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    • 1. 发明申请
    • BORRELIA ANTIGENS
    • BORRELIA抗原
    • WO2008031133A2
    • 2008-03-20
    • PCT/AT2007/000439
    • 2007-09-14
    • INTERCELL AGLUNDBERG, UrbanMEINKE, AndreasNAGY, EszterVON GABAIN, AlexanderNOIGES, BirgitGELBMANN, DieterPOLJAK, AlbinaTRISKA, Christine
    • LUNDBERG, UrbanMEINKE, AndreasNAGY, EszterVON GABAIN, AlexanderNOIGES, BirgitGELBMANN, DieterPOLJAK, AlbinaTRISKA, Christine
    • C07K14/20
    • C07K7/08A61K39/00A61K2039/53C07K7/06C07K14/20Y02A50/401
    • The present invention relates to isolated nucleic acid molecules which encode a protein, isolated nucleic acid molecules which encode a hyperimmune serum reactive antigen, a vector which comprises such nucleic acid molecule, a host cell comprising such vector, a hyperimmune reactive antigen from Borrelia species, proteins which are preferably hyperimmune serum reactive antigens, hyperimmune serum reactive antigens, antigens, a process for producing such proteins, hyperimmune serum reactive antigens or antigens, a process for producing a cell which expresses such protein, hyperimmune serum reactive antigen or antigen, an antibody binding to such protein, hyperimmune serum reactive antigen or antigen, a hybridoma cell producing such antibody, methods for producing such antibody, a pharmaceutical composition comprising such nucleic acid molecule, protein, hyperimmune serum reactive antigen, antigen or antibody, the use of such nucleic acid molecule, protein, hyperimmune serum reactive antigen, antigen or antibody for the manufacture of a medicament, methods for identifying an antagonist capable of reducing or inhibiting the interaction activity of such protein, hyperimmune serum reactive antigen or antigen, methods for diagnosing an infection and methods for the treatment of an infection. More specifically such proteins, hyperimmune serum reactive antigens or antigens are produced by or associated with bacterial pathogens causing Lyme disease or bacterial infections caused by Borrelia burgdorferi s.l.
    • 本发明涉及编码蛋白质的分离的核酸分子,编码超免疫血清反应性抗原的分离的核酸分子,包含该核酸分子的载体,包含该载体的宿主细胞,来自疏螺旋体属物种的超免疫反应性抗原, 优选为超免疫血清反应性抗原的蛋白质,超免疫血清反应性抗原,抗原,制备此类蛋白质的方法,超免疫血清反应性抗原或抗原,生产表达此类蛋白质的细胞的方法,超免疫血清反应性抗原或抗原,抗体 结合这种蛋白质,超免疫血清反应性抗原或抗原,产生此类抗体的杂交瘤细胞,产生此类抗体的方法,包含该核酸分子,蛋白质,超免疫血清反应性抗原,抗原或抗体的药物组合物,使用此类核酸 酸分子,蛋白质,超免疫血清反应蚂蚁 用于制备药物的抗原,抗原或抗体,用于鉴定能够降低或抑制这种蛋白质,超免疫血清反应性抗原或抗原的相互作用活性的拮抗剂的方法,用于诊断感染的方法和用于治疗感染的方法。 更具体地,这种蛋白质,超免疫血清反应性抗原或抗原由细菌病原体产生或与细菌病原体相关,引起莱姆病或由布氏疏螺旋体引起的细菌感染。
    • 3. 发明公开
    • BORRELIA ANTIGENS
    • 疏螺旋体抗原
    • EP2059526A2
    • 2009-05-20
    • EP07815120.6
    • 2007-09-14
    • Intercell AG
    • LUNDBERG, UrbanMEINKE, AndreasNAGY, EszterVON GABAIN, AlexanderNOIGES, BirgitGELBMANN, DieterPOLJAK, AlbinaTRISKA, Christine
    • C07K14/20
    • C07K7/08A61K39/00A61K2039/53C07K7/06C07K14/20Y02A50/401
    • The present invention relates to isolated nucleic acid molecules which encode a protein, isolated nucleic acid molecules which encode a hyperimmune serum reactive antigen, a vector which comprises such nucleic acid molecule, a host cell comprising such vector, a hyperimmune reactive antigen from Borrelia species, proteins which are preferably hyperimmune serum reactive antigens, hyperimmune serum reactive antigens, antigens, a process for producing such proteins, hyperimmune serum reactive antigens or antigens, a process for producing a cell which expresses such protein, hyperimmune serum reactive antigen or antigen, an antibody binding to such protein, hyperimmune serum reactive antigen or antigen, a hybridoma cell producing such antibody, methods for producing such antibody, a pharmaceutical composition comprising such nucleic acid molecule, protein, hyperimmune serum reactive antigen, antigen or antibody, the use of such nucleic acid molecule, protein, hyperimmune serum reactive antigen, antigen or antibody for the manufacture of a medicament, methods for identifying an antagonist capable of reducing or inhibiting the interaction activity of such protein, hyperimmune serum reactive antigen or antigen, methods for diagnosing an infection and methods for the treatment of an infection. More specifically such proteins, hyperimmune serum reactive antigens or antigens are produced by or associated with bacterial pathogens causing Lyme disease or bacterial infections caused by Borrelia burgdorferi s.1.