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1. 发明申请

WO2012024658A3 INTEGRATED ANALYSIS SYSTEM 审中-公开
标题翻译：综合分析系统
公开(公告)号：WO2012024658A3
公开(公告)日：2012-05-31
申请号：PCT/US2011048528
申请日：2011-08-20
申请人： INTEGENX INC , JOVANOVICH STEVAN B , STERN SETH , VAN GELDER EZRA , VANGBO MATTIAS
发明人： JOVANOVICH STEVAN B , STERN SETH , VAN GELDER EZRA , VANGBO MATTIAS
IPC分类号： C12Q1/70 , B01F3/00 , B01J19/00 , G01N1/00
CPC分类号： B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
摘要： The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
摘要翻译：本发明提供用于执行综合分析的系统，设备，方法和套件。综合分析可以包括样品处理，库构建，扩增和测序。集成分析可以在一个或多个流体连接的模块中进行。一个或多个模块可以由计算机控制和/或自动化。可以对组织样品，临床样品或环境样品进行综合分析。集成分析系统可以具有紧凑的格式，并在指定的时间段内返回结果。

2. 发明申请

WO2013028643A8 PREPARATION OF POLYNUCLEOTIDES ON A SOLID SUBSTRATE FOR SEQUENCING 审中-公开
标题翻译：用于测序的固体基底上的多核苷酸的制备
公开(公告)号：WO2013028643A8
公开(公告)日：2013-04-25
申请号：PCT/US2012051632
申请日：2012-08-20
申请人： INTEGENX INC , TANNER MICHAEL , JOVANOVICH STEVAN B , VAN GELDER EZRA , HARRIS DENNIS , PARK CHARLES , STERN SETH
发明人： TANNER MICHAEL , JOVANOVICH STEVAN B , VAN GELDER EZRA , HARRIS DENNIS , PARK CHARLES , STERN SETH
IPC分类号： C07H21/04 , C40B30/04
CPC分类号： C07C49/753 , C12Q1/6855 , C12Q2521/507 , C12Q2535/122 , C12Q2565/543
摘要： The present invention provides methods and devices for performing nucleic acid amplification and sequencing on a solid substrate (e.g., a flow cell), including preparation of libraries of amplified DNA fragments for massively parallel (next-generation) sequencing.
摘要翻译：本发明提供用于在固体底物（例如流动池）上进行核酸扩增和测序的方法和装置，包括制备用于大规模并行（下一代）测序的扩增的DNA片段的文库。

3. 发明申请

WO2011150232A3 CAPILLARY ELECTROPHORESIS DEVICE 审中-公开
标题翻译：毛细管电泳装置
公开(公告)号：WO2011150232A3
公开(公告)日：2012-01-19
申请号：PCT/US2011038180
申请日：2011-05-26
申请人： INTEGENX INC , MAJLOF LARS , VAN GELDER EZRA
发明人： MAJLOF LARS , VAN GELDER EZRA
IPC分类号： B01D57/02
CPC分类号： G01N27/44708
摘要： A capillary electrophoresis device includes capillaries are thermally regulated on a thermally responsive electrical path attached to an electrically insulating circuit board. An optical scanner scans an array of capillaries. A laser, optical detector and optical selector are in an arrangement that allows the optical detector to selectively detect an optical signal from anyone or more of the plurality of electrophoresis capillaries.
摘要翻译：一种毛细管电泳装置，其包括毛细管，其在连接到电绝缘电路板的热响应电路上进行热调节。光学扫描仪扫描毛细管阵列。激光器，光学检测器和光学选择器处于允许光学检测器选择性地检测来自多个电泳毛细管中的任何一个或多个的光学信号的布置。

4. 发明专利

SG176669A1 UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 未知
公开(公告)号：SG176669A1
公开(公告)日：2012-01-30
申请号：SG2011089737
申请日：2010-06-04
申请人： INTEGENX INC
发明人： JOVANOVICH STEVAN B , NIELSEN WILLIAM D , COHEN DAVID S , RECKNOR MICHAEL , VANGBO MATTIAS , VAN GELDER EZRA , MAJLOF LARS , EL-SISSI OMAR
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3, and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.

5. 发明专利

AU2010256429B2 Universal sample preparation system and use in an integrated analysis system 未知
公开(公告)号：AU2010256429B2
公开(公告)日：2015-09-17
申请号：AU2010256429
申请日：2010-06-04
申请人： INTEGENX INC
发明人： JOVANOVICH STEVAN B , NIELSEN WILLIAM D , COHEN DAVID S , RECKNOR MICHAEL , VANGBO MATTIAS , VAN GELDER EZRA , MAJLOF LARS , EL-SISSI OMAR
IPC分类号： C02F1/40
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post- reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft

6. 发明专利

RU2559541C2 УНИВЕРСАЛЬНАЯ СИСТЕМА ПОДГОТОВКИ ОБРАЗЦОВ И ПРИМЕНЕНИЕ В ИНТЕГРИРОВАННОЙ СИСТЕМЕ АНАЛИЗА 未知
公开(公告)号：RU2559541C2
公开(公告)日：2015-08-10
申请号：RU2011151794
申请日：2010-06-04
申请人： INTEGENX INC
发明人： JOVANOVICH STEVAN B , NIELSEN WILLIAM D , CONET DAVID S , RECKNOR MICHAEL , VANGBO MATTIAS , VAN GELDER EZRA , MAJLOF LARS , EL-SISSI OMAR
IPC分类号： C12M1/18 , B01J19/00 , C12M1/42 , C12Q1/68 , G01N1/02 , G01N27/74 , G01N35/08 , G01N35/10
摘要： Изобретениеотноситсяк областибиотехнологии. Системасостоитизследующихэлементов: а) модуляподготовкиобразца, выполненногос возможностьюзахватааналитаизбиологическогообразцав немикрожидкостномобъеменазахватывающейчастице, реагирующейнамагнитноеполе, инаправлениясвязаннойс аналитомзахватывающейчастицы, реагирующейнамагнитноеполе, черезпервыймикрожидкостныйканал; б) реакционногомодуля, включающегореакционнуюкамеру, имеющуюжидкостноесообщениес первыммикрожидкостнымканалом, ивыполненногос возможностьюиммобилизациисвязаннойс аналитомзахватывающейчастицы, реагирующейнамагнитноеполе, ипроведенияреакцииамплификациимножества STR-маркерованалита. Приэтоммодульподготовкиобразцаи реакционныймодульинтегрированыв одноразовыйкартридж, которыйсостоитиз: 1) поменьшеймереоднойсовокупностижидкостныхкамер, 2) платыс реагентамииликартриджас реагентамии 3) одногоилиболеечемодногопневматическиактивируемого MOVe-клапана; в) модуляанализа. Причемсистемасконфигурированадлязахватааналита, дляпроведенияхимическойилибиохимическойреакциис аналитоми дляпроведенияанализапродуктареакциименеечемза 4 часа. Засчетиспользованияв даннойсистеме MOVe-клапановосуществляетсяпереностекучихсредств, устойчивыйк утечкам, ипоявляетсявозможностьуменьшитьразмерыустройствадляподготовкиобразцов. Такжес помощьюданнойсистемыможноотбиратьорганизмымишениизобразцовс большимколичествомфоновыхпримесей, различатьдваразныхштаммабактерий, эффективнозахватыватьклеткии токсины, значительноуменьшитьобъемцелевогообразца. 1 н

7. 发明专利

CA2764464A1 UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 未知
公开(公告)号：CA2764464A1
公开(公告)日：2010-12-09
申请号：CA2764464
申请日：2010-06-04
申请人： INTEGENX INC
发明人： JOVANOVICH STEVAN B , NIELSEN WILLIAM D , COHEN DAVID S , RECKNOR MICHAEL , VANGBO MATTIAS , VAN GELDER EZRA , MAJLOF LARS , EL-SISSI OMAR
IPC分类号： C02F1/40 , C12M1/34 , C12M1/38 , C12N15/10 , C12Q1/68 , G01J3/12 , G01J3/443 , G01N1/00 , G01N21/01 , G01N27/447
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post- reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3, and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.

8. 发明公开

EP2606154A4 INTEGRATED ANALYSIS SYSTEM 有权
标题翻译：综合分析系统
公开(公告)号：EP2606154A4
公开(公告)日：2016-07-20
申请号：EP11818879
申请日：2011-08-20
申请人： INTEGENX INC
发明人： JOVANOVICH STEVAN B , STERN SETH , VAN GELDER EZRA , VANGBO MATTIAS
IPC分类号： C12Q1/70 , B01F3/00 , B01J19/00 , G01N1/00
CPC分类号： B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
摘要： The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.

9. 发明公开

EP2576022A4 CAPILLARY ELECTROPHORESIS DEVICE 有权
标题翻译：毛细管电泳器件
公开(公告)号：EP2576022A4
公开(公告)日：2014-07-09
申请号：EP11787428
申请日：2011-05-26
申请人： INTEGENX INC
发明人： MAJLOF LARS , VAN GELDER EZRA
IPC分类号： B01D57/02 , G01N27/447
CPC分类号： G01N27/44708
摘要： This invention provides a capillary electrophoresis device in which capillaries are thermally regulated on a thermally responsive electrical path attached to an electrically insulating circuit board. This invention also provides an optical scanner useful for scanning an array of capillaries. A laser, optical detector and optical selector are in an arrangement that allows the optical detector to selectively detect an optical signal from any one or more of the plurality of electrophoresis capillaries.

10. 发明公开

EP2438016A4 UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 有权
标题翻译：在EINEM INTEGRIERTEN ANALYSESTEMTEM中的新西兰维也纳大学的研究人员
公开(公告)号：EP2438016A4
公开(公告)日：2013-10-09
申请号：EP10784213
申请日：2010-06-04
申请人： INTEGENX INC
发明人： JOVANOVICH STEVAN B , NIELSEN WILLIAM D , COHEN DAVID S , RECKNOR MICHAEL , VANGBO MATTIAS , VAN GELDER EZRA , MAJLOF LARS , EL-SISSI OMAR
IPC分类号： C02F1/40 , G01N35/00
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
摘要翻译：本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。在某些实施例中，系统包括用于执行分析物捕获的一次性盒。墨盒可以包括流体歧管，其具有与微流体芯片配合的宏流体室，所述微流体芯片在腔室之间引导液体。该系统适合不超过10英尺3的外壳。并且可以是封闭的，便携式的和/或电池供电的系统。该系统可以在不到4小时内从原始样品进行分析。

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