专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO9950268A2 SUBSTITUTED INDOLEALKANOIC ACIDS 审中-公开
标题翻译：取代的吲哚酸性酸
公开(公告)号：WO9950268A2
公开(公告)日：1999-10-07
申请号：PCT/US9907116
申请日：1999-03-31
申请人： INST FOR PHARM DISCOVERY INC , JONES MICHAEL L , GUNN DAVID , JONES JOHN HOWARD , ZANDT MICHAEL C VAN
发明人： JONES MICHAEL L , GUNN DAVID , JONES JOHN HOWARD , VAN ZANDT MICHAEL C
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/428 , A61K31/5377 , A61P3/08 , A61P3/10 , A61P13/12 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07D209/10 , C07D417/06
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译：公开了用于治疗由糖尿病引起的慢性并发症的取代的吲哚烷酸。还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。

2. 发明专利

CZ300706B6 Derivát indolalkanové kyseliny a lécivo pro prevenci nebo zmírnení chronických komplikací vznikajících z diabetes mellitus 未知
公开(公告)号：CZ300706B6
公开(公告)日：2009-07-22
申请号：CZ20003607
申请日：1999-03-31
申请人： INST FOR PHARM DISCOVERY INC
发明人： JONES MICHAEL L , GUNN DAVID , JONES JOHN HOWARD , VAN ZANDT MICHAEL C
IPC分类号： C07D209/10 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/5377 , A61P3/08 , A61P3/10 , A61P13/12 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07D277/62 , C07D401/06 , C07D413/06 , C07D417/06
摘要： Derivát substituované indolalkanové kyseliny obecného vzorce I, kde A je C.sub.1.n.-C.sub.4.n. alkylen prípadne substituovaný C.sub.1.n.-C.sub.2.n. alkylem halogenem; Z je vazba, O, S, C(O)NH nebo C.sub.1.n.-C.sub.3.n. alkylen prípadne substituovaný C.sub.1.n.-C.sub.2.n. alkylem; R.sub.1.n. je vodík, alkyl obsahující 1 až 6 atomu uhlíku, halogen, 2-, 3- nebo 4-pyridyl nebo fenyl, kde fenyl nebo pyridyl je prípadne substituovaný; a ostatní symboly mají význam uvedený v nárocích, použití tohoto derivátu pro výrobu léciva pro prevenci nebo zmírnení chronických komplikací vznikajících z diabetes mellitus jako jsou diabetické katarakty, retinopatie, nefropatie a neuropatie, a farmaceutický prostredek s jeho obsahem.

3. 发明专利

AU774929B2 Substituted indolealkanoic acids 未知
公开(公告)号：AU774929B2
公开(公告)日：2004-07-15
申请号：AU3459599
申请日：1999-03-31
申请人： INST FOR PHARM DISCOVERY INC
发明人： JONES MICHAEL L , GUNN DAVID , JONES JOHN HOWARD , ZANDT MICHAEL C VAN
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/428 , A61K31/5377 , A61P3/08 , A61P3/10 , A61P13/12 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07D209/10 , C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.

4. 发明专利

CZ20003607A3 Substituted indolealkanoic acid 未知
公开(公告)号：CZ20003607A3
公开(公告)日：2001-03-14
申请号：CZ20003607
申请日：1999-03-31
申请人： INST FOR PHARM DISCOVERY INC
发明人： JONES MICHAEL L , GUNN DAVID , JONES JOHN HOWARD , VAN ZANDT MICHAEL C
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/428 , A61K31/5377 , A61P3/08 , A61P3/10 , A61P13/12 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07D209/10 , C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.

5. 发明专利

CA2383983A1 SUBSTITUTED INDOLEALKANOIC ACIDS 未知
公开(公告)号：CA2383983A1
公开(公告)日：1999-10-07
申请号：CA2383983
申请日：1999-03-31
申请人： INST FOR PHARM DISCOVERY INC
发明人： VAN ZANDT MICHAEL C , JONES MICHAEL L , JONES JOHN HOWARD , GUNN DAVID
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/428 , A61K31/5377 , A61P3/08 , A61P3/10 , A61P13/12 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07D209/10 , C07D417/06 , C07D209/00 , C07D277/00 , A61K31/405
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatmen t employing the compounds, as well as methods for their synthesis.

6. 发明专利

CA2383983C SUBSTITUTED INDOLEALKANOIC ACIDS 未知
公开(公告)号：CA2383983C
公开(公告)日：2009-09-29
申请号：CA2383983
申请日：1999-03-31
申请人： INST FOR PHARM DISCOVERY INC
发明人： JONES MICHAEL L , VAN ZANDT MICHAEL C , JONES JOHN HOWARD , GUNN DAVID
IPC分类号： C07D417/06 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/428 , A61K31/5377 , A61P3/08 , A61P3/10 , A61P13/12 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07D209/00 , C07D209/10 , C07D277/00
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and metho ds of treatment employing the compounds, as well as methods for their synthesis.

7. 发明专利

NZ507172A Trifluorobenzothiazol indole acetic acid compounds which interact with and inhibit aldose reductase 未知
公开(公告)号：NZ507172A
公开(公告)日：2003-10-31
申请号：NZ50717299
申请日：1999-03-31
申请人： INST FOR PHARM DISCOVERY INC
发明人： JONES MICHAEL L , GUNN DAVID , JONES JOHN HOWARD , VANZANDT MICHAEL
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/428 , A61K31/5377 , A61P3/08 , A61P3/10 , A61P13/12 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07D209/10 , C07D417/06 , C07D4 , A61P
摘要： A compound of formula (I) wherein A is a C1-C4 alkylene group optionally substituted with C1- C2 alkyl or mono-or disubstituted with halogen; Z is a bond; R1 is hydrogen, alkyl having 1-6 carbon atoms, halogen, or phenyl, where the phenyl or pyridyl is optionally substituted with up to three groups selected from halogen, hydroxy, (C1-C6)alkoxy, (C1-C6)alkyl, nitro, amino, or mono- or di (C1-C6)alkylamino ; R2, R3, R4 and R5 are each independently hydrogen, halogen, nitro, or an alkyl group of 1-6 carbon atoms (which may be substituted with one or more halogens); OR7, SR7, S(0)R7, S(O)2N(R7)2, C(O)N(R7)2, or N(R7)2, wherein each R7 is independently hydrogen, an alkyl group of 1-6 carbon atoms (which may be substituted with one or more halogens) or benzyl, where the phenyl portion is optionally substituted with up to three groups independently selected from halogen, (C1-C6)alkyl, (C1-C6)alkoxy, amino, and mono- or di (C1-C6)) alkylamino; phenyl where phenyl is optionally substituted with up to three groups independently selected from halogen, (C1-C6)alkyl, (C1-C6)alkoxy, amino, and mono- or di (C1-C6) alkylamino; phenoxy where the phenyl portion is optionally substituted with up to three groups independently selected from halogen, (C1-C6)alkyl, (C1- C6)alkoxy, amino, and mono-or di (C1-C6) alkylamino; or a group of the formula (II) where J is a bond, CH2, oxygen, or nitrogen; and each r is independently 2 or 3; R6 is hydroxy or (C1-C6)alkoxy; Ra is hydrogen, (C1-C6)alkyl, fluoro, or trifluoromethyl; Ar represents a benzothiazole ring optionally substituted on the benzo protion by one of iodo, cyano, nitro, perfluoroethyl, trifluoroacetyl, or (C1-C6)) alkanoyl, one or two of fluoro, chloro, bromo, hydroxy, (C1-C6)alkyl, (C1- C6)alkoxy, (C1-C6)alkylthio, trifluoromethoxy, trifluoromethylthio, (C1-C6)alkylsulfinyl, (C1- C6)alkylsulfonyl or trifluoromethyl, or two fluoro or two trifluoromethyl with one hydroxy or one (C1-C6)alkoxy, or one or two fluoro and one trifluoromethyl, or three fluoro. Is described. The compound can be used in a pharmaceutical composition for the treatment of chronic complications arising from diabetes mellitus, which can included diabetic cataracts, retinopathy, nephropathy and neuropathy.

8. 发明专利

BG104819A SUBSTITUTED INDOLEALKANOIC ACIDS 未知
公开(公告)号：BG104819A
公开(公告)日：2001-05-31
申请号：BG10481900
申请日：2000-09-29
申请人： INST FOR PHARM DISCOVERY INC
发明人： JONES MICHAEL L , GUNN DAVID , JONES JOHN H , VAN ZANDT MICHAEL C
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/428 , A61K31/5377 , A61P3/08 , A61P3/10 , A61P13/12 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07D209/10 , C07D417/06 , A61K31/405
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications rising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis. 50 claims

9. 发明专利

NO20004900L 未知
公开(公告)号：NO20004900L
公开(公告)日：2000-10-17
申请号：NO20004900
申请日：2000-09-29
申请人： INST FOR PHARM DISCOVERY INC
发明人： JONES MICHAEL L , GUNN DAVID , JONES JOHN HOWARD , ZANDT MICHAEL V VAN
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/428 , A61K31/5377 , A61P3/08 , A61P3/10 , A61P13/12 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07D209/10 , C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.

10. 发明专利

OA11622A Substituted indolealkanoic acids. 未知
公开(公告)号：OA11622A
公开(公告)日：2004-09-16
申请号：OA1200000269
申请日：1999-03-31
申请人： INST FOR PHARM DISCOVERY INC
发明人： GUNN DAVID , JONES MICHAEL L , JONES JOHN HOWARD , ZANDT VAN MICHAEL C
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/428 , A61K31/5377 , A61P3/08 , A61P3/10 , A61P13/12 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07D209/10 , C07D417/06 , A61K31/405
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式