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1. 发明申请

WO02096479A2 BALLOON CATHETER 审中-公开
标题翻译：气球导管
公开(公告)号：WO02096479A2
公开(公告)日：2002-12-05
申请号：PCT/US0215118
申请日：2002-05-14
申请人： INFRAREDX INC , RYAN S ERIC , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
发明人： RYAN S ERIC , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
IPC分类号： A61B5/00 , A61M
CPC分类号： A61B5/6853 , A61B5/0086 , A61B5/0507 , A61B5/6886
摘要： An apparatus includes a feedback loop for controlling an extent of a gap between a wall of a balloon mounted on a catheter and a wall of a lumen into which the catheter is inserted. The apparatus includes a radiation detector mounted within the balloon for generating a feedback signal having information indicative of whether the extent of the gap is greater than or less than a desired value. The feedback loop receives the feedback signal and controls a size of the balloon to cause the extent of the gap to approach the desired value.
摘要翻译：一种装置包括用于控制安装在导管上的球囊的壁与插入其中的内腔的壁之间的间隙的程度的反馈回路。该装置包括安装在气球内的放射线检测器，用于产生具有指示间隙的程度是否大于或小于期望值的信息的反馈信号。反馈回路接收反馈信号并控制气囊的尺寸以使间隙的程度接近所需值。

2. 发明申请

WO02098478A3 REFERENCING OPTICAL CATHETERS 审中-公开
标题翻译：参考光导体
公开(公告)号：WO02098478A3
公开(公告)日：2003-02-27
申请号：PCT/US0214790
申请日：2002-05-10
申请人： INFRAREDX INC , RYAN S ERIC , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
发明人： RYAN S ERIC , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
IPC分类号： A61B5/00 , G01N21/47 , G01J4/00 , G01N21/55
CPC分类号： A61B5/0084 , A61B5/14535 , A61B2560/0233 , G01N21/4785
摘要： The invention illustrates a catheter (40) with a delivery output fiber (44) and an input fiber (46) and a transmission window (47), in blood (43) within a blood vessel (42). As light exists delivery fiber (44), it passes through the transmission window (47), the blood (43), the surface of the blood wall (42a), the wall (42b) itself, the surface of the lipid pool (45a), and into the lipid pool (45b), of a lipid-rich vulnerable atherosclerotic plaque.
摘要翻译：本发明示出了在血管（42）内的血液（43）中具有输送纤维（44）和输入光纤（46）和透射窗（47）的导管（40）。当光存在输送纤维（44）时，其通过透射窗（47），血液（43），血壁（42a）的表面，壁（42b）本身，脂质池（45a）的表面），并进入富含脂质的易感动脉粥样硬化斑块的脂质池（45b）。

3. 发明申请

WO02096484A3 APPARATUS AND METHOD FOR THE OPTICAL IMAGING OF TISSUE SAMPLES 审中-公开
标题翻译：用于组织样品的光学成像的装置和方法
公开(公告)号：WO02096484A3
公开(公告)日：2003-07-24
申请号：PCT/US0217202
申请日：2002-05-30
申请人： INFRAREDX INC , RYAN S ERIC , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
发明人： RYAN S ERIC , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
IPC分类号： G01N21/27 , A61B5/00 , A61B6/00
CPC分类号： A61B5/0084
摘要： A catheter based optical system (10) for generating data as to the condition of a tissue sample of a mammalian vessel (W). The system includes an elongated catheter shaft (16) having a tissue engaging distal end (18) and a coupled proximal end (20) and an elongated optical delivery fiber arrangement (24) disposed through a lumen of said catheter (16), said optical delivery fiber arrangement (24) having a distal end (28) and a proximal end (32). The distal end of the delivery fiber arrangement (28) has a re-director light emitter (30) thereon for directing light against mammalian tissues (W). An elongated optical collection fiber arrangement (26) is disposed through a lumen of the catheter (16), the optical collection fiber arrangement (26) having distal end (34) and a proximal most end (36). The distal end of the collection fiber arrangement (34) has a re-director light receiver (30) thereon for receiving light reflected from the mammalian tissue (W) by the light emitter (30). The light emitter (42) and the light receiver (40) are longitudinally space (d) apart from one another in the distal end of the catheter (18). The catheter apparatus includes a light source (12) in communication with the delivery fiber (24) and a signal (50) in communication with the receiving fiber (26) for receiving and presenting data collected.
摘要翻译：一种用于产生关于哺乳动物血管（W）的组织样本的状况的数据的基于导管的光学系统（10）。该系统包括具有组织接合远端（18）和耦合的近端（20）的细长导管轴（16）和通过所述导管（16）的内腔设置的细长的光学输送纤维布置（24），所述光学具有远端（28）和近端（32）的输送纤维布置（24）。输送纤维布置（28）的远端在其上具有引导光发射器（30），用于将光引导到哺乳动物组织（W）上。细长的光学收集纤维布置（26）穿过导管（16）的内腔设置，光学收集纤维布置（26）具有远端（34）和最近端（36）。收集纤维布置（34）的远端在其上具有重新引导光接收器（30），用于接收由光发射器（30）从哺乳动物组织（W）反射的光。光发射器（42）和光接收器（40）在导管（18）的远端中彼此分开的纵向空间（d）。导管装置包括与输送光纤（24）通信的光源（12）和与接收光纤（26）通信的用于接收和呈现收集的数据的信号（50）。

4. 发明申请

WO02096484B1 APPARATUS AND METHOD FOR THE OPTICAL IMAGING OF TISSUE SAMPLES 审中-公开
标题翻译：用于组织样本光学成像的装置和方法
公开(公告)号：WO02096484B1
公开(公告)日：2003-09-12
申请号：PCT/US0217202
申请日：2002-05-30
申请人： INFRAREDX INC , RYAN S ERIC , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
发明人： RYAN S ERIC , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
IPC分类号： G01N21/27 , A61B5/00 , A61B6/00
CPC分类号： A61B5/0084
摘要： A catheter based optical system (10) for generating data as to the condition of a tissue sample of a mammalian vessel (W). The system includes an elongated catheter shaft (16) having a tissue engaging distal end (18) and a coupled proximal end (20) and an elongated optical delivery fiber arrangement (24) disposed through a lumen of said catheter (16), said optical delivery fiber arrangement (24) having a distal end (28) and a proximal end (32). The distal end of the delivery fiber arrangement (28) has a re-director light emitter (30) thereon for directing light against mammalian tissues (W). An elongated optical collection fiber arrangement (26) is disposed through a lumen of the catheter (16), the optical collection fiber arrangement (26) having distal end (34) and a proximal most end (36). The distal end of the collection fiber arrangement (34) has a re-director light receiver (30) thereon for receiving light reflected from the mammalian tissue (W) by the light emitter (30). The light emitter (42) and the light receiver (40) are longitudinally space (d) apart from one another in the distal end of the catheter (18). The catheter apparatus includes a light source (12) in communication with the delivery fiber (24) and a signal (50) in communication with the receiving fiber (26) for receiving and presenting data collected.
摘要翻译：一种基于导管的光学系统（10），用于产生关于哺乳动物血管（W）的组织样本的数据的数据。该系统包括具有组织接合远端（18）和联接近端（20）的细长导管轴（16）和穿过所述导管（16）的内腔设置的细长光学传送纤维布置（24），所述光学输送纤维装置（24）具有远端（28）和近端（32）。输送纤维装置（28）的远端在其上具有用于将光导向哺乳动物组织（W）的重导向器光发射器（30）。细长光学收集光纤布置（26）设置成穿过导管（16）的内腔，光学收集光纤布置（26）具有远端（34）和最近端（36）。收集光纤布置（34）的远端在其上具有用于接收由光发射器（30）从哺乳动物组织（W）反射的光的重导向光接收器（30）。光发射器（42）和光接收器（40）在导管（18）的远端中在纵向上彼此间隔开（d）。导管设备包括与输送光纤（24）通信的光源（12）和与接收光纤（26）通信的信号（50），用于接收和呈现收集的数据。

5. 发明申请

WO02096478A2 MULTI-PATH OPTICAL CATHETER 审中-公开
标题翻译：多路光导体
公开(公告)号：WO02096478A2
公开(公告)日：2002-12-05
申请号：PCT/US0215090
申请日：2002-05-14
申请人： INFRAREDX INC , RYAN ERIC S , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
发明人： RYAN ERIC S , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
IPC分类号： A61B5/00 , A61F2/958 , A61M
CPC分类号： A61B1/0615 , A61B1/00096 , A61B1/00183 , A61B1/3137 , A61B5/0084 , A61B5/6853
摘要： First and second optical-redirectors mounted on a catheter couple radiation to a target along separate first and second paths. Either the first or second optical- redirectors, or both, can include a steering mechanism for selecting the first and/or second path.
摘要翻译：安装在导管上的第一和第二光学重定向器沿着分离的第一和第二路径将辐射耦合到目标。第一或第二光学重定向器或两者都可以包括用于选择第一和/或第二路径的转向机构。

6. 发明申请

WO02096478A9 MULTI-PATH OPTICAL CATHETER 审中-公开
标题翻译：多路光导体
公开(公告)号：WO02096478A9
公开(公告)日：2004-02-19
申请号：PCT/US0215090
申请日：2002-05-14
申请人： INFRAREDX INC , RYAN ERIC S , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
发明人： RYAN ERIC S , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
IPC分类号： A61B5/00 , A61F2/958 , A61B5/05 , A61B6/00 , A61B18/18 , A61M29/00 , G02B6/04 , G02B6/06 , G02B6/32 , G02B6/38
CPC分类号： A61B1/0615 , A61B1/00096 , A61B1/00183 , A61B1/3137 , A61B5/0084 , A61B5/6853
摘要： First (32) and second (54) optical-redirectors mounted on a catheter (12) couple radiation to a target along separate first and second paths. Either the first or second optical- redirectors, or both, can include a steering mechanism for selecting the first and/or second path.
摘要翻译：安装在导管（12）上的第一（32）和第二（54）光学重定向器沿着分离的第一和第二路径将辐射耦合到目标。第一或第二光学重定向器或两者都可以包括用于选择第一和/或第二路径的转向机构。

7. 发明申请

WO2004012586A3 NEAR-INFRARED SPECTROSCOPIC ANALYSIS OF BLOOD VESSEL WALLS 审中-公开
标题翻译：血管壁近红外光谱分析
公开(公告)号：WO2004012586A3
公开(公告)日：2004-04-29
申请号：PCT/US0324452
申请日：2003-08-05
申请人： INFRAREDX INC , MARSHIK-GEURTS BARBARA J , TANG JING , ZULUAGA ANDRES F
发明人： MARSHIK-GEURTS BARBARA J , TANG JING , ZULUAGA ANDRES F
IPC分类号： G01N21/35 , A61B5/00 , A61B5/02 , A61B10/00 , A61B6/00
CPC分类号： A61B5/0086 , A61B5/0075
摘要： Screen (120) shows a digitized longitudinal view (134) and a key or scale (135) to show the colors or shades of gray corresponding to the spectral values. Cross section (136) shows a range of colors or shades of gray of different segments of the artery. The segment (136a) indicates that it is likely to be a normal segment. The segment (136b) is very light indicating a diseased tissue, likely to be highly vulnerable.
摘要翻译：屏幕（120）示出了数字化纵向视图（134）和键或刻度（135），以显示对应于频谱值的颜色或阴影。横截面（136）显示了动脉不同部分的灰色范围或灰度。段（136a）表示它可能是正常段。片段（136b）非常轻，表示可能非常脆弱的患病组织。

8. 发明申请

WO2009089372A2 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：用于分析和治疗体液的系统和方法
公开(公告)号：WO2009089372A2
公开(公告)日：2009-07-16
申请号：PCT/US2009030467
申请日：2009-01-08
申请人： CORNOVA INC , TANG JING , RYAN S ERIC
发明人： TANG JING , RYAN S ERIC
IPC分类号： A61F2/958 , A61M31/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/14539 , A61B5/6853 , A61B6/12 , A61B2017/22001 , A61B2018/00345 , A61B2018/00386 , A61B2018/00404 , A61B2018/00577 , A61B2018/00982 , A61B2562/0242 , A61F2/958 , A61M25/1011 , A61M25/1027 , A61M25/104 , A61M29/02 , A61M2025/1079 , A61M2025/1088
摘要： A catheter is provided for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end. The catheter further includes at least one delivery waveguide and at least one collection waveguide positioned along the flexible conduit, the at least one delivery waveguide and the at least one collection waveguide constructed and arranged to transmit radiation at a wavelength in a range of about 250 to 2500 nanometers. The catheter further includes a flexible, expandable first surface encircling surrounding a segment of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the flexible, expandable first surface, and the distal end of at least one of the at least one delivery waveguide and the at least one collection waveguide tethered to the flexible, expandable first surface radially translatable with respect to the flexible, expandable first surface, the at least one transmission input located between a portion of the flexible, expandable first surface and a portion of the second surface.
摘要翻译：提供用于放置在体腔内的导管，所述导管包括沿着纵向轴线伸长的柔性导管，所述柔性导管具有近端和远端。所述导管还包括至少一个传送波导和至少一个收集波导，所述至少一个收集波导沿着所述柔性管道设置，所述至少一个传送波导和所述至少一个收集波导构造并布置成传送波长范围为约250至 2500纳米。所述导管还包括柔性的可扩张的第一表面，所述第一表面环绕所述导管的一部分，所述至少一个递送波导的传输输出和位于所述柔性的可扩张的第一表面内的所述至少一个收集波导的传输输入，所述至少一个输送波导和所述至少一个收集波导中的至少一个的远侧端部系于所述柔性可扩展第一表面，所述柔性可扩展第一表面相对于所述柔性可扩展第一表面可径向平移，所述至少一个变速器输入位于部分柔性可膨胀的第一表面和第二表面的一部分。

9. 发明申请

WO2012040362A3 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：用于分析和治疗体液的系统和方法
公开(公告)号：WO2012040362A3
公开(公告)日：2012-06-14
申请号：PCT/US2011052609
申请日：2011-09-21
申请人： CORNOVA INC , RYAN S ERIC , TANG JING , GAMBALE RICHARD
发明人： RYAN S ERIC , TANG JING , GAMBALE RICHARD
IPC分类号： A61B1/00 , A61B5/027 , G01J3/00
CPC分类号： A61B5/0086 , A61B5/0062 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/1076 , A61B5/4836 , A61B5/6853 , A61M25/104 , G01J3/0218 , G01J3/0264 , G01J3/42
摘要： A system is provided for probing a body lumen that includes a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit. A spectrometer is connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform spectroscopy. A controller system is configured to calculate a distance between the flexible conduit and the wall of the body lumen based on a spectroscopic measurement of the at least one primary radiation signal that traveled between the flexible conduit and body lumen.
摘要翻译：提供了一种用于探测体腔的系统，所述体腔包括沿着纵向轴线伸长的柔性导管，所述柔性导管具有近端和远端，至少一个输送波导和至少一个收集波导，所述收集波导沿着柔性导管，所述至少一个传送波导的传输输出和沿着所述导管的远端部分定位的所述至少一个收集波导的传输输入。分光计连接到至少一个传送波导和至少一个收集波导，分光计配置成执行光谱分析。控制器系统被配置为基于在柔性导管和体腔之间行进的至少一个初级辐射信号的光谱测量来计算柔性导管和体腔的壁之间的距离。

10. 发明申请

WO2007147058A3 METHOD AND APPARATUS FOR IDENTIFYING AND TREATING MYOCARDIAL INFARCTION 审中-公开
标题翻译：用于鉴别和治疗心肌梗塞的方法和装置
公开(公告)号：WO2007147058A3
公开(公告)日：2008-11-06
申请号：PCT/US2007071221
申请日：2007-06-14
申请人： CORNOVA INC , RYAN S ERIC , TANG JING
发明人： RYAN S ERIC , TANG JING
IPC分类号： A61B6/00
CPC分类号： A61M25/06 , A61B5/01 , A61B5/145 , A61B10/04 , A61B18/24 , A61B2010/045 , A61B2017/00061 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2018/00392 , A61B2018/2238 , A61M25/0147 , A61M2025/0096
摘要： A method and apparatus for analyzing and treating internal tissues and, in particular, tissues affected by myocardial infarct. The apparatus includes a catheterized device integrating an optical probe and treatment delivery system. The probe component includes fiber optic lines that can be used in conjunction with infrared spectroscopy to analyze various characteristics of tissues, including chemical, blood, and oxygen content, in order to locate those tissues associated with myocardial infarct, to determine the best location for applying treatment, and to monitor treatment and its effects. Physically integrated with the probe component is a treatment component for delivering treatments including stem cell and gene therapy, known for having beneficial effects on tissues associated with myocardial infarct. A control system coordinates operation of the catheter, including performing chemometric analysis with the use of model data, and for providing control and visual feedback to an operator.
摘要翻译：一种用于分析和治疗内部组织，特别是受到心肌梗死影响的组织的方法和装置。该装置包括集成光学探针和治疗递送系统的导管装置。探针组件包括光纤线路，其可以与红外光谱结合使用以分析组织的各种特征，包括化学，血液和氧气含量，以便定位与心肌梗死相关的那些组织，以确定应用的最佳位置治疗，并监测治疗及其影响。与探针组分物理整合是用于递送治疗的治疗组件，包括干细胞和基因治疗，已知对于与心肌梗死相关的组织具有有益作用。控制系统协调导管的操作，包括使用模型数据执行化学计量分析，以及向操作者提供控制和视觉反馈。

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