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1. 发明申请

WO2004078712A3 ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
标题翻译：异喹啉衍生物及其使用方法
公开(公告)号：WO2004078712A3
公开(公告)日：2005-02-24
申请号：PCT/US2004005849
申请日：2004-02-26
申请人： INOTEK PHARMACEUTICALS CORP , JAGTAP PRAKASH , BALOGLU ERKAN , VAN DUZER JOHN H , SZABO CSABA , SALZMAN ANDREW L , ROY ALOKA , WILLIAMS WILLIAM , NIVOROZHKIN ALEXANDER
发明人： JAGTAP PRAKASH , BALOGLU ERKAN , VAN DUZER JOHN H , SZABO CSABA , SALZMAN ANDREW L , ROY ALOKA , WILLIAMS WILLIAM , NIVOROZHKIN ALEXANDER
IPC分类号： C07D221/18 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4745 , C07D471/02
CPC分类号： C07D221/18 , C07D471/04 , C07D491/04 , C07D495/04
摘要： The invention relates to Isoquinoline Derivatives; compositions comprising an effective amount of an Isoquinoline Derivative; and methods for treating or preventing an inflammatory disease or a reperfusion disease comprising the administration of an effective amount of an Isoquinoline Derivative.
摘要翻译：本发明涉及异喹啉衍生物; 包含有效量的异喹啉衍生物的组合物; 以及用于治疗或预防炎性疾病或再灌注疾病的方法，包括施用有效量的异喹啉衍生物。

2. 发明公开

EP1603568A4 ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
标题翻译：异喹啉和其使用方法
公开(公告)号：EP1603568A4
公开(公告)日：2009-02-25
申请号：EP04715130
申请日：2004-02-26
申请人： INOTEK PHARMACEUTICALS CORP
发明人： JAGTAP PRAKASH , BALOGLU ERKAN , VAN DUZER JOHN H , SZABO CSABA , SALZMAN ANDREW L , ROY ALOKA , WILLIAMS WILLIAM , NIVOROZHKIN ALEXANDER
IPC分类号： C07D471/02 , A61K31/4745 , C07D221/18 , C07D471/04 , C07D491/04 , C07D495/04
CPC分类号： C07D221/18 , C07D471/04 , C07D491/04 , C07D495/04

3. 发明公开

EP1420785A4 SUBSTITUTED INDENO 1,2-c]ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF 有权
标题翻译：取代茚基-1,2-异喹啉衍生物及其用途
公开(公告)号：EP1420785A4
公开(公告)日：2005-10-19
申请号：EP02766175
申请日：2002-08-30
申请人： INOTEK PHARMACEUTICALS CORP
发明人： JAGTAP PRAKASH G , BALOGLU ERKAN , VAN DUZER JOHN H , SZABO CSABA , SALZMAN ANDREW L
IPC分类号： C07D211/00 , A61K31/473 , A61K31/496 , A61K31/5377 , A61P1/02 , A61P1/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P39/06 , A61P43/00 , C07D221/18 , C07D401/12 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/435 , A61K31/00 , A61P35/00
CPC分类号： C07D495/04 , A61K31/435 , A61K31/473 , A61K31/4741 , A61K31/4743 , A61K31/4745 , C07D221/18 , C07D471/04 , C07D491/04
摘要： The invention provides novel classes of substituted indeno[1,2-c]isoquinoline compounds. Pharmaceutical compositions and methods of making and using the compounds are also described.

4. 发明公开

EP1722797A4 ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
标题翻译：异喹啉衍生物及其使用方法
公开(公告)号：EP1722797A4
公开(公告)日：2008-03-19
申请号：EP05723909
申请日：2005-02-25
申请人： INOTEK PHARMACEUTICALS CORP
发明人： JAGTAP PRAKASH , BALOGLU ERKAN , VAN DUZER JOHN H , SZABO CSABA , SALZMAN ANDREW L , ROY ALOKA , WILLIAMS WILLIAM , NIVOROZHKIN ALEXANDER
IPC分类号： A61K31/473 , A61K31/4745 , A61K31/55 , C07D221/18
CPC分类号： A61K31/473 , A61K31/4745 , A61K31/55 , C07D221/18

5. 发明专利

CA2517358A1 ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF 未知
公开(公告)号：CA2517358A1
公开(公告)日：2004-09-16
申请号：CA2517358
申请日：2004-02-26
申请人： INOTEK PHARMACEUTICALS CORP
发明人： ROY ALOKA , JAGTAP PRAKASH , SALZMAN ANDREW L , WILLIAMS WILLIAM , VAN DUZER JOHN H , SZABO CSABA , BALOGLU ERKAN , NIVOROZHKIN ALEXANDER
IPC分类号： C07D221/18 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4745 , C07D471/02
摘要： The invention relates to Isoquinoline Derivatives; compositions comprising a n effective amount of an Isoquinoline Derivative; and methods for treating or preventing an inflammatory disease or a reperfusion disease comprising the administration of an effective amount of an Isoquinoline Derivative.

6. 发明专利

ECSP044997A DERIVADOS SUSTITUIDOS DEL INDENO [1,2-c] ISOQUINOLINA 未知
公开(公告)号：ECSP044997A
公开(公告)日：2004-04-28
申请号：ECSP044997
申请日：2004-02-27
申请人： INOTEK PHARMACEUTICALS CORP
发明人： JAGTAP PRAKASH G , BOLOGLU ERKAN , VAN DUZER JOHN H , SZABO OSABA , SALZMAN ANDREW L
IPC分类号： C07D211/00 , A61K31/00 , A61K31/435 , A61K31/473 , A61K31/496 , A61K31/5377 , A61P1/02 , A61P1/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P39/06 , A61P43/00 , C07D221/18 , C07D401/12 , C07D471/04 , C07D491/04 , C07D495/04 , A61K221/18
摘要： Esta invención relaciona a los compuesos de indeno (1,2-c) isoquinolina; composiciones comprometiendo un compuesto de indeno(1,2-c) isoquinolina; y metodos para tratamiento o prevención de una enfermedad inflamatoria o una enfermedad de reperfusion

7. 发明专利

ES2345436T3 DERIVADOS SUSTITUIDOS DE INDENO-(1,2-C)ISOQUINOLINA Y METODOS DE USO DE LOS MISMOS. 未知
公开(公告)号：ES2345436T3
公开(公告)日：2010-09-23
申请号：ES02766175
申请日：2002-08-30
申请人： INOTEK PHARMACEUTICALS CORP
发明人： JAGTAP PRAKASH G , BALOGLU ERKAN , VAN DUZER JOHN H , SZABO CSABA , SALZMAN ANDREW L
IPC分类号： A61K31/435 , C07D211/00 , A61K31/00 , A61K31/473 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61P1/02 , A61P1/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P39/06 , A61P43/00 , C07D221/18 , C07D401/12 , C07D471/04 , C07D491/04 , C07D495/04
摘要： Un compuesto de la fórmula: **(Ver fórmula)** o una sal o hidrato farmacéuticamente aceptable del mismo, en donde: R5 es O; R6 es -H o C1-C4alquilo; X es -CH2-, -CH(halo)-, -CH(OH)(CH2)n-, -O-, -NH-, -S- o -CH(NR11R12)-, en donde n es un número entero comprendido entre 0 y 5; R11 y R12 son independientemente hidrógeno o C1-C9alquilo, o N, R11 y R12 se consideran juntos para formar una amina heterocíclica; R1, R2, R3, R4, R7, R8, R9 y R10 son independientemente -hidrógeno, -halo, -hidroxi, -O-(C1-C5alquilo), -C1-C10alquilo, -haloalquilo, -C2-C10alquenilo, -C3-C8carbociclo, -arilo, -NH2, -alquilamino, -C(O)OH, -C(O)O(C1-C5alquilo), -OC(O)(C1-C5alquilo), -NO2 o -A-B; en donde A es -SO2-, -SO2NH-, -NHCO-, -NHCONH-, -O-, -CO-, -OC(O)-, -C(O)O-, -CONH-, -CON(C1-C4alquilo)-, -NH-, -CH2-, -S- o -C(S)-; B es -C1-C10alquilo, -C2-C10alquenilo, -heterociclo, -C3-C8carbociclo, -arilo, -NZ1Z2, -alquilamino, -amino- dialquilo, -alquilheterociclo, -arilamido-, -C(O)OH, -C(O)O-(C1-C5alquilo) o -C(O)O-fenilo, cualesquiera de los cuales están insustituidos o sustituidos con uno o más de grupos-O-(C1-C5alquilo), -halo, -haloalquilo, -alcanol, -alquilamino, -hidroxi, -NO2, -NH2, -aminoalquilo, -aminodialquilo, -amina heterocíclica, -C1-C10alquilo, -C2-C10alquenilo, -C2-C10alquinilo, -arilo, -bencilo, -alquilamido, -alquilcarboxi, -C1-C5alquileno-C(O)O-C1-C5alquilo o -C1-C5alquileno-OC(O)-C1-C5alquilo; y Z1 y Z2 son independientemente -H o -C1-C10alquilo, que está insustituido o sustituido con uno más de -halo, -OH o -NZ3Z4, en donde Z3 y Z4 son independientemente -H o -C1-C5alquilo, que está insustituido o sustituido con uno o más de -halo, -hidroxi o -NH2; o N, Z3 y Z4 se consideran juntos para formar una amina heterocíclica insustituida o sustituida; o N, Z1 y Z2 se consideran juntos para formar una amina heterocíclica; en donde "arilo" hace referencia a un grupo fenilo o piridilo, que está insustituido o sustituido con uno o más de -C1-C5alquilo, -halo, -haloalquilo, -hidroxi, -O-C1-C5alquilo, -NH2, -aminoalquilo, -aminodialquilo, -C(O)OH, -C(O)O-(C1-C5alquilo), -OC(O)-(C1-C5alquilo), -NH-amidoalquilo, -C(O)NH2, -Carboxamidoalquilo, o -NO2; en donde "arilamido" hace referencia a un grupo arilo, en el cual uno o más de los átomos de hidrógeno del grupo arilo se ha reemplazado con uno o más grupos-C(O)NH2; en donde "heterociclo" hace referencia a un carbociclo aromático o no aromático de 5-10 miembros, en el cual 1-4 de los átomos de carbono del anillo se han reemplazado independientemente con un átomo N, O o S, y que está insustituido o sustituido con uno o más de -C1-C5alquilo, halo, -haloalquilo, -hidroxi, -O-C1-C5alquilo, -NH2, -aminoalquilo, -aminodialquilo, -C(O)OH, -C(O)O-(C1-C5alquilo), -OC(O)-(C1-C5alquilo), -NH-amidoalquilo, -CONH2, -Carboxamidoalquilo, o -NO2; en donde "alquilheterociclo" hace referencia a un grupo -C1-C5alquilo, en el cual uno de los átomos de hidrógeno del grupo -C1-C5alquilo se ha reemplazado con un heterociclo; y en donde "amina heterocíclica" hace referencia a un heterociclo, que tiene 1-4 átomos de nitrógeno en el anillo, estando el heterociclo insustituido o sustituido con uno o más de -NH-(C1-C5alquilo), -C(O)-(C1-C5alquilo), -NH-C(O)(C1-C4alquilo), -O-(C1-C5alquilo), -halo, -haloalquilo, -alcanol, -alquilamino, -hidroxi, -NO2, -NH2, -aminoalqui- lo, -aminodialquilo, -amina heterocíclica, -C1-C10alquilo, -C2-C10alquenilo, -C2-C10alquinilo, -arilo, -bencilo, -alquila- mido, -alquilcarboxi, -C(O)OH, -C1-C5alquileno-OC(O)-C1-C5alquilo, -C1-C5alquileno-C(O)O-C1-C5alquilo, o un heterociclo o -C3-C8carbociclo que está insustituido o sustituido con uno o más de -C1-C10alquilo, -O-(C1-C5alquilo), -halo, -haloalquilo, -alcanol, -alquilamino, -hidroxi, -NO2 o -NH2; con la salvedad de que el compuesto no es: **(Ver fórmula)** **(Ver fórmula)**

8. 发明专利

DE60236170D1 未知
公开(公告)号：DE60236170D1
公开(公告)日：2010-06-10
申请号：DE60236170
申请日：2002-08-30
申请人： INOTEK PHARMACEUTICALS CORP
发明人： JAGTAP PRAKASH G , BALOGLU ERKAN , VAN DUZER JOHN H , SZABO CSABA , SALZMAN ANDREW L
IPC分类号： A61K31/435 , C07D211/00 , A61K31/00 , A61K31/473 , A61K31/4741 , A61K31/4743 , A61K31/496 , A61K31/5377 , A61P1/02 , A61P1/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P39/06 , A61P43/00 , C07D221/18 , C07D401/12 , C07D471/04 , C07D491/04 , C07D495/04

9. 发明专利

NZ531218A Substituted indeno[1,2-c]isoquinoline derivatives and methods of use thereof 未知
公开(公告)号：NZ531218A
公开(公告)日：2006-02-24
申请号：NZ53121802
申请日：2002-08-30
申请人： INOTEK PHARMACEUTICALS CORP
发明人： JAGTAP PRAKASH G , BALOGLU ERKAN , VAN DUZER JOHN H , SZABO CSABA , SALZMAN ANDREW L
IPC分类号： C07D211/00 , A61K31/473 , A61K31/496 , A61K31/5377 , A61P1/02 , A61P1/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P39/06 , A61P43/00 , C07D221/18 , C07D401/12 , C07D471/04 , C07D491/04 , C07D495/04 , A61P25/16 , C07D419/12
摘要： Indeno[1,2-c]isoquinoline compounds and their derivatives are described wherein in formula (ia): R5 is NH or O; R6 is -H or C1-C4 alkyl ; X is -C(O)-, -CH2-, -CH(halo)-, -CH(OH)(CH2)n-, -CH(OH)-arylene-, -O-, -NH-, -S- or -CH(NR11R12)-, wherein n is an integer ranging from 0-5; R11 and R12 are independently-hydrogen or -C1-C9 alkyl, or N, R11 and R12 are taken together to form a heterocyclic amine; R1, R2, R3, R4, R7, R8, R9 and R10 are independently -hydrogen, -halo, -hydroxy, -O-(C1-C3 alkyl), -C1-C10 alkyl, -akylhalo, -C2-C10alkenyl, -C3-C8carbocycle, -aryl, -NH2, -alkylamino, -C(O)OH, -C(O)O(C1-C5alkyl), -OC(O)(C1-C5alkyl), NO2 or-A-B; wherein A is -SO2-, -SO2NH-, -NHCO-, -NHCONH-, -O-, -CO-, -OC(O)-, -C(O)O-, -CONH-,-CON(C1-C4alkyl)-, -NH-, -CH2-, -S- or -C(S)-; B is -C1-C10alkyl, -C2-C10alkylenyl, -C3-C8 cabocycle, -aryl, -NZ1Z2, -alkylamino, -aminodialkyl, -arylamido, -C(O)OH, -C(O)O-(C1-C5 alkyl) or-C(O)O-phenyl, a 5-10 membered aromatic or non-aromatic carbocycle in which 1-4 of the ring carbon atoms are independently replaced with a N, O, or S atom or B is a C1-C5 alkyl group in which one of the hydrogen atoms is replaced with a 5-10 membered aromatic or non-aromatic carbocycle in which 1-4 of the carbocycle's ring carbon atoms are independently replace with a N, O or S atom, wherein in the foregoing B groups may be optionally substituted; and Z1 and Z2 are independently - H or-C1-C10 alkyl, which is optionally substituted, or N, Z1 and Z2 are taken together to form a 5-10 membered aromatic or non-aromatic carbocycle in which 1-4 ring carbon atoms are independently replaced with a N, O or S atom, at least one of which is a N. The compounds can be used in pharmaceutical compositions for treating an inflammatory condition, diabetes, reoxygenation injury resulting from organ transplant, Parkinson's disease, and reperfusion disease, such as myocardial infarction or stroke.

10. 发明专利

CA2557547A1 ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF 未知
公开(公告)号：CA2557547A1
公开(公告)日：2005-09-09
申请号：CA2557547
申请日：2005-02-25
申请人： INOTEK PHARMACEUTICALS CORP
发明人： WILLIAMS WILLIAM , NIVOROZHKIN ALEXANDER , SALZMAN ANDREW L , ROY ALOKA , JAGTAP PRAKASH , BALOGLU ERKAN , VAN DUZER JOHN H , SZABO CSABA
IPC分类号： A61K31/473 , A61K31/4745 , A61K31/55 , C07D221/18
摘要： The present invention relates to Isoquinoline Derivatives, compositions comprising an effective amount of a Isoquinoline Derivative and methods for treating or preventing an inflammatory disease, a reperfusion injury, an ischemic condition, renal failure, diabetes, a diabetic complication, a vascular disease other than a cardiovascular disease, cardiovascular disease , reoxygenation injury resulting from organ transplantation, Parkinson's disease, or cancer, comprising administering to an animal in need thereof an effective amount of a Isoquinoline Derivative.

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