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1. 发明申请

WO2005118626A2 PEPTIDES FOR INDUCING A CTL AND/OR HTL RESPONSE TO HEPATITIS C VIRUS 审中-公开
标题翻译：用于诱导针对HEPATITIS C病毒的CTL和/或HTL反应的肽
公开(公告)号：WO2005118626A2
公开(公告)日：2005-12-15
申请号：PCT/EP2005/052457
申请日：2005-05-30
申请人： INNOGENETICS N.V. , IDM PHARMA INC. , DEPLA, Erik , BUYSE, Marie-Ange , LASTERS, Ignace , DESMET, Johan , MAERTENS, Geert , BAKER, Denise , CHESNUT, Robert W. , NEWMAN, Mark , SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott
发明人： DEPLA, Erik , BUYSE, Marie-Ange , LASTERS, Ignace , DESMET, Johan , MAERTENS, Geert , BAKER, Denise , CHESNUT, Robert W. , NEWMAN, Mark , SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott
IPC分类号： C07K14/18
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： The present invention is directed to peptides, and nucleic acids encoding them, derived from the Hepatitis C Virus (HCV). The peptides are those which elicit a CTL and/or HTL response in a host. The invention is also directed to compositions and vaccines for prevention and treatment of HCV infection and diagnostic methods for detection of HCV exposure in patients.
摘要翻译：本发明涉及衍生自丙型肝炎病毒（HCV）的肽和编码它们的核酸。肽是在宿主中引起CTL和/或HTL应答的肽。本发明还涉及用于预防和治疗HCV感染的组合物和疫苗以及用于检测患者中HCV暴露的诊断方法。

2. 发明申请

WO02019986A1 INDUCING CELLULAR IMMUNE RESPONSES TO HEPATITIS B VIRUS USING PEPTIDE AND NUCLEIC ACID COMPOSITIONS 审中-公开
标题翻译：用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答
公开(公告)号：WO02019986A1
公开(公告)日：2002-03-14
申请号：PCT/US2000/024802
申请日：2000-09-08
申请人： EPIMMUNE INC. , SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott , VITIELLO, Maria, A. , LIVINGSTONE, Brian, D. , CELIS, Esteban , KUBO, Ralph, T. , GREY, Howard, M. , CHESNUT, Robert, W.
发明人： SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott , VITIELLO, Maria, A. , LIVINGSTONE, Brian, D. , CELIS, Esteban , KUBO, Ralph, T. , GREY, Howard, M. , CHESNUT, Robert, W.
IPC分类号： A61K9/127
CPC分类号： C07K14/005 , A61K38/00 , A61K2039/5154 , C12N2730/10122
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译：本发明使用我们关于T细胞识别抗原以开发针对HBV的基于表位的疫苗的机制的知识。更具体地说，本申请传达了我们对用于预防和治疗HBV感染的药物组合物和方法的发现。

3. 发明申请

WO2004053086A2 PLASMODIUM FALCIPARUM ANTIGENS AND METHODS OF USE 审中-公开
标题翻译： PLASMODIUM FALCIPARUM抗原和使用方法
公开(公告)号：WO2004053086A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/038966
申请日：2003-12-08
申请人： EPIMMUNE, INC. , THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE NAVY , SETTE, Alessandro , DOOLAN, Denise, L. , CARUCCI, Daniel, J. , SIDNEY, John , SOUTHWOOD, Scott
发明人： SETTE, Alessandro , DOOLAN, Denise, L. , CARUCCI, Daniel, J. , SIDNEY, John , SOUTHWOOD, Scott
IPC分类号： C12N
CPC分类号： C12Q1/6837 , A61K39/00 , C07K14/445 , Y02A50/412 , Y10S424/802
摘要： The subject invention provides novel Plasmodium falciparum antigens and novel polynucleotides encoding these antigens. Also provided by the subject invention are methods of using these antigens and polynucleotides.
摘要翻译：本发明提供新型恶性疟原虫抗原和编码这些抗原的新型多核苷酸。本发明还提供了使用这些抗原和多核苷酸的方法。

4. 发明申请

WO2003040165A3 HLA CLASS I AND II BINDING PEPTIDES AND THEIR USES 审中-公开
公开(公告)号：WO2003040165A3
公开(公告)日：2003-05-15
申请号：PCT/US2001/051650
申请日：2001-10-18
申请人： EPIMMUNE INC. , SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott
发明人： SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott
IPC分类号： A61K39/00
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. The peptides are useful to elicit an immune response against a desired antigen.

5. 发明申请

WO2003040165A2 HLA CLASS I AND II BINDING PEPTIDES AND THEIR USES 审中-公开
标题翻译： HLA一级和二级结合肽及其用途
公开(公告)号：WO2003040165A2
公开(公告)日：2003-05-15
申请号：PCT/US2001/051650
申请日：2001-10-18
申请人： EPIMMUNE INC. , SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott
发明人： SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott
IPC分类号： C07K
CPC分类号： A61K39/385 , A61K2039/5154 , A61K2039/5158 , A61K2039/605
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. The peptides are useful to elicit an immune response against a desired antigen.
摘要翻译：本发明提供了选择免疫原性肽的方法和方法以及能够特异性结合由HLA等位基因编码的糖蛋白并诱导由等位基因限制的T细胞中的T细胞活化的免疫原性肽组合物。所述肽可用于引发针对所需抗原的免疫应答。

6. 发明申请

WO2002061435A2 SUBUNIT VACCINES WITH A2 SUPERMOTIFS 审中-公开
标题翻译：亚超疫苗与A2超重
公开(公告)号：WO2002061435A2
公开(公告)日：2002-08-08
申请号：PCT/US2002/002708
申请日：2002-01-29
申请人： EPIMMUNE INC. , SIDNEY, John , SETTE, Alessandro , GREY, Howard, M. , SOUTHWOOD, Scott
发明人： SIDNEY, John , SETTE, Alessandro , GREY, Howard, M. , SOUTHWOOD, Scott
IPC分类号： G01N33/68
CPC分类号： G01N33/6812 , G01N2500/04
摘要： Methods to design vaccines which are effective in individuals bearing A2 supertype alleles are described. Single amino acid substitution analogs of known A2-supertype binding peptides, and large peptide libraries were utilized to rigorously define the peptide binding specificities of A2-supertype molecules. While each molecule was noted to have unique preferences, large overlaps in specificity were found. The presence of the hydrophobic and aliphatic residues L, I, V, M, A, T, and Q in positon 2 of peptide ligands was commonly tolerated by A2-supertype molecules. L, I, V, M, A, and T were tolerated at the C-terminus. While examination of secondary influences on peptide binding revealed allele specific preferences, shared features could also be identified, and were utilized to define an A2-supermotif. Shared features also correlate with cross-reactivity; over 70% of the peptides that bound A*0201 with high affinity were found to bind at least 2 other A2-supertype molecules. Finally, the coefficients for use in the development of algorithms for the prediction of peptide binding to A2-supertype molecules are provided.
摘要翻译：描述了在携带A2超型等位基因的个体中有效的疫苗的设计方法。使用已知的A2-超型结合肽的单个氨基酸取代类似物和大的肽文库来严格限定A2-超型分子的肽结合特异性。虽然每个分子被注意到具有独特的偏好，但发现了特异性的大的重叠。肽配体的位置2中疏水和脂族残基L，I，V，M，A，T和Q的存在通常被A2-超型分子所耐受。 L，I，V，M，A和T在C末端耐受。虽然检测对肽结合的次要影响揭示了等位基因特异性偏好，但也可以鉴定共享特征，并用于定义A2超超敏。共享特征也与交叉反应性相关; 发现以高亲和力结合A * 0201的肽的70％以上结合至少2种其它的A2-超型分子。最后，提供了用于开发用于预测肽结合A2-超型分子的算法的系数。

7. 发明申请

WO2004031211A2 HLA BINDING PEPTIDES AND THEIR USES 审中-公开
标题翻译： HLA结合肽及其用途
公开(公告)号：WO2004031211A2
公开(公告)日：2004-04-15
申请号：PCT/US2003/031308
申请日：2003-10-03
申请人： EPIMMUNE INC. , SIDNEY, John , SOUTHWOOD, Scott , SETTE, Alessandro
发明人： SIDNEY, John , SOUTHWOOD, Scott , SETTE, Alessandro
IPC分类号： C07K
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/35 , C07K14/4746 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/70539 , C07K14/82 , C07K2319/01 , C12N2710/16222 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222 , C12N2770/24222
摘要： Provided herein are peptides in certian pathogens and/or human or murine proteins that are identified as capable of binding one or more MHC molecules and inducing an immume response in a system. Also provided are compositions that include one or more of the peptides and methods for inducing an immune reponse in a system by administering the compositions to the system.
摘要翻译：本文提供了证实为能够结合一种或多种MHC分子并在系统中诱导中止反应的证人病原体和/或人或鼠蛋白质中的肽。还提供了包含一种或多种肽的组合物和通过将组合物施用于系统来诱导系统中免疫应答的方法。

8. 发明申请

WO2017184456A1 TOXOPLASMA GONDII VACCINES AND THEIR USE 审中-公开
标题翻译：弓形虫疫苗及其使用
公开(公告)号：WO2017184456A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/027675
申请日：2017-04-14
申请人： MCLEOD, Rima , EL BISSATI, Kamal , ZHOU, Ying , ALEXANDER, Jeff , VANG, Lo , REED, Steve , PAULILLO, Sara, M. , RAMAN, Senthil, K. , BURKHARD, Peter , MELO, Mariane , IRVINE, Darrel , WEISS, Ron , ZHANG, Yuan , SETTE, Alessandro , SIDNEY, John , LIVINGSTON, Brian, D. , LORENZI, Hernan
发明人： MCLEOD, Rima , EL BISSATI, Kamal , ZHOU, Ying , ALEXANDER, Jeff , VANG, Lo , REED, Steve , PAULILLO, Sara, M. , RAMAN, Senthil, K. , BURKHARD, Peter , MELO, Mariane , IRVINE, Darrel , WEISS, Ron , ZHANG, Yuan , SETTE, Alessandro , SIDNEY, John , LIVINGSTON, Brian, D. , LORENZI, Hernan
IPC分类号： A61K31/7088 , A61K38/17 , A61K39/012 , A61P33/02 , A61P37/04 , C12N15/11 , C12N15/12 , C12N15/63
摘要： Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.
摘要翻译：本文公开了编码多表位多肽及其组装体的多核苷酸，以及它们用于治疗或限制弓形虫感染的用途。

9. 发明授权

EP1089757B1 HLA BINDING PEPTIDES AND THEIR USES 有权
标题翻译： HLA-结合肽和用途
公开(公告)号：EP1089757B1
公开(公告)日：2009-04-22
申请号：EP99928792.3
申请日：1999-06-17
申请人： IDM Pharma, Inc.
发明人： SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott
IPC分类号： A61K39/145 , C07K7/06
CPC分类号： C07K14/70539 , A61K38/00
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. The peptides are useful to elicit an immune response against a desired antigen.

10. 发明公开

EP1756147A2 PEPTIDES FOR INDUCING A CTL AND/OR HTL RESPONSE TO HEPATITIS C VIRUS 审中-公开
标题翻译：肽FOR诱导T-淋巴细胞反应丙型肝炎病毒
公开(公告)号：EP1756147A2
公开(公告)日：2007-02-28
申请号：EP05743155.3
申请日：2005-05-30
申请人： Innogenetics N.V. , Pharmexa Inc.
发明人： DEPLA, Erik , BUYSE, Marie-Ange , LASTERS, Ignace , DESMET, Johan , MAERTENS, Geert , BAKER, Denise , CHESNUT, Robert W. , NEWMAN, Mark , SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott
IPC分类号： C07K14/18 , A61K39/295 , G01N33/576 , A61K38/16
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： The present invention is directed to peptides, and nucleic acids encoding them, derived from the Hepatitis C Virus (HCV). The peptides are those which elicit a CTL and/or HTL response in a host. The invention is also directed to compositions and vaccines for prevention and treatment of HCV infection and diagnostic methods for detection of HCV exposure in patients.

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