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1. 发明授权

US09781919B2 Compositions and methods for improving the quality of processed sperm 有权
公开(公告)号：US09781919B2
公开(公告)日：2017-10-10
申请号：US14997933
申请日：2016-01-18
申请人： Inguran, LLC
发明人： Richard Lenz , Juan Moreno , Ramakrishnan Vishwanath
IPC分类号： A01N1/02 , C12N5/076 , G01N15/14 , G01N15/10
CPC分类号： A01N1/0226 , C12N5/061 , G01N15/1459 , G01N2015/1006
摘要： The present invention generally relates to compositions and methods for the handling of processed sperm populations including samples that are freshly collected, those transported as fresh samples, as well as samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the sperm cell. Such trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the sperm's ability to fertilize an egg, grow into a health embryo and produce a healthy offspring. The present invention relates to novel compounds that can be added to the sperm cell sample to reduce the traumatic effects of physical stress during mild as well as extensive sperm cell processing, methods of using the compounds in standard sperm processing procedures, the end products made from these methods including sperm and embryos, as well as methods of using those end products in assisted reproductive biology techniques in animals.

2. 发明申请

US20160010057A1 SEX SORTED SPERM DEMONSTRATING A DOSE RESPONSE AND METHODS OF PRODUCING SEX SORTED SPERM DEMONSTRATING A DOSE RESPONSE 审中-公开
标题翻译：性别分散的化学成分反应和产生代谢分子的化学反应的方法
公开(公告)号：US20160010057A1
公开(公告)日：2016-01-14
申请号：US14861572
申请日：2015-09-22
申请人： Inguran, LLC
发明人： Ramakrishnan Vishwanath , Kenneth Michael Evans , Thomas B. Gilligan , Juan Moreno , Richard Lenz , Clara Gonzalez-Marin
IPC分类号： C12N5/071 , C12N5/076
CPC分类号： C12N5/0612 , C12N5/061 , G01N1/30 , G01N15/1425 , G01N15/1459 , G01N33/5005 , G01N33/52 , G01N2015/1006 , G01N2015/149
摘要： Embodiments of the claimed invention relate to a method of producing sex sorted sperm having an improved dose response which includes the steps of extending a sperm sample with a buffering holding media and adjusting the concentration of the extended sperm sample to a target concentration range. The extended sperm may then be stained with a DNA selective dye and sex sorted with a flow cytometer into a catch fluid. During the extending and sorting of the sperm sample, the pH may be maintained at a target pH. Additionally, at least one of the buffering holding media, the DNA selective dye and the catch fluid may be supplemented with at least one antioxidant.
摘要翻译：要求保护的发明的实施方案涉及产生具有改善的剂量反应的性别分类精子的方法，其包括以下步骤：用缓冲保持培养基延长精子样品并将扩展的精子样品的浓度调整到目标浓度范围。然后将扩展的精子用DNA选择性染色剂染色并用流式细胞仪分选成捕获液。在精子样品的延伸和分选过程中，pH可以保持在目标pH。此外，至少一种缓冲保持介质，DNA选择性染料和捕获流体可以补充至少一种抗氧化剂。

3. 发明申请

US20130337431A1 COMPOSITIONS AND METHODS FOR IMPROVING THE QUALITY OF PROCESSED SPERM 有权
标题翻译：用于改善加工质量的组合物和方法
公开(公告)号：US20130337431A1
公开(公告)日：2013-12-19
申请号：US13844273
申请日：2013-03-15
申请人： INGURAN, LLC
发明人： Richard Lenz , Juan Moreno , Ramakrishnan Vishwanath
IPC分类号： C12N5/076
CPC分类号： C12N5/0609 , A01N1/0226 , A01N1/0284 , C12N5/061 , C12N5/0612 , C12N2500/30 , C12N2500/38 , C12N2502/04 , G01N15/1459 , G01N2015/149
摘要： Generally, compositions and methods for handling processed sperm populations including samples that are freshly collected, transported as fresh samples, as well as samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the sperm cell. Such trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the sperm's ability to fertilize an egg, grow into a healthy embryo and produce a healthy offspring. The novel compounds described can be added to the sperm cell sample to reduce the traumatic effects of physical stress during mild as well as extensive sperm cell processing, methods of using the compounds in standard sperm processing procedures, the end products made from these methods including sperm and embryos, as well as methods of using those end products in assisted reproductive biology techniques in animals.
摘要翻译：一般来说，用于处理加工的精子群体的组合物和方法，包括新鲜收集的样品，作为新鲜样品运输的样品以及被冷冻和解冻的样品，被分类到一个或多个亚种群中的那些，以及另外加工或处理的那些对精子细胞的创伤。这种创伤可以降低精子的运动力，生育能力，活力和整体完整性，并降低精子施用卵子的能力，生长成健康的胚胎并产生健康的后代。所描述的新化合物可以添加到精子细胞样品中以减轻轻度和广泛的精子细胞处理期间身体应激的创伤作用，在标准精子加工程序中使用化合物的方法，由这些方法制成的最终产物，包括精子和胚胎，以及在动物的辅助生殖生物学技术中使用这些终产物的方法。

4. 发明公开

US20230303970A1 METHOD FOR IMPROVED SPERM CELL POPULATIONS 审中-公开
公开(公告)号：US20230303970A1
公开(公告)日：2023-09-28
申请号：US18134451
申请日：2023-04-13
申请人： Inguran, LLC
发明人： Juan Moreno , Kenneth Michael Evans , Ramakrishnan Vishwanath , Clara Gonzalez-Marin
IPC分类号： C12N5/076 , G01N33/58 , C12N13/00 , G01N1/30
CPC分类号： C12N5/061 , G01N33/582 , C12N13/00 , G01N1/30
摘要： The invention encompasses methods for reducing the proportion of sperm cells with abnormal morphology, and unviable sperm cells, in a sperm cell population.

5. 发明授权

US11653635B2 Methods for increasing genetic progress in a line or breed of swine using sex-selected sperm cells 有权
公开(公告)号：US11653635B2
公开(公告)日：2023-05-23
申请号：US16708007
申请日：2019-12-09
申请人： Inguran, LLC
发明人： Juan Moreno , Gregg Bevier , John Dobrinsky
IPC分类号： A01K67/00 , A01K67/02 , A61D19/02 , A61B34/20 , G16B20/40 , A61B1/04 , A61B1/015 , A61B1/303 , A61B1/313 , A61B8/08 , A61B10/00 , A61M31/00 , G16B20/00
CPC分类号： A01K67/02 , A61B1/015 , A61B1/04 , A61B1/303 , A61B1/313 , A61B8/08 , A61B10/0012 , A61B34/20 , A61D19/027 , A61M31/002 , G16B20/40 , A01K2227/108 , A61B2034/2057 , G16B20/00
摘要： The invention relates to methods of increasing the genetic progress of a line, breed or herd of swine through the use of sex-selected sperm cells in artificial insemination techniques. The invention also encompasses methods of artificially inseminating a swine via deep intrauterine catheter or via a laparoscopic procedure, which allow the use of reduced doses of sex-selected sperm cells.

6. 发明申请

US20190141965A1 METHODS FOR INCREASING GENETIC PROGRESS IN A LINE OR BREED OF SWINE USING SEX-SELECTED SPERM CELLS 审中-公开
公开(公告)号：US20190141965A1
公开(公告)日：2019-05-16
申请号：US16248569
申请日：2019-01-15
申请人： Inguran, LLC
发明人： Juan Moreno , Gregg Bevier , John Dobrinsky
IPC分类号： A01K67/02 , A61B1/04 , A61B8/08 , A61B1/313 , A61D19/02 , A61B34/20 , A61B10/00 , A61B1/015 , A61M31/00 , A61B1/303
CPC分类号： A01K67/02 , A01K2227/108 , A61B1/015 , A61B1/04 , A61B1/303 , A61B1/313 , A61B8/08 , A61B10/0012 , A61B34/20 , A61B2034/2057 , A61D19/027 , A61M31/002 , G16B20/00
摘要： The invention relates to methods of increasing the genetic progress of a line, breed or herd of swine through the use of sex-selected sperm cells in artificial insemination techniques. The invention also encompasses methods of artificially inseminating a swine via deep intrauterine catheter or via a laparoscopic procedure, which allow the use of reduced doses of sex-selected sperm cells.

7. 发明授权

US10226041B2 Compositions and methods for improving the quality of processed sperm 有权
公开(公告)号：US10226041B2
公开(公告)日：2019-03-12
申请号：US15680048
申请日：2017-08-17
申请人： Inguran, LLC
发明人： Richard Lenz , Juan Moreno , Ramakrishnan Vishwanath
IPC分类号： A01N1/02 , C12N5/076 , G01N15/14 , G01N15/10
摘要： The present invention generally relates to compositions and methods for the handling of processed sperm populations including samples that are freshly collected, those transported as fresh samples, as well as samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the sperm cell. Such trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the sperm's ability to fertilize an egg, grow into a health embryo and produce a healthy offspring. The present invention relates to novel compounds that can be added to the sperm cell sample to reduce the traumatic effects of physical stress during mild as well as extensive sperm cell processing, methods of using the compounds in standard sperm processing procedures, the end products made from these methods including sperm and embryos, as well as methods of using those end products in assisted reproductive biology techniques in animals.

8. 发明申请

US20170311577A1 METHODS FOR INCREASING GENETIC PROGRESS IN A LINE OR BREED OF SWINE USING SEX-SELECTED SPERM CELLS 审中-公开
公开(公告)号：US20170311577A1
公开(公告)日：2017-11-02
申请号：US15655663
申请日：2017-07-20
申请人： Inguran, LLC
发明人： Juan Moreno , Gregg Bevier , John Dobrinsky
IPC分类号： A01K67/02 , A61B1/015 , A61B1/04 , A61M31/00 , A61B10/00 , A61B8/08 , A61B34/20 , A61B1/303 , A61B1/313 , A61D19/02 , G06F19/18
CPC分类号： A01K67/02 , A01K2227/108 , A61B1/015 , A61B1/04 , A61B1/303 , A61B1/313 , A61B8/08 , A61B10/0012 , A61B34/20 , A61B2034/2057 , A61D19/027 , A61M31/002 , G06F19/18
摘要： The invention relates to methods of increasing the genetic progress of a line, breed or herd of swine through the use of sex-selected sperm cells in artificial insemination techniques. The invention also encompasses methods of artificially inseminating a swine via deep intrauterine catheter or via a laparoscopic procedure, which allow the use of reduced doses of sex-selected sperm cells.

9. 发明申请

US20130309651A1 COMPOSITIONS AND METHODS FOR IMPROVING THE QUALITY OF PROCESSED SPERM 有权
公开(公告)号：US20130309651A1
公开(公告)日：2013-11-21
申请号：US13844636
申请日：2013-03-15
申请人： INGURAN, LLC
发明人： Richard Lenz , Juan Moreno , Ramakrishnan Vishwanath
IPC分类号： A01N1/02
CPC分类号： C12N5/0609 , A01N1/0226 , A01N1/0284 , C12N5/061 , C12N5/0612 , C12N2500/30 , C12N2500/38 , C12N2502/04 , G01N15/1459 , G01N2015/149
摘要： The present invention relates to compositions and methods for the handling of processed sperm including samples that are freshly collected, those transported as fresh samples, samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the cell. Trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the ability to fertilize, produce an embryo and a healthy offspring. The present invention relates to novel compounds that can be added to the sperm cell sample to reduce the traumatic effects of physical stress during mild as well as extensive sperm cell processing, methods of using the compounds in standard sperm processing procedures, the end products made from these methods including sperm and embryos, as well as methods of using those end products in assisted reproductive biology techniques in animals.

10. 发明授权

US09976119B2 Compositions and methods for improving the quality of processed sperm 有权
公开(公告)号：US09976119B2
公开(公告)日：2018-05-22
申请号：US15157201
申请日：2016-05-17
申请人： Inguran, LLC
发明人： Richard Lenz , Juan Moreno , Ramakrishnan Vishwanath
IPC分类号： A01N1/02 , C12N5/075 , C12N5/076 , C12N5/071 , G01N15/14
CPC分类号： C12N5/0609 , A01N1/0226 , A01N1/0284 , C12N5/061 , C12N5/0612 , C12N2500/30 , C12N2500/38 , C12N2502/04 , G01N15/1459 , G01N2015/149
摘要： The present invention relates to compositions and methods for the handling of processed sperm including samples that are freshly collected, those transported as fresh samples, samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the cell. Trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the ability to fertilize, produce an embryo and a healthy offspring. The present invention relates to novel compounds that can be added to the sperm cell sample to reduce the traumatic effects of physical stress during mild as well as extensive sperm cell processing, methods of using the compounds in standard sperm processing procedures, the end products made from these methods including sperm and embryos, as well as methods of using those end products in assisted reproductive biology techniques in animals.

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