS , NAGY ESZTER , VON AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
IPC分类号： G01N33/50 , A61K39/00 , A61K39/39 , A61K39/395 , A61P31/10 , B64C9/02 , C07K14/195 , C07K14/31 , C07K16/12 , C12N15/02 , C12N15/09 , C12N15/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C40B40/02 , G01N33/15 , G01N33/53
CPC分类号： C40B40/02 , A61K39/00 , C07K14/195 , C07K14/31 , C07K16/1271 , C12N15/1037 , C12N15/1041 , C12Q1/6806 , C12Q2527/125 , C12Q2521/537
摘要： Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps: - providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - screening said at least one expression library with said antibody preparation, - identifying antigens which bind in said screening to antibodies in said antibody preparation, - screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - identifying the hyperimmune serum-reactive antigen portion of said identified antigens and which hyperimmune serum-reactive antigens bind to a relevant portion of said individual antibody preparations from said individual sera and - optionally isolating said hyperimmune serum-reactive antigens and producing said hyperimmune serum-reactive antigens by chemical or recombinant methods.
摘要翻译：描述了用于鉴定，分离和产生来自特异性病原体，肿瘤，变应原或易于自身免疫的组织或宿主的超免疫血清反应性抗原的方法，所述抗原适用于给定类型动物的疫苗其特征在于以下步骤： - 提供来自所述给定类型动物的血浆池或来自人血浆池或个体血清的抗体制剂，其具有抗所述特定病原体，肿瘤，变应原或组织或宿主的抗体易于自身免疫， - 提供至少一种易于自身免疫的所述特异性病原体，肿瘤，变应原或组织或宿主的表达文库， - 用所述抗体制剂筛选所述至少一种表达文库， - 鉴定结合于对所述抗体制剂中的抗体进行筛选， - 从具有抗体的个体的个体血清中筛选鉴别的抗原针对所述特异性病原体，肿瘤，变应原或易于自身免疫的组织或宿主， - 鉴定所述鉴定的抗原的超免疫血清反应性抗原部分，以及哪些超免疫血清反应性抗原与所述单个抗体制剂的相关部分结合所述个体血清和 - 任选地分离所述超免疫血清反应性抗原并通过化学或重组方法产生所述超免疫血清反应性抗原。

4. 发明申请

WO2004013166A3 S. AUREUS ANTIGENE 审中-公开
标题翻译： S.Aureus抗原
公开(公告)号：WO2004013166A3
公开(公告)日：2004-04-08
申请号：PCT/EP0307955
申请日：2003-07-22
申请人： INTERCELL AG , AHSEN UWE , SOELLNER JOHANNES , WEICHHART THOMAS , HAFNER MARTIN
发明人： VON AHSEN UWE , SOELLNER JOHANNES , WEICHHART THOMAS , HAFNER MARTIN
IPC分类号： A61K39/00 , C07K14/31 , A61K39/085 , C07K14/195
CPC分类号： C07K14/31 , A61K39/00
摘要： Described are novel antigens from S. aureus selected from the group consisting of Seq.ID.Nos. 7 to 12, as well as their use in a pharmaceutical preparation, especially in a vaccine.
摘要翻译：描述了来自金黄色葡萄球菌的新型抗原，其选自Seq.ID.Nos。 7至12，以及它们在药物制剂中的用途，特别是在疫苗中的用途。

5. 发明专利

JP2008291035A Method for identification, isolation and production of antigen to specific pathogen 有权
标题翻译：用于鉴定，分离和产生抗特异性病原体的方法
公开(公告)号：JP2008291035A
公开(公告)日：2008-12-04
申请号：JP2008152742
申请日：2008-06-11
申请人： Intercell Ag , インターツェル・アクチェンゲゼルシャフトIntercell Ag
发明人： MEINKE ANDREAS , NAGY ESZTER , VON AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
IPC分类号： C07K14/31 , G01N33/50 , A61K39/00 , A61K39/085 , A61K39/39 , A61K39/395 , A61K45/00 , A61P31/00 , A61P31/10 , B64C9/02 , C07K14/195 , C07K14/47 , C07K16/12 , C12N15/02 , C12N15/09 , C12N15/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C40B40/02 , G01N33/15 , G01N33/53
CPC分类号： C40B40/02 , A61K39/00 , C07K14/195 , C07K14/31 , C07K16/1271 , C12N15/1037 , C12N15/1041 , C12Q1/6806 , C12Q2527/125 , C12Q2521/537
摘要： PROBLEM TO BE SOLVED: To provide a method for identifying antigens effective to a given pathogen or preferably practically (clinically) relating almost complete set of all antigens of given pathogen. SOLUTION: Disclosed are hyperimmune serum-reactive antigens selected from a group comprising Staphylococcus aureus-originating specific sequences; the use of the antigens for production of pharmaceutical preparation; hyperimmune fragments of the antigens reactive to the hyperimmune serum; vaccines containing the antigens or the fragments; the preparation containing antibodies to the antigens or the fragments; a method for production of the preparation; and the use of the preparation for production of a pharmaceutical. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于鉴定对给定病原体有效的抗原或优选实际上（临床上）涉及给定病原体的几乎完整的所有抗原的方法。解决方案：公开了选自包含金黄色葡萄球菌起始特异性序列的组的超免疫血清反应性抗原; 使用抗原制备药物制剂; 对超免疫血清反应的抗原的超免疫片段; 含有抗原或片段的疫苗; 所述制剂含有针对抗原或片段的抗体; 制备方法; 以及使用制备药物的制剂。版权所有（C）2009，JPO＆INPIT

6. 发明专利

FI931018A0 未知
公开(公告)号：FI931018A0
公开(公告)日：1993-03-08
申请号：FI931018
申请日：1993-03-08
申请人： AHSEN UWE , DAVIES JULIAN , SCHROEDER RENEE
发明人： VON AHSEN UWE , DAVIES JULIAN , SCHROEDER RENEE
IPC分类号： A61K31/70 , A61P31/04 , C12N15/00 , C12P19/44

7. 发明申请

WO0192888A3 A METHOD FOR SCREENING AND ISOLATING MICROORGANISMS 审中-公开
标题翻译：一种筛选和分离微生物的方法
公开(公告)号：WO0192888A3
公开(公告)日：2002-07-04
申请号：PCT/EP0106123
申请日：2001-05-30
申请人： CISTEM BIOTECHNOLOGIES GMBH , HANNER MARKUS , HORKY MARKUS , VON GABAIN ALEXANDER , AHSEN UWE
发明人： HANNER MARKUS , HORKY MARKUS , VON GABAIN ALEXANDER , VON AHSEN UWE
IPC分类号： G01N33/569
CPC分类号： G01N33/569
摘要： Described is a method for screening an isolating microorganisms, especially prokaryotic and eukaryotic cells, displaying an antigen, which method is characterized by the following steps: providing a suspension of a multiplicity of viable microorganisms containing one or more microorganisms, especially prokaryotic and eukaryotic cells, displaying at least one type of antigen on their surface, contacting said suspension of microorganisms with a solution containing antibodies, which bind to said at least one type of antigen, incubating said suspension with said antibodies to allow binding of the antibodies to the antigen(s), contacting said suspension of microorganisms with antibody/antigen complexes on their surface with C1q molecules to allow binding of the C1q molecules to the surface located antibody/antigen complexes and isolating viable microorganisms, especially prokaryotic and eukaryotic cel ls, with exhibit C1q molecules bound to an antibody/antigen complex on their surface.
摘要翻译：描述了显示抗原的分离微生物，特别是原核和真核细胞的筛选方法，该方法的特征在于以下步骤：提供多种含有一种或多种微生物，特别是原核和真核细胞的活微生物的悬浮液，在其表面上显示至少一种类型的抗原，使所述微生物悬浮液与含有抗体的溶液接触，所述溶液与所述至少一种类型的抗原结合，将所述悬浮液与所述抗体一起孵育以使抗体与抗原结合），将微生物的悬浮液与其表面上的抗体/抗原复合物与C1q分子接触，以使C1q分子与表面定位的抗体/抗原复合物结合，并分离存活的微生物，特别是原核和真核细胞，并显示C1q分子结合表面上的抗体/抗原复合物。

8. 发明专利

FI931018A 未知
公开(公告)号：FI931018A
公开(公告)日：1993-04-06
申请号：FI931018
申请日：1993-03-08
申请人： AHSEN UWE , DAVIES JULIAN , SCHROEDER RENEE
发明人： VON AHSEN UWE , DAVIES JULIAN , SCHROEDER RENEE
IPC分类号： A61K31/70 , A61P31/04 , C12N15/00 , C12P19/44

9. 发明专利

CA2091264A1 USE OF A 2-DEOXYSTREPTAMINE-TYPE ANTIBIOTIC 未知
公开(公告)号：CA2091264A1
公开(公告)日：1993-01-10
申请号：CA2091264
申请日：1992-07-08
申请人： AHSEN UWE , DAVIES JULIAN , SCHROEDER RENEE
发明人： VON AHSEN UWE , DAVIES JULIAN , SCHROEDER RENEE
IPC分类号： A61K31/70 , A61P31/04 , C12N15/00 , C12P19/44
摘要： 2091264 9300907 PCTABS00019 The invention relates to the use of an antibiotic of the 2-deoxystreptamine type, especially a 4,6 or 4,5 2-deoxystreptamine substituted with amino sugars, to inhibit the growth of organisms containing group I introns, especially in a process for making a medicament.

10. 发明专利

AT309268T 未知
公开(公告)号：AT309268T
公开(公告)日：2005-11-15
申请号：AT02716669
申请日：2002-01-21
申请人： INTERCELL AG
发明人： MEINKE ANDREAS , NAGY ESZTER , VON AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
IPC分类号： G01N33/50 , A61K39/00 , A61K39/39 , A61K39/395 , A61P31/10 , B64C9/02 , C07K14/195 , C07K14/31 , C07K16/12 , C12N15/02 , C12N15/09 , C12N15/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/6806 , C40B40/02 , G01N33/15 , G01N33/53
摘要： Described are hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans.

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