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1. 发明申请

WO2012095432A3 TLR3 BINDING AGENTS 审中-公开
标题翻译： TLR3结合剂
公开(公告)号：WO2012095432A3
公开(公告)日：2012-09-13
申请号：PCT/EP2012050321
申请日：2012-01-10
申请人： INNATE PHARMA , GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE , BONNAFOUS CECILE , ANDERSEN METTE DAHL , ROSSI BENJAMIN
发明人： GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE , BONNAFOUS CECILE , ANDERSEN METTE DAHL , ROSSI BENJAMIN
IPC分类号： A61K39/395 , A61P11/00 , A61P19/02 , A61P37/00 , C07K16/24 , C07K16/28
CPC分类号： A61K39/3955 , A61K31/519 , A61K2039/505 , C07K16/28 , C07K16/2896 , C07K2317/34 , C07K2317/54 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The invention provides anti-TLR3 antibodies as well as methods of making and using them. The antibodies are particularly adapted to the treatment of autoimmune or inflammatory diseases using anti-TLR3 antibodies.
摘要翻译：本发明提供抗TLR3抗体以及制备和使用它们的方法。抗体特别适用于使用抗TLR3抗体治疗自身免疫性或炎性疾病。

2. 发明申请

WO2011004028A2 TLR3 BINDING AGENTS 审中-公开
标题翻译： TLR3结合剂
公开(公告)号：WO2011004028A2
公开(公告)日：2011-01-13
申请号：PCT/EP2010059946
申请日：2010-07-09
申请人： INNATE PHARMA , GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE
发明人： GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , A61K39/3955 , A61K45/06 , A61K47/48561 , A61K47/6849 , C07K2317/34 , C07K2317/35 , C07K2317/54 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies (e.g. monoclonal antibodies), antibody fragments, and derivatives thereof that specifically bind TLR3, and that optionally further modulate, e.g. inhibit, signaling. The invention also relates to cells producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; pharmaceutical compositions comprising the same; methods of using the antibodies to diagnose, treat or prevent diseases, e.g. autoimmune diseases, inflammatory diseases and the like.
摘要翻译：本发明涉及特异性结合TLR3的抗体（例如单克隆抗体），抗体片段及其衍生物，并且任选进一步调节，例如，抑制信号。本发明还涉及产生这种抗体的细胞; 制备此类抗体的方法; 抗体的片段，变体和衍生物; 包含它们的药物组合物; 使用抗体诊断，治疗或预防疾病的方法，例如，自身免疫性疾病，炎症性疾病等。

3. 发明申请

WO2011004028A9 TLR3 BINDING AGENTS 审中-公开
公开(公告)号：WO2011004028A9
公开(公告)日：2011-08-11
申请号：PCT/EP2010059946
申请日：2010-07-09
申请人： INNATE PHARMA , GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE
发明人： GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , A61K39/3955 , A61K45/06 , A61K47/48561 , A61K47/6849 , C07K2317/34 , C07K2317/35 , C07K2317/54 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies (e.g. monoclonal antibodies), antibody fragments, and derivatives thereof that specifically bind TLR3, and that optionally further modulate, e.g. inhibit, signaling. The invention also relates to cells producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; pharmaceutical compositions comprising the same; methods of using the antibodies to diagnose, treat or prevent diseases, e.g. autoimmune diseases, inflammatory diseases and the like.

4. 发明专利

CA2824313A1 TLR3 BINDING AGENTS 未知
公开(公告)号：CA2824313A1
公开(公告)日：2012-07-19
申请号：CA2824313
申请日：2012-01-10
申请人： INNATE PHARMA
发明人： GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE , BONNAFOUS CECILE , ANDERSEN METTE DAHL , ROSSI BENJAMIN
IPC分类号： A61K39/395 , A61P11/00 , A61P19/02 , A61P37/00 , C07K16/24 , C07K16/28
摘要： The invention provides anti-TLR3 antibodies as well as methods of making and using them. The antibodies are particularly adapted to the treatment of autoimmune or inflammatory diseases using anti-TLR3 antibodies.

5. 发明专利

AU2012206614A1 TLR3 binding agents 未知
公开(公告)号：AU2012206614A1
公开(公告)日：2013-08-01
申请号：AU2012206614
申请日：2012-01-10
申请人： INNATE PHARMA
发明人： GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE , BONNAFOUS CECILE , ANDERSEN METTE DAHL , ROSSI BENJAMIN
IPC分类号： C07K16/24 , A61K39/395 , A61P11/00 , A61P19/02 , A61P37/00 , C07K16/28
摘要： The invention provides anti-TLR3 antibodies as well as methods of making and using them. The antibodies are particularly adapted to the treatment of autoimmune or inflammatory diseases using anti-TLR3 antibodies.

6. 发明专利

CA2766747C TLR3 BINDING AGENTS 未知
公开(公告)号：CA2766747C
公开(公告)日：2019-04-02
申请号：CA2766747
申请日：2010-07-09
申请人： INNATE PHARMA
发明人： GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE
IPC分类号： C07K16/28
摘要： The present invention relates to antibodies (e.g. monoclonal antibodies), antibody fragments, and derivatives thereof that specifically bind TLR3, and that optionally further modulate, e.g. inhibit, signaling. The invention also relates to cells producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; pharmaceutical compositions comprising the same; methods of using the antibodies to diagnose, treat or prevent diseases, e.g. autoimmune diseases, inflammatory diseases and the like.

7. 发明专利

CA2766747A1 TLR3 BINDING AGENTS 未知
公开(公告)号：CA2766747A1
公开(公告)日：2011-01-13
申请号：CA2766747
申请日：2010-07-09
申请人： INNATE PHARMA
发明人： GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE
IPC分类号： C07K16/28
摘要： The present invention relates to antibodies (e.g. monoclonal antibodies), antibody fragments, and derivatives thereof that specifically bind TLR3, and that optionally further modulate, e.g. inhibit, signaling. The invention also relates to cells producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; pharmaceutical compositions comprising the same; methods of using the antibodies to diagnose, treat or prevent diseases, e.g. autoimmune diseases, inflammatory diseases and the like.

8. 发明专利

AU2010270163B2 TLR3 binding agents 未知
公开(公告)号：AU2010270163B2
公开(公告)日：2016-05-05
申请号：AU2010270163
申请日：2010-07-09
申请人： INNATE PHARMA SA
发明人： GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE
IPC分类号： C07K16/28
摘要： The present invention relates to antibodies (e.g. monoclonal antibodies), antibody fragments, and derivatives thereof that specifically bind TLR3, and that optionally further modulate, e.g. inhibit, signaling. The invention also relates to cells producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; pharmaceutical compositions comprising the same; methods of using the antibodies to diagnose, treat or prevent diseases, e.g. autoimmune diseases, inflammatory diseases and the like.

9. 发明专利

ES2543095T3 Agentes de unión a TLR3 未知
公开(公告)号：ES2543095T3
公开(公告)日：2015-08-14
申请号：ES10734092
申请日：2010-07-09
申请人： INNATE PHARMA
发明人： GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE
IPC分类号： C07K16/28
摘要： Un anticuerpo monoclonal que se une específicamente a un polipéptido TLR3 humano, en el que dicho anticuerpo inhibe la señalización por el polipéptido TLR3 sin bloquear la unión de un ligando de TLR3 ARNbc al polipéptido TLR3, en el que dicho anticuerpo se une específicamente al polipéptido TLR3 bajo condiciones neutras a un pH entre 6,6 y 7,4 y en condiciones ácidas a un pH de entre 4,5 y 6,5 con una KD sub-nanomolar por su afinidad de unión bivalente; en el que dicho anticuerpo compite para unirse a un polipéptido TLR3 con un anticuerpo seleccionado del grupo que consiste en: (a) un anticuerpo que tiene respectivamente una región VH y VL de SEC ID Nº 34 y 35, y (b) un anticuerpo que tiene respectivamente una región VH y VL de SEC ID Nº 2 y 3.

10. 发明专利

RU2562865C2 TLR3 СВЯЗЫВАЮЩИЕ АГЕНТЫ 未知
公开(公告)号：RU2562865C2
公开(公告)日：2015-09-10
申请号：RU2012103212
申请日：2010-07-09
申请人： INNATE PHARMA
发明人： GAUTHIER LAURENT , MASSACRIER CATHERINE , MOREL YANNIS , PATUREL CARINE
IPC分类号： C07K16/28
摘要： Изобретениеотноситсяк биохимии. Описаномоноклональноеантитело, котороеспецифическисвязывает TLR3 полипептид, гдеуказанноеантителопредставляетсобойтетрамер, состоящийиздвухидентичныхпарполипептидныхцепей, причемкаждаяпараимеетоднулегкуюи однутяжелуюцепьизотипа IgG, игдеуказанноеантителоингибируетпередачусигнала TLR3 полипептидомбезблокированиясвязываниядсРНК TLR3 лигандас TLR3 полипептидом. Представленспособполучениятакогоантитела, атакжефармацевтическаякомпозиция, содержащаяданноеантитело, испособлечения, использующийуказанноеантитело. Изобретениерасширяетарсеналсредствлечениятакихзаболеванийкак: артрит, воспалениелегких, астма, сепсис, ревматоидныйартрити воспалительноезаболеваниекишечника, рак. 9 н. и 33 з.п. ф-лы, 20 ил., 7 табл., 8 пр.

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