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1. 发明申请

WO1991001364A1 SAMPLE MATERIAL TRANSFER DEVICE 审中-公开
标题翻译：样品转移装置
公开(公告)号：WO1991001364A1
公开(公告)日：1991-02-07
申请号：PCT/GB1990001137
申请日：1990-07-24
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , LEHRACH, Hans, Rudolf
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C12M01/32
CPC分类号： C12M33/02 , C12M23/04 , G01N35/0099 , G01N35/1065 , G01N2035/1037
摘要： The present invention provides a device for the replication of arrays of cell colonies comprising a plate with a large number of small projections projecting therefrom. The projections being formed by removing, preferably by machining, the material between the projections, thus enabling a high density of projections to be achieved.
摘要翻译：本发明提供了用于复制细胞集落阵列的装置，其包括具有从其突出的大量小突起的板。通过优选地通过机械移除突起之间的材料而形成突起，从而能够实现高密度的突起。

2. 发明申请

WO1991005044A1 A CULTURE OF SACCHAROMYCES CERVISIAE CONTAINING THE GENE RESPONSIBLE FOR HUNTINGTON'S DISEASE AND USES THEREOF 审中-公开
标题翻译：包含基因组的针对亨特顿病的病原菌的文化及其用途
公开(公告)号：WO1991005044A1
公开(公告)日：1991-04-18
申请号：PCT/GB1990001481
申请日：1990-09-27
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , BATES, Gillian , LEHRACH, Hans, Rudolf , GUSELLA, James, F. , MACDONALD, Marcy, E.
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C12N15/12
CPC分类号： C07K14/47 , C12N15/81 , C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to nucleic acids useful in the detection and/or treatment of Huntington's disease. DNA has been isolated from the p16.3 band of human chromosome 4 and put into Saccharomyces cervisiae clone 488 BT (NCYC2336). The invention also provides nucleic acid fragments capable of hybridising with said clone, polypeptides produced by it, and monoclonal antibodies against the polypeptides.
摘要翻译：本发明涉及可用于检测和/或治疗亨廷顿氏病的核酸。 DNA已经从人类4号染色体的p16.3条带中分离出来，并放入了Saccharomyces cervisiae clone 488 BT（NCYC2336）。本发明还提供能够与所述克隆杂交的核酸片段，由其产生的多肽和针对多肽的单克隆抗体。

3. 发明申请

WO1990008160A1 GROWTH FACTOR RECEPTOR-LIKE PEPTIDES WITHOUT TYROSINE-KINASE ACTIVITY 审中-公开
标题翻译：不含酪氨酸激酶活性的生长因子受体样肽
公开(公告)号：WO1990008160A1
公开(公告)日：1990-07-26
申请号：PCT/GB1990000083
申请日：1990-01-19
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , STERNBERG, Michael, Joseph, Ezra , GULLICK, William, John , CHOTHIA, Cyrus
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C07K07/08
CPC分类号： C07K14/82 , A61K38/00 , C07K14/71
摘要： A peptide which lacks tyurosine kinase activity, having a binding portion of at least 8 contiguous amino acid residues adapted to form an intra-membrane alpha-helix and being capable of reducing tyrosine kinase activity in a target cell, the binding portion having a sequence identical to the sequence at positions P to P of a natural (wild type) or mutant growth factor receptor/tyrosine kinase portein having the motif set out below or having a sequence which differs at not more than 3 positions from the sequence at positions P to P of such a protein, wherein the motif comprises a sequence of 5 contiguous amino acid residues designated: P XXP P , wherein the residues X are the same or different and each is any naturally occurring L-amino acid residue, P is a residue selected from Ala, Gly, Ser, Thr, Pro, Val, Ile and leu, P is a residue selected from Ala, Gly, Met, Val, Ile and Leu and P is a residue selected from Ala, Gly, Thr, Pro and Val.
摘要翻译：缺乏酪氨酸激酶活性的肽，其具有适于形成膜内α-螺旋的至少8个连续氨基酸残基的结合部分，并且能够降低靶细胞中的酪氨酸激酶活性，所述结合部分具有相同的序列至具有以下所示基序的天然（野生型）或突变型生长因子受体/酪氨酸激酶蛋白的位置P 0至P 7的序列，或具有不超过3个位置的序列该蛋白质的位置P <0>至P <7>的序列，其中所述基序包含指定为：P P P P 4的5个连续氨基酸残基的序列，其中残基X为相同或不同，并且各自是任何天然存在的L-氨基酸残基，P 0是选自Ala，Gly，Ser，Thr，Pro，Val，Ile和leu的残基，P 3是选自Ala ，Gly，Met，Val，Ile和Leu，P 4是选自Ala，Gly，Thr，Pro和Val的残基。

4. 发明申请

WO1992011289A1 ANTIGEN PROCESSING 审中-公开
标题翻译：抗原加工
公开(公告)号：WO1992011289A1
公开(公告)日：1992-07-09
申请号：PCT/GB1991002278
申请日：1991-12-19
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , TROWSDALE, John , KELLY, Adrian, Paul , GLYNNE, Richards , POWIS, Stephen, Hugh
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C07K13/00
CPC分类号： C07K14/70539 , A61K38/00
摘要： Genes encoding protein subunits involved in the processing and presentation, in association with MHC class I molecules, of peptide antigens and designated RING4, RING10, RING11 and RING12 are described and claimed together with related proteins and peptides, antibodies, nucleic acids, vectors and other products which are useful in diagnosis and therapy of immune-system disorders and associated diseases.
摘要翻译：编码参与与MHC I类分子相关的肽抗原和命名为RING4，RING10，RING11和RING12的加工和呈递的蛋白质亚基的基因与相关蛋白质和肽，抗体，核酸，载体和其他物质一起被描述和要求可用于诊断和治疗免疫系统疾病及相关疾病的产品。

5. 发明申请

WO1990005142A1 POLYPEPTIDES 审中-公开
标题翻译：多肽
公开(公告)号：WO1990005142A1
公开(公告)日：1990-05-17
申请号：PCT/GB1989001340
申请日：1989-11-10
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , TAYLOR-PAPADIMITRIOU, Joyce , GENDLER, Sandra , BURCHELL, Joy
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C07K07/06
CPC分类号： C07K16/18 , A61K38/00 , C07K14/4727
摘要： Polypeptides including the sequence PDTRP and immunological analogues correspond with an important epitope of the human polymorphic epithelial mucin abnormally expressed in breast cancers and are useful in immunisation and for generating antibodies for diagnosis and therapy. Nucleic acid fragments encoding PDTRP or an immunlogical analogue are useful in probing for diagnosis and producing the polypeptides.
摘要翻译：包括序列PDTRP和免疫学类似物的多肽对应于在乳腺癌中异常表达的人多形性上皮粘蛋白的重要表位，并且可用于免疫和产生用于诊断和治疗的抗体。编码PDTRP或免疫类似物的核酸片段可用于诊断和产生多肽。

6. 发明申请

WO1989000577A1 DIGESTION METHOD 审中-公开
标题翻译：消费方法
公开(公告)号：WO1989000577A1
公开(公告)日：1989-01-26
申请号：PCT/GB1988000591
申请日：1988-07-21
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , STARK, George, Robert , MCINTYRE, Peter
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C07H21/00
CPC分类号： C12Q1/68 , C12N15/1003 , Y02A50/58
摘要： A process for producing a solution of cellular DNA which process consists of treating cells or tissue with a strongly alkaline aqueous medium for a time and at a temperature sufficient to form a clear solution suitable for hybridisation.
摘要翻译：一种用于产生细胞DNA溶液的方法，该方法包括用强碱性水性介质处理细胞或组织一段时间并且足以形成适于杂交的澄清溶液的温度。

7. 发明申请

WO1992000375A1 SEXE DETERMINING GENE 审中-公开
标题翻译：性别决定基因
公开(公告)号：WO1992000375A1
公开(公告)日：1992-01-09
申请号：PCT/GB1991001057
申请日：1991-06-28
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , GOODFELLOW, Peter, Neville , LOVELL-BADGE, Robin
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C12N15/12
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/02 , A01K2267/03 , A61K38/00 , C07K14/47 , C12Q1/6879 , C12Q2600/156 , C12Q2600/158
摘要： The invention provides a DNA encoding a gene which controls the sex of the embryos of eutherian (Placental) mammals. Nucleic acid fragments, proteins, polypeptides, antibodies and related products and their use in medicine and agriculture are provided. The invention may be used in diagnosis or for controlling the sex of the progeny of commercially important animals.
摘要翻译：本发明提供了编码控制埃及（Placental）哺乳动物胚胎性别的基因的DNA。提供核酸片段，蛋白质，多肽，抗体及相关产品及其在医学和农业中的应用。本发明可用于诊断或控制商业上重要的动物后代的性别。

8. 发明申请

WO1991012272A1 PROTEIN FACTOR 审中-公开
标题翻译：蛋白因子
公开(公告)号：WO1991012272A1
公开(公告)日：1991-08-22
申请号：PCT/GB1991000245
申请日：1991-02-15
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , STOKER, Michael , GHERARDI, Ermanno
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C07K13/00
CPC分类号： C07K16/22 , A61K38/00 , C07K14/4753
摘要： A polypeptide or protein comprising at least five contiguous amino acid residues in a sequence corresponding to formula (I): VVNGIPTQTTVGX MVSLX YY wherein the internationally recognised 1-letter code is used to represent amino acid residues and X is any naturally occuring L-amino acid residue and X is any amino acid residue, but is preferably an L-leucine residue (L).
摘要翻译：包含对应于式（I）的序列中的至少五个连续氨基酸残基的多肽或蛋白质：VVNGIPTQTTVGX 1 MVSLX 2 YY其中国际公认的1个字母的代码用于表示氨基酸残基，X <1 >是任何天然存在的L-氨基酸残基，X 2是任何氨基酸残基，但优选L-亮氨酸残基（L）。

9. 发明申请

WO1989001481A1 CHROMOSOME-SPECIFIC NUCLEIC ACID PROBE FOR FAMILIAL POLYPOSIS COLI 审中-公开
标题翻译：用于家族聚脂病毒的染色体特异性核酸探针
公开(公告)号：WO1989001481A1
公开(公告)日：1989-02-23
申请号：PCT/GB1988000665
申请日：1988-08-11
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. , BODMER, Walter, Fred , WILLIAMSON, Robert , MURDAY, Victoria, Alice , BAILEY, Carolyn, Jane
发明人： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.
IPC分类号： C07H21/00
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： A nucleic acid fragment capable of selectively hybridising with the human chromosome 5 at the chromosomal region 5q20-q23.
摘要翻译：能够在染色体区5q20-q23处与人染色体5选择性杂交的核酸片段。

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