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1. 发明申请

WO0200638A2 NEW SUBSTITUTED PHTHALIDES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新替代对苯二甲酸酯，其制备方法和含有它们的药物组合物
公开(公告)号：WO0200638A2
公开(公告)日：2002-01-03
申请号：PCT/IB0101535
申请日：2001-06-27
申请人： INST MATERIA MEDICA , SERVIER LAB , GUO ZONGRU , CHU FENGMING , ZHANG JUNTIAN , YANG GUANGZHONG , XU BAILING , NIU XINYI , REN ZHIHONG , LESTAGE PIERRE , RENARD PIERRE
发明人： GUO ZONGRU , CHU FENGMING , ZHANG JUNTIAN , YANG GUANGZHONG , XU BAILING , NIU XINYI , REN ZHIHONG , LESTAGE PIERRE , RENARD PIERRE
IPC分类号： C07D307/88 , A61K31/34 , A61K31/365 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , C07D239/42 , C07D471/04 , C07D487/04 , C07D307/00
CPC分类号： C07D239/42 , C07D471/04 , C07D487/04
摘要： The invention relates to compounds of formula (I): wherein R represents an alkyl or ureido group, R represents an alkyl group or a hydrogen atom, or R and R together form a 5- or 6-membered ring, R represents a group CN, NO2, NRaR'a, NRaSO2,R'aCZR or CZNRaR'a, R represents a hydrogen atom or a group R .
摘要翻译：本发明涉及式（I）化合物：其中R 1表示烷基或脲基，R 2表示烷基或氢原子，或R 1和R 2一起形成5 - 或6-元环，R 3表示CN，NO 2，NR a R aa，NR a SO 2，R'CZR 5或CZNR a R aa，R 4表示氢原子或基团R 3，。

2. 发明申请

WO0200638A8 SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS 审中-公开
标题翻译：取代的PHTHALIDES作为抗敏药物
公开(公告)号：WO0200638A8
公开(公告)日：2003-08-28
申请号：PCT/IB0101535
申请日：2001-06-27
申请人： INST MATERIA MEDICA , SERVIER LAB , GUO ZONGRU , CHU FENGMING , ZHANG JUNTIAN , YANG GUANGZHONG , XU BAILING , NIU XINYI , REN ZHIHONG , LESTAGE PIERRE , RENARD PIERRE
发明人： GUO ZONGRU , CHU FENGMING , ZHANG JUNTIAN , YANG GUANGZHONG , XU BAILING , NIU XINYI , REN ZHIHONG , LESTAGE PIERRE , RENARD PIERRE
IPC分类号： C07D307/88 , A61K31/34 , A61K31/365 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , C07D239/42 , C07D471/04 , C07D487/04
CPC分类号： C07D239/42 , C07D471/04 , C07D487/04
摘要： The invention relates to compounds of formula (I): wherein R represents an alkyl or ureido group, R represents an alkyl group or a hydrogen atom, or R and R together form a 5- or 6-membered ring, R represents a group CN, NO2, NRaR'a, NRaSO2,R'aCZR or CZNRaR'a, R represents a hydrogen atom or a group R .
摘要翻译：本发明涉及式（I）化合物：其中R 1表示烷基或脲基，R 2表示烷基或氢原子，或R 1和R 2一起形成5 - 或6-元环，R 3表示CN，NO 2，NR a R aa，NR a SO 2，R'CZR 5或CZNR a R aa，R 4表示氢原子或基团R 3，。

3. 发明专利

SK1062003A3 Substituted phthalides as anti-convulsive drugs 未知
公开(公告)号：SK1062003A3
公开(公告)日：2003-05-02
申请号：SK1062003
申请日：2001-06-27
申请人： SERVIER LAB , INST MATERIA MEDICA
发明人： GUO ZONGRU , CHU FENGMING , ZHANG JUNTIAN , YANG GUANGZHONG , XU BAILING , NIU XINYI , REN ZHIHONG , LESTAGE PIERRE , RENARD PIERRE
IPC分类号： C07D307/88 , A61K31/34 , A61K31/365 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , C07D239/42 , C07D471/04 , C07D487/04
摘要： The invention relates to compounds of formula (I):whereinR represents alkyl or ureido,R represents alkyl or hydrogen, or R and R together form a 5- or 6-membered ring,R represents CN, NO2, NRaR'a, NRaSO2R'a, NRaCZR or CZNRaR'a,R represents hydrogen or R ,and medicinal products containing the same which are useful in treating or preventing epilepsy and neurodegenerative diseases.

4. 发明专利

CA2413752A1 SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS 未知
公开(公告)号：CA2413752A1
公开(公告)日：2002-01-03
申请号：CA2413752
申请日：2001-06-27
申请人： INST MATERIA MEDICA , SERVIER LAB
发明人： RENARD PIERRE , LESTAGE PIERRE , ZHANG JUNTIAN , CHU FENGMING , GUO ZONGRU , REN ZHIHONG , XU BAILING , NIU XINYI , YANG GUANGZHONG
IPC分类号： C07D307/88 , A61K31/34 , A61K31/365 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , C07D239/42 , C07D471/04 , C07D487/04
摘要： The invention relates to compounds of formula (I): wherein R1 represents an alkyl or ureido group, R2 represents an alkyl group or a hydrogen atom, or R 1 and R2 together form a 5- or 6-membered ring, R3 represents a group CN, NO2, NRaR'a, NRaSO2,R'aCZR5 or CZNRaR'a, R4 represents a hydrogen atom or a group R3.

5. 发明专利

ZA200210004B Substituted phthalides as anti-convulsive drugs. 未知
公开(公告)号：ZA200210004B
公开(公告)日：2003-12-10
申请号：ZA200210004
申请日：2002-12-10
申请人： INST MATERIA MEDICA , SERVIER LAB
发明人： GUO ZONGRU , CHU FENGMING , ZHANG JUNTIAN , YANG GUANGZHONG , XU BAILING , NIU XINYI , REN ZHIHONG , LESTAGE PIERRE , RENARD PIERRE
IPC分类号： C07D307/88 , A61K31/34 , A61K31/365 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , C07D239/42 , C07D471/04 , C07D487/04 , C07D , A61K , A61P
摘要： The invention relates to compounds of formula (I):whereinR represents alkyl or ureido,R represents alkyl or hydrogen, or R and R together form a 5- or 6-membered ring,R represents CN, NO2, NRaR'a, NRaSO2R'a, NRaCZR or CZNRaR'a,R represents hydrogen or R ,and medicinal products containing the same which are useful in treating or preventing epilepsy and neurodegenerative diseases.

6. 发明专利

BR0112043A 未知
公开(公告)号：BR0112043A
公开(公告)日：2003-10-28
申请号：BR0112043
申请日：2001-06-27
申请人： INST MATERIA MEDICA CAMS , SERVIER LAB
发明人： GUO ZONGRU , CHU FENGMING , ZHANG JUNTIAN , YANG GUANGZHONG , XU BAILING , NIU XINYI , REN ZHIHONG , LESTAGE PIERRE , RENARD PIERRE
IPC分类号： C07D307/88 , A61K31/34 , A61K31/365 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , C07D239/42 , C07D471/04 , C07D487/04 , C07D307/00
摘要： The invention relates to compounds of formula (I):whereinR represents alkyl or ureido,R represents alkyl or hydrogen, or R and R together form a 5- or 6-membered ring,R represents CN, NO2, NRaR'a, NRaSO2R'a, NRaCZR or CZNRaR'a,R represents hydrogen or R ,and medicinal products containing the same which are useful in treating or preventing epilepsy and neurodegenerative diseases.

7. 发明专利

HU0301567A2 SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS 未知
公开(公告)号：HU0301567A2
公开(公告)日：2003-09-29
申请号：HU0301567
申请日：2001-06-27
申请人： INST MATERIA MEDICA , SERVIER LAB
发明人： CHU FENGMING , GUO ZONGRU , LESTAGE PIERRE , NIU XINYI , RENARD PIERRE , RHEN ZHIHONG , XU BAILING , YANG GUANGZHONG , ZHANG JUNTIAN
IPC分类号： C07D307/88 , A61K31/34 , A61K31/365 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , C07D239/42 , C07D471/04 , C07D487/04
摘要： The invention relates to compounds of formula (I):whereinR represents alkyl or ureido,R represents alkyl or hydrogen, or R and R together form a 5- or 6-membered ring,R represents CN, NO2, NRaR'a, NRaSO2R'a, NRaCZR or CZNRaR'a,R represents hydrogen or R ,and medicinal products containing the same which are useful in treating or preventing epilepsy and neurodegenerative diseases.

8. 发明专利

CZ2003245A3 Novel substituted phthalides, process of their preparation and pharmaceutical preparations in which they are comprised 未知
公开(公告)号：CZ2003245A3
公开(公告)日：2003-05-14
申请号：CZ2003245
申请日：2001-06-27
申请人： SERVIER LAB , INST MATERIA MEDICA
发明人： LESTAGE PIERRE , RENARD PIERRE , GUO ZONGRU , CHU FENGMING , ZHANG JUNTIAN , YANG GUANGZHONG , XU BAILING , NIU XINYI , REN ZHIHONG
IPC分类号： C07D307/88 , A61K31/34 , A61K31/365 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , C07D239/42 , C07D471/04 , C07D487/04 , A61K31/343
摘要： The invention relates to compounds of formula (I):whereinR represents alkyl or ureido,R represents alkyl or hydrogen, or R and R together form a 5- or 6-membered ring,R represents CN, NO2, NRaR'a, NRaSO2R'a, NRaCZR or CZNRaR'a,R represents hydrogen or R ,and medicinal products containing the same which are useful in treating or preventing epilepsy and neurodegenerative diseases.

9. 发明专利

PL359373A1 NEW SUBSTITUTED PHTHALIDES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：PL359373A1
公开(公告)日：2004-08-23
申请号：PL35937301
申请日：2001-06-27
申请人： SERVIER LAB , INST MATERIA MEDICA CAMS
发明人： GUO ZONGRU , CHU FENGMING , ZHANG JUNTIAN , YANG GUANGZHONG , XU BAILING , NIU XINYI , REN ZHIHONG , LESTAGE PIERRE , RENARD PIERRE
IPC分类号： C07D307/88 , A61K31/34 , A61K31/365 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , C07D239/42 , C07D471/04 , C07D487/04
摘要： The invention relates to compounds of formula (I):whereinR represents alkyl or ureido,R represents alkyl or hydrogen, or R and R together form a 5- or 6-membered ring,R represents CN, NO2, NRaR'a, NRaSO2R'a, NRaCZR or CZNRaR'a,R represents hydrogen or R ,and medicinal products containing the same which are useful in treating or preventing epilepsy and neurodegenerative diseases.

10. 发明专利

AR030239A1 FTA LIDAS SUBSTITUIDAS, UN PROCEDIMIENTO PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LAS MISMAS 未知
公开(公告)号：AR030239A1
公开(公告)日：2003-08-13
申请号：ARP010103051
申请日：2001-06-27
申请人： SERVIER LAB , INST MATERIA MEDICA
发明人： GUO ZONGRU , CHU FENGMING , ZHANG JUNTIAN , YANG GUANGZHONG , XU BAILING , NIU XINYI , REN ZHIHONG , LESTAGE PIERRE , RENARD PIERRE
IPC分类号： C07D307/88 , A61K31/34 , A61K31/365 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , C07D239/42 , C07D471/04 , C07D487/04
摘要： Ftalidas sustituidas de formula (1): en la cual R1 representa un grupo alquilo (C1-12) lineal o ramificado o un grupo ureido, R2 representa un átomo de hidrogeno o un grupo alquilo (C1-12) lineal o ramificado, o R1 y R2, junto con el átomo de carbono que los lleva, forman un grupo cicloalquilo que contiene 5 o 6 átomos de carbono, R3 representa un grupo CN, CNO2, NRaR'a, NRaSO2R'a, NRaCZR5 o CZNRaR'a donde Z representa un átomos de oxígeno o azufre y R5 representa un grupo ORa, Ra o NRaR'a (donde Ra y R'a pueden ser iguales o diferentes, representan un átomo de hidrogeno o un grupo alquilo (C1-6) lineal o ramificado, un grupo de cicloalquilo (C3-8), un grupo de cicloalquilo(C3-8)-alquilo(C1-6) en el cual la parte de alquilo es lineal o ramificada, un grupo fenilo o un grupo fenilo-alquilo (C1-6) en el cual la parte alquilo es lineal o ramificada), R4 representa un átomo de hidrogeno o un grupo R3 segun lo precedentemente definido, se entiende que: los grupos fenilo o fenilalquilo se pueden sustituir en el anillo benceno por uno o más sustituyentes seleccionados entre alquilo (C1-6) lineal o ramificado, hidroxi, alcoxi (C1-6) lineal o ramificado, amino, alquilamino (C1-6) lineal o ramificado, di-alquilamino (C1-6) en los cuales cada parte alquilo es lineal o ramificada, NO2 y átomos de halogeno, el grupo alquilo se puede sustituir por uno o más sustituyentes seleccionados entre hidroxi, carboxi, alquilo (C1-6) lineal o ramificado, átomos de halogenos y alcoxi (C1-6) lineal o ramificado, los grupos cicloalquilo o cicloalquilalquilo se pueden sustituir en la parte cíclica por uno o más sustituyentes seleccionados entre hidroxi, carboxi, átomos de halogeno y alcoxi (C1-6) lineal o ramificado y siempre que el compuesto de la formula (1) no pueda representar 3-metil, 3-etil, 3,3-dimetil- o 3,3-dietil-6-nitro-ftalida o 3-metil- o 3,3 ûdimetil- -6-amino-ftalida o 3,3-dimetil-6-(dimetilamino)-ftalida, sus enantiomeros y diastereoisomeros, y sales de adicion de los mismos con un ácido o una base farmacéuticamente aceptable. Un procedimiento para prepararlas y composiciones farmacéuticas que las comprenden. Medicamentos.

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