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1. 发明申请

WO1997030159A2 RECOMBINANT PROTEIN CONTAINING A C-TERMINAL FRAGMENT OF PLASMODIUM MSP-1 审中-公开
标题翻译：含有MSP-1的C末端片段的重组蛋白
公开(公告)号：WO1997030159A2
公开(公告)日：1997-08-21
申请号：PCT/FR1997000291
申请日：1997-02-14
申请人： INSTITUT PASTEUR , NEW YORK UNIVERSITY , LONGACRE-ANDRE, Shirley , ROTH, Charles , NATO, Faridabano , BARNWELL, John, W. , MENDIS, Kamini
发明人： INSTITUT PASTEUR , NEW YORK UNIVERSITY
IPC分类号： C12N15/30
CPC分类号： C07K14/445 , A61K39/00 , C07K16/205 , C12N2799/026 , Y02A50/412
摘要： The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 42 kilodaltons (p42) of the surface protein 1 (protein MSP-1) of the merozoite form of a parasite of the Plasmodium type, particularly Plasmodium falciparum, which is infectious for humans, said p42 fragment being particularly deleted of its region II and, if necessary, also of its region III. Said recombinant protein is applicable to the production of vaccines against malaria.
摘要翻译：本发明涉及在杆状病毒系统中制备的重组蛋白质，其主要组成型多肽序列是裂殖子形式的表面蛋白1（蛋白质MSP-1）的42千道尔顿（p42）的C-末端片段疟原虫类型的寄生虫，特别是对人感染的恶性疟原虫，所述p42片段特别缺失其II区，如果需要，也是其区域III。所述重组蛋白适用于生产针对疟疾的疫苗。

2. 发明申请

WO1997030158A3 RECOMBINANT PROTEIN CONTAINING A C-TERMINAL FRAGMENT OF PLASMODIUM MSP-1 审中-公开
公开(公告)号：WO1997030158A3
公开(公告)日：1997-08-21
申请号：PCT/FR1997000290
申请日：1997-02-14
申请人： INSTITUT PASTEUR , NEW YORK UNIVERSITY , LONGACRE-ANDRE, Shirley , ROTH, Charles , NATO, Faridabano , BARNWELL, John, W. , MENDIS, Kamini
发明人： INSTITUT PASTEUR , NEW YORK UNIVERSITY
IPC分类号： C12N15/30

3. 发明申请

WO1990011772A1 MEROZOITE ANTIGENS LOCALIZED AT THE APICAL END OF THE PARASITE 审中-公开
标题翻译：本地化的天然抗氧化剂的天然抗菌剂
公开(公告)号：WO1990011772A1
公开(公告)日：1990-10-18
申请号：PCT/US1990001849
申请日：1990-04-03
申请人： NEW YORK UNIVERSITY , BARNWELL, John, W. , GALINSKI, Mary, R. , WERTHEIMER, Samuel, P.
发明人： NEW YORK UNIVERSITY
IPC分类号： A61K37/04
CPC分类号： C07K16/205 , A61K38/00 , A61K39/00 , C07K14/445 , C07K2319/00 , C07K2319/40 , Y02A50/412
摘要： Disclosed are compounds comprising an amino acid sequence selected from the group consisting of malarial merozoite proteins located at the apical end of merozoites and peptides the peptides comprising synthetic versions, derivatives, analogs and fragments of the merozoite proteins. Certain of these compounds have the property of binding to a Duffy blood group antigen from primate red blood cells. Disclosed are also nucleic acids comprising a nucleotide sequence encoding such peptides or proteins and nucleic acids hybridizing therewith. The compounds and antibodies recognizing these compounds are useful in inhibiting invasion of susceptible primate red blood cells by malarial merozoites.
摘要翻译：公开了包含选自位于裂殖子的顶端的疟疾裂殖子蛋白质的氨基酸序列的化合物和肽，其包含裂殖子蛋白的合成形式，衍生物，类似物和片段。这些化合物中的某些具有与灵长类红细胞结合的Duffy血型抗原的性质。还公开了包含编码这样的肽或蛋白质的核苷酸序列和与其杂交的核酸的核酸。识别这些化合物的化合物和抗体可用于抑制疟疾裂殖子对敏感的灵长类红细胞的侵袭。

4. 发明申请

WO1998003657A1 VIRAL INTERLEUKIN-6 审中-公开
公开(公告)号：WO1998003657A1
公开(公告)日：1998-01-29
申请号：PCT/EP1996003199
申请日：1996-07-19
申请人： BEHRING DIAGNOSTICS GMBH , NEW YORK UNIVERSITY , FLECKENSTEIN, Bernhard , ALBRECHT, Jens-Christian , NEIPEL, Frank , FRIEDMAN-KIEN, Alvin , HUANG, Yao-Qi
发明人： BEHRING DIAGNOSTICS GMBH , NEW YORK UNIVERSITY
IPC分类号： C12N15/33
CPC分类号： C07K14/005 , A61K38/00 , C07K14/5412 , C07K16/085 , C12N2710/16422 , C12N2710/16622 , G01N33/6869
摘要： The present invention relates to viral interleukin-6 (v-IL-6), which can be obtained by recombinant expression of the DNA of human herpesvirus type 8 (HHV-8), and which may be used in diagnosis and treatment of human diseases such as kaposi sarcoma, Castleman's disease, multiple myeloma, kidney cell carcinoma, mesangial proliferative glomerulonephritis or B cell lymphoma.
摘要翻译：本发明涉及通过重组表达人疱疹病毒8型（HHV-8）的DNA获得的病毒白细胞介素-6（v-IL-6），其可用于人类疾病的诊断和治疗如卡波西肉瘤，卡斯尔曼氏病，多发性骨髓瘤，肾细胞癌，肾小球膜增生性肾小球性肾炎或B细胞淋巴瘤。

5. 发明申请

WO1997041142A1 NANOCONSTRUCTIONS OF GEOMETRICAL OBJECTS AND LATTICES FROM ANTIPARALLEL NUCLEIC ACID DOUBLE CROSSOVER MOLECULES 审中-公开
标题翻译：几何核酸双歧杆菌分子的几何对象和细胞的纳米结构
公开(公告)号：WO1997041142A1
公开(公告)日：1997-11-06
申请号：PCT/US1997007041
申请日：1997-04-28
申请人： NEW YORK UNIVERSITY
发明人： NEW YORK UNIVERSITY , SEEMAN, Nadrian , LI, Xiaojun , YANG, Xiaoping , QI, Jing
IPC分类号： C07H21/02
CPC分类号： C12N15/1031 , C07H21/02 , C07H21/04 , Y10S977/792 , Y10S977/793 , Y10S977/795 , Y10S977/898
摘要： Two- and three-dimensional polynucleic acid structures, such as periodic lattices, may be constructed from an ordered array of antiparallel double crossover molecules assembled from single stranded oligonucleotides or polynucleotides. These antiparallel double crossover molecules have the structural rigidity necessary to serve as building block components for two- and three-dimensional structures having the high translational symmetry associated with crystals.
摘要翻译：可以从由单链寡核苷酸或多核苷酸组装的反向平行双交换分子的有序阵列构建二维和三维多核酸结构，例如周期性晶格。这些反向平行双交叉分子具有必要的结构刚性，用作具有与晶体相关的高翻译对称性的二维和三维结构的结构单元组分。

6. 发明申请

WO1997035018A1 GROWTH FACTOR INDUCIBLE SERINE/THREONINE PHOSPHATASE FIN13 审中-公开
标题翻译：生长因子诱导丝氨酸/磷酸肌磷酸酶FIN13
公开(公告)号：WO1997035018A1
公开(公告)日：1997-09-25
申请号：PCT/US1997005075
申请日：1997-03-21
申请人： NEW YORK UNIVERSITY
发明人： NEW YORK UNIVERSITY , GUTHRIDGE, Mark, A. , BASILICO, Claudio
IPC分类号： C12N15/55
CPC分类号： C07H21/00 , A61K38/00 , A61K48/00 , A61K2039/51 , C07K2319/00 , C12N9/16 , C12N2799/021 , C12N2799/022 , C12N2799/027 , C12N2799/028
摘要： A serine/threonine, FIN13, which includes a collagen-homology domain, an acidic box domain, a catalytic domain, and a putative nuclear translocation sequence. The present invention further relates to the modulation of cellular proliferation, by regulating the activity of the novel serine/threonine phosphatase. Thus, the invention provides the phosphatase, nucleic acids encoding the phosphatase, oligonucleotides specific for such nucleic acids, antibodies to the phosphatase, and method for increasing (or decreasing) the activity of the phosphatase to inhibit (or enhance) cellular proliferation and, thus, tissue growth. Various diagnostic and therapeutic aspects of the invention particularly relate to detection and treatment of hyperproliferative disorders, neoplasms, and tumors. In specific examples, FIN13 is expressed in proliferating cells, notably germ cells of the testes. Increased levels of expression of FIN13 in transfected cells results in a decrease in the cell growth rate.
摘要翻译：丝氨酸/苏氨酸FIN13，其包括胶原同源结构域，酸性盒结构域，催化结构域和推定的核易位序列。本发明还涉及通过调节新型丝氨酸/苏氨酸磷酸酶的活性来调节细胞增殖。因此，本发明提供磷酸酶，编码磷酸酶的核酸，对这种核酸特异性的寡核苷酸，对磷酸酶的抗体，以及增加（或降低）磷酸酶活性以抑制（或增强）细胞增殖的方法，因此，组织生长。本发明的各种诊断和治疗方面特别涉及过度增殖性疾病，肿瘤和肿瘤的检测和治疗。在具体实例中，FIN13在增殖细胞中表达，特别是睾丸的生殖细胞。转染细胞中FIN13的表达水平升高导致细胞生长速率降低。

7. 发明申请

WO1997028838A1 METHOD AND APPARATUS FOR OPTIMIZING THE CONTINUOUS POSITIVE AIRWAY PRESSURE FOR TREATING OBSTRUCTIVE SLEEP APNEA 审中-公开
标题翻译：用于优化连续积极空气压力的方法和装置，用于治疗阻塞性睡眠APNEA
公开(公告)号：WO1997028838A1
公开(公告)日：1997-08-14
申请号：PCT/US1997001718
申请日：1997-02-11
申请人： NEW YORK UNIVERSITY
发明人： NEW YORK UNIVERSITY , RAPOPORT, David, M. , NORMAN, Robert, G.
IPC分类号： A61M16/00
CPC分类号： A61B5/0002 , A61B5/4818 , A61B5/6803 , A61B5/7239 , A61M16/0069 , A61M16/026 , A61M16/0677 , A61M39/228 , A61M2016/0036 , A61M2016/0039 , A61M2230/04 , A61M2230/08 , A61M2230/205 , A61M2230/62 , A61M2230/005
摘要： For the treatment of apnea, a method and apparatus are disclosed. The preferred breathing apparatus consists of an analog to digital converter (118), microprocessor (110), a patient supply hose (108), a nose fitting (102), and a pressure transducer (104).
摘要翻译：为了治疗呼吸暂停，公开了一种方法和装置。优选的呼吸器由模数转换器（118），微处理器（110），患者供应软管（108），鼻配件（102）和压力传感器（104）组成。

8. 发明申请

WO1996029614A1 OPEN PERMANENT MAGNET STRUCTURE FOR GENERATING HIGHLY UNIFORM FIELD 审中-公开
标题翻译：开放用于产生高均匀场的永磁体结构
公开(公告)号：WO1996029614A1
公开(公告)日：1996-09-26
申请号：PCT/US1996003358
申请日：1996-03-12
申请人： NEW YORK UNIVERSITY
发明人： NEW YORK UNIVERSITY , ABELE, Manlio, G. , RUSINEK, Henry , JENSEN, Jens
IPC分类号： G01V03/00
CPC分类号： G01R33/3873 , G01R33/3806 , G01R33/383
摘要： A hybrid permanent magnet structure (71) for providing a uniform magnetic field within a region of interest while allowing access via open ends by a patient for NMR scanning and by a surgeon to the patient via a large opening (56) at the top. The magnet structure comprises nested inner and outer magnetic structures separated by ferromagnetic material and surrounded by a ferromagnetic yoke (70). The inner magnetic sections comprise end blocks of triangular cross section (64, 66), and the outer magnetic sections comprise end blocks of trapezoidal cross section (65, 67, 68). Field distortion compensating means is provided by a primary filter structure to the ferromagnetic material and by magnetic insertions or a secondary filter structure.
摘要翻译：一种混合永磁体结构（71），用于在感兴趣的区域内提供均匀的磁场，同时通过开放端通过患者进行NMR扫描，并且外科医生通过顶部的大开口（56）向患者提供。磁体结构包括由铁磁材料分隔并被铁磁轭（70）包围的嵌套的内和外磁结构。内磁性部分包括三角形横截面（64,66）的端块，并且外磁性部分包括梯形横截面（65,67,68）的端块。场失真补偿装置由初级过滤器结构提供给铁磁材料，并通过磁性插入或次级过滤器结构提供。

9. 发明申请

WO1996018738A2 PROBIN TYROSINE KINASE (PYK2) ITS cDNA CLONING AND ITS USES 审中-公开
标题翻译： PROBIN TYROSINE KINASE（PYK2）ITS cDNA克隆及其用途
公开(公告)号：WO1996018738A2
公开(公告)日：1996-06-20
申请号：PCT/US1995015846
申请日：1995-12-06
申请人： SUGEN, INC. , NEW YORK UNIVERSITY
发明人： SUGEN, INC. , NEW YORK UNIVERSITY , LEV, Sima , SCHLESSINGER, Joseph
IPC分类号： C12N15/54
CPC分类号： C12N9/1205
摘要： The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a PYK2 protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a PYK2 protein.
摘要翻译：本发明的特征在于一种具有特征在于信号转导途径异常的疾病或病症的生物体的方法，其中所述信号转导途径包括PYK2蛋白。本发明还具有用于诊断这些疾病和筛选可用于治疗这些疾病的药剂的方法。本发明还具有编码PYK2蛋白质的纯化和/或分离的核酸。

10. 发明申请

WO1996007731A1 METHOD FOR DELIVERY OF NUCLEIC ACIDS TO CELLS USING HYPERICIN POLYAMINE COMPLEXES 审中-公开
标题翻译：使用高分子聚氨酯复合物将核酸递送到细胞的方法
公开(公告)号：WO1996007731A1
公开(公告)日：1996-03-14
申请号：PCT/US1995011709
申请日：1995-09-05
申请人： NEW YORK UNIVERSITY , NEW YORK BLOOD CENTER
发明人： NEW YORK UNIVERSITY , NEW YORK BLOOD CENTER , LAVIE, Gad , PRINCE, Alfred, M.
IPC分类号： C12N05/00
CPC分类号： C07C69/00 , C07C50/36 , C07C50/38 , C07C2603/00
摘要： A method for transfection of cultured mammalian cells is provided. Nucleic acid is mixed with polylysine and hypericin (or a hypericin analog), and a complex is formed. The complex is then contacted with cultured mammalian cells to deliver the nucleic acid into the cells.
摘要翻译：提供了用于转染培养的哺乳动物细胞的方法。将核酸与聚赖氨酸和金丝桃素（或金丝桃素类似物）混合，形成复合物。然后将复合物与培养的哺乳动物细胞接触以将核酸递送到细胞中。

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