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1. 发明申请

WO2012140187A1 ASSAY METHOD FOR INTRINSIC ACUTE KIDNEY INJURY 审中-公开
标题翻译：内科急性KIDNEY损伤的测定方法
公开(公告)号：WO2012140187A1
公开(公告)日：2012-10-18
申请号：PCT/EP2012/056754
申请日：2012-04-13
申请人： IMMUNDIAGNOSTIK AG , CHARITE - UNIVERSITÄTSMEDIZIN BERLIN , WESTHOFF, Timm, H. , HELLER, Frank , ARMBRUSTER, Franz Paul
发明人： WESTHOFF, Timm, H. , HELLER, Frank , ARMBRUSTER, Franz Paul
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/566 , G01N2800/347
摘要： Method of diagnosis of prerenal and intrinsic acute kidney injury and to equipment and kits for use in these methods. The method comprises the step of assessing the calprotectin level in a urine sample taken from a patient suspected of suffering from intrinsic acute kidney injury as well as a lateral flow immunochromatographic device for instant assessment of the urinary calprotectin level.
摘要翻译：诊断肾上腺和内在急性肾损伤的方法以及用于这些方法的设备和试剂盒。该方法包括评估取自怀疑患有内在急性肾损伤的患者的尿液样本中的钙卫蛋白水平的步骤以及用于即时评估尿钙蛋白水平的侧流免疫层析装置。

2. 发明公开

EP2697647A1 ASSAY METHOD FOR INTRINSIC ACUTE KIDNEY INJURY 有权
标题翻译： TESTVERFAHRENFÜRINTRINSISCH AKUTE NIERENVERLETZUNG
公开(公告)号：EP2697647A1
公开(公告)日：2014-02-19
申请号：EP12717075.1
申请日：2012-04-13
申请人： Immundiagnostik AG , Charite - Universitätsmedizin Berlin
发明人： WESTHOFF, Timm, H. , HELLER, Frank , ARMBRUSTER, Franz Paul
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/566 , G01N2800/347
摘要： Method of diagnosis of prerenal and intrinsic acute kidney injury and to equipment and kits for use in these methods. The method comprises the step of assessing the calprotectin level in a urine sample taken from a patient suspected of suffering from intrinsic acute kidney injury as well as a lateral flow immunochromatographic device for instant assessment of the urinary calprotectin level.
摘要翻译：诊断肾上腺和内在急性肾损伤的方法以及用于这些方法的设备和试剂盒。该方法包括评估取自怀疑患有内在急性肾损伤的患者的尿液样品中的钙卫蛋白水平以及用于即时评估尿钙蛋白水平的侧流免疫层析装置的步骤。

3. 发明申请

WO2009068688A2 COMPOSITION FOR TREATMENT AND PREVENTION OF HAIR LOSS AND PREMATURE GRAYING OF HAIR 审中-公开
标题翻译：用于治疗和预防头发的损失和预防毛发的组合物
公开(公告)号：WO2009068688A2
公开(公告)日：2009-06-04
申请号：PCT/EP2008/066542
申请日：2008-12-01
申请人： IMMUNDIAGNOSTIK AG , ARMBRUSTER, Franz Paul , PAUS, Ralf , LANGAN, Dorothee
发明人： ARMBRUSTER, Franz Paul , PAUS, Ralf , LANGAN, Dorothee
CPC分类号： A61K38/08 , A61K8/64 , A61K38/2292 , A61Q7/00
摘要： Composition for treatment and prevention of human hair loss and/or hair greying, comprising an effective amount of thymic peptides of the family thymulin, thymosin alpha-1 and thymosin beta-4 and pharmaceutical excipient, diluent or carrier. Method and pharmaceutical composition for treatment and prevention of balding, hair loss, and alopecia.
摘要翻译：用于治疗和预防人脱发和/或头发变灰的组合物，其包含有效量的家族胸腺素，胸腺素α-1和胸腺素β-4的胸腺肽和药物赋形剂，稀释剂或载体。用于治疗和预防秃发，脱发和脱发的方法和药物组合物。

4. 发明申请

WO2008092917A1 DIRECT DETERMINATION OF VITAMIN D IN SERUM OR PLASMA 审中-公开
标题翻译：维生素D在血清或血浆中的直接测定
公开(公告)号：WO2008092917A1
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051162
申请日：2008-01-30
申请人： IMMUNDIAGNOSTIK AG , ARMBRUSTER, Franz Paul , ROTH, Heinz-Juergen , FRIEDL, Sabine , SCHUMANN, Claudia
发明人： ARMBRUSTER, Franz Paul , ROTH, Heinz-Juergen , FRIEDL, Sabine , SCHUMANN, Claudia
IPC分类号： G01N33/82
CPC分类号： G01N33/82
摘要： A method for quantitating vitamin D metabolites directly in blood plasma or serum, without the need for prior purification of the vitamin D metabolites, comprising a digestion of the serum proteins with a serine protease such as proteinase K and sequence of steps for inhibiting the proteinase K activity in the competitive binding analysis. The advantages of this method are its high accuracy over the whole range of physiologically relevant values and that it can be easily adapted for a fully automated analysis of serum and plasma samples.
摘要翻译：一种在血浆或血清中直接定量维生素D代谢物的方法，不需要先前纯化维生素D代谢物，包括用丝氨酸蛋白酶如蛋白酶K消化血清蛋白和抑制蛋白酶K的步骤顺序竞争性结合分析中的活动。该方法的优点是在生理相关值的整个范围内具有高精度，并且可以容易地适应于血清和血浆样品的全自动分析。

5. 发明申请

WO2012136720A1 BESTIMMUNG VON VITAMIN-D-METABOLITEN IN TROCKENBLUT 审中-公开
标题翻译：维生素D的代谢产物在干燥测定血
公开(公告)号：WO2012136720A1
公开(公告)日：2012-10-11
申请号：PCT/EP2012/056204
申请日：2012-04-04
申请人： IMMUNDIAGNOSTIK AG , ARMBRUSTER, Franz Paul , GRÖN, Hans Jürgen , SCHUMANN, Claudia
发明人： ARMBRUSTER, Franz Paul , GRÖN, Hans Jürgen , SCHUMANN, Claudia
IPC分类号： G01N33/82
CPC分类号： G01N33/82
摘要： Verfahren und Testkit zur quantitativen Bestimmung von Vitamin-D-Metaboliten in Blut, wobei präanalytisch auf einem festen Sorptionsmaterial eine vorgegebene Menge Blut immobilisiert wird. Dadurch hat eine Hämolyse des Bluts auf die Analytik der Vitamin-D- Metabolite keine Auswirkung. Für die quantitative Analyse wird der Trockenblutspot auf dem Sorptionsmaterial angelöst mit einem detergenshaltigen wässrigem Lösepuffer, pH 7,0 bis 10,0 und die Vitamin-D-Metabolite eluiert mit einer protischen organischen Lösung, welche eine Permittivität kleiner 35 besitzt. Das Eluat wird auf Vitamin-D- Metabolite in üblicher weise analysiert.
摘要翻译：用于定量测定的在血液中维生素D代谢物，其中的血液präanalytisch预定量的固定于固体吸附材料的方法和检验试剂盒。这对维生素D代谢物分析的血液溶血没有任何效果。对于干燥血点的定量分析部分溶解在与含洗涤剂水溶剂缓冲液，pH7.0〜10.0的吸附剂材料，并用质子性有机溶剂，其具有介电常数小于35洗脱的维生素D代谢物将洗脱液分析以常规方式的维生素D代谢物。

6. 发明申请

WO2011000970A3 BONE GRAFT AND BIOCOMPOSITE FOR PROSTHETIC DENTISTRY 审中-公开
公开(公告)号：WO2011000970A3
公开(公告)日：2011-01-06
申请号：PCT/EP2010/059588
申请日：2010-07-05
申请人： ARMBRUSTER BIOTECHNOLOGY GMBH , ARMBRUSTER, Franz Paul , BRIANT, Rolf
发明人： ARMBRUSTER, Franz Paul , BRIANT, Rolf
IPC分类号： A61L27/36 , A61L27/42
摘要： A bone graft or biocomposite for treating osseous defects and neogenesis of bone which is a composite of a biodegradable polymer and granules of beta-tricalciumphosphate, further comprising as active ingredient and embedded in the biodegradable polymer a physiologically effective amount of underglycosylated recombinant human BSP as a mutidental clathrate with a basic organic compound which simulataneously is active as a plasticizer for the biodegradable polymer. The biocomposite is moldable and shapable, hardens rapidly in situ when placed by surgery or prosthetic dentistry and which furthers osseous repair and the healing of damage or diseased tissues and lesions.

7. 发明申请

WO2023017050A1 DIFFERENTIAL DIAGNOSIS OF HISTAMINE INTOLERANCE SYNDROME 审中-公开
公开(公告)号：WO2023017050A1
公开(公告)日：2023-02-16
申请号：PCT/EP2022/072378
申请日：2022-08-09
申请人： IMMUNDIAGNOSTIK AG
发明人： ARMBRUSTER, Franz Paul , DIESNER, Max
IPC分类号： G01N33/68
摘要： A method for diagnosing histamine intolerance syndrome in a patient suspected of suffering from insufficient histamine inactivation activity. The diagnostic procedure involves spiking or administering of histamine labelled with a stable isotope. Samples (usually serum, plasma, urine) are taken after one or more predetermined periods of time and an aprotic solvent is added to remove proteins and organic salts. The amounts of isotopically labelled histamine in the samples and, if applicable, one or more isotopically labelled inactivation products of histamine are determined by hydrophilic interaction chromatography and mass spectrometry. The histamine inactivation activity can then be determined from the amounts and ratios of isotopically labelled histamine, imidazole acetic acid, and methylhistamine, and optionally methylimidazole acetic acid. Diagnosis is based on the comparison with the histamine inactivation found in healthy individuals.

8. 发明申请

WO2020094880A3 BONE SIALOPROTEIN FUNCTIONALIZED MATERIALS FOR DIRECTED BONE REGENERATION 审中-公开
公开(公告)号：WO2020094880A3
公开(公告)日：2020-05-14
申请号：PCT/EP2019/080768
申请日：2019-11-08
申请人： IMMUNDIAGNOSTIK AG , JOHANNES GUTENBERG-UNIVERSITÄT MAINZ
发明人： ARMBRUSTER, Franz Paul , ROMMENS, Pol Maria , RITZ, Ulrike
IPC分类号： A61L27/18 , A61L27/24 , A61L27/48 , A61L27/54 , A61L27/56 , B33Y70/00 , B33Y80/00
摘要： A prosthetic polylactide or collagen-containing scaffold material for treating osseous defects and neogenesis of bone, obtained by the steps of printing a scaffold composed of strings of polylactide and porous microstructures which allow passage and ingrowth of bone tissue. A soluble mixture of BSP and/or collagen is provided, and BSP and/or collagen is applied onto the strings and in the pores of the printed body to obtain a prosthetic material which induces tissue-directed ingrowth of bone tissue as well as repair and healing of damaged or diseased bone tissues and lesions. The prosthetic material has thereby been made osseo-inductive and osseo-conductive. The BSP in the prosthetic scaffold material induces a tissue-directed growth of osseous tissue. No undirectional callous or overgrowing bone and cartilage tissue is observed.

9. 发明申请

WO2019134948A1 METHOD OF MEASURING THE ENDOCYTIC VITAMIN D STATUS 审中-公开
公开(公告)号：WO2019134948A1
公开(公告)日：2019-07-11
申请号：PCT/EP2019/050121
申请日：2019-01-03
申请人： IMMUNDIAGNOSTIK AG
发明人： ARMBRUSTER, Franz Paul , SCHAEFER, Liliana
IPC分类号： G01N33/82
摘要： Test kit, composition and a method of measuring vitamin D and its metabolites in a sample of bodily fluid from a subject, which sample contains vitamin D binding protein (DBP), comprising the steps of contacting said sample with megalin and/or a soluble fragment thereof under binding conditions to form a ternary complex containing DBP, a vitamin D metabolite and megalin or a fragment thereof; determining the amount of DBP bound by megalin; and relating the amount of megalin-bound DBP to the effective status of vitamin D in the circulation of said subject.

10. 发明申请

WO2023025913A1 STOOL COLLECTION AND EXTRACTION SYSTEM FOR HUMAN MICROBIOM ANALYSIS 审中-公开
公开(公告)号：WO2023025913A1
公开(公告)日：2023-03-02
申请号：PCT/EP2022/073728
申请日：2022-08-25
申请人： IMMUNDIAGNOSTIK AG
发明人： ARMBRUSTER, Franz Paul , RITTINGHAUS, Bernd , ZUDE, Ingmar
IPC分类号： A61B10/00
摘要： A specimen collecting system (10) with an elongated sampling utensil (100) for fecal matter and an integrated container for transport, preservation, and extraction of the collected sample. The system comprises an open-ended tubular structure (30) with a fitting hole at an intermediate position (50). The tubular structure can be tightly closed at both ends by screw caps (20, 40). The top cap (20) is integrally molded with or attached to a sampling utensil (100) that is inserted into the tubular structure (30) in the axial direction. The bottom cap (40) forms a liquid-tight distal chamber (32) with the tubular structure (30) and the sampling utensil (100) when inserted into the fitting hole, which is, therefore, capable of receiving a buffer solution. The elongated sampling utensil (100) has a fenestrated segment (110) with a sampling cavity (104) at its axial distal end and a cut-out member (106) at its forward end. The outer dimensions of the sampling utensil and the fenestrated segment (110) cooperate with the fitting hole. The proximal compartment (33) of the tubular structure (30) contains integrally formed with the inner wall spaced guide ribs (310) which direct the sampling utensil (100) through the fitting hole so that fecal matter adhering to or exiting the fenestrated segment (110) is retained in the proximal compartment (33) and displaced into the free space between the guide ribs (310) or within the proximal compartment (33). The fecal specimen collecting system is beneficial for microbiome studies as patients can use the self- explanatory sampling utensil and the cookie-cutter method for a reproducible collection of defined volumes of a stool samples.

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