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1. 发明申请

WO2011117847A1 METHOD TO INCREASE THE NUMBER OF DETECTABLE PHOTONS DURING THE IMAGING OF A BIOLOGICAL MARKER 审中-公开
标题翻译：提高生物标志物成像过程中检测到的光子数量的方法
公开(公告)号：WO2011117847A1
公开(公告)日：2011-09-29
申请号：PCT/IB2011/051282
申请日：2011-03-25
申请人： INSTITUT PASTEUR , ROGERS, Kelly , SHORTE, Spencer L. , DRAGAVON, Joseph , BLAZQUEZ, Samantha
发明人： ROGERS, Kelly , SHORTE, Spencer L. , DRAGAVON, Joseph , BLAZQUEZ, Samantha
IPC分类号： G01N21/64 , B82Y15/00
CPC分类号： G01N21/6486 , B82Y15/00 , G01N21/6428 , G01N2201/06193
摘要： The present invention relates a method to determine the presence of a photon producing biological marker in a cell, tissue or organism of interest. The method is based on Fluorescence by Unbound Excitation from Luminescence (FUEL) and comprises the steps of a) providing conditions suitable for the biological marker to produce at least one first photon by luminescence; b) providing a FUEL probe pair-upper (FPP-U) disposed in proximity to the cell, tissue or organism, wherein the at least one first photon of step a) excites the FPP-U, which emits at least one second photon. The FPP-U may be selected from the group of quantum dots, carbon nanotubes, fluorescent proteins, diamond nanocrystals and metalloporphyrins. This method is charcterized in that said biological marker and said FPP-U are not bound and in that each of the at least one second photon (s) are of a longer wavelength than each of the at least one first photon (s).
摘要翻译：本发明涉及确定感兴趣的细胞，组织或生物中产生光子的生物标志物的存在的方法。该方法基于来自发光的未结合激发的荧光（FUEL），并且包括以下步骤：a）提供适于生物标志物通过发光产生至少一个第一光子的条件; b）提供布置在细胞，组织或生物体附近的FUEL探针对（FPP-U），其中步骤a）的至少一个第一光子激发发射至少一个第二光子的FPP-U。 FPP-U可以选自量子点，碳纳米管，荧光蛋白，金刚石纳米晶体和金属卟啉。该方法的特征在于，所述生物学标记和所述FPP-U没有结合，并且至少一个第二光子中的每一个具有比所述至少一个第一光子中的每一个更长的波长。 / p>

2. 发明授权

EP2553431B1 METHOD TO INCREASE THE NUMBER OF DETECTABLE PHOTONS DURING THE IMAGING OF A BIOLOGICAL MARKER 有权
标题翻译：提高生物标志物成像过程中检测到的光子数量的方法
公开(公告)号：EP2553431B1
公开(公告)日：2017-05-10
申请号：EP11722878.3
申请日：2011-03-25
申请人： Institut Pasteur
发明人： ROGERS, Kelly , SHORTE, Spencer L. , DRAGAVON, Joseph , BLAZQUEZ, Samantha
IPC分类号： G01N21/64 , B82Y15/00
CPC分类号： G01N21/6486 , B82Y15/00 , G01N21/6428 , G01N2201/06193

3. 发明公开

EP2553431A1 METHOD TO INCREASE THE NUMBER OF DETECTABLE PHOTONS DURING THE IMAGING OF A BIOLOGICAL MARKER 有权
标题翻译：法提高检测的光子的数量的生物标记物的过程中PICTURE
公开(公告)号：EP2553431A1
公开(公告)日：2013-02-06
申请号：EP11722878.3
申请日：2011-03-25
申请人： Institut Pasteur
发明人： ROGERS, Kelly , SHORTE, Spencer L. , DRAGAVON, Joseph , BLAZQUEZ, Samantha
IPC分类号： G01N21/64 , B82Y15/00
CPC分类号： G01N21/6486 , B82Y15/00 , G01N21/6428 , G01N2201/06193
摘要： The present invention relates a method to determine the presence of a photon producing biological marker in a cell, tissue or organism of interest. The method is based on Fluorescence by Unbound Excitation from Luminescence (FUEL) and comprises the steps of a) providing conditions suitable for the biological marker to produce at least one first photon by luminescence; b) providing a FUEL probe pair-upper (FPP-U) disposed in proximity to the cell, tissue or organism, wherein the at least one first photon of step a) excites the FPP-U, which emits at least one second photon. The FPP-U may be selected from the group of quantum dots, carbon nanotubes, fluorescent proteins, diamond nanocrystals and metalloporphyrins. This method is charcterized in that said biological marker and said FPP-U are not bound and in that each of the at least one second photon (s) are of a longer wavelength than each of the at least one first photon (s).
摘要翻译：本发明涉及到确定性挖掘的光子在细胞，组织或感兴趣的生物体生产生物标志物的存在的方法。该方法是基于从发光（燃料）由未结合的激发荧光和包括以下步骤：a）提供的条件适合于生物标志物，以产生由发光b。至少一个第一光子）提供燃料探针对的高位（FPP-U ），其设置在接近所述细胞，组织或生物体，worin步骤的至少一个第一光子一）激发FPP-U，其发射至少一个第二光子。在FPP-U可以从组量子点，碳纳米管，荧光蛋白，金刚石纳米晶体，和金属卟啉中选择。该方法在这所述生物标志物为特征的和Said FPP-U不结合和中那样每个所述至少一个第二个光子（S）的比所述至少一个第一光子（S）的较长波长的。

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