专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

AU2013254326A1 Labelled quinoxaline derivatives as multimodal radiopharmaceuticals and their precursors 未知
公开(公告)号：AU2013254326A1
公开(公告)日：2014-10-30
申请号：AU2013254326
申请日：2013-04-19
申请人： INST NAT SANTE RECH MED , UNIV CLERMONT AUVERGNE , CYCLOPHARMA LAB
发明人： CHEZAL JEAN-MICHEL , RBAH-VIDAL LATIFA , BILLAUD EMILIE , AUZELOUX PHILIPPE , MADELMONT JEAN-CLAUDE , VIDAL AURELIEN , MIOT-NOIRAULT ELISABETH , PAPON JANINE , MAISONIAL AURELIE
IPC分类号： C07B59/00 , C07D241/44 , C07D403/12 , C07F7/22
摘要： The present invention relates to the compound of formula (I), in which R1 represents Sn(R)

2. 发明专利

ES2394274T3 Análogos marcados de halobenzamidas como radiofármacos 未知
公开(公告)号：ES2394274T3
公开(公告)日：2013-01-30
申请号：ES07805258
申请日：2007-07-27
申请人： INST NAT SANTE RECH MED , UNIV CLERMONT AUVERGNE
发明人： MADELMONT JEAN-CLAUDE , CHEZAL JEAN-MICHEL , CHAVIGNON OLIVER , TEULADE JEAN-CLAUDE , MOINS NICOLE
IPC分类号： C07D471/04 , A61K31/165 , C07D209/42 , C07D215/54 , C07D217/26 , C07D219/06 , C07D233/62 , C07D235/24 , C07D237/26 , C07D333/68
摘要： Compuesto de fórmula (I): en la que R1 representa un radionúclido, Ar es un grupo heteroarílico, m es un número entero que varía de 2 a 4, R2 y R3 representan, independientemente entre sí, un átomo de hidrógeno, un grupo alquilo (C1-C6) o un grupo alquenilo (C1-C6), en el que el grupo heteroarilo es un anillo aromático de 5 ó 6 miembros, que comprende 1 ó 2 átomos de nitrógeno, o un núcleo aromático bi- o tricíclico que comprende de 1 a 4 átomos de nitrógeno o que comprende un átomo de azufre, presentando al menos uno de los anillos 6 miembros anulares, presentando el otro anillo o anillos condensados 5 ó 6 miembros anulares, siendo posible que dicho grupo heteroarílico esté monosustituido por: - un átomo de halógeno opcionalmente marcado, - un grupo alcoxi (C1-C4), - un grupo alquilo (C1-C4), - un grupo oxo, o - un grupo anilino, el cual puede estar en sí mismo sustituido por entre 1 y 3 grupos, que se pueden seleccionar de entre un grupo alquilo (C1-C4) o un grupo alcoxi (C1-C4), un grupo hidroxilo, un átomo de halógeno o un grupo NHRe, en el que Re representa un hidrógeno, o un grupo CORa, un grupo COORa o un 20 grupo SO2Ra, en los que Ra representa un grupo arilo o un grupo alquilo (C1-C10) opcionalmente sustituido con un grupo oxo; y en la que R1 está enlazado con el núcleo aromático como tal, o, cuando el sustituyente del núcleo aromático es un grupo anilino, R1 puede estar enlazado con el grupo fenilo del grupo anilino, y en la que Ar se selecciona de entre un grupo piridilo, fenazinilo, naftiridinilo, indolilo, imidazopiridilo, bencimidazolilo, quinolilo, quinolonilo, isoquinolilo, quinoxalinilo, benzotienilo, acridinilo o acridonilo, siendo posible que dicho grupo esté monosustituido por un grupo metilo, un grupo metoxi o un átomo de halógeno opcionalmente marcado, y un grupo acridinilo sustituido por un grupo anilino el cual puede estar en sí mismo sustituido por entre 1 y 3 grupos que se pueden seleccionar de entre un grupo alquilo (C1-C4) o alcoxi (C1-C4), un grupo hidroxilo, un átomo de halógeno o un grupo NHRc, en el que Re representa un hidrógeno, o un grupo CORa, un grupo COORa o un 30 grupo SO2Ra, en los que Ra representa un grupo arilo o un grupo alquilo (C1-C10) opcionalmente sustituido por un grupo oxo, y sus sales de adición con ácidos farmacéuticamente aceptables, para su uso en una composición radiofarmacéutica en el diagnóstico y/o el tratamiento del melanoma.

3. 发明专利

AU2007278041B9 Labelled analogues of halobenzamides as radiopharmaceuticals 未知
公开(公告)号：AU2007278041B9
公开(公告)日：2012-11-22
申请号：AU2007278041
申请日：2007-07-27
申请人： INST NAT SANTE RECH MED , UNIV CLERMONT AUVERGNE
发明人： MADELMONT JEAN-CLAUDE , CHEZAL JEAN-MICHEL , MOINS NICOLE , TEULADE JEAN-CLAUDE , CHAVIGNON OLIVIER
IPC分类号： C07D209/42 , A61K31/165 , C07D215/54 , C07D217/26 , C07D219/06 , C07D233/62 , C07D235/24 , C07D237/26 , C07D333/68 , C07D471/04
摘要： The present invention relates to the use of a compound of formula (I): in which R1 represents a radionuclide, Ar represents an aromatic nucleus, m is an integer varying from 2 to 4, R2 and R3 represent, independently of one another, a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkenyl group or an aryl group chosen from a phenyl, benzyl, imidazolyl, pyridyl, pyrimidinyl, pyrazinyl, indolyl, indazolyl, furyl and thienyl group, and their addition salts with pharmaceutically acceptable acids, in the preparation of a radiopharmaceutical composition intended for the diagnosis and/or treatment of melanoma.

4. 发明专利

AU2007278041B2 Labelled analogues of halobenzamides as radiopharmaceuticals 未知
公开(公告)号：AU2007278041B2
公开(公告)日：2012-08-16
申请号：AU2007278041
申请日：2007-07-27
申请人： INST NAT SANTE RECH MED , UNIV CLERMONT AUVERGNE
发明人： MADELMONT JEAN-CLAUDE , CHEZAL JEAN-MICHEL , MOINS NICOLE , TEULADE JEAN-CLAUDE , CHAVIGNON OLIVIER
IPC分类号： C07D209/42 , A61K31/165 , C07D215/54 , C07D217/26 , C07D219/06 , C07D233/62 , C07D235/24 , C07D237/26 , C07D333/68 , C07D471/04
摘要： The present invention relates to the use of a compound of formula (I): in which R1 represents a radionuclide, Ar represents an aromatic nucleus, m is an integer varying from 2 to 4, R2 and R3 represent, independently of one another, a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkenyl group or an aryl group chosen from a phenyl, benzyl, imidazolyl, pyridyl, pyrimidinyl, pyrazinyl, indolyl, indazolyl, furyl and thienyl group, and their addition salts with pharmaceutically acceptable acids, in the preparation of a radiopharmaceutical composition intended for the diagnosis and/or treatment of melanoma.

5. 发明专利

AU2009208631A1 Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors 未知
公开(公告)号：AU2009208631A1
公开(公告)日：2009-08-06
申请号：AU2009208631
申请日：2009-01-28
申请人： COMMISSARIAT ENERGIE ATOMIQUE , INST NAT SANTE RECH MED , CYCLOPHARMA LAB , UNIV CLERMONT AUVERGNE
发明人： MAISONIAL AURELIE , TAVITIAN BERTRAND , MIOT-NOIRAULT ELISABETH , DOLLE FREDERIC , MADELMONT JEAN-CLAUDE , CHEZAL JEAN-MICHEL , PAPON JANINE , MOINS NICOLE , KUHNAST BERTAND , BOISGARD RAPHAEL
IPC分类号： C07D401/12 , A61K31/47 , A61K31/498 , A61P35/00 , C07D215/48 , C07D215/50 , C07D215/54 , C07D241/44
摘要： The present invention relates to the compound of formula (I): in which R 1 represents a hydrogen atom, an optionally labelled halogen atom, a radionuclide or a Sn[(C 1 -C 4 )alkyl] 3 group, Ar represents an aryl group or a heteroaryl group, R 9 represents a hydrogen atom, a (C 1 -C 4 )alkyl group or forms together with the group R 1 -Ar a ring fused with the Ar group, A represents a group of formula (²) or (´): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ -(CH 2 ) t -€ƒ€ƒ€ƒ€ƒ€ƒ(²) R 3 and R 4 independently represent a hydrogen atom, a (C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkenyl group or a group of formula (y): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ -Y-Z-W-R 11 €ƒ€ƒ€ƒ€ƒ€ƒ(³) wherein R 11 represents an optionally labelled halogen atom, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen atom, a radionuclide, a -NO 2 group, a -NR 5 R 6 group, a -N + R 5 R 6 R 7 X - group, or a -OSO 2 R 12 group, and their addition salts with pharmaceutically acceptable acids. The present invention also relates to pharmaceutical compositions comprising them and to their use in diagnosis, in particular with SPECT, PET and in therapy.

6. 发明专利

AU2007278041A1 Labelled analogues of halobenzamides as radiopharmaceuticals 未知
公开(公告)号：AU2007278041A1
公开(公告)日：2008-01-31
申请号：AU2007278041
申请日：2007-07-27
申请人： INST NAT SANTE RECH MED , UNIV CLERMONT AUVERGNE
发明人： TEULADE JEAN-CLAUDE , CHEZAL JEAN-MICHEL , MADELMONT JEAN-CLAUDE , CHAVIGNON OLIVIER , MOINS NICOLE
IPC分类号： A61K31/165 , C07D209/42 , C07D215/54 , C07D217/26 , C07D219/06 , C07D233/62 , C07D235/24 , C07D237/26 , C07D333/68 , C07D471/04
摘要： The present invention relates to the use of a compound of formula (I): in which R 1 represents a radionuclide, Ar represents an aromatic nucleus, m is an integer varying from 2 to 4, R 2 and R 3 represent, independently of one another, a hydrogen atom, a (C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkenyl group or an aryl group chosen from a phenyl, benzyl, imidazolyl, pyridyl, pyrimidinyl, pyrazinyl, indolyl, indazolyl, furyl and thienyl group, and their addition salts with pharmaceutically acceptable acids, in the preparation of a radiopharmaceutical composition intended for the diagnosis and/or treatment of melanoma.

7. 发明申请

WO2009095872A3 LABELLED ANALOGUES OF HALOBENZAMIDES AS MULTIMODAL RADIOPHARMACEUTICALS AND THEIR PRECURSORS 审中-公开
标题翻译：作为多模式放射治疗剂及其前体的哈芬碱的标记类似物
公开(公告)号：WO2009095872A3
公开(公告)日：2009-12-03
申请号：PCT/IB2009050355
申请日：2009-01-28
申请人： INST NAT SANTE RECH MED , COMMISSARIAT ENERGIE ATOMIQUE , UNIV D AUVERGNE CLERMONT 1 , CYCLOPHARMA LAB , CHEZAL JEAN-MICHEL , DOLLE FREDERIC , MADELMONT JEAN-CLAUDE , MAISONIAL AURELIE , MIOT-NOIRAULT ELISABETH , MOINS NICOLE , PAPON JANINE , KUHNAST BERTAND , TAVITIAN BERTRAND , BOISGARD RAPHAEL
发明人： CHEZAL JEAN-MICHEL , DOLLE FREDERIC , MADELMONT JEAN-CLAUDE , MAISONIAL AURELIE , MIOT-NOIRAULT ELISABETH , MOINS NICOLE , PAPON JANINE , KUHNAST BERTAND , TAVITIAN BERTRAND , BOISGARD RAPHAEL
IPC分类号： C07D401/12 , A61K31/47 , A61K31/498 , A61P35/00 , C07D215/48 , C07D215/50 , C07D215/54 , C07D241/44
CPC分类号： A61K49/0002 , C07D213/65 , C07D213/76 , C07D215/54 , C07D241/44 , C07D401/12 , C07D487/04
摘要： The present invention relates to the compound of formula (I): in which R1 represents a hydrogen atom, an optionally labelled halogen, a radionuclide or a Sn[(C1 -C4 )alkyl]3 group, Ar represents an aryl group or a heteroaryl group, R9 represents a hydrogen atom, a (C1 -C4 )alkyl group or forms together with the group R1 -Ar a ring fused with the Ar group, A represents a group of formula (ß) or (d): R3 and R4 independently represent a hydrogen atom, a (C1 -C6 )alkyl group, a (C1 -C6 )alkenyl group or a group of formula (y): wherein R11 represents an optionally labelled halogen, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen, a radionuclide, a -NO2 group, a -NR5 R6 group, a N+R5R6R7X- group, or a -OSO2R12 group, and their addition salts with pharmaceutically acceptable acids. The present invention also relates to pharmaceutical compositions comprising themand to their use in diagnosis, in particular with SPECTor PET imaging and in therapyofmelanoma, viatargeted radionuclide therapy.
摘要翻译：本发明涉及式（I）化合物：其中R 1表示氢原子，任选标记的卤素，放射性核素或Sn [（C 1 -C 4）烷基] 3基团，Ar表示芳基或杂芳基基团，R 9表示氢原子，（C 1 -C 4）烷基或与Ar基团稠合的基团R 1 -Ar a，A表示式（ß）或（d）的基团：R 3和R 4 独立地表示氢原子，（C1-C6）烷基，（C1-C6）烯基或式（y）的基团：其中R11表示任选标记的卤素，放射性核素，芳基或杂芳基任选取代通过任选标记的卤素，放射性核素，-NO 2基团，-NR 5 R 6基团，N + R 5 R 6 R 7 X基或-OSO 2 R 12基团，以及它们与药学上可接受的酸的加成盐。本发明还涉及包含它们的药物组合物，并且用于诊断，特别是用于SPECTOR PET成像和黑素瘤治疗靶向放射性核素治疗。

8. 发明申请

WO2008012782A2 LABELLED ANALOGUES OF HALOBENZAMIDES AS RADIOPHARMACEUTICALS 审中-公开
标题翻译：作为放射性核素的哈芬珠菌的标记的类似物
公开(公告)号：WO2008012782A2
公开(公告)日：2008-01-31
申请号：PCT/IB2007052992
申请日：2007-07-27
申请人： INST NAT SANTE RECH MED , MADELMONT JEAN-CLAUDE , CHEZAL JEAN-MICHEL
发明人： MADELMONT JEAN-CLAUDE , CHEZAL JEAN-MICHEL
IPC分类号： C07D471/04 , A61K31/165 , C07D209/42 , C07D215/54 , C07D217/26 , C07D219/06 , C07D233/62 , C07D235/24 , C07D237/26 , C07D333/68
CPC分类号： C07D471/04 , C07B2200/05 , C07C233/62 , C07D209/42 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D215/56 , C07D217/26 , C07D219/04 , C07D219/06 , C07D219/08 , C07D235/24 , C07D241/44 , C07D241/46 , C07D333/68
摘要： The present invention relates to the use of a compound of formula (I): in which R1 represents a radionuclide, Ar represents an aromatic nucleus, m is an integer varying from 2 to 4, R2 and R3 represent, independently of one another, a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkenyl group or an aryl group chosen from a phenyl, benzyl, imidazolyl, pyridyl, pyrimidinyl, pyrazinyl, indolyl, indazolyl, furyl and thienyl group, and their addition salts with pharmaceutically acceptable acids, in the preparation of a radiopharmaceutical composition intended for the diagnosis and/or treatment of melanoma.
摘要翻译：本发明涉及式（I）化合物的用途：其中R1表示放射性核素，Ar表示芳香核，m表示2至4的整数，R2和R3彼此独立地表示氢原子，（C1-C6）烷基，（C1-C6）烯基或选自苯基，苄基，咪唑基，吡啶基，嘧啶基，吡嗪基，吲哚基，吲唑基，呋喃基和噻吩基的芳基，与药学上可接受的酸的加成盐，用于制备用于诊断和/或治疗黑素瘤的放射性药物组合物。

9. 发明申请

WO9009170A3 AGENTS FOR DIAGNOSING AND TREATING MELANOMAS, AROMATIC HALOGENATED DERIVATIVES USABLE AS SUCH AGENTS AND THEIR PREPARATION 审中-公开
标题翻译：用于诊断和处理微生物的试剂，可用作这些试剂的芳族化合物衍生物及其制备
公开(公告)号：WO9009170A3
公开(公告)日：1990-11-01
申请号：PCT/FR9000107
申请日：1990-02-14
申请人： INST NAT SANTE RECH MED , ORIS SA
发明人： MOREAU MARIE-FRANCE , MICHELOT JOSETTE , VEYRE ANNIE , MADELMONT JEAN-CLAUDE , GODENECHE DENISE , LABARRE PIERRE , PARRY DANIEL , MEYNIEL GASTON
IPC分类号： A61K31/165 , A61K31/18 , A61K31/63 , A61K49/00 , A61K51/00 , A61K51/04 , A61P35/00 , C07B59/00 , C07C217/10 , C07C217/20 , C07C231/02 , C07C233/40 , C07C233/78 , C07C237/06 , C07C309/69 , C07C309/73 , C07C311/13 , C07C311/18 , C07C317/28 , C07C323/25
CPC分类号： C07C311/18 , A61K31/165 , A61K31/18 , A61K31/63 , A61K51/0406 , C07C233/78
摘要： The invention concerns agents for diagnosing and treating malignant melanomas, of general formula (I), in which X denotes a hydrogen or halogen atom, Y denotes a Z-CONH-, Z-O-, Z-S(O)-n1 group, n1 being equal to 0, 1, 2 or 3, a Z-SO2-NH- or Z-NHCO- group, Z being a bond, a -CH2- or -CH(C6H5)- group, n is an integer between 2 and 4, and R1 and R2 each denote a hydrogen atom, a C1 to C6 alkyl group or a C6 to C12 aryl or aralkyl group, these compounds possibly being labelled by radioisotopes chosen from ?123I, 125I, 123I, 75Br, 77Br, 18F, or 11¿C or by stable isotopes chosen from ?13C and 19¿F, as well as their addition salts with pharmaceutically acceptable acids. The invention also concerns the use of these compounds to manufacture an agent for diagnosing and/or treating malignant melanomas.

10. 发明专利

DE60013818T2 未知
公开(公告)号：DE60013818T2
公开(公告)日：2005-11-17
申请号：DE60013818
申请日：2000-06-22
申请人： INST NAT SANTE RECH MED
发明人： MADELMONT JEAN-CLAUDE , GIRAUD ISABELLE , NICOLAS COLETTE , MAURIZIS JEAN-CLAUDE , RAPP MARYSE , OLLIER MONIQUE , RENARD PIERRE , CAIGNARD DANIEL-HENRI
IPC分类号： A61K31/165 , A61K31/4045 , A61K31/5415 , A61K31/555 , A61K31/7008 , A61K49/00 , A61K51/00 , A61P19/00 , C07C231/12 , C07C237/20 , C07D259/00 , C07D279/02 , C07D409/06 , C07D417/12 , C07F13/00 , C07H5/06 , C07H15/12 , C07H15/26
摘要： A compound of formula corresponding to either formula (Ia) or (Ib): wherein: M represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, R 1 , R 2 and R 3 represent alkyl, or R 1 , R 2 and R 3 together with the nitrogen atom carrying them, form a heterocycle, X represents a (C 1 -C 6 )alkylene chain in which one or more -CH 2 - groups are optionally replaced by sulphur, oxygen, or -NR-, -CO-, -CO-NH-, -CO 2 -, -SO- or -SO 2 -, n represents 0 or 1, Hal represents halogen, or, R 4 represents alkyl, Hal represents halogen, represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, wherein the nitrogen atom may optionally be included in a saturated or unsaturated nitrogen-containing heterocyclic system, or included in a double bond.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式