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1. 发明专利

IL279563D0 Flow cell systems and methods related to same 未知
公开(公告)号：IL279563D0
公开(公告)日：2021-01-31
申请号：IL27956320
申请日：2020-12-17
申请人： ILLUMINA INC , RIVAL ARNAUD , AGAH ALI , DEHLINGER DIETRICH , FUNG TRACY H , CAI XIUYU
发明人： RIVAL ARNAUD , AGAH ALI , DEHLINGER DIETRICH , FUNG TRACY H , CAI XIUYU
IPC分类号： B01L3/00 , B01L9/00 , G01N21/05 , G01N21/64 , G01N21/76
摘要： Flow cells systems and corresponding methods are provided. The flow cells systems may include a socket comprising a base portion, a plurality of electrical contacts and a cover portion that includes a first port. The flow cells systems may also include a flow cell device secured within an enclosure of the socket. The flow cell device may comprise a frameless light detection device comprising a base wafer portion, a plurality of dielectric layers, a reaction structure, a plurality of light guides, a plurality of light sensors, and device circuitry electrically coupled to the light sensors. The flow cell device may also comprise a lid forming a flow channel over the reaction structure that includes a second port in communication with the flow channel and the first port of the socket. The device circuity of the light detection device may be electrically coupled to the electrical contacts of the socket.

2. 发明专利

IL271227B Image sensor structure 未知
公开(公告)号：IL271227B
公开(公告)日：2022-11-01
申请号：IL27122719
申请日：2019-12-05
申请人： ILLUMINA INC , FUNG TRACY HELEN , CAI XIUYU , AGAH ALI , DEHLINGER DIETRICH
发明人： FUNG TRACY HELEN , CAI XIUYU , AGAH ALI , DEHLINGER DIETRICH
IPC分类号： G01N21/05 , G01N21/64 , G01N33/50 , H01L27/146
摘要： An example image sensor structure includes an image layer with an array of light detectors disposed therein. A device stack is disposed over the image layer, with an array of light guides disposed therein. Each light guide is associated with at least one light detector of the array of light detectors. A passivation stack is disposed over the device stack, comprising a passivation layer and a chemical protection layer disposed over the passivation layer, and preferably including a bottom surface in direct contact with a top surface of the light guides. An array of nanowells is disposed in a top layer of the passivation stack, with the contours of the nanowells formed by a top layer of the passivation stack. Each nanowell is associated with a light guide. A crosstalk blocking metal structure is disposed in the passivation stack, which reduces crosstalk within the passivation stack.

3. 发明专利

IL271227D0 Image sensor structure 未知
公开(公告)号：IL271227D0
公开(公告)日：2020-01-30
申请号：IL27122719
申请日：2019-12-05
申请人： ILLUMINA INC , FUNG TRACY HELEN , CAI XIUYU , AGAH ALI , DEHLINGER DIETRICH
发明人： FUNG TRACY HELEN , CAI XIUYU , AGAH ALI , DEHLINGER DIETRICH
IPC分类号： H01L20060101
摘要： An example image sensor structure (100) includes an image layer (108) with an array of light detectors (112) disposed therein. A device stack (126) is disposed over the image layer (108), with an array of light guides (130) disposed therein. Each light guide (130) is associated with at least one light detector of the array of light detectors (112). A passivation stack (104) is disposed over the device stack (126), comprising a passivation layer (142) and a chemical protection layer (144) disposed over the passivation layer (142), and preferably including a bottom surface (140) in direct contact with a top surface (132) of the light guides (130). An array of nanowells (120) is disposed in a top layer (144) of the passivation stack (104), with the contours of the nanowells (120) formed by a top layer (144) of the passivation stack (104). Each nanowell (120) is associated with a light guide (130). A crosstalk blocking metal structure (102/106) is disposed in the passivation stack (104), which reduces crosstalk within the passivation stack (104).

4. 发明专利

IL279384D0 Flow cells and methods related to same 未知
公开(公告)号：IL279384D0
公开(公告)日：2021-01-31
申请号：IL27938420
申请日：2020-12-10
申请人： ILLUMINA INC , BOWEN M SHANE , FUNG TRACY HELEN , KHURANA TARUN , AGAH ALI , DEHLINGER DIETRICH , SABOUNCHI POORYA , RIVAL ARNAUD , CIESLA CRAIG M
发明人： BOWEN M SHANE , FUNG TRACY HELEN , KHURANA TARUN , AGAH ALI , DEHLINGER DIETRICH , SABOUNCHI POORYA , RIVAL ARNAUD , CIESLA CRAIG M
IPC分类号： G01N21/05 , G01N15/14 , G01N21/64 , G01N35/00
摘要： Flow cells and corresponding methods are provided. The flow cells may include a support frame with top and back sides, and at least one cavity extending from the top side. The flow cells may include at least one light detection device with an active area disposed within the at least one cavity. The flow cells may include a support material disposed within the at least one cavity between the support frame and the periphery of the at least one light detection device coupling them together. The flow cells may include a lid extending over the at least one light detection device and coupled to the support frame about the periphery of the at least one light detection device. The lid and at least a top surface of the at least one light detection device form a flow channel therebetween.

5. 发明专利

IL279427D0 Sensors having an active surface 未知
公开(公告)号：IL279427D0
公开(公告)日：2021-01-31
申请号：IL27942720
申请日：2020-12-13
申请人： ILLUMINA INC , EMADI ARVIN , RIVAL ARNAUD , AGAH ALI
发明人： EMADI ARVIN , RIVAL ARNAUD , AGAH ALI
IPC分类号： G01N21/05 , G01N15/00 , G01N21/64 , H01L23/00 , H01L27/146
摘要： Disclosed in one example is an apparatus including a substrate, a sensor over the substrate including an active surface and a sensor bond pad, a molding layer over the substrate and covering sides of the sensor, the molding layer having a molding height relative to a top surface of the substrate that is greater than a height of the active surface of the sensor relative to the top surface of the substrate, and a lidding layer over the molding layer and over the active surface. The lidding layer and the molding layer form a space over the active surface of the sensor that defines a flow channel.

6. 发明专利

RU2769537C1 СИСТЕМА ПРОТОЧНЫХ КЮВЕТ И СВЯЗАННЫЙ С НЕЙ СПОСОБ 未知
公开(公告)号：RU2769537C1
公开(公告)日：2022-04-01
申请号：RU2021118515
申请日：2019-11-08
申请人： ILLUMINA INC
发明人： RIVAL ARNAUD , AGAH ALI , DEHLINGER DIETRICH , FUNG TRACY H , CAI XIUYU
IPC分类号： G01N21/64
摘要： Изобретениеотноситсяк системепроточныхкювети соответствующемуспособу. Системапроточныхкюветсодержитгнездо, содержащееоснование, множествоэлектрическихконтактови закрывающуючасть, соединеннуюс основанием, содержащимпоменьшеймереодинпервыйпорт, причемоснованиеи закрывающаячастьвместеобразуюткамеру, приэтомэлектрическиеконтактыпроходятмеждукамеройи наружнойсторонойоснования, ипричемпоменьшеймереодинпервыйпортпроходитмеждукамеройи наружнойсторонойзакрывающейчасти; иустройствопроточнойкюветы, закрепленноевнутрикамерыгнезда, содержащеебескорпусноеустройствообнаружениясвета, содержащеечастьбазовойпластины, множестводиэлектрическихслоев, проходящихнадчастьюбазовойпластины, реакционнуюструктуру, проходящуюнаддиэлектрическимислоями, котораясодержитповерхностьдетектора, множествосветочувствительныхдатчиков, электрическуюсхемуустройства, проходящуючерездиэлектрическиеслои, электрическисоединеннуюсосветочувствительнымидатчикамидляпередачисигналовданныхнаоснованиифотонов, обнаруженныхсветочувствительнымидатчиками, имножествосветоводов, связанныхсосветочувствительнымидатчиками, икрышку, проходящуюнадповерхностьюдетекторас проточнымканаломмеждуними, причемкрышкасодержитпоменьшеймереодинвторойпорт, находящийсяв сообщениис проточнымканаломи поменьшеймереоднимпервымпортомгнезда, приэтомэлектрическаясхемаустройстваобнаружениясветаустройствапроточнойкюветыэлектрическисоединенас электрическимиконтактамигнезда. Техническимрезультатомявляетсяуменьшениеразмерапроточнойкюветы. 3 н. и 20 з.п. ф-лы, 15 ил.

7. 发明专利

AU2021225127A1 Systems and devices for high-throughput sequencing with semiconductor-based detection 未知
公开(公告)号：AU2021225127A1
公开(公告)日：2021-09-30
申请号：AU2021225127
申请日：2021-08-30
申请人： ILLUMINA INC
发明人： DEHLINGER DIETRICH , AGAH ALI , FUNG TRACY HELEN , KOSTEM EMRAH , HETHERINGTON CRAIG
IPC分类号： G01N21/64 , B01L3/00 , C12Q1/68 , C40B30/04 , C40B50/14 , G01N21/76 , H01L27/146
摘要： In one embodiment, a sample surface of a biosensor includes pixel areas and holds a plurality of clusters during a sequence of sampling events such that the clusters are distributed unevenly over the pixel areas. In another embodiment, a biosensor has a sample surface that includes pixel areas and an array of wells overlying the pixel areas, the biosensor including two wells and two clusters per pixel area. The two wells per pixel area include a dominant well and a subordinate well. The dominant well has a larger cross section over the pixel area than the subordinate well. In another embodiment, an illumination system is coupled to a biosensor that illuminates the pixel areas with different angles of illumination during a sequence of sampling events, including, for a sampling event, illuminating each of the wells with off-axis illumination to produce asymmetrically illuminated well regions in each of the wells.

8. 发明专利

PH12020552295A1 FLOW CELLS AND METHODS RELATED TO SAME 未知
公开(公告)号：PH12020552295A1
公开(公告)日：2021-09-01
申请号：PH12020552295
申请日：2020-12-22
申请人： ILLUMINA INC
发明人： RIVAL ARNAUD , AGAH ALI , FUNG TRACY H , DEHLINGER DIETRICH , SABOUNCHI POORYA , KHURANA TARUN , CIESLA CRAIG M , BOWEN SHANE M
IPC分类号： G01N15/14 , B01L3/00 , G01N21/03 , G01N33/49
摘要： Flow cells and corresponding methods are provided. The flow cells may include a support frame with top and back sides, and at least one cavity extending from the top side. The flow cells may include at least one light detection device with an active area disposed within the at least one cavity. The flow cells may include a support material disposed within the at least one cavity between the support frame and the periphery of the at least one light detection device coupling them together. The flow cells may include a lid extending over the at least one light detection device and coupled to the support frame about the periphery of the at least one light detection device. The lid and at least a top surface of the at least one light detection device form a flow channel therebetween.

9. 发明专利

SG11202012939PA METHODS AND DEVICES FOR MIXING IN A MICROFLUIDIC SYSTEM 未知
公开(公告)号：SG11202012939PA
公开(公告)日：2021-01-28
申请号：SG11202012939P
申请日：2020-02-07
申请人： ILLUMINA INC
发明人： KARUNAKARAN AATHAVAN , RIVAL ARNAUD , AGAH ALI , ABEILLE FABIEN , BARNARD STEVEN , CIESLA CRAIG , VENKATESAN MURALI , GHEISSARI PARGOL , WANG JENNIFER , DEHLINGER DIETRICH
IPC分类号： B01F5/06 , B01F13/00 , B01F5/10 , B01F11/02 , B01F13/08
摘要： A method for reducing sequencing by synthesis cycle time using a microfluidic device is provided. The microfluidic device comprises a flow cell having an inlet port, an outlet port, and a flow channel extending between the inlet port and the outlet port, wherein the flow channel receives an analyte of interest and one or more reagents for analyzing and detecting molecules. To aid in the acceleration of the reactions, the microfluidic device comprises a mixing device to increase the rates of diffusion of the reagents from the fluid bulk to an active surface of the flow cell. The mixing device comprises at least one of an electrothermal mixing device, an active mechanical mixing device, and a vibrational mixing device.

10. 发明专利

SG11202012810TA SYSTEM AND METHOD FOR STORAGE 未知
公开(公告)号：SG11202012810TA
公开(公告)日：2021-01-28
申请号：SG11202012810T
申请日：2020-05-26
申请人： ILLUMINA INC
发明人： SIU MEREK , AGAH ALI , HONG STANLEY , KHURANA TARUN , KARUNAKARAN AATHAVAN , CIESLA CRAIG , KIA AMIRALI
IPC分类号： G11C29/04 , G11C13/04
摘要： Devices, systems, and methods for non-volatile storage include a well activation device operable to modify one or more wells from a plurality of wells of a flow cell to provide a set of readable wells. Readable wells are configured to allow exposure of a well to substances from nucleotide sequencing fluids, and prevent exposure to other substances and fluids, such as nucleotide synthesizing fluids. The well activation device may also modify wells to provide a set of writeable wells. This set of wells is configured to allow exposure to the nucleotide synthesizing fluids and substances; and prevent exposure to the nucleotide sequencing fluids and substances. There may also be provisions made for risk mitigation for data errors such as generating commands to write specified data to a nucleotide sequence associated with a particular location in a storage device, reading the nucleotide sequence and performing a comparison.

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