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1. 发明申请

WO2009030092A1 CULTURE MEDIUM AND METHOD FOR IN VITRO CULTURING HUMAN ADULT PRIMARY MESENCHYMAL STEM CELLS ON A LARGE SCALE, PRIMARY MESENCHYMAL STEM CELLS OBTAINED BY THE METHOD, THE USES THEREOF 审中-公开
标题翻译：文化培养基和方法培养人类成年原代细胞干细胞在大规模，主要的细胞干细胞获得方法，其用途
公开(公告)号：WO2009030092A1
公开(公告)日：2009-03-12
申请号：PCT/CN2007070637
申请日：2007-09-05
申请人： INST BASIC MED SCIENCES PLA , ZHAO CHUNHUA , HAN QIN , LI JING , SUN ZHAO , HU JIANLI , ZHU YASHU , LU SHAN , BIAN CHUNJING
发明人： ZHAO CHUNHUA , HAN QIN , LI JING , SUN ZHAO , HU JIANLI , ZHU YASHU , LU SHAN , BIAN CHUNJING
IPC分类号： A61K35/28 , A61P35/00 , C12N5/0775
CPC分类号： C12N5/0663 , A61K35/28
摘要： A method for in vitro preparing human adult primary mesenchymal stem cells (pMSCs, which are positive for Flk1 marker and Nanog marker) derived from human adult tissues (marrow) on a large scale and the products obtained by the same are provided. Uses of the method and the products obtained by the same in inhibiting the proliferation of tumor cells are also provided. By modifying the key processes and parameters of the preparation of pMSCs, for example simplifying the process of magnetic cell sorting, using human serum culture medium instead of bovine serum culture medium, and using the culture condition at low concentration oxygen (2%), the aim of preparing pMSCs on a large scale is achieved. By using the property of expressing Nanog gene of pMSCs, the novel use of pMSCs in inhibiting the proliferation of tumor cells is invented.
摘要翻译：提供了一种从人成人组织（骨髓）大量产生的人成体原代间充质干细胞（pMSCs，对Flk1标记和Nanog标记物呈阳性）的体外制备方法。还提供了该方法及其获得的产品在抑制肿瘤细胞增殖方面的用途。通过修改pMSCs制备的关键过程和参数，例如简化磁性细胞分选过程，使用人血清培养基代替牛血清培养基，并使用低浓度氧气（2％）的培养条件，实现大规模制备pMSCs的目的。通过使用表达pMSCs的Nanog基因的性质，发明了pMSCs在抑制肿瘤细胞增殖中的新用途。

2. 发明专利

CA2311686A1 TELESCOPIC HASP WINDOW LOCK 未知
公开(公告)号：CA2311686A1
公开(公告)日：2001-12-23
申请号：CA2311686
申请日：2000-06-23
申请人： CHEN CHANG SHUN , XIANG MING , LU SHAN
发明人： LU ZAI MING , XIANG MING , LU SHAN
IPC分类号： E05B63/00 , E05C19/00 , E06B9/02 , E06B3/68
摘要： The invention provides a special structure lock for windows. It consists of a Telescopic Hasp and a Rotatable Lock. One end of the Telescopic Hasp looks like a normal padlock hasp. Another end of the Telescopic Hasp has a hinge plate that has some holes for receiving scre ws to mount the plate to a window frame. The Rotatable Lock is a padlock body connected to another hinge plate that also has some holes for fixing. After the Telescopic Hasp and Rotatable Lock have been installed on opposite sides of a window frame, the Rotatable Lock can lock the Telescopic Hasp directly. Then the whole lock works as an openable window security bar. Compare with variety of openable window security arrangement, this window lo ck has a uniform and beautiful appearance.

3. 发明申请

WO2008005929A3 RECOMBINANT HIV-1 GP120 IMMUNOGEN WITH THREE DIFFERENT V3 LOOPS FROM VIRUSES OF DIFFERENT CLADES 审中-公开
标题翻译：重组HIV-1 GP120免疫原具有三种不同的病毒V3病毒
公开(公告)号：WO2008005929A3
公开(公告)日：2008-07-03
申请号：PCT/US2007072660
申请日：2007-07-02
申请人： UNIV NEW YORK , UNIV MASSACHUSETTS , ZOLLA-PAZNER SUSAN , LU SHAN , WANG SHIXIA
发明人： ZOLLA-PAZNER SUSAN , LU SHAN , WANG SHIXIA
IPC分类号： C12N1/20 , C12Q1/68
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , C07K2319/00 , C12N2740/16122 , C12N2740/16134
摘要： A novel immunogenic HIV-1 Env, particularlygp120, DNA construct is disclosed in which either the V1/V2 loop and the V4 loop, or all three variable loops, including V3, are replaced with a V3 sequence each of which is from a different viral isolate. Preferably, each replacement V3 loop is a consensus sequence of V3 of a different clade. Such constructs are useful as immunogens as each presents three independent V3 epitopes, so that the immunized subject generates a more broadly reactive neutralizing antibody response than with conventional gp120 or V3 DNA or polypeptide immunogens. Also disclosed are methods of using the DNA construct to immunize a mammal, preferably a human, particularly in a priming regiment in which the DNA immunogen is followed by administration of a V3 fusion protein boosting immunogen.
摘要翻译：公开了一种新的免疫原性HIV-1 Env，特别是gp120 DNA构建体，其中V1 / V2环和V4环或全部三个可变环（包括V3）被V3序列置换，每个V3序列来自不同的病毒隔离。优选地，每个置换V3环是不同进化枝的V3的共有序列。这种构建体作为免疫原是有用的，因为每个呈递三个独立的V3表位，使得免疫的受试者产生比常规gp120或V3 DNA或多肽免疫原更广泛的反应性中和抗体应答。还公开了使用DNA构建体免疫哺乳动物，优选人免疫的方法，特别是在引发免疫原之后给予V3融合蛋白加强免疫原的免疫原。

4. 发明申请

WO2004112315A8 A MULTIPLE IDENTIFICATION LOGON METHOD OF INSTANT MESSENGER SYSTEM 审中-公开
标题翻译：实时信号系统的多种识别登录方法
公开(公告)号：WO2004112315A8
公开(公告)日：2005-04-21
申请号：PCT/CN2004000627
申请日：2004-06-11
申请人： TENCENT TECH SHENZHEN CO LTD , QIN PENGCHENG , LU SHAN , ZHANG JIANGUI
发明人： QIN PENGCHENG , LU SHAN , ZHANG JIANGUI
IPC分类号： H04L29/06 , H04L12/24 , H04L9/00
CPC分类号： H04L63/0815 , H04L29/12594 , H04L51/04 , H04L51/28 , H04L61/3065 , H04L61/307
摘要： A multiple identification logon method of instant messenger system includes: setting the corresponding relation among at least one user identifications; after the instant messenger system receiving the logon request, the user logging in according to the relation among the user identification. The present invention can provide the logon with several kinds of user identification simultaneously, resolve the shortages that the instant messenger can't provide the logon with several kinds of user identification simultaneously in prior art, make the user log in the instant messenger system more conveniently and improve the interest of the instant messenger. The present invention involves better practical applicability.
摘要翻译：即时消息系统的多重识别登录方法包括：设置至少一个用户标识之间的对应关系; 在即时消息系统接收到登录请求之后，用户根据用户身份之间的关系登录。本发明可以同时提供多种用户识别登录，解决了现有技术中即时消息不能同时登录几种用户识别的短缺，使用户更方便地登录即时消息系统并提高即时通讯员的兴趣。本发明涉及更好的实际应用。

5. 发明申请

WO2012050893A3 IMMUNOGENIC POLYPEPTIDES HAVING AN IMMUNOGENIC SCAFFOLD PROTEIN AND A LOOP PEPTIDE, PRESENTING A 3074- OR 2219/2557- MONOCLONAL ANTIBODY-TARGETED EPITOPE, WHICH IS PRESENT IN THE HIV GP120 PROTEIN 审中-公开
标题翻译：具有免疫原性SCAFFOLD蛋白和环腺苷的免疫多肽具有存在于HIV GP120蛋白质中的3074-或2219 / 2557-单克隆抗体靶向抗原决定簇
公开(公告)号：WO2012050893A3
公开(公告)日：2012-06-07
申请号：PCT/US2011053686
申请日：2011-09-28
申请人： UNIV NEW YORK , UNIV NEW JERSEY MED , MOLSOFT LLC , UNIV MASSACHUSETTS , CARDOZO TIMOTHY , KONG XIANG-PENG , ZOLLA-PAZNER SUSAN , PINTER ABRAHAM , KRACHMAROV CHAVDAR , LU SHAN , WANG SHIXIA , TOTROV MAXIM
发明人： CARDOZO TIMOTHY , KONG XIANG-PENG , ZOLLA-PAZNER SUSAN , PINTER ABRAHAM , KRACHMAROV CHAVDAR , LU SHAN , WANG SHIXIA , TOTROV MAXIM
IPC分类号： C07K14/155 , A61K39/21 , C12N15/49
CPC分类号： C07K14/001 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/55555 , A61K2039/6037 , C07K7/08 , C07K14/005 , C07K14/245 , C07K14/28 , C12N2740/16034
摘要： The present invention is directed to a recombinant immunogenic polypeptide. The polypeptide includes a loop peptide inserted into an immunogenic scaffold protein. The loop polypeptide has an amino acid sequence which presents the 3074 mAb- or the 2219/2557 mAb-targeted epitope of the HIV gpl20 protein and not other known epitopes of the HIV gpl20 protein. When used as an immunogen, the polypeptide induces an antibody response which neutralizes heterologous HIV-1 viruses in a pattern similar to that observed for the 3074 mAb- or the 2219/2557 mAb-targeted epitope, respectively. Pharmaceutical compositions containing the immunogenic polypeptide as well as methods of making and using it are also disclosed.
摘要翻译：本发明涉及重组免疫原性多肽。多肽包括插入免疫原性支架蛋白的环肽。环多肽具有呈现HIV gp120蛋白的3074mAb或2219 / 2557mAb靶向表位的氨基酸序列，而不是HIV gp120蛋白的其他已知表位。当用作免疫原时，多肽诱导抗体应答，其分别以与针对3074mAb-或2219 / 2557mAb靶向表位观察到的模式相似的方式中和异源HIV-1病毒。还公开了含有免疫原性多肽的药物组合物及其制备和使用方法。

6. 发明申请

WO9961049A3 MODEL FOR INFECTION BY A PATHOGEN USING ADMINISTRATION OF NUCLEIC ACIDS 审中-公开
标题翻译：使用核酸管理感染病毒的模型
公开(公告)号：WO9961049A3
公开(公告)日：2000-02-03
申请号：PCT/US9911251
申请日：1999-05-20
申请人： UNIV MASSACHUSETTS MEDICAL , LU SHAN , HERRMANN JOHN E
发明人： LU SHAN , HERRMANN JOHN E
IPC分类号： A61K39/00 , A61P31/18 , C12N7/00 , C12N15/85 , A01K67/027
CPC分类号： C12N15/8509 , A01K2267/0337 , A61K39/00 , C12N7/00 , C12N2740/15011
摘要： Methods are described for generating a model for infection of a host by a pathogen of interest, such as an immunodeficiency virus, and for generating organisms for use in a live, attenuated vaccine against a pathogen, by administering nucleic acids from the pathogen to the host.
摘要翻译：描述了用于通过将来自病原体的核酸给予宿主来产生感兴趣的病原体（例如免疫缺陷病毒）感染宿主的模型和用于产生用于针对病原体的活的减毒疫苗的生物体的方法。

7. 发明申请

WO2007067960A2 THE OR GENE AND ITS USE IN MANIPULATING CAROTENOID CONTENT AND COMPOSITION IN PLANTS AND OTHER ORGANISMS 审中-公开
标题翻译：该基因及其在植物和其他有机体中的处理中的应用
公开(公告)号：WO2007067960A2
公开(公告)日：2007-06-14
申请号：PCT/US2006061754
申请日：2006-12-07
申请人： US AGRICULTURE , BOYCE THOMPSON INST INC , CORNELL UNIVERSITY RES FOUNDAT , LI LI , LU SHAN , GARVIN DAVID F , VREBALOV JULIA , O'HALLORAN DIANA M
发明人： LI LI , LU SHAN , GARVIN DAVID F , VREBALOV JULIA , O'HALLORAN DIANA M
IPC分类号： A01H5/00
CPC分类号： C12N15/8243 , C07K14/415 , C12N15/825
摘要： The cauliflower (Brassica oleracea L var. botrytis) Or gene is a semi-dominant, single-locus mutation. It induces the accumulation of high levels of beta-carotene in various tissues that are normally devoid of carotenoids, turning them orange. Using a map-based cloning strategy, we identified a single candidate gene representing Or and successfully verified its identity by phenotypic complementation in the wild type cauliflower. The Or gene encodes a plastid membrane protein containing the DnaJ zinc figure domain. A likely gain-of-function mutation from a 4.3-kb retrotransposon insertion in the Or allele confers the orange phenotype in the mutant. Southern blot analysis revealed that Or is a single-copy sequence in the cauliflower genome. High level of expression of the Or gene and the protein was found in very young leaves, curds, and flowers at comparable abundance between wild type and the Or mutant.Or likely functions in regulating the differentiation of some non-photosynthetic plastids into chromoplasts, which provide the deposition "sink" for carotenoid accumulation. Or orthologs with high degree of sequence homology were found in many other higher plants, including Arabidopsis, tomato, maize, and rice. Successful phenotypic complementation of Or in Arabidopsis provides strong evidence that Or can work across species to enhance carotenoid accumulation in other important crops.
摘要翻译：花椰菜（Brassica oleracea L var。botrytis）或基因是半显性的单基因座突变。它引起高水平的β-胡萝卜素在各种组织中的积累，通常不含类胡萝卜素，使其变成橙色。使用基于地图的克隆策略，我们确定了代表Or的单个候选基因，并通过野生型花椰菜的表型互补成功验证了其同一性。 Or基因编码含有DnaJ锌图形结构域的质体膜蛋白。来自Or等位基因中的4.3-kb反转录转座子插入的可能的功能增益赋予突变体中的橙色表型。 Southern印迹分析显示Or是花椰菜基因组中的单拷贝序列。 Or基因和蛋白质的高水平表达在野生型和Or突变体之间的相当丰度的非常年轻的叶子，凝乳和花中发现。可能在调节一些非光合质体到色素的分化中起作用为类胡萝卜素积累提供沉积“沉”。在许多其他高等植物，包括拟南芥，番茄，玉米和水稻中，发现具有高度序列同源性的直向同源物。在拟南芥中成功的表型互补提供了强有力的证据，或者可以在物种间工作，以增强其他重要作物的类胡萝卜素积累。

8. 发明申请

WO2006104615A3 INFLUENZA NUCLEIC ACIDS, POLYPEPTIDES, AND USES THEREOF 审中-公开
标题翻译：流感核酸，多聚核苷酸及其用途
公开(公告)号：WO2006104615A3
公开(公告)日：2007-04-26
申请号：PCT/US2006006701
申请日：2006-02-24
申请人： UNIV MASSACHUSETTS , LU SHAN , WANG SHIXIA
发明人： LU SHAN , WANG SHIXIA
IPC分类号： C07K14/11 , A61K39/145 , C07K16/00 , C12N7/01 , C12N15/00 , C12N15/44
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , Y10S514/888
摘要： Codon-optimized nucleic acids encoding influenza polypeptides and uses of the nucleic acids and polypeptides for inducing immune responses are provided herein.
摘要翻译：编码流感多肽的密码子优化的核酸和用于诱导免疫应答的核酸和多肽的用途在此提供。

9. 发明申请

WO2004093820A2 METHODS AND COMPOSITIONS FOR SOLID TUMOR TREATMENT 审中-公开
标题翻译：用于固体肿瘤治疗的方法和组合物
公开(公告)号：WO2004093820A2
公开(公告)日：2004-11-04
申请号：PCT/US2004013142
申请日：2004-04-23
申请人： UNIV MASSACHUSETTS , LU SHAN , CHOU TE-HUI W , WANG SHIXIA
发明人： LU SHAN , CHOU TE-HUI W , WANG SHIXIA
IPC分类号： A61K20060101 , A61K48/00 , C07H21/04 , C07K14/535 , C07K14/54 , C07K14/55 , C07K14/705 , C12N15/63 , A61K
CPC分类号： C07K14/70575 , C07K14/5428 , C07K14/55
摘要： Nucleic acid compositions and methods of use in treating solid tumors are disclosed. The nucleic acid compositions include a plurality of nucleic acid plasmids. Each plasmid encodes a single protein, either a cytokine or an anti-tumor protein. Each composition includes a plurality of these nucleic acid plasmids that encode a combination of two or more cytokines, a combination of cytokines and anti-tumor proteins, a combination of anti-tumor proteins, or an anti-tumor protein. The nucleic acid compositions of the invention can be delivered locally to a solid tumor.
摘要翻译：公开了核酸组合物和用于治疗实体瘤的方法。核酸组合物包括多个核酸质粒。每个质粒编码单一蛋白，细胞因子或抗肿瘤蛋白。每种组合物包括编码两种或更多种细胞因子的组合，细胞因子和抗肿瘤蛋白的组合，抗肿瘤蛋白或抗肿瘤蛋白的组合的多种这些核酸质粒。本发明的核酸组合物可以局部递送至实体瘤。

10. 发明申请

WO2004076645A2 COMPOSITIONS AND METHODS FOR CYTOMEGALOVIRUS TREATMENT 审中-公开
标题翻译：用于细胞病毒治疗的组合物和方法
公开(公告)号：WO2004076645A2
公开(公告)日：2004-09-10
申请号：PCT/US2004005923
申请日：2004-02-27
申请人： UNIV MASSACHUSETTS , LU SHAN , SHEN SIYUAN
发明人： LU SHAN , SHEN SIYUAN
IPC分类号： A01N43/04 , A61K39/245 , A61K48/00 , C07H21/02 , C07K14/045 , C12N20060101 , C12N15/00 , C12N
CPC分类号： C07K14/005 , A61K39/12 , A61K39/245 , A61K2039/53 , A61K2039/57 , C12N2710/16122 , C12N2710/16134
摘要： A panel of nucleic acids encoding human cytomegalovirus (HCMV) antigens is disclosed. These include nucleic acids encoding any one or more of the following antigenic proteins: glycoprotein B (gB), glycoprotein M (gM), glycoprotein N (gN), glycoprotein complex II (gM/N), glycoprotein complex III, phosphoprotein pp65 (pp65), phosphoprotein pp150 (pp150), and antigenic fragments of any of these. These nucleic acids can be used in kits and methods of treating HCMV infections.
摘要翻译：公开了一组编码人巨细胞病毒（HCMV）抗原的核酸。这些包括编码任何一种或多种以下抗原蛋白的核酸：糖蛋白B（gB），糖蛋白M（gM），糖蛋白N（gN），糖蛋白复合物II（gM / N），糖蛋白复合物III，磷酸蛋白pp65 ），磷蛋白pp150（pp150），以及任何这些的抗原片段。这些核酸可用于治疗HCMV感染的试剂盒和方法。

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