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    • 2. 发明申请
    • HUMAN C-TYPE LECTIN
    • 人C型LECTIN
    • WO9802456A3
    • 2002-10-17
    • PCT/US9712342
    • 1997-07-15
    • INCYTE PHARMA INCAU-YOUNG JANICECOCKS BENJAMIN GRAEMEGOLI SURYA KHILLMAN JENNIFER L
    • AU-YOUNG JANICECOCKS BENJAMIN GRAEMEGOLI SURYA KHILLMAN JENNIFER L
    • A61K38/00C07K14/47C12N15/54C12N1/21C12N9/12C12N15/70
    • C07K14/4726A61K38/00
    • The present invention provides a polynucleotide (mctl) which identifies and encodes a novel human C-type lectin (MCTL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding MCTL. The invention also provides for the use of substantially purified MCTL and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of MCTL. Additionally, the invention provides for the use of antisense molecules to mctl in pharmaceutical compositions for treatment of diseases associated with the expression of MCTL. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of mctl. The present invention also relates to anti-MCTL antibodies which specifically bind to MCTL.
    • 本发明提供鉴定和编码新型人C型凝集素(MCTL)的多核苷酸(mct1)。 本发明提供了包含编码MCTL的核酸序列的遗传工程表达载体和宿主细胞。 本发明还提供在商业生产重组蛋白质和用于治疗与MCTL表达相关的疾病的药物组合物中使用基本上纯化的MCTL及其激动剂。 另外,本发明提供了用于治疗与MCTL表达相关的疾病的药物组合物中的mct1的反义分子的用途。 本发明还描述了使用包含与mct1的基因组序列或转录物杂交的多核苷酸,其片段或其互补体的诊断组合物的诊断测定法。 本发明还涉及特异性结合MCTL的抗MCTL抗体。